Clofilium is a quaternary ammonium compound that acts as potassium channel blocker. Clofilium is a class III agent. Clofilium increases atrial and ventricular effective refractory period without changing conduction time and, despite no apparent change in premature ventricular complex frequency, it can abolish the ability to induce ventricular tachycardia by programmed stimulation and is also well tolerated.

Dazmegrel [UK 38485] is a thromboxane synthetase inhibitor which was undergoing development in the treatment of thrombosis, ischaemic heart disease, arrhythmias and asthma. Pfizer were conducting phase II studies in Denmark and the UK, phase I studies in Germany and Italy, and preclinical studies in France. Later this research was discontinued.

8-oxyberberine (8-Oxoberberine, JKL1073A), an oxoderivative of berberine, is an alkaloid isolated from Argemone mexicana. 8-oxyberberine has been initially reported to exert anti-proliferative effects against a series of cancers. 8-oxyberberine inhibited the cell proliferation in human colon cancer cells. 8-Oxoberberine, a derivative of berberine, has been reported to exert antiarrhythmic activity, much like a class III antiarrhythmic agent. 8-Oxoberberine, like berberine, exerted positive inotropic and negative chronotropic actions. In rat left atria 8-oxoberberine, 10 to 100 uM, increased atrial contractility. In spontaneously beating right atria, 8-oxoberberine increased atrial contractility but slightly decreased the rate of contractions. 8-Oxoberberine inhibited the integral of the transient outward current (Ito) with a KD value of approximately 4 uM in either human or rat atrial myocytes. 8-Oxoberberine inhibited Ito by binding to open-state channels or by shifting the steady state inactivation curve of Ito.

Ergocryptinine is the ergot alkaloid. Ergotaminine, ergocryptinine, ergosinine and ergocorninine show vasoconstrictory effect, i.e. they cause the contraction of smooth muscles of blood vessels. Ergocryptinine shortened the duration of arrhythmia induced by adrenalin in rats. Ergocryptinine, ergocristinine and ergocorninine can be used in the treatment of arterial hypertension, heart insufficiency, heart arrhythmia and cephalalgia.

Panaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) that exhibits anti-inflammatory, hepatoprotective, anti-arrhythmic, and antioxidative activities. Panaxatriol increases expression of heme oxygenase 1 (HO-1) and activation of Nrf2 signaling in neurons in a PI3K/Akt-dependent manner. Panaxatriol also decreases acetaminophen-induced increases in ALT and TNF-α, preventing liver injury in vivo. Additionally, panaxatriol inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential. Panaxatriol is a tyrosine hydroxylase inducer. It shows neuroprotective and cardioprotective effects in vivo. Panaxatriol enhances antioxidant activity and inhibits mitochondria-mediated apoptosis. Pretreatment with ginseng total saponin, especially panaxatriol, ameliorates I/R-induced myocardial damage and this protection is caused by reducing oxidative stress. Panaxatriol can relieve myelosuppression induced by radiation injury. The abilities of regulating the expression of hemopoietic growth factor GM-CSF and promoting the maturation of bone marrow cells may be responsible for some of these beneficial effects.

Deslanoside is a cardiotonic glycoside from the leaves of Digitalis lanata. It is used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). It also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.

Potassium magnesium aspartate (K,Mg aspartate) is used in treating and preventing cardiac disruptions caused by electrolytic disturbances, primarily low potassium (K) and magnesium (Mg) levels (e.g. in the treatment with cardiac glycosides and diuretic drugs). It is used as a mineral supplement. The proposed mechanisms of action of magnesium-potassium aspartate include: Stabilization of cellular membranes by normalization of the levels of magnesium and potassium in the cells. Detoxification of ammonia or increase in the tricarboxylic acid-cycle flux. As increased levels of ammonia and depleted levels of potassium and magnesium ions in the plasma are associated with exercise-induced fatigue, this combination of aspartate (which detoxifies ammonia) and magnesium and potassium is particularly relevant in sports nutrition. Potassium magnesium aspartate is reported as an ingredient of Aspara in Japan, Panangin in Russian Federation, Bulgaria, China, Hungary, Romania etc., Asparkam in Georgia. Trophicard in Germany.

Malic acid is a tart-tasting organic dicarboxylic acid that contributes to the taste of many sour or tart foods such as apples. Sodium Malate is the sodium salt of Malic Acid. Malic Acid and Sodium Malate can be found in a wide range of cosmetics and personal care products. Sodium Malate functions as a skin conditioning agent-humectant. As a food additive, Sodium Malate has the E number E350. Sodium Malate has demonstrated protective effect on cisplatin-induced toxicity in mice. Sodium malate could become a useful agent for the reduction of CDDP-induced toxicity, particularly nephrotoxicity and hepatotoxicity.

Beta-methyl digoxin (beta-methyl digoxin; Metildigoxin (INN, or medigoxin BAN, or methyldigoxin) is a methyl derivative (methyl group in position 4 of the digitoxose residue) of digoxin is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). The substance is closely related to digoxin; it differs from the latter only by an O-methyl group on the terminal monosaccharide.

There is no available information about this compound