U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Status:
Investigational
Source:
INN:octrizole [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Octrizole (UV-329) is used as UV stabilizer within products to increase stability to light. It protects polymers as well as organic pigments from UV radiation helping to preserve the original appearance and physical integrity of polymeric systems; particularly in polyesters, polyvinyl chlorides, styrenics, acrylics, polycarbonates and polyvinyl butyral during outdoor weathering. Octrizole is an indirect additive used in food contact substances. It is used in cosmetics. The use levels of Octrizole (UV-329) range between 0.10 and 1.0%, depending on substrate and performance requirements of the final application. The product can be used alone or in combination with other additives such as light stabilizers (hindered amines), antioxidants (hindered phenols, phosphites, thiosynergists, hydroxylamines, benzofuranones), and other functional stabilizers and additives. The use of UV-329 in combination with hindered amine light stabilizers is particularly noteworthy in that a synergistic performance is often observed. Performance data of UV- 329 alone or in combination with other additives are available in selected substrates.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (MIXED)


Ethylhexyl triazone is a PABA-derivative used in sunscreens to absorb UVB radiation. It is marketed as Uvinul T 150 by BASF. Ethylhexyl triazone has an absorption maximum of 314 nm. Ethylhexyl triazone is not approved as an active ingredient in the U.S., but used in rare cases to boost efficacy of some products. Ethylhexyl triazone is approved for use up to 5% in EU and Japan. It blocks UVB and extremely stable, it is the most effective UVB filter. Only small concentrations are required to achieve high SPF value, has good affinity to keratin and completely insoluble in water, making it particularly good choice for water-resistant sunscreens. Very stable in light – ability to filter UV rays remains practically unchanged even when exposed to intense radiation.