U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 61 - 70 of 175 results

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ABSOLUTE)

1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE is a glycerophosphocholine lipid molecule also known as dioleoyl lecithin. It is considered to be practically insoluble in water and acidic. Formerly, it was used in liposome studies and biological systems research.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Versetamide is a chelating agent. It is a pharmaceutic aid.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Status:
Possibly Marketed Outside US
Source:
Zeniquin by Hoffman-La Roche
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Marbofloxacin is an anti-bacterial veterinary medication which is approved by FDA and EMEA for the treatment of bacterial diseases in dogs and cats. The drug exerts its action by inhibiting bacterial DNA gyrase.
Status:
Possibly Marketed Outside US
Source:
NCT00818467: Phase 4 Interventional Completed Vitamin D Status
(2008)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:


Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

N,N-Dimethylacetamide (DMA) is a multipurpose reagent which delivers its own H, C, N and O atoms for the synthesis of a variety of compounds under a number of different experimental conditions. N,N-Dimethylacetamide is a water-miscible solvent, FDA approved as excipient and therefore widely used as drug-delivery vehicle. It has been shown that DMA is epigenetically active since it binds bromodomains and inhibits osteoclastogenesis and inflammation. DMA has a potential as an anti-osteoporotic agent via the inhibition of osteoclast mediated bone resorption and enhanced bone regeneration. N,N-Dimethylacetamide is used as a polar solvent in organic synthesis as well as in reactions involving strong bases such as sodium hydroxide. N,N-Dimethylacetamide finds application as a reaction medium in the production of pharmaceuticals, agrochemicals, dyes and plasticizers. It is widely used in polymer industry due to its high solving power for high molecular-weight polymers and synthetic resins. It plays an important role as a catalyst in various reactions viz. cyclization, halogenation, cynidation, alkylation and dehydrogenation and increases the yield of main products. It is also used as an extracting agent for oil and gases, in paint removers, in the production of photo-resist stripping compounds and as booster solvent in coatings.
Status:
Possibly Marketed Outside US
First approved in 1999

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Toluene is a colorless, water-insoluble liquid with the smell associated with paint thinners. It is a mono-substituted benzene derivative, consisting of a CH3 group attached to a phenyl group. The major use of toluene is as a mixture added to gasoline to improve octane ratings. Toluene is also usedto produce benzene and as a solvent in paints, coatings, synthetic fragrances, adhesives, inks, and cleaningagents. Toluene is also used in the production of polymers used to make nylon, plastic soda bottles, andpolyurethanes and for pharmaceuticals, dyes, cosmetic nail products, and the synthesis of organicchemicals. The CNS is the primary target organ for toluene toxicity in both humans and animals for acute and chronicexposures. CNS dysfunction (which is often reversible) and narcosis have been frequently observed inhumans acutely exposed to low or moderate levels of toluene by inhalation; symptoms include fatigue,sleepiness, headaches, and nausea. CNS depression and death have occurred at higher levels of exposure. Toluene is used in veterinary medicine as a treatment for various parasites in dogs and cats. It is used for the removal of ascarids (Toxocara canis and Toxascaris leonina) and hookworms (Ancylostoma caninum and Uncinaria stenocephala) and as an aid in removing tapeworms (Taenia pisiformis, Dipylidium caninum, and Echinococcus granulosus) from dogs and cats.