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This repository is under review for potential modification in compliance with Administration directives.

Details

Stereochemistry ACHIRAL
Molecular Formula C17H15BrClFN4O3
Molecular Weight 457.681
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SELUMETINIB

SMILES

CN1C=NC2=C(F)C(NC3=C(Cl)C=C(Br)C=C3)=C(C=C12)C(=O)NOCCO

InChI

InChIKey=CYOHGALHFOKKQC-UHFFFAOYSA-N
InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/17332304

Selumetinib (AZD6244 or ARRY-142886) is a potent, selective, and ATP-uncompetitive inhibitor of Ras-Raf-mitogen-activated protein kinase kinase (MEK1/2). This inhibition can prevent ERK activation, disrupt downstream signal transduction, and inhibit cancer cell proliferation and survival. Selumetinib has shown tumour suppressive activity in multiple rodent models of human cancer including melanoma, pancreatic, colon, lung, and breast cancers. AstraZeneca is responsible for development and commercialization of selumetinib.

CNS Activity

Curator's Comment: I.p. injection of AZD6244 prevented the development of pain in rats subjected to the chronic constriction injury and reversed already established pain in the spared nerve injury model. No human data available.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
1207 ng/mL
75 mg single, oral
dose: 75 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SELUMETINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
863 ng/mL
50 mg single, oral
dose: 50 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SELUMETINIB plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
647 ng/mL
100 mg single, oral
dose: 100 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SELUMETINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
6335 ng × h/mL
75 mg single, oral
dose: 75 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SELUMETINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
2620 ng × h/mL
50 mg single, oral
dose: 50 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SELUMETINIB plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
3299 ng × h/mL
100 mg single, oral
dose: 100 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SELUMETINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
5.33 h
75 mg single, oral
dose: 75 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SELUMETINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
7.34 h
50 mg single, oral
dose: 50 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SELUMETINIB plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
10 h
100 mg single, oral
dose: 100 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SELUMETINIB plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
0.4%
50 mg single, oral
dose: 50 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
SELUMETINIB plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
25 mg/m2 2 times / day steady, oral
Recommended
unhealthy, 10.2 years (range: 3.5 - 17.4 years)
Disc. AE: Creatinine increased, Weight increased...
AEs leading to
discontinuation/dose reduction:
Creatinine increased (2%)
Weight increased (2%)
Diarrhea (2%)
Paronychia (2%)
Malignant peripheral nerve sheath tumor (2%)
Acute kidney injury (2%)
Skin ulcer (2%)
Sources:
25 mg/m2 2 times / day steady, oral
Recommended
Dose: 25 mg/m2, 2 times / day
Route: oral
Route: steady
Dose: 25 mg/m2, 2 times / day
Sources:
unhealthy, 10.2 years (range: 3.5 - 17.4 years)
Health Status: unhealthy
Age Group: 10.2 years (range: 3.5 - 17.4 years)
Sex: M+F
Sources:
Disc. AE: Vomiting, Paronychia...
AEs leading to
discontinuation/dose reduction:
Vomiting (>5)
Paronychia (>5)
Diarrhea (>5)
Nausea (>5)
Abdominal pain (>5)
Rash (>5)
Skin infection (>5)
Influenza like illness (>5)
Pyrexia (>5)
Weight gain (>5)
Sources:
100 mg 2 times / day steady, oral
Dose: 100 mg, 2 times / day
Route: oral
Route: steady
Dose: 100 mg, 2 times / day
Sources:
unhealthy, 57.9 years (range: 30-76 years)
Health Status: unhealthy
Age Group: 57.9 years (range: 30-76 years)
Sex: M+F
Sources:
DLT: Acneiform dermatitis, Pleural effusion...
Dose limiting toxicities:
Acneiform dermatitis (grade 3)
Pleural effusion (grade 3)
Sources:
75 mg 2 times / day steady, oral
Dose: 75 mg, 2 times / day
Route: oral
Route: steady
Dose: 75 mg, 2 times / day
Sources:
unhealthy, 57.9 years (range: 30-76 years)
Health Status: unhealthy
Age Group: 57.9 years (range: 30-76 years)
Sex: M+F
Sources:
DLT: Fatigue...
Dose limiting toxicities:
Fatigue (grade 3)
Sources:
300 mg 2 times / day steady, oral
Highest studied dose
Dose: 300 mg, 2 times / day
Route: oral
Route: steady
Dose: 300 mg, 2 times / day
Sources:
unhealthy, 58 years (range: 29–78 years)
Health Status: unhealthy
Age Group: 58 years (range: 29–78 years)
Sex: M+F
Sources:
Other AEs: Dermatitis acneiform, Rash...
Other AEs:
Dermatitis acneiform (grade 3-4, 2 patients)
Rash (grade 3-4, 2 patients)
Rash erythematous (grade 3-4, 2 patients)
Rash maculo-papular (grade 3-4, 2 patients)
Rash pruritic (grade 3-4, 2 patients)
Diarrhea (grade 3-4, 1 patient)
Nausea (grade 1-2, 3 patients)
Fatigue (grade 1-2, 2 patients)
Peripheral edema (grade 1-2, 2 patients)
Vomiting (grade 1-2, 2 patients)
Blurred vision (grade 1-2, 3 patients)
Sources:
AEs

