Showing 1 - 8 of 8 results
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Cortexolone 17α-propionate (WINLEVI, BREEZULA) is a steroid belonging to the family of cortexolone derivatives. It is a topical and peripherally selective androgen antagonist. WINLEVI is used for the treatment of acne and has completed Phase II clini...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Finasteride is a synthetic 4-azasteroid compound. This drug is a competitive and specific inhibitor of Type II 5a-reductase, an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). Two distinct isozymes are ...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
PGD2 (Prostaglandin D2) is a major cellular regulator, has been shown to bind different receptors: D prostanoid receptor (DP) and chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). PGD2 reportedly inhibits platelet aggregati...
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
11-Epiprostaglandin E1 is a synthetic prostaglandin analogue. The activity of the racemic synthetic prostaglandin is approximately one-half that of the naturally occurring compound. 11-Epiprostaglandin E1 is 13%, 3.6% and 12%as potent as PGE1 in cont...
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
PF-998425 is a selective non-steroidal androgen receptor antagonist. It is rapidly metabolized systemically, and demonstrated efficacy for treatment of androgenic alopecia in preclinical model.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
8-Epiprostaglandin E1 (8-iso-PGE1) arises by isomerization of PGE1. This isoprostane found in human semen. 8-iso-PGE1 has very low biological activity relative to PGE1. Intravenous administration of 8-iso-PGE1 decreased systemic arterial pressure sli...
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
RU58841 is a topically active non-steroidal antiandrogen. It demonstrated efficacy in animal models of androgen-dependent skin disorders such as acne and androgenetic alopecia. Under name of PSK 3841 was being developed by ProStrakan. It underwent cl...
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Alfatradiol (17a-estradiol, Ell-Cranell® alpha) is a stereoisomer of the female hormone 17b-estradiol. It inhibits the conversion of testosterone to the metabolite dihydrotestosterone (DHT) by suppressing 5a-reductase activity. In addition, by inhibi...