Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Selumetinib (AZD6244 or ARRY-142886) is a potent, selective, and ATP-uncompetitive inhibitor of Ras-Raf-mitogen-activated protein kinase kinase (MEK1/2). This inhibition can prevent ERK activation, disrupt downstream signal transduction, and inhibit ...
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Vandetanib, 4-anilinoquinazoline, is an anti-cancer drug that with the potential for use in a broad range of tumour types. In 2011 vandetanib (trade name Caprelsa) was approved by the FDA to treat nonresectable, locally advanced, or metastatic medull...
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
CUDC-907 is a small molecule inhibitor of histone deacetylase and PI3 kinase developed by Curis. It is investigated in clinical trials for the treatment of relapsed or refractory lymphomas, thyroid cancer, multiple myeloma, breast cancer and other ma...
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Motesanib (AMG 706), a novel nicotinamide, was identified as a potent, orally bioavailable inhibitor of the VEGFR1/Flt1, VEGFR2/kinase domain receptor/Flk-1, VEGFR3/Flt4 and Kit receptors. Motesanib was expected to reduce vascular permeability and b...
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Broquinaldol is a halogenated derivative of quinoline and a member of the class of compounds known as halogenated phenazines. Broquinaldol and related compounds have demonstrated efficacy against antibiotic-tolerant bacterial biofilms and Mycobacteri...
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
PLX-4720 is a pre-clinical analog of vemurafenib which selectively targets BRAFV600E. PLX-4720 was developed by Plexxikon for the treatment of thyroid cancer, however the drug did not reach clinical phase.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
First synthesized in 2004 by the group of Peter G. Schultz, reversine is a 2,6- diamino substituted purine showing a potent inhibition on Aurora B, a protein kinase overexpressed in a variety of solid tumors. Due to its relevance in the cell cycle re...
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
6-Methoxy-2-naphthalenecarboxaldehyde is a substrate of aldehyde dehydrogenase enzymes (class I, class II and class III). It was examined as indicator of the aldehyde dehydrogenase (ALDH) activity in human tissue homogenates and accessible body fluid...
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
IODINE I-123 is a radioactive isotope of iodine used in nuclear medicine imaging, including single photon emission computed tomography (SPECT) and X-ray computed tomography (X-Ray CT) scans. Iodine-123 is usually supplied as sodium iodide (NaI) and h...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Aclarubicin (INN) or aclacinomycin A is an anthracycline drug is primarily indicated in conditions like Acute non-lymphoblastic leukemia, Breast cancer, Gastric cancer, Lymphoma, Ovarian coma, Small cell lung cancer, Thyroid cancer. Soil bacteria Str...