Inxight Drugs

Showing 1 - 10 of 60 results

Status:

US Approved Rx (1968)

First approved in 1968

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Conditions:

Fentanyl is a potent agonist of mu opioid receptor. It is used to relieve severe pain, such as after surgery or during cancer treatment, and breakthrough pain (flare-ups of intense pain despite round-the-clock narcotic treatment). Fentanyl is an extr...

DROPERIDOL LACTATE

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09NO5N37E0

Status:

US Approved Rx (1988)

First approved in 1968

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Conditions:

Droperidol produces marked tranquilization and sedation. It allays apprehension and provides a state of mental detachment and indifference while maintaining a state of reflex alertness. Droperidol produces an antiemetic effect as evidenced by the ant...

Azathioprine

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MRK240IY2L

Status:

US Approved Rx (1999)

First approved in 1968

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Conditions:

Azathioprine remains one of the most important and widely prescribed drugs for immunosuppression/immunomodulation in autoimmune disease over 30 years after its introduction. Azathioprine is licensed for the treatment of only a limited range of autoim...

mune disorders, which is probably a reflection on the age of the drug. Widening the license for a drug is both costly and time consuming, and it would make no commercial sense for manufacturers to do so, at this late stage of life, for azathioprine. However, azathioprine is now so well established as an immunomodulating drug in autoimmune disorders that it represents the gold standard by which other drugs are compared. Azathioprine is indicated as an adjunct for the prevention of rejection in renal homotransplantation. It is also indicated for the management of active rheumatoid arthritis to reduce signs and symptoms. The combined use of azathioprine tablets with disease modifying anti-rheumatic drugs (DMARDs) has not been studied for either added benefit or unexpected adverse effects. The use of azathioprine tablets with these agents cannot be recommended. Azathioprine is a pro-drug, converted in the body to the active metabolite 6-mercaptopurine. Azathioprine acts to inhibit purine synthesis necessary for the proliferation of cells, especially leukocytes and lymphocytes. It is a safe and effective drug used alone in certain autoimmune diseases, or in combination with other immunosuppressants in organ transplantation. Its most severe side effect is bone marrow suppression, and it should not be given in conjunction with purine analogues such as allopurinol. The enzyme thiopurine S-methyltransferase (TPMT) deactivates 6-mercaptopurine. Genetic polymorphisms of TPMT can lead to excessive drug toxicity, thus assay of serum TPMT may be useful to prevent this complication. Azathioprine is metabolized to 6-mercaptopurine (6-MP). Both compounds are rapidly eliminated from blood and are oxidized or methylated in erythrocytes and liver; no azathioprine or mercaptopurine is detectable in urine after 8 hours. Activation of 6-mercaptopurine occurs via hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and a series of multi-enzymatic processes involving kinases to form 6-thioguanine nucleotides (6-TGNs) as major metabolites.

CARBAMAZEPINE DIHYDRATE

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78M1RMW7Q8

Status:

US Approved Rx (2022)

First approved in 1968

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Conditions:

Carbamazepine is an analgesic, anti-epileptic agent that is FDA approved for the treatment of epilepsy, trigeminal neuralgia. It appears to act by reducing polysynaptic responses and blocking the post-tetanic potentiation. It depresses thalamic poten...

DICLOXACILLIN

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COF19H7WBK

Status:

US Approved Rx (2022)

First approved in 1968

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Conditions:

Dicloxacillin sodium USP is a semisynthetic antibiotic substance which resists destruction by the enzyme penicillinase (beta-lactamase). It is monosodium (2S,5R,6R)-6-[3-(2,6-dichlorophenyl)-5-methyl-4- isoxazolecarboxamido]-3,3-dimethyl-7-oxo-4-thia...

