ETHYLHEXYL TRIAZONE

Details

Stereochemistry	MIXED
Molecular Formula	C48H66N6O6
Molecular Weight	823.0742
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCC(CC)COC(=O)C1=CC=C(NC2=NC(NC3=CC=C(C=C3)C(=O)OCC(CC)CCCC)=NC(NC4=CC=C(C=C4)C(=O)OCC(CC)CCCC)=N2)C=C1

InChI

InChIKey=JGUMTYWKIBJSTN-UHFFFAOYSA-N

InChI=1S/C48H66N6O6/c1-7-13-16-34(10-4)31-58-43(55)37-19-25-40(26-20-37)49-46-52-47(50-41-27-21-38(22-28-41)44(56)59-32-35(11-5)17-14-8-2)54-48(53-46)51-42-29-23-39(24-30-42)45(57)60-33-36(12-6)18-15-9-3/h19-30,34-36H,7-18,31-33H2,1-6H3,(H3,49,50,51,52,53,54)

HIDE SMILES / InChI

Molecular Formula	C48H66N6O6
Molecular Weight	823.0742
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://worldaccount.basf.com/wa/msds/showpdf/36574200_13153256_-8
Curator's Comment: Description was created based on several sources, including http://www.fda.gov/ohrms/dockets/dailys/04/july04/070804/03n-0233-sup0002-001-vol3.pdf and https://www.carecreations.basf.com/product-formulations/products/products-detail/UVINUL%20T%20150/30035119

Ethylhexyl triazone is a PABA-derivative used in sunscreens to absorb UVB radiation. It is marketed as Uvinul T 150 by BASF. Ethylhexyl triazone has an absorption maximum of 314 nm. Ethylhexyl triazone is not approved as an active ingredient in the U.S., but used in rare cases to boost efficacy of some products. Ethylhexyl triazone is approved for use up to 5% in EU and Japan. It blocks UVB and extremely stable, it is the most effective UVB filter. Only small concentrations are required to achieve high SPF value, has good affinity to keratin and completely insoluble in water, making it particularly good choice for water-resistant sunscreens. Very stable in light – ability to filter UV rays remains practically unchanged even when exposed to intense radiation.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Sunburn and skin cancer 2 Sources: https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/5466-77-3_508.pdf https://dewolfchem.com/wp-content/uploads/2013/11/Uvinul-T150-TDS.pdf	Preventing		Approved 8429	UVINUL T 150 Approved Use Used in Skin and sun care products for protection against uv radiation. Launch Date 1989

PubMed

Title	Date	PubMed
Determination and validation of six sunscreen agents in suncare products by UPLC and HPLC.	2008 Nov-Dec	19156330
Validation of HPLC method for the simultaneous and quantitative determination of 12 UV-filters in cosmetics.	2010 Feb	20412202

Patents

Sample Use Guides

In Vivo Use Guide

Ethylhexyl triazone (Uvinul T 150) is used in concentrations of up to 5% in sunscreen compositions topically.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:25:19 GMT 2023` Edited by `admin` on `Fri Dec 15 16:25:19 GMT 2023`
Record UNII	XQN8R9SAK4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ETHYLHEXYL TRIAZONE

Official Name

English

2,4,6-TRIANILINO-(P-CARBO-2'-ETHYLHEXYL-1'-OXY)-1,3,5-TRIAZINE

Common Name

English

BENZOIC ACID, 4,4',4''-(1,3,5-TRIAZINE-2,4,6-TRIYLTRIIMINO)TRIS-, TRIS(2-ETHYLHEXYL) ESTER

Common Name

English

ETHYLHEXYL TRIAZONE [INCI]

Common Name

English

ETHYLHEXYL TRIAZONE [MI]

Common Name

English

UVINUL T 150

Brand Name

English

ETHYLHEXYL TRIAZONE [USP-RS]

Common Name

English

Octyl triazone [WHO-DD]

Common Name

English

OCTIL TRIAZONE

Common Name

English

Code System Code Type Description

DAILYMED

XQN8R9SAK4