U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 81 - 90 of 587 results

Status:
Possibly Marketed Outside US
Source:
part343
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Vanillyl butyl ether is an ether of monohydroxybenzoic acid. It is added to food products as a flavoring agent. It has a characteristic trigeminal, burning, hot pepper nature and can be used in spice flavors like pepper, cinnamon and ginger. It is also present in cosmetics and personal care products as a fragrance ingredient, oral care agent, hair conditioning agent, and warming or cooling agent. Vanilloids contain vanillyl groups that bind to the transient receptor potential type V1 channel (Vanilloid receptor-1, TRPV1) that respond to noxious stimuli such as high temperatures and acidic pH. This causes neurons to release glutamate, adenosine triphosphate (ATP) and a variety of neuropeptides, resulting in the warming sensation. Vanillyl butyl ether causes serious eye irritation and may cause an allergic skin reaction.
Status:
Possibly Marketed Outside US
Source:
Canada:MELENGESTROL ACETATE
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Melengestrol is a steroidal progestin and antineoplastic agent which was never marketed. An acylated derivative, melengestrol acetate, is used as a growth promoter in animals. Melengestrol acetate (MGA) is one of six steroidal hormone growth promoters approved for use in Canada and USA. These products are used to improve growth rate and feed efficiency, as well as to suppress estrus in beef heifers (CFIA 2008). They are not approved for use in any species other than beef cattle meant for slaughter. MGA is the only drug of its kind that is administered in animal feed, and its labelled dose in Canada is 0.4mg per heifer per day (CFIA 2008). A mandatory withdrawal of 2 days before slaughter is applied to any animal that is administered MGA.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ABSOLUTE)



CAPRYLYL GLUCOSIDE is a mild and non-denaturing detergent for the solubilization and reconsititution of membrane bound proteins. Treatment with 1.2% N-octylglucoside for 5 min completely inhibited HIV-1 infectivity. CAPRYLYL GLUCOSIDE being nontoxic and inexpensive agent in inhibiting Staphylococcus epidermidis and Pseudomonas aeruginosa adhesion to conventional and silicone-hydrogel contact lenses. CAPRYLYL GLUCOSIDE was tested for the treatment of pulmonary tuberculosis. It was shown, that surfactant is proficient in removing Mycobacterium tuberculosis shield. Thus, it may also enhance the effectiveness of antibiotics and the immune system's response in the treatment of pulmonary tuberculosis.