Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C17H19FN4O4 |
| Molecular Weight | 362.3556 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1CCN(CC1)C2=C3OCN(C)N4C=C(C(O)=O)C(=O)C(C=C2F)=C34
InChI
InChIKey=BPFYOAJNDMUVBL-UHFFFAOYSA-N
InChI=1S/C17H19FN4O4/c1-19-3-5-21(6-4-19)14-12(18)7-10-13-16(14)26-9-20(2)22(13)8-11(15(10)23)17(24)25/h7-8H,3-6,9H2,1-2H3,(H,24,25)
CNS Activity
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Inclusion of marbofloxacin in PMMA orthopaedic cement: an in vitro experimental study. | 2006 |
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| Pharmacokinetics, urinary excretion and dosage regimen of levofloxacin following a single intramuscular administration in cross bred calves. | 2006 Dec |
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| Clinical efficacy of intravenous administration of marbofloxacin in a Staphylococcus aureus infection in tissue cages in ponies. | 2006 Dec |
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| Determination of fluoroquinolones in milk samples by postcolumn derivatization liquid chromatography with luminescence detection. | 2006 Dec 27 |
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| Pharmacokinetics of marbofloxacin in blue and gold macaws (Ara ararauna). | 2006 Jun |
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| Comparative pharmacokinetics of marbofloxacin after a single intramuscular administration at two dosages to camels (Camelus dromedarius). | 2006 Jun |
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| Preliminary single-dose pharmacokinetics of marbofloxacin in ball pythons (Python regius). | 2006 Mar |
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| Multiresidue method for the determination of quinolone antibiotics in bovine raw milk by capillary electrophoresis-tandem mass spectrometry. | 2006 Nov 15 |
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| Comparison of pharmacodynamic and pharmacokinetic indices of efficacy for 5 fluoroquinolones toward pathogens of dogs and cats. | 2006 Nov-Dec |
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| Mucosal permeability of water-soluble drugs in the equine jejunum: a preliminary investigation. | 2006 Oct |
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| Enrofloxacin and marbofloxacin in horses: comparison of pharmacokinetic parameters, use of urinary and metabolite data to estimate first-pass effect and absorbed fraction. | 2006 Oct |
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| Effect of chronic FIV infection, and efficacy of marbofloxacin treatment, on Mycoplasma haemofelis infection. | 2006 Oct 31 |
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| Field evaluation of the efficacy of tolfenamic acid administered in one single preoperative injection for the prevention of postoperative pain in the dog. | 2007 Dec |
|
| Naïve averaged, naïve pooled, and population pharmacokinetics of orally administered marbofloxacin in juvenile harbor seals. | 2007 Feb 1 |
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| [Determination of 16 quinolone residues in animal tissues using high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry]. | 2007 Jul |
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| Pharmacokinetics of a single intravenous dose of marbofloxacin in adult donkeys. | 2007 Jul 28 |
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| In vitro antimicrobial activity of marbofloxacin and enrofloxacin against bacterial strains isolated from companion animals. | 2007 Jun |
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| Separation of fifteen quinolones by high performance liquid chromatography: application to pharmaceuticals and ofloxacin determination in urine. | 2007 Jun |
|
| Identification and comparison of marbofloxacin metabolites from the plasma of ball pythons (Python regius) and blue and gold macaws (Ara ararauna). | 2007 Jun |
|
| Comparative pharmacokinetics of marbofloxacin in healthy and Mannheimia haemolytica infected calves. | 2007 Jun |
|
| Microbiological detection of 10 quinolone antibiotic residues and its application to artificially contaminated poultry samples. | 2007 Mar |
|
| Stability of frozen stock solutions of beta-lactam antibiotics, cephalosporins, tetracyclines and quinolones used in antibiotic residue screening and antibiotic susceptibility testing. | 2007 Mar 14 |
|
| Simultaneous determination of trace levels of 10 quinolones in swine, chicken, and shrimp muscle tissues using HPLC with programmable fluorescence detection. | 2007 May 16 |
|
| Single-dose pharmacokinetics of marbofloxacin in Egyptian buffalo (Bubalus bubalis L.) steers. | 2007 May-Jun |
|
| Comparative activity of pradofloxacin against anaerobic bacteria isolated from dogs and cats. | 2007 Nov |
|
| Multiresidue method for simultaneous determination of quinolone antibacterials in pig kidney samples by liquid chromatography with fluorescence detection. | 2007 Nov 15 |
|
| Susceptibility of Pseudomonas isolates from the ears and skin of dogs to enrofloxacin, marbofloxacin, and ciprofloxacin. | 2007 Nov-Dec |
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| Antimicrobial testing of selected fluoroquinolones against Pseudomonas aeruginosa isolated from canine otitis. | 2007 Nov-Dec |
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| Allometric scaling of marbofloxacin, moxifloxacin, danofloxacin and difloxacin pharmacokinetics: a retrospective analysis. | 2007 Oct |
