IODOHIPPURATE SODIUM I-131

First approved in 1968

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H7INO3.Na
Molecular Weight	331.0527
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[O-]C(=O)CNC(=O)C1=CC=CC=C1[131I]

InChI

InChIKey=XYITYKDGJLHYPW-UDYUCQKZSA-M

InChI=1S/C9H8INO3.Na/c10-7-4-2-1-3-6(7)9(14)11-5-8(12)13;/h1-4H,5H2,(H,11,14)(H,12,13);/q;+1/p-1/i10+4;

HIDE SMILES / InChI

Molecular Formula	C9H7INO3
Molecular Weight	308.0629
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23424193
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/20150248 | https://www.ncbi.nlm.nih.gov/pubmed/12766604 | https://www.ncbi.nlm.nih.gov/pubmed/10321824

IODOHIPPURIC ACID I-131 (ortho-Iodohippuric Acid I-131, [I-123]-OIH) is an iodine-containing compound used in pyelography as a radiopaque medium. Iodine-123 labelled ortho-Iodohippuric acid was used in the early 1970's as a kidney imaging agent or tracer that "lights-up" inside your body when scanned, but over the years its use has declined. [I-123]-OIH is primarily extracted by the renal tubules and has excellent pharmacokinetic properties, with a clearance only slightly less than that of p-aminohippuran, but its use has been compromised by the suboptimal imaging characteristics of the 364-keV photon of 131I and the delivery of relatively high radiation doses to kidneys and thyroid in patients with impaired renal function

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Kidney Diseases 2 Sources: http://www.nuclearonline.org/PI/Mallinckrodt%20Hippuran.pdf	Diagnostic		Approved 8429	HIPPURAN I 131 Approved Use Hippuran I 131 Injection is a diagnostic aid in determining renal function, renal blood flow, ar urinary tract obstruction, and a renal imaging agent. Launch Date 1968

PubMed

Title	Date	PubMed
Chemical and thermodynamic characteristics of the isotopic exchange reaction between radioiodine and iodohippuric acid isomers.	2003 Sep	14516090

Patents

Sample Use Guides

In Vivo Use Guide

After the coinjection of approximately 74 MBq (;2 mCi) of 99mTc(CO)3(NTA) and approximately 11.1 MBq (300 mCi) of 131I-OIH, imaging was performed for 24 min using an Infinia camera (GE Healthcare) with a 9.5-mm (3/8-in) crystal fitted with a high-energy collimator

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:11:25 GMT 2023` Edited by `admin` on `Fri Dec 15 15:11:25 GMT 2023`
Record UNII	9BRV734R3E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IODOHIPPURATE SODIUM I-131

Common Name

English

SODIUM IODOHIPPURATE (131I)

Official Name

English

IODOHIPPURATE SODIUM,I-131

Common Name

English

IODOHIPPURATE SODIUM I 131 [USP IMPURITY]

Common Name

English

IODOHIPPURATE SODIUM I 131 [USAN]

Common Name

English

SODIUM IODOHIPPURATE (131 I)

Common Name

English

IODOHIPPURATE SODIUM, I-131

Common Name

English

MONOSODIUM O-IODO-(SUP 131)I-HIPPURATE

Common Name

English

IODOHIPPURATE I131 SODIUM

Common Name

English

sodium iodohippurate (¹³¹I) [INN]

Common Name

English

IODOHIPPURATE SODIUM I-131 [ORANGE BOOK]

Common Name

English

HIPPURAN I 131

Brand Name

English

O-IODOHIPPURATE SODIUM 131I-LABELED FORM [MI]

Common Name

English

O-IODOHIPPURATE SODIUM 131I-LABELED FORM

Common Name

English

SODIUM IODOHIPPURATE I 131

Common Name

English

IODOHIPPURATE SODIUM,I-131 [VANDF]

Common Name

English

Sodium iodohippurate (131 i) [WHO-DD]

Common Name

English

IODOHIPPURATE SODIUM I 131

Official Name

English

Classification Tree Code System Code

WHO-ATC

V09CX02