| Stereochemistry | ACHIRAL |
| Molecular Formula | C17H18F3N3O3 |
| Molecular Weight | 369.3383 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1(C)N(CCCCO)C(=O)N(C1=O)C2=CC(=C(C=C2)C#N)C(F)(F)F
InChI
InChIKey=ARBYGDBJECGMGA-UHFFFAOYSA-N
InChI=1S/C17H18F3N3O3/c1-16(2)14(25)23(15(26)22(16)7-3-4-8-24)12-6-5-11(10-21)13(9-12)17(18,19)20/h5-6,9,24H,3-4,7-8H2,1-2H3
| Molecular Formula | C17H18F3N3O3 |
| Molecular Weight | 369.3383 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
RU58841 is a topically active non-steroidal antiandrogen. It demonstrated efficacy in animal models of androgen-dependent skin disorders such as acne and androgenetic alopecia. Under name of PSK 3841 was being developed by ProStrakan. It underwent clinical evaluation for the treatment of androgen-dependent conditions, such as acne and alopecia. Following the conclusion of phase II trials, no further development was reported. Based on this and the fact the compound is not listed on the companies pipeline, development is presumed discontinued.
Originator
Approval Year
Sourcing
PubMed
Patents
Sample Use Guides
Mice: topically (5 days/week) with RU58841 1% in ethanol.
Stumptailed macaques: the topical application of RU58841 (a 5% solution in a propyleneglycol and isopropanol mixture).
Route of Administration:
Transdermal
