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Details

Stereochemistry ABSOLUTE
Molecular Formula C10H16N3O6S.Na
Molecular Weight 329.305
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLUTATHIONE SODIUM

SMILES

[Na+].N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C([O-])=O

InChI

InChIKey=QWXDICNEPRTOLR-GEMLJDPKSA-M
InChI=1S/C10H17N3O6S.Na/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16;/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19);/q;+1/p-1/t5-,6-;/m0./s1

HIDE SMILES / InChI

Molecular Formula C10H16N3O6S
Molecular Weight 306.316
Charge -1
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/23036594 | https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3ef475c9-7938-4870-b336-fb0c2dafb3cd | https://clinicaltrials.gov/ct2/show/NCT01450267

Glutathione (GSH, also called as reduced glutathione) is a tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes such as, glutathione reductase, glutathione peroxidases, peroxiredoxins. Glutathione S-transferases catalyse the conjugation of GSH via a sulfhydryl group to electrophilic centers on a wide variety of substrates in order to make the compounds more water-soluble. As a part of homeopathic product, glutathione is used for temporary relief of symptoms related to Free Radical Toxicity including tingling in hands and feet, mood changes, frequent colds, poor digestion, fatigue, and constipation. In addition, for temporary relief of pain in the back from urinating, constant urging and frequent urination, kidneys sensitive to pressure, and pain from back extending down the thigh. Glutathione is an important nutrient for brain function and loss of glutathione has been implicated in Parkinson's disease. In phase II of the clinical trial was investigated whether administration of either dose of glutathione, as a nasal spray, improves PD symptoms over time in a population of individuals with Parkinson's disease (PD). In addition in phase II of clinical trial was shown, that reduced glutathione, an ingredient of RayGel™, has been helpful in decreasing some radiation therapy side effects to the skin. Reduced glutathione plays a vital role in both making DNA and cell repair. Cystic fibrosis (CF) is the most common inherited disease among the Caucasian population with considerable morbidity and reduced life expectancy. Glutathione (GSH) represents the first-line defence of the lung against oxidative stress-induced cell injury. Therapeutic approaches with inhaled GSH could improve the reduced lung antioxidant capacity in order to counterbalance the oxidant stress linked to the chronic airway inflammation and bacterial infection.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Glutathione S-transferases
Target ID: P00390
Gene ID: 2936.0
Gene Symbol: GSR
Target Organism: Homo sapiens (Human)
Conditions
PubMed

PubMed

TitleDatePubMed
Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells.
2000 Apr 14
Synergistic effect of diesel organic extracts and allergen Der p 1 on the release of chemokines by peripheral blood mononuclear cells from allergic subjects: involvement of the map kinase pathway.
2000 Aug
The protective effect of glutathione administration on adriamycin-induced acute cardiac toxicity in rats.
2000 Aug
Apoptosis induced by extracellular glutathione is mediated by H(2)O(2) production and DNA damage.
2000 Aug 1
Novel biphasic effect of pyrrolidine dithiocarbamate on neuronal cell viability is mediated by the differential regulation of intracellular zinc and copper ion levels, NF-kappaB, and MAP kinases.
2000 Jan 1
Mu-class GSTs are responsible for aflatoxin B(1)-8, 9-epoxide-conjugating activity in the nonhuman primate macaca fascicularis liver.
2000 Jul
Mitochondrial adaptations to obesity-related oxidant stress.
2000 Jun 15
Ligand-induced changes in the structure and dynamics of a human class Mu glutathione S-transferase.
2000 Jun 27
The catalytic Tyr-9 of glutathione S-transferase A1-1 controls the dynamics of the C terminus.
2000 Jun 9
Reactive oxygen species and proinflammatory cytokine signaling in endothelial cells: effect of selenium supplementation.
2000 Mar 15
Simultaneous inhibition of renal phospholipase A(2) and glutathione synthesis by manoalide and DL-buthionine sulfoximine induces acute tubular dysfunction in rats.
2000 Mar-Apr
A lens glutathione S-transferase, class mu, with thiol-specific antioxidant activity.
2000 Sep
Contribution of the mesangium to elastic strength and anchorage of the glomerular capillary tuft.
2001
Nitrogen monoxide (no) and glucose: unexpected links between energy metabolism and no-mediated iron mobilization from cells.
2001 Feb 16
Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of substrate binding to the active site of glutathione transferases.
2001 Feb 23
High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes.
2001 Jan
The activity of NF-kappaB in Swiss 3T3 cells exposed to aqueous extracts of cigarette smoke is dependent on thioredoxin.
2001 Jan
Ochratoxin A-induced tumor formation: is there a role of reactive ochratoxin A metabolites?
2001 Jan
Cellular thiols and reactive oxygen species in drug-induced apoptosis.
2001 Jan
Glutathione attenuates coronary constriction to acetylcholine in patients with coronary spastic angina.
2001 Jan
Greater susceptibility of failing cardiac myocytes to oxygen free radical-mediated injury.
2001 Jan
Glutathione in induced sputum of healthy individuals and patients with asthma.
2001 Jan
Genomic organization and putative promoters of highly conserved glutathione S-transferases originating by alternative splicing in Anopheles dirus.
2001 Jan
The intracellular oxidation of 2',7'-dichlorofluorescin in murine T lymphocytes.
2001 Jan 1
Thiols can either enhance or suppress DNA damage induction by catecholestrogens.
2001 Jan 1
Superoxide radical-initiated apoptotic signalling pathway in selenite-treated HepG(2) cells: mitochondria serve as the main target.
2001 Jan 1
Tamoxifen mutagenesis and carcinogenesis in livers of lambda/lacI transgenic rats: selective influence of phenobarbital promotion.
2001 Jan 10
Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities.
2001 Jan 12
Affinity labeling of rat glutathione S-transferase isozyme 1-1 by 17beta -iodoacetoxy-estradiol-3-sulfate.
2001 Jan 19
The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene.
2001 Jan 26
In vitro binding of ribosomes to the beta subunit of the Sec61p protein translocation complex.
2001 Jan 26
Reconstitution of pterin-free inducible nitric-oxide synthase.
2001 Jan 5
2-acetylaminofluorene up-regulates rat mdr1b expression through generating reactive oxygen species that activate NF-kappa B pathway.
2001 Jan 5
Eosinophil peroxidase oxidation of thiocyanate. Characterization of major reaction products and a potential sulfhydryl-targeted cytotoxicity system.
2001 Jan 5
Inhibition of adenylate cyclase activity by 5-aminolevulinic acid in rat and human brain.
2001 Mar
Role of multidrug resistance protein 1 (MRP1) and glutathione S-transferase A1-1 in alkylating agent resistance. Kinetics of glutathione conjugate formation and efflux govern differential cellular sensitivity to chlorambucil versus melphalan toxicity.
2001 Mar 16
A proteome analysis of the cadmium response in Saccharomyces cerevisiae.
2001 Mar 16
Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine beta-synthase and serine acetyltransferase from Trypanosoma.
2001 Mar 2
WD repeat domains target dictyostelium myosin heavy chain kinases by binding directly to myosin filaments.
2001 Mar 2
Enhanced multispecificity of arabidopsis vacuolar multidrug resistance-associated protein-type ATP-binding cassette transporter, AtMRP2.
2001 Mar 23
Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor.
2001 Mar 30
Carbon dioxide stimulates the production of thiyl, sulfinyl, and disulfide radical anion from thiol oxidation by peroxynitrite.
2001 Mar 30
CyaG, a novel cyanobacterial adenylyl cyclase and a possible ancestor of mammalian guanylyl cyclases.
2001 Mar 30
Functional characterization of and cooperation between the double-stranded RNA-binding motifs of the protein kinase PKR.
2001 Mar 30
A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells.
2001 Mar 30
Phosphorylation of tau is regulated by PKN.
2001 Mar 30
Different metabolizing ability of thiol reactants in human and rat blood: biochemical and pharmacological implications.
2001 Mar 9
Zinc release from the CH2C6 zinc finger domain of FILAMENTOUS FLOWER protein from Arabidopsis thaliana induces self-assembly.
2001 Mar 9
A genetic investigation of the essential role of glutathione: mutations in the proline biosynthesis pathway are the only suppressors of glutathione auxotrophy in yeast.
2001 Mar 9
Expression-independent consumption of substrates in cell-free expression system from Escherichia coli.
2001 Nov 17
Patents

