Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C15H26O |
Molecular Weight | 222.3663 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC[C@@H](C)[C@]13C[C@H](C2(C)C)[C@](C)(O)CC3
InChI
InChIKey=SVURIXNDRWRAFU-OGMFBOKVSA-N
InChI=1S/C15H26O/c1-10-5-6-11-13(2,3)12-9-15(10,11)8-7-14(12,4)16/h10-12,16H,5-9H2,1-4H3/t10-,11+,12-,14-,15+/m1/s1
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/18640184
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18640184
Cedrol is a sesquiterpene alcohol found in the essential oil of conifers (cedar oil), especially in the genera Cupressus (cypress) and Juniperus (juniper). It has also been identified in Origanum onites, a plant related to oregano. Cedrol is a fragrance ingredient used in decorative cosmetics, fine fragrances, shampoos, toilet soaps and other toiletries as well as in non-cosmetic products such as household cleaners and detergents. Its use worldwide is in the region of 1–10 metric tonnes per annum. The maximum skin level in formulae that go into fine fragrances has been reported to be 1.51% assuming use of the fragrance oil at levels up to 20% in the final product. The 97.5 percentile use level in formulae for use in cosmetics in general has been reported to be 1.3%, which would result in a maximum daily exposure on the skin of 0.0331 mg/kg for high end users of these products. Finding the natural source of this compound might help to elucidate why Anopheles gambiae and Anopheles arabiensis prefer to lay eggs in habitats containing it. Cedrol is the first compound confirmed as an oviposition attractant for gravid An. gambiae s.l. This finding paves the way for developing new ‘attract and kill strategies’ for malaria vector control.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL250 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15742349 |
10.9 µM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18640184
The maximum skin level in formulae that go into fine fragrances has been reported to be 1.51% assuming use of the fragrance oil at levels up to 20% in the final product. The 97.5 percentile use level in formulae for use in cosmetics in general has been reported to be 1.3%, which would result in a maximum daily exposure on the skin of 0.0331 mg/kg for high end users of these products
Route of Administration:
Topical
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25885703
Anopheles gambiae species females were two times more likely to lay eggs in lake water infused for six days with soil from a natural oviposition site in western Kenya compared to lake water alone or to the same but autoclaved infusion. One of the soil infusion volatiles was readily identified as the sesquiterpene alcohol cedrol. Its widespread presence in natural aquatic habitats in the study area was confirmed by analysing the chemical headspace of 116 water samples collected from different aquatic sites in the field and was therefore selected for evaluation in oviposition bioassays. Twice as many gravid females were attracted to cedrol-treated water than to water alone in two choice cage bioassays and in experiments conducted in large-screened cages with free-flying mosquitoes. When tested in the field, wild malaria vector females were three times more likely to be collected in the traps baited with cedrol than in the traps containing water alone.
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JECFA EVALUATION |
(+)-CEDROL
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201-035-6
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m3183
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63ZM9703BO
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65575
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1670019
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8265
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CEDROL
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SUBSTANCE RECORD