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Showing 1 - 10 of 41 results

Status:
US Approved Rx (2006)
First approved in 1991

Class (Stereo):
CHEMICAL (ABSOLUTE)



Pravastatin (marketed as Pravachol or Selektine) is a member of the drug class of statins, used in combination with diet, exercise, and weight loss for lowering cholesterol and preventing cardiovascular disease. Pravastatin acts as a lipoprotein-lowe...
Status:
US Approved Rx (2001)
First approved in 1987

Class (Stereo):
CHEMICAL (ABSOLUTE)



Lovastatin acid is an active metabolite of hypolipidemic drug Lovastatin. Lovastatin acid inhibits HMG-CoA reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, which is an early and rate limiting step in the biosynthesis of chole...
Status:
US Approved Rx (2010)
First approved in 1981

Class (Stereo):
CHEMICAL (ACHIRAL)



Gemfibrozil, a fibric acid antilipemic agent similar to clofibrate, is used to treat hyperlipoproteinemia and as a second-line therapy for type IIb hypercholesterolemia. It acts to reduce triglyceride levels, reduce VLDL levels, reduce LDL levels (mo...
Status:
US Approved Rx (2018)
First marketed in 1921

Class (Stereo):
CHEMICAL (ACHIRAL)



Pentaerythritol tetranitrate is an organic nitrate that has been used for the treatment of angina pectoris. Upon administration, the drug undergoes exstensive metabolism to NO which causes vasodilation and the relaxation of smooth muscle cells. The c...
Status:
Investigational

Class (Stereo):
CHEMICAL (ACHIRAL)



Dalcetrapib (JTT-705) is a modulator than an inhibitor of cholesteryl ester transfer protein (CETP) activity and it may interact with and decrease CETP activity by a unique mechanism without an off-target effect. Dalcetrapib increased high-density li...
Status:
Investigational

Class (Stereo):
CHEMICAL (ABSOLUTE)



Torcetrapib is a CETP inhibitor which was developed by Pfizer for the treatment of diseases associated with elevated level of cholesterol. The drug was tested in phase III (in combination with atorvastatin) of clinical trials in coronary heart diseas...
Cyclovirobuxine D (CVB-D) is an active compound extracted from Buxus microphylla, which has been used of cardiac insufficiency and arrhythmias in China. The antiarrhythmic and proarrhythmic potential of this drug might be concerned with prolongation ...
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)



2-Phenylaminoadenosine (CV-1808) is an adenosine A2 receptor agonist. CV-1808 is a coronary vasodilator, antihypertensive and antipsychotic following systemic administration in vivo. CV-1808 appeared to be effective for salvaging ischemic myocardium....
Status:
Possibly Marketed Outside US
First approved in 2007

Class (Stereo):
CHEMICAL (ACHIRAL)



Lycopene is the fat-soluble pigment that gives tomatoes, watermelon, pink grapefruit, and other foods their red color. Bioavailability of lycopene is enhanced in the presence of lipids and thermal processing. Lycopene accounts for about 50% of the ca...
Status:
Possibly Marketed Outside US
First approved in 2007

Class (Stereo):
CHEMICAL (ACHIRAL)



Doconexent (Docosahexaenoic acid, DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina. DHA is widely used as a food supplement, and is beleived to support healthy brain developmen...