MARBOFLOXACIN

First approved in 1999

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H19FN4O4
Molecular Weight	362.3556
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCN(CC1)C2=C3OCN(C)N4C=C(C(O)=O)C(=O)C(C=C2F)=C34

InChI

InChIKey=BPFYOAJNDMUVBL-UHFFFAOYSA-N

InChI=1S/C17H19FN4O4/c1-19-3-5-21(6-4-19)14-12(18)7-10-13-16(14)26-9-20(2)22(13)8-11(15(10)23)17(24)25/h7-8H,3-6,9H2,1-2H3,(H,24,25)

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Description

Marbofloxacin is an anti-bacterial veterinary medication which is approved by FDA and EMEA for the treatment of bacterial diseases in dogs and cats. The drug exerts its action by inhibiting bacterial DNA gyrase.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Bacterial DNA gyrase 55	Inhibitor 6502	Urinary Tract Infections

Conditions

Condition	Modality	Targets	Highest Phase	Product
Urinary Tract Infections 221	Primary	Bacterial DNA gyrase	Approved 7817	Zeniquin
Skin Diseases, Bacterial 59	Primary	Bacterial DNA gyrase	Approved 7817	Zeniquin
Soft Tissue Infections 13	Primary	Bacterial DNA gyrase	Approved 7817	Zeniquin

PubMed

Title	Date	PubMed
Simultaneous determination of quinolone antibacterials in bovine milk by liquid chromatography-mass spectrometry.	2008 Nov	18651586
Simultaneous determination of 13 quinolones in eggs using column high-performance liquid chromatography/electrospray ionization-tandem mass spectrometry and depletion of pefloxacin methanesulfonate in eggs.	2008 Nov-Dec	19202815
Influence of systemic fluoroquinolone administration on the presence of Pasteurella multocida in the upper respiratory tract of clinically healthy calves.	2008 Sep 22	18808692
Single- and multiple-dose pharmacokinetics of marbofloxacin after oral administration to rabbits.	2009 Apr	19335109
Are liquid chromatography/electrospray tandem quadrupole fragmentation ratios unequivocal confirmation criteria?	2009 Apr	19241450
Fully automatic sample treatment by integration of microextraction by packed sorbents into commercial capillary electrophoresis-mass spectrometry equipment: application to the determination of fluoroquinolones in urine.	2009 Apr 15	19284777
Water-compatible molecularly imprinted polymer for the selective recognition of fluoroquinolone antibiotics in biological samples.	2009 Jan	18839153
Resolution of tongue lesions caused by Leishmania infantum in a dog treated with the association miltefosine-allopurinol.	2009 Mar 26	19426445
Pharmacokinetics of marbofloxacin after a single oral dose to loggerhead sea turtles (Caretta caretta).	2009 Oct	19375138
Pharmacokinetic and pharmacodynamic modelling of marbofloxacin administered alone and in combination with tolfenamic acid in goats.	2010 May	19299172

Patents

Sample Use Guides

In Vivo Use Guide

1.25 mg per pound (/lb) of body weight once daily, but may be increased to 2.5 mg/lb of body weight once daily.

Route of Administration: Oral; Topical

In Vitro Use Guide

MIC50 values of marbofloxacin against pathogens isolated from skin, soft tissue and urinary tract infections in dogs were: Staphylococcus intermedius - 0.25 ug/ml, Escherichia coli - 0.03 ug/ml, Proteus mirabilis - 0.06 ug/ml, Beta-hemolytic Streptococcus, (not Group A or Group B) - 1 ug/ml, Streptococcus, Group D enterococcus - 1 ug/ml, Pasteurella multocida - 0.015 ug/ml, Staphylococcus aureus - 0.25 ug/ml, Enterococcus faecalis - 2 ug/ml, Klebsiella pneumoniae - 0.06 ug/ml.

Name

Type

Language

MARBOFLOXACIN

Official Name

English

9-FLUORO-2,3-DIHYDRO-3-METHYL-10-(4-METHYL-1-PIPERAZINYL)-7-OXO-7H-PYRIDO(3,2,1-IJ)(4,1,2)BENZOXADIAZINE-6-CARBOXYLIC ACID

Systematic Name

English

MARBOFLOXACIN [GREEN BOOK]

Common Name

English

MARBOFLOXACIN [MART.]

Common Name

English

MARBOFLOXACIN [INN]

Common Name

English

MARBOFLOXACIN [MI]

Common Name

English

RO 09-1168

Code

English

MARBOCYL

Brand Name

English

Classification Tree Code System Code

CFR

21 CFR 520.1310