U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C24H31FO5
Molecular Weight 418.4983
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DESCINOLONE ACETONIDE

SMILES

[H][C@@]12C[C@@]3([H])[C@]4([H])CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]1(OC(C)(C)O2)C(C)=O

InChI

InChIKey=BSHYASCHOGHGHW-PIQRJGQMSA-N
InChI=1S/C24H31FO5/c1-13(26)24-19(29-20(2,3)30-24)11-17-16-7-6-14-10-15(27)8-9-21(14,4)23(16,25)18(28)12-22(17,24)5/h8-10,16-19,28H,6-7,11-12H2,1-5H3/t16-,17-,18-,19+,21-,22-,23-,24+/m0/s1

HIDE SMILES / InChI
Descinolone acetonide (an analog of triamcinolone acetonide) is a glucocorticoid which was developed for the treatment of skin disorders. It was tested on patients with psoriasis and atopic dermatitis, however there is no information about its further development.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P04150
Gene ID: 2908.0
Gene Symbol: NR3C1
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Relative potency of percutaneously absorbed corticosteroids in the suppression of pituitary-adrenal function.
1965 Nov
Laboratory evaluation of 21-deoxytriamcinolone acetonide.
1967 Sep

Sample Use Guides

The topical cream (1%) was applied 10, 20 or 40 g b.i.d.
Route of Administration: Topical
In Vitro Use Guide
Unknown
Name Type Language
DESCINOLONE ACETONIDE
USAN  
USAN  
Official Name English
PREGNA-1,4-DIENE-3,20-DIONE, 9-FLUORO-11-HYDROXY-16,17-((1-METHYLETHYLIDENE)BIS(OXY))-, (11.BETA.,16.ALPHA.)-
Common Name English
CL 27,071
Code English
9-Fluoro-11β,16α,17-trihydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone
Common Name English
CL-27071
Code English
DESCINOLONE ACETONIDE [USAN]
Common Name English
NSC-44827
Code English
Classification Tree Code System Code
NCI_THESAURUS C521
Created by admin on Fri Dec 15 15:01:40 GMT 2023 , Edited by admin on Fri Dec 15 15:01:40 GMT 2023
Code System Code Type Description
ECHA (EC/EINECS)
218-368-8
Created by admin on Fri Dec 15 15:01:40 GMT 2023 , Edited by admin on Fri Dec 15 15:01:40 GMT 2023
PRIMARY
FDA UNII
ENR9Z582HW
Created by admin on Fri Dec 15 15:01:40 GMT 2023 , Edited by admin on Fri Dec 15 15:01:40 GMT 2023
PRIMARY
NCI_THESAURUS
C98254
Created by admin on Fri Dec 15 15:01:40 GMT 2023 , Edited by admin on Fri Dec 15 15:01:40 GMT 2023
PRIMARY
PUBCHEM
11954034
Created by admin on Fri Dec 15 15:01:40 GMT 2023 , Edited by admin on Fri Dec 15 15:01:40 GMT 2023
PRIMARY
NSC
44827
Created by admin on Fri Dec 15 15:01:40 GMT 2023 , Edited by admin on Fri Dec 15 15:01:40 GMT 2023
PRIMARY
EPA CompTox
DTXSID60943909
Created by admin on Fri Dec 15 15:01:40 GMT 2023 , Edited by admin on Fri Dec 15 15:01:40 GMT 2023
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ChEMBL
CHEMBL2106177
Created by admin on Fri Dec 15 15:01:40 GMT 2023 , Edited by admin on Fri Dec 15 15:01:40 GMT 2023
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WIKIPEDIA
Descinolone acetonide
Created by admin on Fri Dec 15 15:01:40 GMT 2023 , Edited by admin on Fri Dec 15 15:01:40 GMT 2023
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CAS
2135-14-0
Created by admin on Fri Dec 15 15:01:40 GMT 2023 , Edited by admin on Fri Dec 15 15:01:40 GMT 2023
PRIMARY