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Status:
US Previously Marketed
Source:
PAGITANE by LILLY
(1953)
Source URL:
First approved in 1953
Source:
PAGITANE by LILLY
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
CYCRIMINE is an antispasmodic drug used for the treatment of Parkinson's disease (PD). It binds the muscarinic acetylcholine receptor M1, effectively reducing levels of acetylcholine. This decrease in acetylcholine restores the normal dopamine-acetylcholine balance and relieves the symptoms of PD.
Status:
First approved in 1949
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Caramiphen is a muscarinic M1 acetylcholine receptor antagonist, which was used for the treatment of Parkinson Disease and cough, but then there using were discontinued. Caramiphen is also used in local anesthesia, and effect could be achieved through the suppression of voltage-gated Na⁺ currents.
Status:
First approved in 1949
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Caramiphen is a muscarinic M1 acetylcholine receptor antagonist, which was used for the treatment of Parkinson Disease and cough, but then there using were discontinued. Caramiphen is also used in local anesthesia, and effect could be achieved through the suppression of voltage-gated Na⁺ currents.
Status:
Possibly Marketed Outside US
Source:
Enada by Birkmayer, G.D.
Source URL:
First approved in 2010
Source:
Bonogenhair care shampoo by Bonogen Co., Ltd
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
NADIDE (NAD+) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. NADIDE was marketed under the brand name Enada. Although Enada (NADH) is marketed as a nutritional supplement, Birkmayer
Pharmaceuticals has launched two clinical trials to prove scientifically that Enada is effective.
Before these studies could get started they had to also prove to the Food and Drug Administration (FDA) that the stable oral form of Enada (NADH) is a safe substance.
Since the mid-‘80s more than 3,000 parkinsonian patients have received NADH, either as
intravenous infusion or in the form of oral tablets. Enada (NADH) is the world‘s first and only stabilized, absorbable, patented, tablet-form
NADH dietary supplement. It is now available to everyone whose lifestyle demands increased
energy, vitality and mental clarity. In other words, it is beneficial not only for patients
suffering from chronic fatigue syndrome, Alzheimer‘s disease, depression or Parkinson‘s
disease, but for any normal, healthy individual whose lifestyle demands more energy. NADIDE (NADH) may be considered as a therapeutic adjunct for
cancer patients to protect them against the general toxic effects of substances such as
doxorubicin or cisplatin by stimulating the DNA repair system and by promoting normal cellular
biosynthetic responses after chemotherapy. NADH seems to exhibit a chemo preventive effect.
Status:
Possibly Marketed Outside US
Source:
Enada by Birkmayer, G.D.
Source URL:
First approved in 2010
Source:
Bonogenhair care shampoo by Bonogen Co., Ltd
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
NADIDE (NAD+) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. NADIDE was marketed under the brand name Enada. Although Enada (NADH) is marketed as a nutritional supplement, Birkmayer
Pharmaceuticals has launched two clinical trials to prove scientifically that Enada is effective.
Before these studies could get started they had to also prove to the Food and Drug Administration (FDA) that the stable oral form of Enada (NADH) is a safe substance.
Since the mid-‘80s more than 3,000 parkinsonian patients have received NADH, either as
intravenous infusion or in the form of oral tablets. Enada (NADH) is the world‘s first and only stabilized, absorbable, patented, tablet-form
NADH dietary supplement. It is now available to everyone whose lifestyle demands increased
energy, vitality and mental clarity. In other words, it is beneficial not only for patients
suffering from chronic fatigue syndrome, Alzheimer‘s disease, depression or Parkinson‘s
disease, but for any normal, healthy individual whose lifestyle demands more energy. NADIDE (NADH) may be considered as a therapeutic adjunct for
cancer patients to protect them against the general toxic effects of substances such as
doxorubicin or cisplatin by stimulating the DNA repair system and by promoting normal cellular
biosynthetic responses after chemotherapy. NADH seems to exhibit a chemo preventive effect.
Status:
Possibly Marketed Outside US
Source:
Enada by Birkmayer, G.D.
Source URL:
First approved in 2010
Source:
Bonogenhair care shampoo by Bonogen Co., Ltd
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
NADIDE (NAD+) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. NADIDE was marketed under the brand name Enada. Although Enada (NADH) is marketed as a nutritional supplement, Birkmayer
Pharmaceuticals has launched two clinical trials to prove scientifically that Enada is effective.
Before these studies could get started they had to also prove to the Food and Drug Administration (FDA) that the stable oral form of Enada (NADH) is a safe substance.
Since the mid-‘80s more than 3,000 parkinsonian patients have received NADH, either as
intravenous infusion or in the form of oral tablets. Enada (NADH) is the world‘s first and only stabilized, absorbable, patented, tablet-form
NADH dietary supplement. It is now available to everyone whose lifestyle demands increased
energy, vitality and mental clarity. In other words, it is beneficial not only for patients
suffering from chronic fatigue syndrome, Alzheimer‘s disease, depression or Parkinson‘s
disease, but for any normal, healthy individual whose lifestyle demands more energy. NADIDE (NADH) may be considered as a therapeutic adjunct for
cancer patients to protect them against the general toxic effects of substances such as
doxorubicin or cisplatin by stimulating the DNA repair system and by promoting normal cellular
biosynthetic responses after chemotherapy. NADH seems to exhibit a chemo preventive effect.
