| Stereochemistry | ABSOLUTE |
| Molecular Formula | C6H10O6 |
| Molecular Weight | 178.14 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O
InChI
InChIKey=PHOQVHQSTUBQQK-SQOUGZDYSA-N
InChI=1S/C6H10O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-5,7-10H,1H2/t2-,3-,4+,5-/m1/s1
| Molecular Formula | C6H10O6 |
| Molecular Weight | 178.14 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Gluconolactone, a lactone of D-glucuronic acid, is a food additive with the E number E575. Gluconolactone is commonly found in honey, fruit juices, wine. In medcine, gluconolactone is used as a component of irrigation solution Renacidin for dissolution of bladder calculi of the struvite or apatite variety, and to prevent or minimize encrustations of indwelling urinary tract catheters.
Originator
Approval Year
Sourcing
PubMed
Patents
Sample Use Guides
For dissolution of bladder calculi, 30 mL (one container) of Renacidin should be instilled into the bladder via a urethral catheter or cystostomy tube. For prevention of encrustations in urethral catheters and cystostomy tube, 30 mL (one container) of Renacidin should be instilled into the urethral catheter or cystostomy tube. As a food additive, gluconolactone is administered orally.
Route of Administration:
Other
Chemolysis rate was tested using an in-vitro urinary-tract model. A laboratory-proved large human struvite stone was divided into 3.5-g fragments, which were placed in the model. In the experimental group, Renacidin irrigation was performed through the high-flow low-pressure irrigation system. In the control group, Renacidin solution was infused at 120 mL/hour through a nephrostomy tube. The overall chemolysis rates with the high-flow low-pressure irrigation and control systems were 0.12 g/hr and 0.06 g/hr, respectively.
