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Details

Stereochemistry ACHIRAL
Molecular Formula C17H19FN4O4
Molecular Weight 362.3556
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MARBOFLOXACIN

SMILES

CN1CCN(CC1)C2=C3OCN(C)N4C=C(C(O)=O)C(=O)C(C=C2F)=C34

InChI

InChIKey=BPFYOAJNDMUVBL-UHFFFAOYSA-N
InChI=1S/C17H19FN4O4/c1-19-3-5-21(6-4-19)14-12(18)7-10-13-16(14)26-9-20(2)22(13)8-11(15(10)23)17(24)25/h7-8H,3-6,9H2,1-2H3,(H,24,25)

HIDE SMILES / InChI

Description

Marbofloxacin is an anti-bacterial veterinary medication which is approved by FDA and EMEA for the treatment of bacterial diseases in dogs and cats. The drug exerts its action by inhibiting bacterial DNA gyrase.

CNS Activity

Originator

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

PubMed

PubMed

TitleDatePubMed
Simultaneous determination of quinolone antibacterials in bovine milk by liquid chromatography-mass spectrometry.
2008 Nov
Simultaneous determination of 13 quinolones in eggs using column high-performance liquid chromatography/electrospray ionization-tandem mass spectrometry and depletion of pefloxacin methanesulfonate in eggs.
2008 Nov-Dec
Influence of systemic fluoroquinolone administration on the presence of Pasteurella multocida in the upper respiratory tract of clinically healthy calves.
2008 Sep 22
Single- and multiple-dose pharmacokinetics of marbofloxacin after oral administration to rabbits.
2009 Apr
Are liquid chromatography/electrospray tandem quadrupole fragmentation ratios unequivocal confirmation criteria?
2009 Apr
Fully automatic sample treatment by integration of microextraction by packed sorbents into commercial capillary electrophoresis-mass spectrometry equipment: application to the determination of fluoroquinolones in urine.
2009 Apr 15
Water-compatible molecularly imprinted polymer for the selective recognition of fluoroquinolone antibiotics in biological samples.
2009 Jan
Resolution of tongue lesions caused by Leishmania infantum in a dog treated with the association miltefosine-allopurinol.
2009 Mar 26
Pharmacokinetics of marbofloxacin after a single oral dose to loggerhead sea turtles (Caretta caretta).
2009 Oct
Pharmacokinetic and pharmacodynamic modelling of marbofloxacin administered alone and in combination with tolfenamic acid in goats.
2010 May
Patents

Sample Use Guides

In Vivo Use Guide
1.25 mg per pound (/lb) of body weight once daily, but may be increased to 2.5 mg/lb of body weight once daily.
Route of Administration: Oral; Topical
In Vitro Use Guide
MIC50 values of marbofloxacin against pathogens isolated from skin, soft tissue and urinary tract infections in dogs were: Staphylococcus intermedius - 0.25 ug/ml, Escherichia coli - 0.03 ug/ml, Proteus mirabilis - 0.06 ug/ml, Beta-hemolytic Streptococcus, (not Group A or Group B) - 1 ug/ml, Streptococcus, Group D enterococcus - 1 ug/ml, Pasteurella multocida - 0.015 ug/ml, Staphylococcus aureus - 0.25 ug/ml, Enterococcus faecalis - 2 ug/ml, Klebsiella pneumoniae - 0.06 ug/ml.
Name Type Language
MARBOFLOXACIN
GREEN BOOK   INN   MART.   MI  
INN  
Official Name English
9-FLUORO-2,3-DIHYDRO-3-METHYL-10-(4-METHYL-1-PIPERAZINYL)-7-OXO-7H-PYRIDO(3,2,1-IJ)(4,1,2)BENZOXADIAZINE-6-CARBOXYLIC ACID
Systematic Name English
MARBOFLOXACIN [GREEN BOOK]
Common Name English
MARBOFLOXACIN [MART.]
Common Name English
MARBOFLOXACIN [INN]
Common Name English
MARBOFLOXACIN [MI]
Common Name English
RO 09-1168
Code English
MARBOCYL
Brand Name English
Classification Tree Code System Code
CFR 21 CFR 520.1310
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
WHO-VATC QJ01MA93
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
Code System Code Type Description
RXCUI
69256
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
PRIMARY RxNorm
CAS
115550-35-1
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
PRIMARY
INN
6807
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
PRIMARY
WIKIPEDIA
MARBOFLOXACIN
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
PRIMARY
MERCK INDEX
M7085
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
PRIMARY Merck Index
ChEMBL
CHEMBL478120
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
PRIMARY
EPA CompTox
115550-35-1
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
PRIMARY
NCI_THESAURUS
C80640
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
PRIMARY
PUBCHEM
60651
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
PRIMARY SWITZERF
EVMPD
SUB08648MIG
Created by admin on Tue Mar 06 11:25:16 UTC 2018 , Edited by admin on Tue Mar 06 11:25:16 UTC 2018
PRIMARY