DESCINOLONE ACETONIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H31FO5
Molecular Weight	418.4983
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@@]3([H])[C@]4([H])CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]1(OC(C)(C)O2)C(C)=O

InChI

InChIKey=BSHYASCHOGHGHW-PIQRJGQMSA-N

InChI=1S/C24H31FO5/c1-13(26)24-19(29-20(2,3)30-24)11-17-16-7-6-14-10-15(27)8-9-21(14,4)23(16,25)18(28)12-22(17,24)5/h8-10,16-19,28H,6-7,11-12H2,1-5H3/t16-,17-,18-,19+,21-,22-,23-,24+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C24H31FO5
Molecular Weight	418.4983
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5321337

Descinolone acetonide (an analog of triamcinolone acetonide) is a glucocorticoid which was developed for the treatment of skin disorders. It was tested on patients with psoriasis and atopic dermatitis, however there is no information about its further development.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glucocorticoid receptor 172 Target ID: P04150 Gene ID: 2908.0 Gene Symbol: NR3C1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/5321337	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Psoriasis 84 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5321337	Primary		Phase I 428	Unknown Approved Use Unknown
Atopic dermatitis 43 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5321337	Primary		Phase I 428	Unknown Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
Alfa Chemistry	ACM2135140	http://www.alfa-chemistry.com/search.aspx?q=ACM2135140
Compound Cloud	11954034
NCI Plated 2007	44827

PubMed

Title	Date	PubMed
Relative potency of percutaneously absorbed corticosteroids in the suppression of pituitary-adrenal function.	1965 Nov	5321337
Laboratory evaluation of 21-deoxytriamcinolone acetonide.	1967 Sep	6057560

Sample Use Guides

In Vivo Use Guide

The topical cream (1%) was applied 10, 20 or 40 g b.i.d.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:01:40 GMT 2023` Edited by `admin` on `Fri Dec 15 15:01:40 GMT 2023`
Record UNII	ENR9Z582HW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DESCINOLONE ACETONIDE

Official Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 9-FLUORO-11-HYDROXY-16,17-((1-METHYLETHYLIDENE)BIS(OXY))-, (11.BETA.,16.ALPHA.)-

Common Name

English

CL 27,071

Code

English

9-Fluoro-11β,16α,17-trihydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone

Common Name

English

CL-27071

Code

English

DESCINOLONE ACETONIDE [USAN]

Common Name

English

NSC-44827

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C521