Class (Stereo):
CHEMICAL (ACHIRAL)
Doramapimod (BIRB-796) is a p38 MAPK inhibitor, relatively potent against alpha isoform. Oral doramapimod exerts anti-inflammatory potential in humans in vivo. Doramapimod has entered clinical trials for the treatment of autoimmune diseases.
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Atizoram (CP-80633) is a phosphodiesterase IV inhibitor with bronchodilatory and antiinflammatory properties. It was in phase II trials with Pfizer in the US for the treatment of asthma, atopic dermatitis and psoriasis. Development of atizoram has be...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Cycloheximide is an antibiotic produced by fermentation culture of Streptomyces griseus, Streptomyces noursei, Streptomyces albulus, Streptomyces naraensis, or other cycloheximide-producing microorganism. It was first discovered by A. Whiffen et al. ...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Descinolone acetonide (an analog of triamcinolone acetonide) is a glucocorticoid which was developed for the treatment of skin disorders. It was tested on patients with psoriasis and atopic dermatitis, however there is no information about its furthe...
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
GSK 0660 is a selective PPARdelta antagonist. The compound reduced psoriasis-like changes in a preclinical model and demonstrated neuroprotection in an in vitro model of Parkinson’s disease. When given alone GSK 0660 exhibits inverse agonist effects.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
NDT 9513727 is small molecule, orally bioavailable, selective, and potent inverse agonist of the human C5aR. NDT 9513727 inhibited C5a-stimulated responses, including guanosine 5’-3-O-(thio)triphosphate binding, Ca2+ mobilization, oxidative burst, de...
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
N-MPPP HYDROCHLORIDE is high-affinity κ agonist with no measured binding at μ or δ sites.
Status:
Other
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
RO-20-1724 is a potent inhibitor of Phosphodiesterase 4 (PDE4) originally developed by Roche. It showed some promise as a potential treatment for psoriasis, but it was discontinued when it could not match the efficacy of existing treatments. RO-20-...
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
AMG-487 is a potent and selective orally bioavailable chemokine (C-X-C motif) receptor 3 (CXCR3) antagonist that displays dose- and time-dependent pharmacokinetics in human subjects after multiple oral dosing. AMG-487 is an 8-azaquinazolinone, it can...
Bz-423 is an inhibitor of the mitochondrial F(1)F(0)-ATPase, with therapeutic properties in murine models of immune diseases.Bz-423,a proapoptotic 1,4-benzodiazepine, potently suppresses disease in the murine model of lupus by selectively killing pat...