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Showing 1 - 10 of 10 results
Status:
US Previously Marketed
Source:
AMLEXANOX by ULURU
(2004)
Source URL:
First approved in 1996
Source:
APHTHASOL by ULURU
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Amlexanox is an ant allergic drug, clinically effective for atopic diseases, especially allergic asthma and rhinitis. Amlexanox as a topical paste is a well-tolerated treatment of recurrent aphthous ulcers. Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and 50% of the general population. The mechanism of action by which amlexanox accelerates healing of aphthous ulcers is unknown. In vitro studies have demonstrated amlexanox to be a potent inhibitor of the formation and/or release of inflammatory mediators (histamine and leukotrienes) from mast cells, neutrophils and mononuclear cells. Given orally to animals, amlexanox has demonstrated anti-allergic and anti-inflammatory activities and has been shown to suppress both immediate and delayed type hypersensitivity reactions. The relevance of these activities of amlexanox to its effects on aphthous ulcers has not been established. Amlexanox inhibits chemical mediatory release of the slow-reacting substance of anaphylaxis (SRS-A) and may have antagonistic effects on interleukin-3. When cells are under stress, they release an inactive form of human fibroblast growth factor 1 (FGF-1), a potent mitogen (entity that causes mitosis). Amlexanox binds to FGF1, increasing its conformational stability, sterically blocking Cu(2+) induced oxidation which normally leads to activation of FGF-1. This drug has been discontinued in the U.S
Status:
Possibly Marketed Outside US
First approved in 1996
Source:
DEBACTEROL Canker Sore Pain Relief by EPIEN Medical Inc
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Ammonium phenolsulfonate is an ingredient of deodorant, possesses antimicrobial properties to help the inhibition of the growth of microorganism of the skin. In addition, some studies were shown, that that ammonium para-hydroxy phenyl arsonate when used with phenolsulfonates in a concentration of 0.0238% in the drinking water was effective in the prevention of hemorrhage in chicks.
Status:
Possibly Marketed Outside US
Source:
JAMA Netw Open. May 2024;7(5):e248661.: Phase 4 Human clinical trial Completed Vaginosis, Bacterial
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Dequalinium is a quaternary ammonium cation commonly available as the dichloride salt. Dequalinium chloride has an antiseptic effect against a wide range of bacteria, yeasts, and some fungi and viruses. It kills the micro-organisms associated with various mild infections of the mouth and throat. Also, Dequalinium chloride is active against the bacteria which cause bacterial vaginosis. Dequalinium Chloride (DECA) is a PKC inhibitor and high-affinity blocker CNGA1 channel, and nearly as effective on heteromeric CNGA1+CNGB1 channels. Common side effects are: vaginal discharge; vaginal itching or vaginal burning; vaginal yeast infection (thrush); tender tongue.
Status:
Possibly Marketed Outside US
First approved in 1996
Source:
DEBACTEROL Canker Sore Pain Relief by EPIEN Medical Inc
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Ammonium phenolsulfonate is an ingredient of deodorant, possesses antimicrobial properties to help the inhibition of the growth of microorganism of the skin. In addition, some studies were shown, that that ammonium para-hydroxy phenyl arsonate when used with phenolsulfonates in a concentration of 0.0238% in the drinking water was effective in the prevention of hemorrhage in chicks.
Status:
Possibly Marketed Outside US
First approved in 1996
Source:
DEBACTEROL Canker Sore Pain Relief by EPIEN Medical Inc
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Ammonium phenolsulfonate is an ingredient of deodorant, possesses antimicrobial properties to help the inhibition of the growth of microorganism of the skin. In addition, some studies were shown, that that ammonium para-hydroxy phenyl arsonate when used with phenolsulfonates in a concentration of 0.0238% in the drinking water was effective in the prevention of hemorrhage in chicks.
Status:
Possibly Marketed Outside US
First approved in 1996
Source:
DEBACTEROL Canker Sore Pain Relief by EPIEN Medical Inc
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Ammonium phenolsulfonate is an ingredient of deodorant, possesses antimicrobial properties to help the inhibition of the growth of microorganism of the skin. In addition, some studies were shown, that that ammonium para-hydroxy phenyl arsonate when used with phenolsulfonates in a concentration of 0.0238% in the drinking water was effective in the prevention of hemorrhage in chicks.
Status:
Possibly Marketed Outside US
First approved in 1996
Source:
DEBACTEROL Canker Sore Pain Relief by EPIEN Medical Inc
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Ammonium phenolsulfonate is an ingredient of deodorant, possesses antimicrobial properties to help the inhibition of the growth of microorganism of the skin. In addition, some studies were shown, that that ammonium para-hydroxy phenyl arsonate when used with phenolsulfonates in a concentration of 0.0238% in the drinking water was effective in the prevention of hemorrhage in chicks.
Status:
Possibly Marketed Outside US
Source:
JAMA Netw Open. May 2024;7(5):e248661.: Phase 4 Human clinical trial Completed Vaginosis, Bacterial
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Dequalinium is a quaternary ammonium cation commonly available as the dichloride salt. Dequalinium chloride has an antiseptic effect against a wide range of bacteria, yeasts, and some fungi and viruses. It kills the micro-organisms associated with various mild infections of the mouth and throat. Also, Dequalinium chloride is active against the bacteria which cause bacterial vaginosis. Dequalinium Chloride (DECA) is a PKC inhibitor and high-affinity blocker CNGA1 channel, and nearly as effective on heteromeric CNGA1+CNGB1 channels. Common side effects are: vaginal discharge; vaginal itching or vaginal burning; vaginal yeast infection (thrush); tender tongue.
Status:
Possibly Marketed Outside US
Source:
JAMA Netw Open. May 2024;7(5):e248661.: Phase 4 Human clinical trial Completed Vaginosis, Bacterial
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Dequalinium is a quaternary ammonium cation commonly available as the dichloride salt. Dequalinium chloride has an antiseptic effect against a wide range of bacteria, yeasts, and some fungi and viruses. It kills the micro-organisms associated with various mild infections of the mouth and throat. Also, Dequalinium chloride is active against the bacteria which cause bacterial vaginosis. Dequalinium Chloride (DECA) is a PKC inhibitor and high-affinity blocker CNGA1 channel, and nearly as effective on heteromeric CNGA1+CNGB1 channels. Common side effects are: vaginal discharge; vaginal itching or vaginal burning; vaginal yeast infection (thrush); tender tongue.
Status:
Possibly Marketed Outside US
Source:
JAMA Netw Open. May 2024;7(5):e248661.: Phase 4 Human clinical trial Completed Vaginosis, Bacterial
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Dequalinium is a quaternary ammonium cation commonly available as the dichloride salt. Dequalinium chloride has an antiseptic effect against a wide range of bacteria, yeasts, and some fungi and viruses. It kills the micro-organisms associated with various mild infections of the mouth and throat. Also, Dequalinium chloride is active against the bacteria which cause bacterial vaginosis. Dequalinium Chloride (DECA) is a PKC inhibitor and high-affinity blocker CNGA1 channel, and nearly as effective on heteromeric CNGA1+CNGB1 channels. Common side effects are: vaginal discharge; vaginal itching or vaginal burning; vaginal yeast infection (thrush); tender tongue.