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Details

Stereochemistry ABSOLUTE
Molecular Formula C10H16N3O6S.Na
Molecular Weight 329.305
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLUTATHIONE SODIUM

SMILES

[Na+].N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C([O-])=O

InChI

InChIKey=QWXDICNEPRTOLR-GEMLJDPKSA-M
InChI=1S/C10H17N3O6S.Na/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16;/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19);/q;+1/p-1/t5-,6-;/m0./s1

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C10H16N3O6S
Molecular Weight 306.316
Charge -1
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/23036594 | https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3ef475c9-7938-4870-b336-fb0c2dafb3cd | https://clinicaltrials.gov/ct2/show/NCT01450267

Glutathione (GSH, also called as reduced glutathione) is a tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes such as, glutathione reductase, glutathione peroxidases, peroxiredoxins. Glutathione S-transferases catalyse the conjugation of GSH via a sulfhydryl group to electrophilic centers on a wide variety of substrates in order to make the compounds more water-soluble. As a part of homeopathic product, glutathione is used for temporary relief of symptoms related to Free Radical Toxicity including tingling in hands and feet, mood changes, frequent colds, poor digestion, fatigue, and constipation. In addition, for temporary relief of pain in the back from urinating, constant urging and frequent urination, kidneys sensitive to pressure, and pain from back extending down the thigh. Glutathione is an important nutrient for brain function and loss of glutathione has been implicated in Parkinson's disease. In phase II of the clinical trial was investigated whether administration of either dose of glutathione, as a nasal spray, improves PD symptoms over time in a population of individuals with Parkinson's disease (PD). In addition in phase II of clinical trial was shown, that reduced glutathione, an ingredient of RayGel™, has been helpful in decreasing some radiation therapy side effects to the skin. Reduced glutathione plays a vital role in both making DNA and cell repair. Cystic fibrosis (CF) is the most common inherited disease among the Caucasian population with considerable morbidity and reduced life expectancy. Glutathione (GSH) represents the first-line defence of the lung against oxidative stress-induced cell injury. Therapeutic approaches with inhaled GSH could improve the reduced lung antioxidant capacity in order to counterbalance the oxidant stress linked to the chronic airway inflammation and bacterial infection.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Glutathione S-transferases
Target ID: P00390
Gene ID: 2936.0
Gene Symbol: GSR
Target Organism: Homo sapiens (Human)
Target ID: Glutathione peroxidases
Conditions
PubMed

PubMed

TitleDatePubMed
Elevation of glutathione level in rat hepatocytes by hepatocyte growth factor via induction of gamma-glutamylcysteine synthetase.
1999 Nov
Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells.
2000 Apr 14
Synergistic effect of diesel organic extracts and allergen Der p 1 on the release of chemokines by peripheral blood mononuclear cells from allergic subjects: involvement of the map kinase pathway.
2000 Aug
A rice functional transcriptional activator, RISBZ1, responsible for endosperm-specific expression of storage protein genes through GCN4 motif.
2001 Apr 27
Major changes in human ocular UV protection with age.
2001 Jan
Dose response of carboplatin-induced hearing loss in rats: antioxidant defense system.
2001 Jan
Overcoming drug resistance in ovarian carcinoma.
2001 Jan
Glutathione in induced sputum of healthy individuals and patients with asthma.
2001 Jan
Tamoxifen mutagenesis and carcinogenesis in livers of lambda/lacI transgenic rats: selective influence of phenobarbital promotion.
2001 Jan 10
Affinity labeling of rat glutathione S-transferase isozyme 1-1 by 17beta -iodoacetoxy-estradiol-3-sulfate.
2001 Jan 19
Role of multidrug resistance protein 1 (MRP1) and glutathione S-transferase A1-1 in alkylating agent resistance. Kinetics of glutathione conjugate formation and efflux govern differential cellular sensitivity to chlorambucil versus melphalan toxicity.
2001 Mar 16
Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine beta-synthase and serine acetyltransferase from Trypanosoma.
2001 Mar 2
Enhanced multispecificity of arabidopsis vacuolar multidrug resistance-associated protein-type ATP-binding cassette transporter, AtMRP2.
2001 Mar 23
Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor.
2001 Mar 30
Carbon dioxide stimulates the production of thiyl, sulfinyl, and disulfide radical anion from thiol oxidation by peroxynitrite.
2001 Mar 30
A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells.
2001 Mar 30
Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex.
2001 Mar 9
Different metabolizing ability of thiol reactants in human and rat blood: biochemical and pharmacological implications.
2001 Mar 9
Patents

Sample Use Guides

For temporary relief of symptoms related to Free Radical Toxicity: 1-10 drops under the tongue, 3 times a day or as directed by a health professional. Consult a physician for use in children under 12 years of age. pain in the back from urinating: 10 drops orally, 3 times a day. Consult a physician for use in children under 12 years of age. Breast Cancer: RayGel Topical Cream applied in thin layer to the area exposed to radiation 60-90 minutes prior to radiotherapy, standard skin care between treatments. Cystic Fibrosis: Inhaled Reduced Glutathione 10 mg/kg, twice daily, 12 months
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 17 15:02:26 UTC 2022
Edited
by admin
on Sat Dec 17 15:02:26 UTC 2022
Record UNII
H0X6UKX533
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GLUTATHIONE SODIUM
WHO-DD  
Systematic Name English
REDUCED GLUTATHIONE SODIUM SALT
Common Name English
GLYCINE, L-.GAMMA.-GLUTAMYL-L-CYSTEINYL-, SODIUM SALT
Common Name English
Glutathione sodium [WHO-DD]
Common Name English
Code System Code Type Description
FDA UNII
H0X6UKX533
Created by admin on Sat Dec 17 15:02:26 UTC 2022 , Edited by admin on Sat Dec 17 15:02:26 UTC 2022
PRIMARY
EVMPD
SUB76116
Created by admin on Sat Dec 17 15:02:26 UTC 2022 , Edited by admin on Sat Dec 17 15:02:26 UTC 2022
ALTERNATIVE
EVMPD
SUB13991MIG
Created by admin on Sat Dec 17 15:02:26 UTC 2022 , Edited by admin on Sat Dec 17 15:02:26 UTC 2022
PRIMARY
PUBCHEM
92043348
Created by admin on Sat Dec 17 15:02:26 UTC 2022 , Edited by admin on Sat Dec 17 15:02:26 UTC 2022
PRIMARY
EPA CompTox
DTXSID90955757
Created by admin on Sat Dec 17 15:02:26 UTC 2022 , Edited by admin on Sat Dec 17 15:02:26 UTC 2022
PRIMARY
CAS
34212-83-4
Created by admin on Sat Dec 17 15:02:26 UTC 2022 , Edited by admin on Sat Dec 17 15:02:26 UTC 2022
NON-SPECIFIC STOICHIOMETRY
CAS
20167-21-9
Created by admin on Sat Dec 17 15:02:26 UTC 2022 , Edited by admin on Sat Dec 17 15:02:26 UTC 2022
PRIMARY
ECHA (EC/EINECS)
251-884-1
Created by admin on Sat Dec 17 15:02:26 UTC 2022 , Edited by admin on Sat Dec 17 15:02:26 UTC 2022
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY