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Details

Stereochemistry ACHIRAL
Molecular Formula C17H19FN4O4
Molecular Weight 362.3556
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MARBOFLOXACIN

SMILES

CN1CCN(CC1)C2=C3OCN(C)N4C=C(C(O)=O)C(=O)C(C=C2F)=C34

InChI

InChIKey=BPFYOAJNDMUVBL-UHFFFAOYSA-N
InChI=1S/C17H19FN4O4/c1-19-3-5-21(6-4-19)14-12(18)7-10-13-16(14)26-9-20(2)22(13)8-11(15(10)23)17(24)25/h7-8H,3-6,9H2,1-2H3,(H,24,25)

HIDE SMILES / InChI

Description

Marbofloxacin is an anti-bacterial veterinary medication which is approved by FDA and EMEA for the treatment of bacterial diseases in dogs and cats. The drug exerts its action by inhibiting bacterial DNA gyrase.

CNS Activity

Originator

Target Info

Target Info

Primary TargetPharmacologyConditionPotency
Condition Info

Condition Info

PMID

PMID

TitleDatePMID
Inclusion of marbofloxacin in PMMA orthopaedic cement: an in vitro experimental study.
2006
Pharmacokinetics, urinary excretion and dosage regimen of levofloxacin following a single intramuscular administration in cross bred calves.
2006 Dec
Clinical efficacy of intravenous administration of marbofloxacin in a Staphylococcus aureus infection in tissue cages in ponies.
2006 Dec
Determination of fluoroquinolones in milk samples by postcolumn derivatization liquid chromatography with luminescence detection.
2006 Dec 27
Preliminary single-dose pharmacokinetics of marbofloxacin in ball pythons (Python regius).
2006 Mar
Multiresidue method for the determination of quinolone antibiotics in bovine raw milk by capillary electrophoresis-tandem mass spectrometry.
2006 Nov 15
Comparison of pharmacodynamic and pharmacokinetic indices of efficacy for 5 fluoroquinolones toward pathogens of dogs and cats.
2006 Nov-Dec
Mucosal permeability of water-soluble drugs in the equine jejunum: a preliminary investigation.
2006 Oct
Enrofloxacin and marbofloxacin in horses: comparison of pharmacokinetic parameters, use of urinary and metabolite data to estimate first-pass effect and absorbed fraction.
2006 Oct
Effect of chronic FIV infection, and efficacy of marbofloxacin treatment, on Mycoplasma haemofelis infection.
2006 Oct 31
Field evaluation of the efficacy of tolfenamic acid administered in one single preoperative injection for the prevention of postoperative pain in the dog.
2007 Dec
Naïve averaged, naïve pooled, and population pharmacokinetics of orally administered marbofloxacin in juvenile harbor seals.
2007 Feb 1
[Determination of 16 quinolone residues in animal tissues using high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry].
2007 Jul
Pharmacokinetics of a single intravenous dose of marbofloxacin in adult donkeys.
2007 Jul 28
In vitro antimicrobial activity of marbofloxacin and enrofloxacin against bacterial strains isolated from companion animals.
2007 Jun
Separation of fifteen quinolones by high performance liquid chromatography: application to pharmaceuticals and ofloxacin determination in urine.
2007 Jun
Identification and comparison of marbofloxacin metabolites from the plasma of ball pythons (Python regius) and blue and gold macaws (Ara ararauna).
2007 Jun
Comparative pharmacokinetics of marbofloxacin in healthy and Mannheimia haemolytica infected calves.
2007 Jun
Microbiological detection of 10 quinolone antibiotic residues and its application to artificially contaminated poultry samples.
2007 Mar
Stability of frozen stock solutions of beta-lactam antibiotics, cephalosporins, tetracyclines and quinolones used in antibiotic residue screening and antibiotic susceptibility testing.
2007 Mar 14
Simultaneous determination of trace levels of 10 quinolones in swine, chicken, and shrimp muscle tissues using HPLC with programmable fluorescence detection.
2007 May 16
Single-dose pharmacokinetics of marbofloxacin in Egyptian buffalo (Bubalus bubalis L.) steers.
2007 May-Jun
Comparative activity of pradofloxacin against anaerobic bacteria isolated from dogs and cats.
2007 Nov
Multiresidue method for simultaneous determination of quinolone antibacterials in pig kidney samples by liquid chromatography with fluorescence detection.
2007 Nov 15
Susceptibility of Pseudomonas isolates from the ears and skin of dogs to enrofloxacin, marbofloxacin, and ciprofloxacin.
2007 Nov-Dec
Antimicrobial testing of selected fluoroquinolones against Pseudomonas aeruginosa isolated from canine otitis.
2007 Nov-Dec
Allometric scaling of marbofloxacin, moxifloxacin, danofloxacin and difloxacin pharmacokinetics: a retrospective analysis.
2007 Oct
Pharmacokinetic behavior and pharmacokinetic/pharmacodynamic integration of marbofloxacin after subcutaneous administration in goats.
2007 Sep
Comparative quantification of the in vitro activity of veterinary fluoroquinolones.
2007 Sep 20
Pulmonary function and antimicrobial concentration after marbofloxacin inhalation in horses.
2007 Sep 8
Improved determination of quinolones in milk at their MRL levels using LC-UV, LC-FD, LC-MS and LC-MS/MS and validation in line with regulation 2002/657/EC.
2008 Apr 14
Comprehensive screening and quantification of veterinary drugs in milk using UPLC-ToF-MS.
2008 Jul
Development of an immunochromatography strip for the rapid detection of 12 fluoroquinolones in chicken muscle and liver.
2008 Jul 23
[Multiresidue determination of quinolones in animal and fishery products by HPLC].
2008 Jun
Intraocular pharmacokinetics of intravenously administered marbofloxacin in rabbits with experimentally induced acute endophthalmitis.
2008 Mar
Marbofloxacin for the treatment of experimentally induced Mycoplasma haemofelis infection in cats.
2008 Mar-Apr
In-line solid-phase extraction preconcentration in capillary electrophoresis-tandem mass spectrometry for the multiresidue detection of quinolones in meat by pressurized liquid extraction.
2008 May
Efficacy of different treatment regimens of marbofloxacin in canine visceral leishmaniosis: a pilot study.
2008 May 31
Simultaneous determination of quinolone antibacterials in bovine milk by liquid chromatography-mass spectrometry.
2008 Nov
Simultaneous determination of 13 quinolones in eggs using column high-performance liquid chromatography/electrospray ionization-tandem mass spectrometry and depletion of pefloxacin methanesulfonate in eggs.
2008 Nov-Dec
Tissue distribution of marbofloxacin after 'systemic' administration into the isolated perfused bovine udder.
2008 Oct
Antimicrobial resistance and genetic characterization of fluoroquinolone resistance of Pseudomonas aeruginosa isolated from canine infections.
2008 Sep 18
Influence of systemic fluoroquinolone administration on the presence of Pasteurella multocida in the upper respiratory tract of clinically healthy calves.
2008 Sep 22
Single- and multiple-dose pharmacokinetics of marbofloxacin after oral administration to rabbits.
2009 Apr
Are liquid chromatography/electrospray tandem quadrupole fragmentation ratios unequivocal confirmation criteria?
2009 Apr
Fully automatic sample treatment by integration of microextraction by packed sorbents into commercial capillary electrophoresis-mass spectrometry equipment: application to the determination of fluoroquinolones in urine.
2009 Apr 15
Water-compatible molecularly imprinted polymer for the selective recognition of fluoroquinolone antibiotics in biological samples.
2009 Jan
Resolution of tongue lesions caused by Leishmania infantum in a dog treated with the association miltefosine-allopurinol.
2009 Mar 26
Pharmacokinetics of marbofloxacin after a single oral dose to loggerhead sea turtles (Caretta caretta).
2009 Oct
Pharmacokinetic and pharmacodynamic modelling of marbofloxacin administered alone and in combination with tolfenamic acid in goats.
2010 May
Patent

Sample Use Guides

In Vivo Use Guide
1.25 mg per pound (/lb) of body weight once daily, but may be increased to 2.5 mg/lb of body weight once daily.
Route of Administration: Oral; Topical
In Vitro Use Guide
MIC50 values of marbofloxacin against pathogens isolated from skin, soft tissue and urinary tract infections in dogs were: Staphylococcus intermedius - 0.25 ug/ml, Escherichia coli - 0.03 ug/ml, Proteus mirabilis - 0.06 ug/ml, Beta-hemolytic Streptococcus, (not Group A or Group B) - 1 ug/ml, Streptococcus, Group D enterococcus - 1 ug/ml, Pasteurella multocida - 0.015 ug/ml, Staphylococcus aureus - 0.25 ug/ml, Enterococcus faecalis - 2 ug/ml, Klebsiella pneumoniae - 0.06 ug/ml.
Name Type Language
MARBOFLOXACIN
GREEN BOOK   INN   MART.   MI  
INN  
Official Name English
9-FLUORO-2,3-DIHYDRO-3-METHYL-10-(4-METHYL-1-PIPERAZINYL)-7-OXO-7H-PYRIDO(3,2,1-IJ)(4,1,2)BENZOXADIAZINE-6-CARBOXYLIC ACID
Systematic Name English
MARBOFLOXACIN [GREEN BOOK]
Common Name English
MARBOFLOXACIN [MART.]
Common Name English
MARBOFLOXACIN [INN]
Common Name English
MARBOFLOXACIN [MI]
Common Name English
RO 09-1168
Code English
MARBOCYL
Brand Name English
Classification Tree Code System Code
CFR 21 CFR 520.1310
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
WHO-VATC QJ01MA93
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
Code System Code Type Description
RXCUI
69256
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
PRIMARY RxNorm
CAS
115550-35-1
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
PRIMARY
INN
6807
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
PRIMARY
WIKIPEDIA
MARBOFLOXACIN
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
PRIMARY
MERCK INDEX
M7085
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
PRIMARY Merck Index
ChEMBL
CHEMBL478120
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
PRIMARY
EPA CompTox
115550-35-1
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
PRIMARY
NCI_THESAURUS
C80640
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
PRIMARY
PUBCHEM
60651
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
PRIMARY SWITZERF
EVMPD
SUB08648MIG
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
PRIMARY