Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C10H16N3O6S.Na |
Molecular Weight | 329.305 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C([O-])=O
InChI
InChIKey=QWXDICNEPRTOLR-GEMLJDPKSA-M
InChI=1S/C10H17N3O6S.Na/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16;/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19);/q;+1/p-1/t5-,6-;/m0./s1
Molecular Formula | C10H16N3O6S |
Molecular Weight | 306.316 |
Charge | -1 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | Na |
Molecular Weight | 22.9898 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/23036594 |
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3ef475c9-7938-4870-b336-fb0c2dafb3cd | https://clinicaltrials.gov/ct2/show/NCT01450267
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/23036594 |
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3ef475c9-7938-4870-b336-fb0c2dafb3cd | https://clinicaltrials.gov/ct2/show/NCT01450267
Glutathione (GSH, also called as reduced glutathione) is a tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes such as, glutathione reductase, glutathione peroxidases, peroxiredoxins. Glutathione S-transferases catalyse the conjugation of GSH via a sulfhydryl group to electrophilic centers on a wide variety of substrates in order to make the compounds more water-soluble. As a part of homeopathic product, glutathione is used for temporary relief of symptoms related to Free Radical Toxicity including tingling in hands and feet, mood changes, frequent colds, poor digestion, fatigue, and constipation. In addition, for temporary relief of pain in the back from urinating, constant urging and frequent urination, kidneys sensitive to pressure, and pain from back extending down the thigh. Glutathione is an important nutrient for brain function and loss of glutathione has been implicated in Parkinson's disease. In phase II of the clinical trial was investigated whether administration of either dose of glutathione, as a nasal spray, improves PD symptoms over time in a population of individuals with Parkinson's disease (PD). In addition in phase II of clinical trial was shown, that reduced glutathione, an ingredient of RayGel™, has been helpful in decreasing some radiation therapy side effects to the skin. Reduced glutathione plays a vital role in both making DNA and cell repair. Cystic fibrosis (CF) is the most common inherited disease among the Caucasian population with considerable morbidity and reduced life expectancy. Glutathione (GSH) represents the first-line defence of the lung against oxidative stress-induced cell injury. Therapeutic approaches with inhaled GSH could improve the reduced lung antioxidant capacity in order to counterbalance the oxidant stress linked to the chronic airway inflammation and bacterial infection.
CNS Activity
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Glutathione S-transferases Sources: https://www.ncbi.nlm.nih.gov/pubmed/4436301 |
|||
Target ID: P00390 Gene ID: 2936.0 Gene Symbol: GSR Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/23036594 |
|||
Target ID: Glutathione peroxidases Sources: https://www.ncbi.nlm.nih.gov/pubmed/23036594 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Palliative | Unknown Approved UseUnknown |
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Palliative | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
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Palliative | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
Synergistic effect of diesel organic extracts and allergen Der p 1 on the release of chemokines by peripheral blood mononuclear cells from allergic subjects: involvement of the map kinase pathway. | 2000 Aug |
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Contribution of the mesangium to elastic strength and anchorage of the glomerular capillary tuft. | 2001 |
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Detection of phosphorylation-dependent interactions by far-western gel overlay. | 2001 |
|
Perturbation of the pore of the cystic fibrosis transmembrane conductance regulator (CFTR) inhibits its atpase activity. | 2001 Apr 13 |
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A rice functional transcriptional activator, RISBZ1, responsible for endosperm-specific expression of storage protein genes through GCN4 motif. | 2001 Apr 27 |
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Nitrogen monoxide (no) and glucose: unexpected links between energy metabolism and no-mediated iron mobilization from cells. | 2001 Feb 16 |
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Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of the catalytic activity of glutathione transferases. | 2001 Feb 23 |
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Cloning, expression, and up-regulation of inducible rat prostaglandin e synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis. | 2001 Feb 9 |
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Effects of phenytoin on glutathione status and oxidative stress biomarker gene mRNA levels in cultured precision human liver slices. | 2001 Jan |
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The activity of NF-kappaB in Swiss 3T3 cells exposed to aqueous extracts of cigarette smoke is dependent on thioredoxin. | 2001 Jan |
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Ochratoxin A-induced tumor formation: is there a role of reactive ochratoxin A metabolites? | 2001 Jan |
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Dual effects of nitric oxide in functional and regressing rat corpus luteum. | 2001 Jan |
|
Effects of dietary supplementation of alpha-lipoic acid on early glomerular injury in diabetes mellitus. | 2001 Jan |
|
Major changes in human ocular UV protection with age. | 2001 Jan |
|
Dose response of carboplatin-induced hearing loss in rats: antioxidant defense system. | 2001 Jan |
|
Oxidative stress and antioxidant defenses in goldfish Carassius auratus during anoxia and reoxygenation. | 2001 Jan |
|
Overcoming drug resistance in ovarian carcinoma. | 2001 Jan |
|
Glutathione attenuates coronary constriction to acetylcholine in patients with coronary spastic angina. | 2001 Jan |
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Antioxidant modulation in response to metal-induced oxidative stress in algal chloroplasts. | 2001 Jan |
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Mechanism and significance of increased glutathione level in human hepatocellular carcinoma and liver regeneration. | 2001 Jan |
