U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 121 - 130 of 472 results

Status:
Possibly Marketed Outside US
Source:
Canada:TELLURIUM METALLICUM
Source URL:
First approved in 2015

Class (Stereo):
CHEMICAL (ACHIRAL)

Tellurium (Te) is widely used in industry. Tellurium (IV) compounds present antitumoral, immunomodulatory and neuroprotective effects due to their ability to inhibit cysteine proteases. Tellurium (IV) compounds exert anticonvulsant effects associated with the inhibition of caspases. Thus, organotellurium (IV) possesses a promising therapeutic potential as antiepileptogenic agents.
Status:
Possibly Marketed Outside US
Source:
Canada:GLYOXAL
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Glyoxal refers to the reactive electrophilic species (RES) and is formed during different processes, e.g., lipid peroxidation, DNA oxidation. RES cause the damage of proteins and nucleotides and thus can cause different diseases in human, e.g., diabetes. Glyoxal reacting with free guanines in RNAs can be is used for chemical probing of RNA structure.
Status:
Possibly Marketed Outside US
Source:
Canada:PALLADIUM
Source URL:
First approved in 2015

Class (Stereo):
CHEMICAL (ACHIRAL)

Palladium is a rare and lustrous silvery-white metal. Palladium has the lowest melting point and is the least dense of platinum group metals. The primary use for palladium is in catalytic converters for the automotive industry. Palladium-based complexes are appealing alternative metal-based drugs because of significant similarities regarding structure and coordination chemistry with the platinum agents. Research suggests that one of the big reasons for the negative side effects of most anti-cancer drugs could be the use of the metal platinum as the core element in most of them. There is, however, evidence that the side-effects could be minimised by replacing it with a close metal relative, palladium. Currently, palladium complexes are being studied for their anti-cancer activity. Palladium nanoparticles (PdNPs) have attracted wide attention owing to their multifaceted utility in catalysis, sensors, and biomedical applications. Their therapeutic spectrum includes anticancer, antiviral, antibacterial, antifungal, antidiabetic, antioxidant potential which rationalizes the exploration of diverse physical, chemical, and biological routes for fabrication.
Ponazuril, sold by the Bayer Corporation under the trade name Marquis, was the first FDA-approved treatment for equine protozoal myeloencephalitis (EPM) in horse, caused by Sarcocystis neurona. Also this drug was used in animals such as cats, dogs against coccidia, an intestinal parasite. Coccidia treatment is far shorter than treatment for EPM.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Cedrol is a sesquiterpene alcohol found in the essential oil of conifers (cedar oil), especially in the genera Cupressus (cypress) and Juniperus (juniper). It has also been identified in Origanum onites, a plant related to oregano. Cedrol is a fragrance ingredient used in decorative cosmetics, fine fragrances, shampoos, toilet soaps and other toiletries as well as in non-cosmetic products such as household cleaners and detergents. Its use worldwide is in the region of 1–10 metric tonnes per annum. The maximum skin level in formulae that go into fine fragrances has been reported to be 1.51% assuming use of the fragrance oil at levels up to 20% in the final product. The 97.5 percentile use level in formulae for use in cosmetics in general has been reported to be 1.3%, which would result in a maximum daily exposure on the skin of 0.0331 mg/kg for high end users of these products. Finding the natural source of this compound might help to elucidate why Anopheles gambiae and Anopheles arabiensis prefer to lay eggs in habitats containing it. Cedrol is the first compound confirmed as an oviposition attractant for gravid An. gambiae s.l. This finding paves the way for developing new ‘attract and kill strategies’ for malaria vector control.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Showing 121 - 130 of 472 results