Status:
Possibly Marketed Outside US
Source:
Enada by Birkmayer, G.D.
Source URL:
First approved in 2010
Source:
Bonogenhair care shampoo by Bonogen Co., Ltd
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
NADIDE (NAD+) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. NADIDE was marketed under the brand name Enada. Although Enada (NADH) is marketed as a nutritional supplement, Birkmayer
Pharmaceuticals has launched two clinical trials to prove scientifically that Enada is effective.
Before these studies could get started they had to also prove to the Food and Drug Administration (FDA) that the stable oral form of Enada (NADH) is a safe substance.
Since the mid-‘80s more than 3,000 parkinsonian patients have received NADH, either as
intravenous infusion or in the form of oral tablets. Enada (NADH) is the world‘s first and only stabilized, absorbable, patented, tablet-form
NADH dietary supplement. It is now available to everyone whose lifestyle demands increased
energy, vitality and mental clarity. In other words, it is beneficial not only for patients
suffering from chronic fatigue syndrome, Alzheimer‘s disease, depression or Parkinson‘s
disease, but for any normal, healthy individual whose lifestyle demands more energy. NADIDE (NADH) may be considered as a therapeutic adjunct for
cancer patients to protect them against the general toxic effects of substances such as
doxorubicin or cisplatin by stimulating the DNA repair system and by promoting normal cellular
biosynthetic responses after chemotherapy. NADH seems to exhibit a chemo preventive effect.
Status:
Possibly Marketed Outside US
First approved in 2006
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Carnosine is a dipeptide composed of the amino acids beta-histidine and l-alanine. It is widely present in muscle and brain tissues. It possesses strong and specific antioxidant properties, protects against radiation damage, and promotes wound healing. The antioxidant mechanism of carnosine is attributed to its chelating effect against metal ions, superoxide dismutase (SOD)-like activity, ROS and free radicals scavenging ability. In addition, was shown, that carnosine significantly protects against TCA-induced liver carcinogenesis in rats, through its antioxidant, antinutritive, and anti-inflammatory effects, and induction of apoptosis. It also may be a therapeutic agent against Parkinson's disease. Experiments on animal have shown the sepsis healing therapeutic potential of carnosine.
Status:
Possibly Marketed Outside US
First approved in 2006
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Carnosine is a dipeptide composed of the amino acids beta-histidine and l-alanine. It is widely present in muscle and brain tissues. It possesses strong and specific antioxidant properties, protects against radiation damage, and promotes wound healing. The antioxidant mechanism of carnosine is attributed to its chelating effect against metal ions, superoxide dismutase (SOD)-like activity, ROS and free radicals scavenging ability. In addition, was shown, that carnosine significantly protects against TCA-induced liver carcinogenesis in rats, through its antioxidant, antinutritive, and anti-inflammatory effects, and induction of apoptosis. It also may be a therapeutic agent against Parkinson's disease. Experiments on animal have shown the sepsis healing therapeutic potential of carnosine.
Status:
Possibly Marketed Outside US
First approved in 2003
Source:
BLA125063
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Glutathione (GSH, also called as reduced glutathione) is a tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes such as, glutathione reductase, glutathione peroxidases, peroxiredoxins. Glutathione S-transferases catalyse the conjugation of GSH via a sulfhydryl group to electrophilic centers on a wide variety of substrates in order to make the compounds more water-soluble. As a part of homeopathic product, glutathione is used for temporary relief of symptoms related to Free Radical Toxicity including tingling in hands and feet, mood changes, frequent colds, poor digestion, fatigue, and constipation. In addition, for temporary relief of pain in the back from urinating, constant urging and frequent urination, kidneys sensitive to pressure, and pain from back extending down the thigh. Glutathione is an important nutrient for brain function and loss of glutathione has been implicated in Parkinson's disease. In phase II of the clinical trial was investigated whether administration of either dose of glutathione, as a nasal spray, improves PD symptoms over time in a population of individuals with Parkinson's disease (PD). In addition in phase II of clinical trial was shown, that reduced glutathione, an ingredient of RayGel™, has been helpful in decreasing some radiation therapy side effects to the skin. Reduced glutathione plays a vital role in both making DNA and cell repair. Cystic fibrosis (CF) is the most common inherited disease among the Caucasian population with considerable morbidity and reduced life expectancy. Glutathione (GSH) represents the first-line defence of the lung against oxidative stress-induced cell injury. Therapeutic approaches with inhaled GSH could improve the reduced lung antioxidant capacity in order to counterbalance the oxidant stress linked to the chronic airway inflammation and bacterial infection.