Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H34O5 |
| Molecular Weight | 354.481 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCC[C@H](O)\C=C\[C@H]1[C@@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O
InChI
InChIKey=GMVPRGQOIOIIMI-FZYGRIMQSA-N
InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19-/m0/s1
| Molecular Formula | C20H34O5 |
| Molecular Weight | 354.481 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 1 |
| Optical Activity | UNSPECIFIED |
11-Epiprostaglandin E1 is a synthetic prostaglandin analogue. The activity of the racemic synthetic prostaglandin is approximately one-half that of the naturally occurring compound. 11-Epiprostaglandin E1 is 13%, 3.6% and 12%as potent as PGE1 in contracting the rat uterus, guinea pig ileum and rabbit jejunum, respectively. Nevertheless, this unnatural compound was proposed as a prostaglandin D2 receptor antagonist for use in the treatment of androgenic alopecia.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Biological activity of synthetic prostaglandins. | 1969 Mar 29 |
|
| Relationship between the chemical structure of prostaglandins and their vasoactivities in dogs. | 1972 Jan |
|
| Conformational analysis of prastaglandins. III. Study on active sites and conformation-action relationship. | 1977 Dec |
|
| Quantitative determination of alprostadil (PGE) in bulk drug and pharmaceutical formulations by high-performance liquid chromatography. | 1984 Jan 20 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:42:23 GMT 2023
by
admin
on
Sat Dec 16 08:42:23 GMT 2023
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| Record UNII |
U0DO49Q8Y4
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| Record Status |
Validated (UNII)
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| Record Version |
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24570-01-2
Created by
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5283098
Created by
admin on Sat Dec 16 08:42:23 GMT 2023 , Edited by admin on Sat Dec 16 08:42:23 GMT 2023
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U0DO49Q8Y4
Created by
admin on Sat Dec 16 08:42:23 GMT 2023 , Edited by admin on Sat Dec 16 08:42:23 GMT 2023
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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