AEs

AESignificanceDosePopulation
Acute kidney injury 2%
Disc. AE
25 mg/m2 2 times / day steady, oral
Recommended
unhealthy, 10.2 years (range: 3.5 - 17.4 years)
Creatinine increased 2%
Disc. AE
25 mg/m2 2 times / day steady, oral
Recommended
unhealthy, 10.2 years (range: 3.5 - 17.4 years)
Diarrhea 2%
Disc. AE
25 mg/m2 2 times / day steady, oral
Recommended
unhealthy, 10.2 years (range: 3.5 - 17.4 years)
Malignant peripheral nerve sheath tumor 2%
Disc. AE
25 mg/m2 2 times / day steady, oral
Recommended
unhealthy, 10.2 years (range: 3.5 - 17.4 years)
Paronychia 2%
Disc. AE
25 mg/m2 2 times / day steady, oral
Recommended
unhealthy, 10.2 years (range: 3.5 - 17.4 years)
Skin ulcer 2%
Disc. AE
25 mg/m2 2 times / day steady, oral
Recommended
unhealthy, 10.2 years (range: 3.5 - 17.4 years)
Weight increased 2%
Disc. AE
25 mg/m2 2 times / day steady, oral
Recommended
unhealthy, 10.2 years (range: 3.5 - 17.4 years)
Abdominal pain >5
Disc. AE
25 mg/m2 2 times / day steady, oral
Recommended
Dose: 25 mg/m2, 2 times / day
Route: oral
Route: steady
Dose: 25 mg/m2, 2 times / day
Sources:
unhealthy, 10.2 years (range: 3.5 - 17.4 years)
Health Status: unhealthy
Age Group: 10.2 years (range: 3.5 - 17.4 years)
Sex: M+F
Sources:
Diarrhea >5
Disc. AE
25 mg/m2 2 times / day steady, oral
Recommended
Dose: 25 mg/m2, 2 times / day
Route: oral
Route: steady
Dose: 25 mg/m2, 2 times / day
Sources:
unhealthy, 10.2 years (range: 3.5 - 17.4 years)
Health Status: unhealthy
Age Group: 10.2 years (range: 3.5 - 17.4 years)
Sex: M+F
Sources:
Influenza like illness >5
Disc. AE
25 mg/m2 2 times / day steady, oral
Recommended
Dose: 25 mg/m2, 2 times / day
Route: oral
Route: steady
Dose: 25 mg/m2, 2 times / day
Sources:
unhealthy, 10.2 years (range: 3.5 - 17.4 years)
Health Status: unhealthy
Age Group: 10.2 years (range: 3.5 - 17.4 years)
Sex: M+F
Sources:
Nausea >5
Disc. AE
25 mg/m2 2 times / day steady, oral
Recommended
Dose: 25 mg/m2, 2 times / day
Route: oral
Route: steady
Dose: 25 mg/m2, 2 times / day
Sources:
unhealthy, 10.2 years (range: 3.5 - 17.4 years)
Health Status: unhealthy
Age Group: 10.2 years (range: 3.5 - 17.4 years)
Sex: M+F
Sources:
Paronychia >5
Disc. AE
25 mg/m2 2 times / day steady, oral
Recommended
Dose: 25 mg/m2, 2 times / day
Route: oral
Route: steady
Dose: 25 mg/m2, 2 times / day
Sources:
unhealthy, 10.2 years (range: 3.5 - 17.4 years)
Health Status: unhealthy
Age Group: 10.2 years (range: 3.5 - 17.4 years)
Sex: M+F
Sources:
Pyrexia >5
Disc. AE
25 mg/m2 2 times / day steady, oral
Recommended
Dose: 25 mg/m2, 2 times / day
Route: oral
Route: steady
Dose: 25 mg/m2, 2 times / day
Sources:
unhealthy, 10.2 years (range: 3.5 - 17.4 years)
Health Status: unhealthy
Age Group: 10.2 years (range: 3.5 - 17.4 years)
Sex: M+F
Sources:
Rash >5
Disc. AE
25 mg/m2 2 times / day steady, oral
Recommended
Dose: 25 mg/m2, 2 times / day
Route: oral
Route: steady
Dose: 25 mg/m2, 2 times / day
Sources:
unhealthy, 10.2 years (range: 3.5 - 17.4 years)
Health Status: unhealthy
