U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Showing 1 - 10 of 111 results

Status:
US Approved Rx (2009)
First approved in 1990

Class (Stereo):
CHEMICAL (ACHIRAL)



Fluconazole, a synthetic antifungal agent of the imidazole class, is used to treat vaginal candidiasis. It inhibits the fungal lanosterol 14 alpha-demethylase which thereby prevents the formation of ergosterol which is an essential component in the f...
Status:
US Approved Rx (2023)
First approved in 1990

Class (Stereo):
CHEMICAL (RACEMIC)



Eflornithine is a prescription drug indicated in the treatment of facial hirsutism (excessive hair growth). Eflornithine hydrochloride cream for topical application is intended for use in women suffering from facial hirsutism and is sold by Allergan,...
Status:
US Approved Rx (2022)
First approved in 1990

Class (Stereo):
CHEMICAL (RACEMIC)



Doxazosin mesylate is a quinazoline compound sold by Pfizer under the brand name CARDURA. CARDURA is indicated for the treatment of both the urinary outflow obstruction and obstructive and irritative symptoms associated with BPH: obstructive symptoms...
Status:
US Approved Rx (2007)
First approved in 1990

Class (Stereo):
CHEMICAL (ABSOLUTE)



Idarubicin is an antineoplastic in the anthracycline class.Idarubicin hydrochloride is a DNA-intercalating analog of daunorubicin which has an inhibitory effect on nucleic acid synthesis and interacts with the enzyme topoisomerase II. The absence of ...
Status:
US Approved Rx (1990)
First approved in 1990

Class (Stereo):
CHEMICAL (ABSOLUTE)



Nafarelin acetate (brand name Synarel) is a synthetic agonist of gonadotrophin-releasing hormone (GnRH) [luteinising hormone-releasing hormone (LH-RH), which is indicated for management of endometriosis, including pain relief and reduction of endomet...
Status:
US Approved Rx (2004)
First approved in 1990

Class (Stereo):
CHEMICAL (RACEMIC)



Ofloxacin is one of a new generation of fluorinated quinolones structurally related to nalidixic acid, primary mechanism of action is inhibition of bacterial DNA gyrase. It is an orally administered broad spectrum antibacterial drug active against mo...
Status:
US Approved Rx (2006)
First approved in 1990

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Isradipine (tradenames DynaCirc, Prescal) is a calcium channel blocker of the dihydropyridine class. It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack. Except for diuretic activit...
Status:
US Approved Rx (2023)
First approved in 1990

Class (Stereo):
CHEMICAL (ABSOLUTE)



Halobetasol Propionate is the propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses across cell membranes to interact with cytopl...
Status:
US Approved Rx (1990)
First approved in 1990

Class (Stereo):
CHEMICAL (ABSOLUTE)

Targets:


Gluconolactone, a lactone of D-glucuronic acid, is a food additive with the E number E575. Gluconolactone is commonly found in honey, fruit juices, wine. In medcine, gluconolactone is used as a component of irrigation solution Renacidin for dissoluti...
Status:
US Approved Rx (2023)
First approved in 1990

Class (Stereo):
CHEMICAL (ACHIRAL)