LEVONORGESTREL

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5W7SIA7YZW

Status:

US Approved Rx (2015)

First approved in 1968

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Conditions:

Levonorgestrel (LNG) is a synthetic progestational hormone with actions similar to those of progesterone and about twice as potent as its racemic or (+-)-isomer (norgestrel). It is used for contraception, control of menstrual disorders, and treatment...

of endometriosis. It is usually supplied in a racemic mixture (Norgestrel, 6533-00-2). Only the levonorgestrel isomer is active. Within an Intrauterine device (IUD), sold as Mirena among others, it is effective for long term prevention of pregnancy. The local mechanism by which continuously released LNG enhances contraceptive effectiveness of Mirena has not been conclusively demonstrated. Studies of Mirena and similar LNG IUS prototypes have suggested several mechanisms that prevent pregnancy: thickening of cervical mucus preventing passage of sperm into the uterus, inhibition of sperm capacitation or survival, and alteration of the endometrium. Mirena has mainly local progestogenic effects in the uterine cavity. The high local levels of levonorgestrel lead to morphological changes including stromal pseudodecidualization, glandular atrophy, a leukocytic infiltration and a decrease in glandular and stromal mitoses. Ovulation is inhibited in some women using Mirena. In a 1-year study, approximately 45% of menstrual cycles were ovulatory, and in another study after 4 years, 75% of cycles were ovulatory. There has been much debate regarding levonorgestrel emergency contraception's (LNG-EC's) method of action since 1999 when the Food and Drug Administration first approved its use. Proponents of LNG-EC have argued that they have moral certitude that LNG-EC works via a non-abortifacient mechanism of action, and claim that all the major scientific and medical data consistently support this hypothesis. However, newer medical data serve to undermine the consistency of the non-abortifacient hypothesis and instead support the hypothesis that preovulatory administration of LNG-EC has significant potential to work via abortion. The implications of the newer data have important ramifications for medical personnel, patients, and both Catholic and non-Catholic emergency room protocols. In the future, technology such as the use of early pregnancy factor may have the potential to quantify how frequently preovulatory LNG-EC works via abortion. The latest scientific and medical evidence now demonstrates that levonorgestrel emergency contraception theoretically works via abortion quite often. The implications of the newer data have important ramifications for medical personnel, patients, and both Catholic and non-Catholic emergency room rape protocols.

DEFEROXAMINE

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J06Y7MXW4D

Status:

US Approved Rx (2017)

First approved in 1968

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Conditions:

Deferoxamine (brand name Desferal) an iron chelator, is a drug for the treatment of acute iron intoxication and of chronic iron overload due to transfusion-dependent anemias. Deferoxamine chelates iron by forming a stable complex that prevents the ir...

CEPHALORIDINE

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LVZ1VC61HB

Status:

US Previously Marketed

First approved in 1968

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Conditions:

Cephaloridine (or cefaloridine) is a first generation semisynthetic derivative of cephalosporin C. It is unique among cephalosporins in that it exists as a zwitterion. It is of semi synthetic origin and belongs to cephem carboxylate. It belongs to Pe...

IODOHIPPURIC ACID I-131

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16O34995MB

Status:

US Previously Marketed

First approved in 1968

Class (Stereo):

CHEMICAL (ACHIRAL)

Conditions:

IODOHIPPURIC ACID I-131 (ortho-Iodohippuric Acid I-131, [I-123]-OIH) is an iodine-containing compound used in pyelography as a radiopaque medium. Iodine-123 labelled ortho-Iodohippuric acid was used in the early 1970's as a kidney imaging agent or tr...

ETHYL LACTATE

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F3P750VW8I

Status:

Possibly Marketed Outside US

First approved in 1968

Class (Stereo):

CHEMICAL (RACEMIC)

Approval Year

Development Status

Primary Target

Highest Phase

Condition

Treatment Modality

CNS Activity

Originator

Substance Class

Code System

ATC Level 1

ATC Level 2

ATC Level 3

ATC Level 4

Substance Form

FENTANYL

UF599785JZ

DROPERIDOL LACTATE

09NO5N37E0

Azathioprine

MRK240IY2L

CARBAMAZEPINE DIHYDRATE

78M1RMW7Q8

DICLOXACILLIN

COF19H7WBK

LEVONORGESTREL

5W7SIA7YZW

DEFEROXAMINE

J06Y7MXW4D

CEPHALORIDINE

LVZ1VC61HB

IODOHIPPURIC ACID I-131

16O34995MB

ETHYL LACTATE

F3P750VW8I