Age Group: 10.2 years (range: 3.5 - 17.4 years)
Sex: M+F
Sources:
Skin infection >5
Disc. AE
25 mg/m2 2 times / day steady, oral
Recommended
Dose: 25 mg/m2, 2 times / day
Route: oral
Route: steady
Dose: 25 mg/m2, 2 times / day
Sources:
unhealthy, 10.2 years (range: 3.5 - 17.4 years)
Health Status: unhealthy
Age Group: 10.2 years (range: 3.5 - 17.4 years)
Sex: M+F
Sources:
Vomiting >5
Disc. AE
25 mg/m2 2 times / day steady, oral
Recommended
Dose: 25 mg/m2, 2 times / day
Route: oral
Route: steady
Dose: 25 mg/m2, 2 times / day
Sources:
unhealthy, 10.2 years (range: 3.5 - 17.4 years)
Health Status: unhealthy
Age Group: 10.2 years (range: 3.5 - 17.4 years)
Sex: M+F
Sources:
Weight gain >5
Disc. AE
25 mg/m2 2 times / day steady, oral
Recommended
Dose: 25 mg/m2, 2 times / day
Route: oral
Route: steady
Dose: 25 mg/m2, 2 times / day
Sources:
unhealthy, 10.2 years (range: 3.5 - 17.4 years)
Health Status: unhealthy
Age Group: 10.2 years (range: 3.5 - 17.4 years)
Sex: M+F
Sources:
Acneiform dermatitis grade 3
DLT
100 mg 2 times / day steady, oral
Dose: 100 mg, 2 times / day
Route: oral
Route: steady
Dose: 100 mg, 2 times / day
Sources:
unhealthy, 57.9 years (range: 30-76 years)
Health Status: unhealthy
Age Group: 57.9 years (range: 30-76 years)
Sex: M+F
Sources:
Pleural effusion grade 3
DLT
100 mg 2 times / day steady, oral
Dose: 100 mg, 2 times / day
Route: oral
Route: steady
Dose: 100 mg, 2 times / day
Sources:
unhealthy, 57.9 years (range: 30-76 years)
Health Status: unhealthy
Age Group: 57.9 years (range: 30-76 years)
Sex: M+F
Sources:
Fatigue grade 3
DLT
75 mg 2 times / day steady, oral
Dose: 75 mg, 2 times / day
Route: oral
Route: steady
Dose: 75 mg, 2 times / day
Sources:
unhealthy, 57.9 years (range: 30-76 years)
Health Status: unhealthy
Age Group: 57.9 years (range: 30-76 years)
Sex: M+F
Sources:
Fatigue grade 1-2, 2 patients
300 mg 2 times / day steady, oral
Highest studied dose
Dose: 300 mg, 2 times / day
Route: oral
Route: steady
Dose: 300 mg, 2 times / day
Sources:
unhealthy, 58 years (range: 29–78 years)
Health Status: unhealthy
Age Group: 58 years (range: 29–78 years)
Sex: M+F
Sources:
Peripheral edema grade 1-2, 2 patients
300 mg 2 times / day steady, oral
Highest studied dose
Dose: 300 mg, 2 times / day
Route: oral
Route: steady
Dose: 300 mg, 2 times / day
Sources:
unhealthy, 58 years (range: 29–78 years)
Health Status: unhealthy
Age Group: 58 years (range: 29–78 years)
Sex: M+F
Sources:
Vomiting grade 1-2, 2 patients
300 mg 2 times / day steady, oral
Highest studied dose
Dose: 300 mg, 2 times / day
Route: oral
Route: steady
Dose: 300 mg, 2 times / day
Sources:
unhealthy, 58 years (range: 29–78 years)
Health Status: unhealthy
Age Group: 58 years (range: 29–78 years)
Sex: M+F
Sources:
Blurred vision grade 1-2, 3 patients
300 mg 2 times / day steady, oral
Highest studied dose
Dose: 300 mg, 2 times / day
Route: oral
Route: steady
Dose: 300 mg, 2 times / day
Sources:
unhealthy, 58 years (range: 29–78 years)
Health Status: unhealthy
Age Group: 58 years (range: 29–78 years)