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The intracellular oxidation of 2',7'-dichlorofluorescin in murine T lymphocytes. | 2001 Jan 1 |
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Thiols can either enhance or suppress DNA damage induction by catecholestrogens. | 2001 Jan 1 |
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Differential effects of bcl-2 on cell death triggered under ATP-depleting conditions. | 2001 Jan 1 |
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Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism. | 2001 Jan 1 |
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Association with the nuclear matrix and interaction with Groucho and RUNX proteins regulate the transcription repression activity of the basic helix loop helix factor Hes1. | 2001 Jan 12 |
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Affinity labeling of rat glutathione S-transferase isozyme 1-1 by 17beta -iodoacetoxy-estradiol-3-sulfate. | 2001 Jan 19 |
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Reconstitution of pterin-free inducible nitric-oxide synthase. | 2001 Jan 5 |
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2-acetylaminofluorene up-regulates rat mdr1b expression through generating reactive oxygen species that activate NF-kappa B pathway. | 2001 Jan 5 |
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Eosinophil peroxidase oxidation of thiocyanate. Characterization of major reaction products and a potential sulfhydryl-targeted cytotoxicity system. | 2001 Jan 5 |
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Role of multidrug resistance protein 1 (MRP1) and glutathione S-transferase A1-1 in alkylating agent resistance. Kinetics of glutathione conjugate formation and efflux govern differential cellular sensitivity to chlorambucil versus melphalan toxicity. | 2001 Mar 16 |
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A proteome analysis of the cadmium response in Saccharomyces cerevisiae. | 2001 Mar 16 |
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Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine beta-synthase and serine acetyltransferase from Trypanosoma. | 2001 Mar 2 |
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Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1. | 2001 Mar 2 |
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The cytosolic O-acetylserine(thiol)lyase gene is regulated by heavy metals and can function in cadmium tolerance. | 2001 Mar 23 |
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gamma -glutamyltransferase and its isoform mediate an endoplasmic reticulum stress response. | 2001 Mar 23 |
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A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission. | 2001 Mar 30 |
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Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor. | 2001 Mar 30 |
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Carbon dioxide stimulates the production of thiyl, sulfinyl, and disulfide radical anion from thiol oxidation by peroxynitrite. | 2001 Mar 30 |
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CyaG, a novel cyanobacterial adenylyl cyclase and a possible ancestor of mammalian guanylyl cyclases. | 2001 Mar 30 |
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Functional characterization of and cooperation between the double-stranded RNA-binding motifs of the protein kinase PKR. | 2001 Mar 30 |
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Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury. | 2001 Mar 30 |
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Phosphorylation of tau is regulated by PKN. | 2001 Mar 30 |
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Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p. | 2001 Mar 9 |
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Interaction with p53 enhances binding of cisplatin-modified DNA by high mobility group 1 protein. | 2001 Mar 9 |
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The modulation of oxygen radical production by nitric oxide in mitochondria. | 2001 Mar 9 |
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Hierarchy of merlin and ezrin N- and C-terminal domain interactions in homo- and heterotypic associations and their relationship to binding of scaffolding proteins EBP50 and E3KARP. | 2001 Mar 9 |
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Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex. | 2001 Mar 9 |
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A genetic investigation of the essential role of glutathione: mutations in the proline biosynthesis pathway are the only suppressors of glutathione auxotrophy in yeast. | 2001 Mar 9 |
|
Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. | 2001 Mar 9 |
|
Expression-independent consumption of substrates in cell-free expression system from Escherichia coli. | 2001 Nov 17 |
Patents
Sample Use Guides
For temporary relief of symptoms related to Free Radical Toxicity: 1-10 drops under the tongue, 3 times a day or as directed by a health professional. Consult a physician for use in children under 12 years of age.
pain in the back from urinating: 10 drops orally, 3 times a day. Consult a physician for use in children under 12 years of age.
Breast Cancer: RayGel Topical Cream applied in thin layer to the area exposed to radiation 60-90 minutes prior to radiotherapy, standard skin care between treatments.
Cystic Fibrosis: Inhaled Reduced Glutathione 10 mg/kg, twice daily, 12 months
Route of Administration:
Other
Substance Class |
Chemical
Created
by
admin
on
Edited
Thu Jul 06 09:10:00 UTC 2023
by
admin
on
Thu Jul 06 09:10:00 UTC 2023
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Record UNII |
H0X6UKX533
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Record Status |
Validated (UNII)
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Record Version |
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H0X6UKX533
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100000078214
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SUB76116
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SUB13991MIG
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92043348
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DTXSID90955757
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34212-83-4
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NON-SPECIFIC STOICHIOMETRY | |||
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20167-21-9
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251-884-1
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ACTIVE MOIETY |