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| Pharmacokinetic behavior and pharmacokinetic/pharmacodynamic integration of marbofloxacin after subcutaneous administration in goats. | 2007 Sep |
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| Comparative quantification of the in vitro activity of veterinary fluoroquinolones. | 2007 Sep 20 |
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| Pulmonary function and antimicrobial concentration after marbofloxacin inhalation in horses. | 2007 Sep 8 |
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| Comprehensive screening and quantification of veterinary drugs in milk using UPLC-ToF-MS. | 2008 Jul |
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| Development of an immunochromatography strip for the rapid detection of 12 fluoroquinolones in chicken muscle and liver. | 2008 Jul 23 |
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| [Multiresidue determination of quinolones in animal and fishery products by HPLC]. | 2008 Jun |
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| Intraocular pharmacokinetics of intravenously administered marbofloxacin in rabbits with experimentally induced acute endophthalmitis. | 2008 Mar |
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| Marbofloxacin for the treatment of experimentally induced Mycoplasma haemofelis infection in cats. | 2008 Mar-Apr |
|
| In-line solid-phase extraction preconcentration in capillary electrophoresis-tandem mass spectrometry for the multiresidue detection of quinolones in meat by pressurized liquid extraction. | 2008 May |
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| Efficacy of different treatment regimens of marbofloxacin in canine visceral leishmaniosis: a pilot study. | 2008 May 31 |
|
| Simultaneous determination of quinolone antibacterials in bovine milk by liquid chromatography-mass spectrometry. | 2008 Nov |
|
| Simultaneous determination of 13 quinolones in eggs using column high-performance liquid chromatography/electrospray ionization-tandem mass spectrometry and depletion of pefloxacin methanesulfonate in eggs. | 2008 Nov-Dec |
|
| Tissue distribution of marbofloxacin after 'systemic' administration into the isolated perfused bovine udder. | 2008 Oct |
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| Antimicrobial resistance and genetic characterization of fluoroquinolone resistance of Pseudomonas aeruginosa isolated from canine infections. | 2008 Sep 18 |
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| Influence of systemic fluoroquinolone administration on the presence of Pasteurella multocida in the upper respiratory tract of clinically healthy calves. | 2008 Sep 22 |
|
| Single- and multiple-dose pharmacokinetics of marbofloxacin after oral administration to rabbits. | 2009 Apr |
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| Are liquid chromatography/electrospray tandem quadrupole fragmentation ratios unequivocal confirmation criteria? | 2009 Apr |
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| Water-compatible molecularly imprinted polymer for the selective recognition of fluoroquinolone antibiotics in biological samples. | 2009 Jan |
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| Resolution of tongue lesions caused by Leishmania infantum in a dog treated with the association miltefosine-allopurinol. | 2009 Mar 26 |
|
| Pharmacokinetics of marbofloxacin after a single oral dose to loggerhead sea turtles (Caretta caretta). | 2009 Oct |
|
| Pharmacokinetic and pharmacodynamic modelling of marbofloxacin administered alone and in combination with tolfenamic acid in goats. | 2010 May |
Patents
Sample Use Guides
1.25 mg per pound (/lb) of body weight once daily, but may be increased to 2.5 mg/lb of body weight once daily.
Route of Administration:
Oral; Topical
MIC50 values of marbofloxacin against pathogens isolated from skin, soft tissue and urinary tract infections in dogs were: Staphylococcus intermedius - 0.25 ug/ml, Escherichia coli - 0.03 ug/ml, Proteus mirabilis - 0.06 ug/ml, Beta-hemolytic Streptococcus, (not Group A or Group B) - 1 ug/ml, Streptococcus, Group D enterococcus - 1 ug/ml, Pasteurella multocida - 0.015 ug/ml, Staphylococcus aureus - 0.25 ug/ml, Enterococcus faecalis - 2 ug/ml, Klebsiella pneumoniae - 0.06 ug/ml.
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| Classification Tree | Code System | Code | ||
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CFR |
21 CFR 520.1310
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NCI_THESAURUS |
C795
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WHO-VATC |
QJ01MA93
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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69256
Created by
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PRIMARY | RxNorm | ||
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115550-35-1
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PRIMARY | |||
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6807
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MARBOFLOXACIN
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M7085
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PRIMARY | Merck Index | ||
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CHEMBL478120
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115550-35-1
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PRIMARY | |||
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C80640
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60651
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SUB08648MIG
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ACTIVE MOIETY