Sex: M+F
Sources:
Nausea grade 1-2, 3 patients
300 mg 2 times / day steady, oral
Highest studied dose
Dose: 300 mg, 2 times / day
Route: oral
Route: steady
Dose: 300 mg, 2 times / day
Sources:
unhealthy, 58 years (range: 29–78 years)
Health Status: unhealthy
Age Group: 58 years (range: 29–78 years)
Sex: M+F
Sources:
Diarrhea grade 3-4, 1 patient
300 mg 2 times / day steady, oral
Highest studied dose
Dose: 300 mg, 2 times / day
Route: oral
Route: steady
Dose: 300 mg, 2 times / day
Sources:
unhealthy, 58 years (range: 29–78 years)
Health Status: unhealthy
Age Group: 58 years (range: 29–78 years)
Sex: M+F
Sources:
Dermatitis acneiform grade 3-4, 2 patients
300 mg 2 times / day steady, oral
Highest studied dose
Dose: 300 mg, 2 times / day
Route: oral
Route: steady
Dose: 300 mg, 2 times / day
Sources:
unhealthy, 58 years (range: 29–78 years)
Health Status: unhealthy
Age Group: 58 years (range: 29–78 years)
Sex: M+F
Sources:
Rash erythematous grade 3-4, 2 patients
300 mg 2 times / day steady, oral
Highest studied dose
Dose: 300 mg, 2 times / day
Route: oral
Route: steady
Dose: 300 mg, 2 times / day
Sources:
unhealthy, 58 years (range: 29–78 years)
Health Status: unhealthy
Age Group: 58 years (range: 29–78 years)
Sex: M+F
Sources:
Rash maculo-papular grade 3-4, 2 patients
300 mg 2 times / day steady, oral
Highest studied dose
Dose: 300 mg, 2 times / day
Route: oral
Route: steady
Dose: 300 mg, 2 times / day
Sources:
unhealthy, 58 years (range: 29–78 years)
Health Status: unhealthy
Age Group: 58 years (range: 29–78 years)
Sex: M+F
Sources:
Rash pruritic grade 3-4, 2 patients
300 mg 2 times / day steady, oral
Highest studied dose
Dose: 300 mg, 2 times / day
Route: oral
Route: steady
Dose: 300 mg, 2 times / day
Sources:
unhealthy, 58 years (range: 29–78 years)
Health Status: unhealthy
Age Group: 58 years (range: 29–78 years)
Sex: M+F
Sources:
Rash grade 3-4, 2 patients
300 mg 2 times / day steady, oral
Highest studied dose
Dose: 300 mg, 2 times / day
Route: oral
Route: steady
Dose: 300 mg, 2 times / day
Sources:
unhealthy, 58 years (range: 29–78 years)
Health Status: unhealthy
Age Group: 58 years (range: 29–78 years)
Sex: M+F
Sources:
OverviewDrug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
no
no
no
no
no
no
weak [IC50 45.3 uM]
weak [IC50 52.1 uM]
weak [IC50 >100 uM]
weak [IC50 >100 uM]
weak [IC50 >70 uM]
weak [IC50 >70 uM]
weak [IC50 >70 uM]
weak [IC50 >70 uM]
weak [IC50 >70 uM]
weak
weak
weak
weak
weak
weak
weak
weak
weak
weak
weak
yes [IC50 19 uM]
yes [IC50 8.76 uM]
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
weak
weak
weak
weak
weak
yes
yes
yes
yes (co-administration study)
Comment: fluconazole increased selumetinib AUC by 53%
Page: 101, 107
yes
yes (co-administration study)
Comment: itraconazole increased selumetinib AUC by 49%; fluconazole increased selumetinib exposure 50%; rifampicin reduced selumetinib exposure 51%; erythromycin increased selumetinib AUC by 40%; efavirenz reduced selumetinib AUC by 40%
Page: 92, 101, 106
Tox targets

