CYCRIMINE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H29NO.ClH
Molecular Weight	323.901
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.OC(CCN1CCCCC1)(C2CCCC2)C3=CC=CC=C3

InChI

InChIKey=WBCWFMFZMRFRLT-UHFFFAOYSA-N

InChI=1S/C19H29NO.ClH/c21-19(18-11-5-6-12-18,17-9-3-1-4-10-17)13-16-20-14-7-2-8-15-20;/h1,3-4,9-10,18,21H,2,5-8,11-16H2;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C19H29NO
Molecular Weight	287.4397
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://www.hmdb.ca/metabolites/HMDB0015077 | http://www.druglib.com/activeingredient/cycrimine/ | https://www.ncbi.nlm.nih.gov/pubmed/13214268 | https://www.ncbi.nlm.nih.gov/pubmed/13133049

CYCRIMINE is an antispasmodic drug used for the treatment of Parkinson's disease (PD). It binds the muscarinic acetylcholine receptor M1, effectively reducing levels of acetylcholine. This decrease in acetylcholine restores the normal dopamine-acetylcholine balance and relieves the symptoms of PD.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Muscarinic acetylcholine receptor M1 169 Target ID: P11229 Gene ID: 1128.0 Gene Symbol: CHRM1 Target Organism: Homo sapiens (Human) Sources: http://www.druglib.com/activeingredient/cycrimine/	Antagonist 2778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Parkinson's disease 226 Sources: https://www.drugbank.ca/drugs/DB00942 http://www.druglib.com/activeingredient/cycrimine/	Primary		Approved 8429	Pagitane Approved Use Cycrimine is used for Parkinson's disease. Launch Date 1952

F_unbound

Value	Dose	Co-administered	Analyte	Population
79% OTHER https://go.drugbank.com/drugs/DB00942	2.5 mg 4 times / day unknown, oral dose: 2.5 mg route of administration: Oral experiment type: UNKNOWN co-administered:		CYCRIMINE plasma	Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY571137	https://www.001chemical.com/chem/77-39-4
AA Blocks	AA0039D0	https://www.aablocks.com/goods/Goods/detail?id=AA0039D0
AAA Chemistry	AR-1K9623
ABI Chem	AC1L1ER2
ABI Chem	AC1Q76Z6
ABI Chem	AC1Q77DQ
BOC Sciences	77-39-4
ChemMol	99151447	http://www.chemmol.com/chemmol/99151447.html
ChemShuttle	178195
Chemieliva Pharmaceutical Co., Ltd	PBCM1414266
HongKong Chemhere	SCE40324
Molcore	MC571137	https://www.molcore.com/product/77-39-4
MuseChem	I005950
NCI Plated 2007	169452
NovoSeek	2911
Smolecule	S524761	http://www.smolecule.com/products/s524761
Smolecule	S772551	https://www.smolecule.com/products/s772551
THE BioTek	bt-266234	https://www.thebiotek.com/product/inhibitors/bt-266234
ZINC	ZINC000000000199	http://zinc15.docking.org/substances/ZINC000000000199
ZINC	ZINC000002041282	http://zinc15.docking.org/substances/ZINC000002041282
eMolecules	110011064
eNovation Chemicals	D673916	https://www.enovationchem.com/ProductDetails.asp?ProductID=D673916
eNovation Chemicals	Y1076546	https://www.enovationchem.com/ProductDetails.asp?ProductID=Y1076546
iChemical	EBD3676564	http://www.ichemical.com/products/77-39-4.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs

PubMed

Title	Date	PubMed
Clinical evaluation of pagitane hydrochloride in parkinsonism.	1954 Jan	13133049
Treatment of parkinsonism with pagitane hydrochloride; results in 142 patients.	1954 Sep	13214268
Cycrimine on rat diaphragm.	1976 Jan	1267542

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:32:07 GMT 2023` Edited by `admin` on `Fri Dec 15 16:32:07 GMT 2023`
Record UNII	9RB4L4K895
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CYCRIMINE HYDROCHLORIDE

Common Name

English

CYCRIMINE HYDROCHLORIDE [ORANGE BOOK]

Common Name

English

Cycrimine hydrochloride [WHO-DD]

Common Name

English

1-PIPERIDINEPROPANOL, .ALPHA.-CYCLOPENTYL-.ALPHA.-PHENYL-, HYDROCHLORIDE

Systematic Name

English

CYCRIMINE HCL

Common Name

English

NSC-169452

Code

English

PAGITANE

Brand Name

English

CYCRIMINE HYDROCHLORIDE [MI]

Common Name

English

α-Cyclopentyl-α-phenyl-1-piperidinepropanol hydrochloride

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29704