U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry MIXED
Molecular Formula C48H66N6O6
Molecular Weight 823.0761
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ETHYLHEXYL TRIAZONE

SMILES

CCCCC(CC)COC(=O)c1ccc(cc1)Nc2nc(Nc3ccc(cc3)C(=O)OCC(CC)CCCC)nc(Nc4ccc(cc4)C(=O)OCC(CC)CCCC)n2

InChI

InChIKey=JGUMTYWKIBJSTN-UHFFFAOYSA-N
InChI=1S/C48H66N6O6/c1-7-13-16-34(10-4)31-58-43(55)37-19-25-40(26-20-37)49-46-52-47(50-41-27-21-38(22-28-41)44(56)59-32-35(11-5)17-14-8-2)54-48(53-46)51-42-29-23-39(24-30-42)45(57)60-33-36(12-6)18-15-9-3/h19-30,34-36H,7-18,31-33H2,1-6H3,(H3,49,50,51,52,53,54)

HIDE SMILES / InChI

Molecular Formula C48H66N6O6
Molecular Weight 823.0761
Charge 0
Count
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment:: Description was created based on several sources, including http://www.fda.gov/ohrms/dockets/dailys/04/july04/070804/03n-0233-sup0002-001-vol3.pdf and https://www.carecreations.basf.com/product-formulations/products/products-detail/UVINUL%20T%20150/30035119

Ethylhexyl triazone is a PABA-derivative used in sunscreens to absorb UVB radiation. It is marketed as Uvinul T 150 by BASF. Ethylhexyl triazone has an absorption maximum of 314 nm. Ethylhexyl triazone is not approved as an active ingredient in the U.S., but used in rare cases to boost efficacy of some products. Ethylhexyl triazone is approved for use up to 5% in EU and Japan. It blocks UVB and extremely stable, it is the most effective UVB filter. Only small concentrations are required to achieve high SPF value, has good affinity to keratin and completely insoluble in water, making it particularly good choice for water-resistant sunscreens. Very stable in light – ability to filter UV rays remains practically unchanged even when exposed to intense radiation.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
UVINUL T 150

Approved Use

Used in Skin and sun care products for protection against uv radiation.

Launch Date

603936000000
PubMed

PubMed

TitleDatePubMed
Determination and validation of six sunscreen agents in suncare products by UPLC and HPLC.
2008 Nov-Dec
Validation of HPLC method for the simultaneous and quantitative determination of 12 UV-filters in cosmetics.
2010 Feb
Patents

Sample Use Guides

Ethylhexyl triazone (Uvinul T 150) is used in concentrations of up to 5% in sunscreen compositions topically.
Route of Administration: Topical
Substance Class Chemical
Created
by admin
on Sat Jun 26 10:28:17 UTC 2021
Edited
by admin
on Sat Jun 26 10:28:17 UTC 2021
Record UNII
XQN8R9SAK4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ETHYLHEXYL TRIAZONE
INCI   MI   USP-RS  
INCI  
Official Name English
2,4,6-TRIANILINO-(P-CARBO-2'-ETHYLHEXYL-1'-OXY)-1,3,5-TRIAZINE
Common Name English
BENZOIC ACID, 4,4',4''-(1,3,5-TRIAZINE-2,4,6-TRIYLTRIIMINO)TRIS-, TRIS(2-ETHYLHEXYL) ESTER
Common Name English
ETHYLHEXYL TRIAZONE [INCI]
Common Name English
ETHYLHEXYL TRIAZONE [MI]
Common Name English
UVINUL T 150
Brand Name English
ETHYLHEXYL TRIAZONE [USP-RS]
Common Name English
OCTIL TRIAZONE
Common Name English
Code System Code Type Description
FDA UNII
XQN8R9SAK4
Created by admin on Sat Jun 26 10:28:17 UTC 2021 , Edited by admin on Sat Jun 26 10:28:17 UTC 2021
PRIMARY
USP_CATALOG
1265537
Created by admin on Sat Jun 26 10:28:17 UTC 2021 , Edited by admin on Sat Jun 26 10:28:17 UTC 2021
PRIMARY USP-RS
MERCK INDEX
M5134
Created by admin on Sat Jun 26 10:28:17 UTC 2021 , Edited by admin on Sat Jun 26 10:28:17 UTC 2021
PRIMARY Merck Index
DRUG BANK
DB15469
Created by admin on Sat Jun 26 10:28:17 UTC 2021 , Edited by admin on Sat Jun 26 10:28:17 UTC 2021
PRIMARY
EVMPD
SUB35560
Created by admin on Sat Jun 26 10:28:17 UTC 2021 , Edited by admin on Sat Jun 26 10:28:17 UTC 2021
PRIMARY
RXCUI
1314657
Created by admin on Sat Jun 26 10:28:17 UTC 2021 , Edited by admin on Sat Jun 26 10:28:17 UTC 2021
PRIMARY RxNorm
CAS
88122-99-0
Created by admin on Sat Jun 26 10:28:17 UTC 2021 , Edited by admin on Sat Jun 26 10:28:17 UTC 2021
PRIMARY
PUBCHEM
159201
Created by admin on Sat Jun 26 10:28:17 UTC 2021 , Edited by admin on Sat Jun 26 10:28:17 UTC 2021
PRIMARY
WIKIPEDIA
ETHYLHEXYL TRIAZONE
Created by admin on Sat Jun 26 10:28:17 UTC 2021 , Edited by admin on Sat Jun 26 10:28:17 UTC 2021
PRIMARY