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Thiamine deficiency

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Oxidative Stress

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Thiamin pyrophosphokinase 1

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carbohydrate metabolic process

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Eijkman, C.

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Research group from Japan

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VITAMINS

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VITAMIN B1, PLAIN AND IN COMBINATION WITH VITAMIN B6 AND B12

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Vitamin B1, plain

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Salts, Hydrates, Esters, etc.

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Showing 1 - 10 of 13 results

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THIAMINE ION

4ABT0J945J

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Status:

US Approved Rx (1972)

First approved in 1947

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Thiamin pyrophosphokinase 1

Oxidative Stress

carbohydrate metabolic process

Conditions:

Thiamine deficiency

Thiamine, also known as vitamin B1, plays a key role in the human metabolism. It is present in many dietary sources such as meats, eggs, fish, beans and peas, nuts, and whole grains. Upon administration thiamine is converted by thiamine pyrophosphoki...

nase-1 (TPK1) to the active form, thiamine pyrophosphate, which serves as a cofactor for enzymes involved in the TCA cycle and the non-oxidative part of the pentose phosphate pathway. The lack of thiamine may cause the thiamine deficiency. The classical syndrome caused primarily by thiamine deficiency in humans is beriberi, however, symptoms of thiamine deficiency also include congestive heart failure, metabolic acidosis, confusion, ataxia and seizures. Thiamine is a component of many vitamin complexes, which are approved for the treatmen and prevention of general vitamin deficiency, including the thiamine deficiency.

FURSULTIAMINE

05J61265PX

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Status:

Possibly Marketed Outside US

First approved in 2018

Class (Stereo):

CHEMICAL (RACEMIC)

Conditions:

Autism spectrum disorder

Thiamine deficiency

Alzheimer’s disease

Fursultiamine, also known as thiamine tetrahydrofurfuryl disulfide (TTFD) is an oral FDA- approved thiamine derivative for treating vitamin B1 deficiency and is very rapidly metabolized into thiamine. Fursultiamine possesses a mild beneficial effect ...

in patients with Alzheimer's disease. The improvement could be observed not only in their emotional or other mental symptoms but also in intellectual function. Only mildly impaired subjects showed cognitive improvement. In addition was shown, that fursultiamine have a beneficial clinical effect on some autistic children. Some relatively recent experiments have revealed that fursultiamine was a unique antagonist of hepcidin in vitro that could serve as a template for the development of drug candidates that inhibit the hepcidin-ferroportin interaction. This inhibition is a key for the treatment of anemia of inflammation (AI), a common in patients with infection, autoimmune diseases, cancer, and chronic kidney disease.

THIAMINE CAMSILATE

AS1A8DF3EU

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Status:

US Approved Rx (1972)

First approved in 1947

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Thiamin pyrophosphokinase 1

Oxidative Stress

carbohydrate metabolic process

Conditions:

Thiamine deficiency

Thiamine, also known as vitamin B1, plays a key role in the human metabolism. It is present in many dietary sources such as meats, eggs, fish, beans and peas, nuts, and whole grains. Upon administration thiamine is converted by thiamine pyrophosphoki...

nase-1 (TPK1) to the active form, thiamine pyrophosphate, which serves as a cofactor for enzymes involved in the TCA cycle and the non-oxidative part of the pentose phosphate pathway. The lack of thiamine may cause the thiamine deficiency. The classical syndrome caused primarily by thiamine deficiency in humans is beriberi, however, symptoms of thiamine deficiency also include congestive heart failure, metabolic acidosis, confusion, ataxia and seizures. Thiamine is a component of many vitamin complexes, which are approved for the treatmen and prevention of general vitamin deficiency, including the thiamine deficiency.

THIAMINE

X66NSO3N35

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Status:

US Approved Rx (1972)

First approved in 1947

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Thiamin pyrophosphokinase 1

Oxidative Stress

carbohydrate metabolic process

Conditions:

Thiamine deficiency

Thiamine, also known as vitamin B1, plays a key role in the human metabolism. It is present in many dietary sources such as meats, eggs, fish, beans and peas, nuts, and whole grains. Upon administration thiamine is converted by thiamine pyrophosphoki...

nase-1 (TPK1) to the active form, thiamine pyrophosphate, which serves as a cofactor for enzymes involved in the TCA cycle and the non-oxidative part of the pentose phosphate pathway. The lack of thiamine may cause the thiamine deficiency. The classical syndrome caused primarily by thiamine deficiency in humans is beriberi, however, symptoms of thiamine deficiency also include congestive heart failure, metabolic acidosis, confusion, ataxia and seizures. Thiamine is a component of many vitamin complexes, which are approved for the treatmen and prevention of general vitamin deficiency, including the thiamine deficiency.

THIAMINE HYDROBROMIDE HEMIHYDRATE

WV7TS40872

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Status:

US Approved Rx (1972)

First approved in 1947

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Thiamin pyrophosphokinase 1

Oxidative Stress

carbohydrate metabolic process

Conditions:

Thiamine deficiency

Thiamine, also known as vitamin B1, plays a key role in the human metabolism. It is present in many dietary sources such as meats, eggs, fish, beans and peas, nuts, and whole grains. Upon administration thiamine is converted by thiamine pyrophosphoki...

nase-1 (TPK1) to the active form, thiamine pyrophosphate, which serves as a cofactor for enzymes involved in the TCA cycle and the non-oxidative part of the pentose phosphate pathway. The lack of thiamine may cause the thiamine deficiency. The classical syndrome caused primarily by thiamine deficiency in humans is beriberi, however, symptoms of thiamine deficiency also include congestive heart failure, metabolic acidosis, confusion, ataxia and seizures. Thiamine is a component of many vitamin complexes, which are approved for the treatmen and prevention of general vitamin deficiency, including the thiamine deficiency.