Tox targets

PubMed

PubMed

TitleDatePubMed
Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.
2010 Nov 24
Comprehensive analysis of kinase inhibitor selectivity.
2011 Oct 30
Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification.
2012 Jul
MEK and the inhibitors: from bench to bedside.
2013 Apr 12
Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells.
2013 Sep 1
Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids.
2014 Mar
Patents

Sample Use Guides

Oral selumetinib (50, 100 and 200mg bid for 28-day cycles) was well tolerated in patients with refractory solid tumours. The maximum tolerated dose was established to be 200mg bid. 100 mg dose of selumetinib proved to be more tolerable than the 200mg dose over prolonged periods. The 100mg dose has been chosen for phase II studies.
Route of Administration: Oral
The sensitivity of a large panel of cell lines to Selumetinib (AZD6244 or ARRY-142886) was evaluated in vitro and correlated with RAS and BRAF gene mutation status. There was a wide range of sensitivity to AZD6244 from highly sensitive (IC50, <100 nmol/L) to highly resistant (>10 μmol/L)
Name Type Language
SELUMETINIB
INN   USAN   WHO-DD  
INN   USAN  
Official Name English
selumetinib [INN]
Preferred Name English
5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
Systematic Name English
SELUMETINIB [MI]
Common Name English
ARRY-886
Code English
AZD6244
Code English
Selumetinib [WHO-DD]
Common Name English
AZD-6244
Code English
1H-BENZIMIDAZOLE-6-CARBOXAMIDE, 5-((4-BROMO-2-CHLOROPHENYL)AMINO)-4-FLUORO-N-(2- HYDROXYETHOXY)-1-METHYL-
Common Name English
SELUMETINIB [USAN]
Common Name English
Classification Tree Code System Code
EU-Orphan Drug EU/3/18/2050
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
NCI_THESAURUS C69145
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
NCI_THESAURUS C129825
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
FDA ORPHAN DRUG 475815
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
FDA ORPHAN DRUG 624017
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
FDA ORPHAN DRUG 471015
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
Code System Code Type Description
RXCUI
2289380
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
PRIMARY
INN
9078
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
PRIMARY
EPA CompTox
DTXSID3048944
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
PRIMARY
SMS_ID
100000124313
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
PRIMARY
CAS
606143-52-6
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
PRIMARY
DRUG CENTRAL
5388
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
PRIMARY
NCI_THESAURUS
C66939
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
PRIMARY
DAILYMED
6UH91I579U
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
PRIMARY
USAN
XX-36
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
PRIMARY
MERCK INDEX
m12218
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
PRIMARY
WIKIPEDIA
SELUMETINIB
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
PRIMARY
CHEBI
90227
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
PRIMARY
FDA UNII
6UH91I579U
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
PRIMARY
PUBCHEM
10127622
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
PRIMARY
DRUG BANK
DB11689
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
PRIMARY
ChEMBL
CHEMBL1614701
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
PRIMARY
EVMPD
SUB32237
Created by admin on Mon Mar 31 18:26:39 GMT 2025 , Edited by admin on Mon Mar 31 18:26:39 GMT 2025
PRIMARY