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Details

Stereochemistry ACHIRAL
Molecular Formula C9H8INO3
Molecular Weight 309.0712
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IODOHIPPURIC ACID I-131

SMILES

c1ccc(c(c1)C(=NCC(=O)O)O)I

InChI

InChIKey=CORFWQGVBFFZHF-AKGSDVBQSA-N
InChI=1S/C9H8INO3/c10-7-4-2-1-3-6(7)9(14)11-5-8(12)13/h1-4H,5H2,(H,11,14)(H,12,13)/i10+4

HIDE SMILES / InChI

Description
Curator's Comment:: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/20150248 | https://www.ncbi.nlm.nih.gov/pubmed/12766604 | https://www.ncbi.nlm.nih.gov/pubmed/10321824

IODOHIPPURIC ACID I-131 (ortho-Iodohippuric Acid I-131, [I-123]-OIH) is an iodine-containing compound used in pyelography as a radiopaque medium. Iodine-123 labelled ortho-Iodohippuric acid was used in the early 1970's as a kidney imaging agent or tracer that "lights-up" inside your body when scanned, but over the years its use has declined. [I-123]-OIH is primarily extracted by the renal tubules and has excellent pharmacokinetic properties, with a clearance only slightly less than that of p-aminohippuran, but its use has been compromised by the suboptimal imaging characteristics of the 364-keV photon of 131I and the delivery of relatively high radiation doses to kidneys and thyroid in patients with impaired renal function

Originator

Sources: Proceedings of the Society for Experimental Biology and Medicine, Volume 103, Pages 497-8, Journal, 1960

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
HIPPURAN I 131

Approved Use

Hippuran I 131 Injection is a diagnostic aid in determining renal function, renal blood flow, ar urinary tract obstruction, and a renal imaging agent.

Launch Date

-5.08032E10
PubMed

PubMed

TitleDatePubMed
Chemical and thermodynamic characteristics of the isotopic exchange reaction between radioiodine and iodohippuric acid isomers.
2003 Sep
Patents

Patents

Sample Use Guides

After the coinjection of approximately 74 MBq (;2 mCi) of 99mTc(CO)3(NTA) and approximately 11.1 MBq (300 mCi) of 131I-OIH, imaging was performed for 24 min using an Infinia camera (GE Healthcare) with a 9.5-mm (3/8-in) crystal fitted with a high-energy collimator
Route of Administration: Intravenous
In Vitro Use Guide
Unknown
Name Type Language
IODOHIPPURIC ACID I-131
Common Name English
GLYCINE, N-(2-(IODO-131I)BENZOYL)-
Common Name English
O-IODOHIPPURIC ACID, I-131
Common Name English
131I-ORTHO-IODO-HIPPURATE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C2124
Created by admin on Sat Jun 26 14:51:33 UTC 2021 , Edited by admin on Sat Jun 26 14:51:33 UTC 2021
NDF-RT N0000000205
Created by admin on Sat Jun 26 14:51:33 UTC 2021 , Edited by admin on Sat Jun 26 14:51:33 UTC 2021
WHO-ATC V09CX02
Created by admin on Sat Jun 26 14:51:33 UTC 2021 , Edited by admin on Sat Jun 26 14:51:33 UTC 2021
NDF-RT N0000177914
Created by admin on Sat Jun 26 14:51:33 UTC 2021 , Edited by admin on Sat Jun 26 14:51:33 UTC 2021
Code System Code Type Description
FDA UNII
16O34995MB
Created by admin on Sat Jun 26 14:51:33 UTC 2021 , Edited by admin on Sat Jun 26 14:51:33 UTC 2021
PRIMARY
PUBCHEM
71800
Created by admin on Sat Jun 26 14:51:33 UTC 2021 , Edited by admin on Sat Jun 26 14:51:33 UTC 2021
PRIMARY
CAS
1203-90-3
Created by admin on Sat Jun 26 14:51:33 UTC 2021 , Edited by admin on Sat Jun 26 14:51:33 UTC 2021
PRIMARY
NCI_THESAURUS
C80645
Created by admin on Sat Jun 26 14:51:33 UTC 2021 , Edited by admin on Sat Jun 26 14:51:33 UTC 2021
PRIMARY