THIAMINE HYDROBROMIDE ANHYDROUS

K971V37HSF

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Status:

US Approved Rx (1972)

First approved in 1947

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Thiamin pyrophosphokinase 1

Oxidative Stress

carbohydrate metabolic process

Conditions:

Thiamine deficiency

Thiamine, also known as vitamin B1, plays a key role in the human metabolism. It is present in many dietary sources such as meats, eggs, fish, beans and peas, nuts, and whole grains. Upon administration thiamine is converted by thiamine pyrophosphoki...

nase-1 (TPK1) to the active form, thiamine pyrophosphate, which serves as a cofactor for enzymes involved in the TCA cycle and the non-oxidative part of the pentose phosphate pathway. The lack of thiamine may cause the thiamine deficiency. The classical syndrome caused primarily by thiamine deficiency in humans is beriberi, however, symptoms of thiamine deficiency also include congestive heart failure, metabolic acidosis, confusion, ataxia and seizures. Thiamine is a component of many vitamin complexes, which are approved for the treatmen and prevention of general vitamin deficiency, including the thiamine deficiency.

THIAMINE BIS-LAURYLSULFATE

226A8HU328

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Status:

US Approved Rx (1972)

First approved in 1947

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Thiamin pyrophosphokinase 1

Oxidative Stress

carbohydrate metabolic process

Conditions:

Thiamine deficiency

Thiamine, also known as vitamin B1, plays a key role in the human metabolism. It is present in many dietary sources such as meats, eggs, fish, beans and peas, nuts, and whole grains. Upon administration thiamine is converted by thiamine pyrophosphoki...

nase-1 (TPK1) to the active form, thiamine pyrophosphate, which serves as a cofactor for enzymes involved in the TCA cycle and the non-oxidative part of the pentose phosphate pathway. The lack of thiamine may cause the thiamine deficiency. The classical syndrome caused primarily by thiamine deficiency in humans is beriberi, however, symptoms of thiamine deficiency also include congestive heart failure, metabolic acidosis, confusion, ataxia and seizures. Thiamine is a component of many vitamin complexes, which are approved for the treatmen and prevention of general vitamin deficiency, including the thiamine deficiency.

THIAMINE NAPHTHALENE-1,5-DISULFONATE

ZWY7D9M9UB

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Status:

US Approved Rx (1972)

First approved in 1947

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Thiamin pyrophosphokinase 1

Oxidative Stress

carbohydrate metabolic process

Conditions:

Thiamine deficiency

Thiamine, also known as vitamin B1, plays a key role in the human metabolism. It is present in many dietary sources such as meats, eggs, fish, beans and peas, nuts, and whole grains. Upon administration thiamine is converted by thiamine pyrophosphoki...

nase-1 (TPK1) to the active form, thiamine pyrophosphate, which serves as a cofactor for enzymes involved in the TCA cycle and the non-oxidative part of the pentose phosphate pathway. The lack of thiamine may cause the thiamine deficiency. The classical syndrome caused primarily by thiamine deficiency in humans is beriberi, however, symptoms of thiamine deficiency also include congestive heart failure, metabolic acidosis, confusion, ataxia and seizures. Thiamine is a component of many vitamin complexes, which are approved for the treatmen and prevention of general vitamin deficiency, including the thiamine deficiency.

THIAMINE BROMIDE

JIJ7B8T57F

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Status:

US Approved Rx (1972)

First approved in 1947

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Thiamin pyrophosphokinase 1

Oxidative Stress

carbohydrate metabolic process

Conditions:

Thiamine deficiency

Thiamine, also known as vitamin B1, plays a key role in the human metabolism. It is present in many dietary sources such as meats, eggs, fish, beans and peas, nuts, and whole grains. Upon administration thiamine is converted by thiamine pyrophosphoki...

nase-1 (TPK1) to the active form, thiamine pyrophosphate, which serves as a cofactor for enzymes involved in the TCA cycle and the non-oxidative part of the pentose phosphate pathway. The lack of thiamine may cause the thiamine deficiency. The classical syndrome caused primarily by thiamine deficiency in humans is beriberi, however, symptoms of thiamine deficiency also include congestive heart failure, metabolic acidosis, confusion, ataxia and seizures. Thiamine is a component of many vitamin complexes, which are approved for the treatmen and prevention of general vitamin deficiency, including the thiamine deficiency.

THIAMINE HYDROCHLORIDE

M572600E5P

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Status:

US Approved Rx (1972)

First approved in 1947

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Thiamin pyrophosphokinase 1

Oxidative Stress

carbohydrate metabolic process

Conditions:

Thiamine deficiency

Thiamine, also known as vitamin B1, plays a key role in the human metabolism. It is present in many dietary sources such as meats, eggs, fish, beans and peas, nuts, and whole grains. Upon administration thiamine is converted by thiamine pyrophosphoki...

nase-1 (TPK1) to the active form, thiamine pyrophosphate, which serves as a cofactor for enzymes involved in the TCA cycle and the non-oxidative part of the pentose phosphate pathway. The lack of thiamine may cause the thiamine deficiency. The classical syndrome caused primarily by thiamine deficiency in humans is beriberi, however, symptoms of thiamine deficiency also include congestive heart failure, metabolic acidosis, confusion, ataxia and seizures. Thiamine is a component of many vitamin complexes, which are approved for the treatmen and prevention of general vitamin deficiency, including the thiamine deficiency.

Showing 1 - 10 of 13 results

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