CAPRYLYL GLUCOSIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C14H28O6
Molecular Weight	292.3685
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

InChI

InChIKey=HEGSGKPQLMEBJL-RKQHYHRCSA-N

InChI=1S/C14H28O6/c1-2-3-4-5-6-7-8-19-14-13(18)12(17)11(16)10(9-15)20-14/h10-18H,2-9H2,1H3/t10-,11-,12+,13-,14-/m1/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/756493 | https://www.ncbi.nlm.nih.gov/pubmed/17502827 | https://www.ncbi.nlm.nih.gov/pubmed/20952734 | https://www.ncbi.nlm.nih.gov/pubmed/21136887

CAPRYLYL GLUCOSIDE is a mild and non-denaturing detergent for the solubilization and reconsititution of membrane bound proteins. Treatment with 1.2% N-octylglucoside for 5 min completely inhibited HIV-1 infectivity. CAPRYLYL GLUCOSIDE being nontoxic and inexpensive agent in inhibiting Staphylococcus epidermidis and Pseudomonas aeruginosa adhesion to conventional and silicone-hydrogel contact lenses. CAPRYLYL GLUCOSIDE was tested for the treatment of pulmonary tuberculosis. It was shown, that surfactant is proficient in removing Mycobacterium tuberculosis shield. Thus, it may also enhance the effectiveness of antibiotics and the immune system's response in the treatment of pulmonary tuberculosis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cellular membranes 1 Target ID: Cellular membranes Sources: https://www.ncbi.nlm.nih.gov/pubmed/20952734	Modulator 828

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pulmonary tuberculosis 17 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20952734	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Improved synthesis of n-octyl-beta-D-glucoside: a nonionic detergent of considerable potential in membrane biochemistry.	1978	756493
Effect of alterations in the amphipathic microenvironment on the conformational stability of bovine opsin. 1. Mechanism of solubilization of disk membranes by the nonionic detergent, octyl glucoside.	1978 Jan 24	619986
The use of octyl beta-D-glucoside as detergent for hog kidney brush border membrane.	1979 Oct 19	549635

Patents

Sample Use Guides

In Vivo Use Guide

Mice: 25 ul of surfactant in 0.15M NaCl was administered utilizing a Penn-Century syringe and shaft. Two days in succession weekly for three weeks and once in the fourth week.

Route of Administration: Other

In Vitro Use Guide

Treatment with 1.2% N-octylglucoside for 5 min completely inhibited HIV-1 infectivity.

Name

Type

Language

CAPRYLYL GLUCOSIDE

Official Name

English

N-OCTYL-.BETA.-D-GLUCOSIDE [MI]

Common Name

English

OCTYL D-GLUCOSIDE

Common Name

English

OCTYL GLUCOSIDE

Common Name

English

CAPRYLYL GLUCOSIDE [INCI]

Common Name

English

SUCRAPH AG-8

Common Name

English

OCTYL BETA-D-GLUCOPYRANOSIDE

Common Name

English

Code System Code Type Description

CHEBI

41128