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Details

Stereochemistry ACHIRAL
Molecular Formula C9H7INO3.Na
Molecular Weight 331.053
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IODOHIPPURATE SODIUM I-131

SMILES

c1ccc(c(c1)C(=NCC(=O)[O-])O)I.[Na+]

InChI

InChIKey=XYITYKDGJLHYPW-UDYUCQKZSA-M
InChI=1S/C9H8INO3.Na/c10-7-4-2-1-3-6(7)9(14)11-5-8(12)13;/h1-4H,5H2,(H,11,14)(H,12,13);/q;+1/p-1/i10+4;

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C9H7INO3
Molecular Weight 308.0633
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/20150248 | https://www.ncbi.nlm.nih.gov/pubmed/12766604 | https://www.ncbi.nlm.nih.gov/pubmed/10321824

IODOHIPPURIC ACID I-131 (ortho-Iodohippuric Acid I-131, [I-123]-OIH) is an iodine-containing compound used in pyelography as a radiopaque medium. Iodine-123 labelled ortho-Iodohippuric acid was used in the early 1970's as a kidney imaging agent or tracer that "lights-up" inside your body when scanned, but over the years its use has declined. [I-123]-OIH is primarily extracted by the renal tubules and has excellent pharmacokinetic properties, with a clearance only slightly less than that of p-aminohippuran, but its use has been compromised by the suboptimal imaging characteristics of the 364-keV photon of 131I and the delivery of relatively high radiation doses to kidneys and thyroid in patients with impaired renal function

Originator

Sources: Proceedings of the Society for Experimental Biology and Medicine, Volume 103, Pages 497-8, Journal, 1960

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
HIPPURAN I 131

Approved Use

Hippuran I 131 Injection is a diagnostic aid in determining renal function, renal blood flow, ar urinary tract obstruction, and a renal imaging agent.

Launch Date

-5.08032E10
PubMed

PubMed

TitleDatePubMed
Patents

Patents

Sample Use Guides

After the coinjection of approximately 74 MBq (;2 mCi) of 99mTc(CO)3(NTA) and approximately 11.1 MBq (300 mCi) of 131I-OIH, imaging was performed for 24 min using an Infinia camera (GE Healthcare) with a 9.5-mm (3/8-in) crystal fitted with a high-energy collimator
Route of Administration: Intravenous
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Jun 25 23:48:08 UTC 2021
Edited
by admin
on Fri Jun 25 23:48:08 UTC 2021
Record UNII
9BRV734R3E
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
IODOHIPPURATE SODIUM I-131
ORANGE BOOK  
Common Name English
SODIUM IODOHIPPURATE (131I)
INN  
INN  
Official Name English
IODOHIPPURATE SODIUM,I-131
VANDF  
Common Name English
IODOHIPPURATE SODIUM I 131 [USAN]
Common Name English
SODIUM IODOHIPPURATE (131 I)
WHO-DD  
Common Name English
IODOHIPPURATE SODIUM, I-131
Common Name English
MONOSODIUM O-IODO-(SUP 131)I-HIPPURATE
Common Name English
IODOHIPPURATE I131 SODIUM
Common Name English
SODIUM IODOHIPPURATE (131 I) [WHO-DD]
Common Name English
SODIUM IODOHIPPURATE (131I) [INN]
Common Name English
IODOHIPPURATE SODIUM I 131 [USP]
Common Name English
IODOHIPPURATE SODIUM I-131 [ORANGE BOOK]
Common Name English
HIPPURAN I 131
Brand Name English
O-IODOHIPPURATE SODIUM 131I-LABELED FORM [MI]
Common Name English
O-IODOHIPPURATE SODIUM 131I-LABELED FORM
MI  
Common Name English
SODIUM IODOHIPPURATE I 131
Common Name English
IODOHIPPURATE SODIUM,I-131 [VANDF]
Common Name English
IODOHIPPURATE SODIUM I 131
USAN   USP  
USAN  
Official Name English
Classification Tree Code System Code
WHO-ATC V09CX02
Created by admin on Fri Jun 25 23:48:08 UTC 2021 , Edited by admin on Fri Jun 25 23:48:08 UTC 2021
WHO-VATC QV09CX02
Created by admin on Fri Jun 25 23:48:08 UTC 2021 , Edited by admin on Fri Jun 25 23:48:08 UTC 2021
NDF-RT N0000177914
Created by admin on Fri Jun 25 23:48:08 UTC 2021 , Edited by admin on Fri Jun 25 23:48:08 UTC 2021
NCI_THESAURUS C2124
Created by admin on Fri Jun 25 23:48:08 UTC 2021 , Edited by admin on Fri Jun 25 23:48:08 UTC 2021
Code System Code Type Description
EVMPD
SUB12296MIG
Created by admin on Fri Jun 25 23:48:08 UTC 2021 , Edited by admin on Fri Jun 25 23:48:08 UTC 2021
PRIMARY
MERCK INDEX
M6347
Created by admin on Fri Jun 25 23:48:08 UTC 2021 , Edited by admin on Fri Jun 25 23:48:08 UTC 2021
PRIMARY Merck Index
INN
2806
Created by admin on Fri Jun 25 23:48:08 UTC 2021 , Edited by admin on Fri Jun 25 23:48:08 UTC 2021
PRIMARY
RXCUI
91540
Created by admin on Fri Jun 25 23:48:08 UTC 2021 , Edited by admin on Fri Jun 25 23:48:08 UTC 2021
PRIMARY RxNorm
EPA CompTox
881-17-4
Created by admin on Fri Jun 25 23:48:08 UTC 2021 , Edited by admin on Fri Jun 25 23:48:08 UTC 2021
PRIMARY
ChEMBL
CHEMBL1681
Created by admin on Fri Jun 25 23:48:08 UTC 2021 , Edited by admin on Fri Jun 25 23:48:08 UTC 2021
PRIMARY
DRUG BANK
DB09382
Created by admin on Fri Jun 25 23:48:08 UTC 2021 , Edited by admin on Fri Jun 25 23:48:08 UTC 2021
PRIMARY
EVMPD
SUB15299MIG
Created by admin on Fri Jun 25 23:48:08 UTC 2021 , Edited by admin on Fri Jun 25 23:48:08 UTC 2021
PRIMARY
PUBCHEM
23663553
Created by admin on Fri Jun 25 23:48:08 UTC 2021 , Edited by admin on Fri Jun 25 23:48:08 UTC 2021
PRIMARY
DRUG CENTRAL
4828
Created by admin on Fri Jun 25 23:48:08 UTC 2021 , Edited by admin on Fri Jun 25 23:48:08 UTC 2021
PRIMARY
NCI_THESAURUS
C76280
Created by admin on Fri Jun 25 23:48:08 UTC 2021 , Edited by admin on Fri Jun 25 23:48:08 UTC 2021
PRIMARY
CAS
881-17-4
Created by admin on Fri Jun 25 23:48:08 UTC 2021 , Edited by admin on Fri Jun 25 23:48:08 UTC 2021
PRIMARY
FDA UNII
9BRV734R3E
Created by admin on Fri Jun 25 23:48:08 UTC 2021 , Edited by admin on Fri Jun 25 23:48:08 UTC 2021
PRIMARY
LACTMED
Iodohippurate Sodium I 131
Created by admin on Fri Jun 25 23:48:08 UTC 2021 , Edited by admin on Fri Jun 25 23:48:08 UTC 2021
PRIMARY
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