Sample Use Guides

For temporary relief of symptoms related to Free Radical Toxicity: 1-10 drops under the tongue, 3 times a day or as directed by a health professional. Consult a physician for use in children under 12 years of age. pain in the back from urinating: 10 drops orally, 3 times a day. Consult a physician for use in children under 12 years of age. Breast Cancer: RayGel Topical Cream applied in thin layer to the area exposed to radiation 60-90 minutes prior to radiotherapy, standard skin care between treatments. Cystic Fibrosis: Inhaled Reduced Glutathione 10 mg/kg, twice daily, 12 months
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 03:01:48 GMT 2023
Edited
by admin
on Sat Dec 16 03:01:48 GMT 2023
Record UNII
H0X6UKX533
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GLUTATHIONE SODIUM
WHO-DD  
Systematic Name English
REDUCED GLUTATHIONE SODIUM SALT
Common Name English
GLYCINE, L-.GAMMA.-GLUTAMYL-L-CYSTEINYL-, SODIUM SALT
Common Name English
Glutathione sodium [WHO-DD]
Common Name English
Code System Code Type Description
FDA UNII
H0X6UKX533
Created by admin on Sat Dec 16 03:01:49 GMT 2023 , Edited by admin on Sat Dec 16 03:01:49 GMT 2023
PRIMARY
SMS_ID
100000078214
Created by admin on Sat Dec 16 03:01:49 GMT 2023 , Edited by admin on Sat Dec 16 03:01:49 GMT 2023
PRIMARY
EVMPD
SUB76116
Created by admin on Sat Dec 16 03:01:49 GMT 2023 , Edited by admin on Sat Dec 16 03:01:49 GMT 2023
ALTERNATIVE
EVMPD
SUB13991MIG
Created by admin on Sat Dec 16 03:01:49 GMT 2023 , Edited by admin on Sat Dec 16 03:01:49 GMT 2023
PRIMARY
PUBCHEM
92043348
Created by admin on Sat Dec 16 03:01:49 GMT 2023 , Edited by admin on Sat Dec 16 03:01:49 GMT 2023
PRIMARY
EPA CompTox
DTXSID90955757
Created by admin on Sat Dec 16 03:01:49 GMT 2023 , Edited by admin on Sat Dec 16 03:01:49 GMT 2023
PRIMARY
CAS
34212-83-4
Created by admin on Sat Dec 16 03:01:49 GMT 2023 , Edited by admin on Sat Dec 16 03:01:49 GMT 2023
NON-SPECIFIC STOICHIOMETRY
CAS
20167-21-9
Created by admin on Sat Dec 16 03:01:49 GMT 2023 , Edited by admin on Sat Dec 16 03:01:49 GMT 2023
PRIMARY
ECHA (EC/EINECS)
251-884-1
Created by admin on Sat Dec 16 03:01:49 GMT 2023 , Edited by admin on Sat Dec 16 03:01:49 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
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ACTIVE MOIETY