U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Showing 1 - 10 of 60 results

Status:
US Approved Rx (2014)
First marketed in 1937

Class (Stereo):
CHEMICAL (ACHIRAL)



Niacin (also known as vitamin B3 and nicotinic acid) is bio converted to nicotinamide which is further converted to nicotinamide adenine dinucleotide (NAD+) and the hydride equivalent (NADH) which are coenzymes necessary for tissue metabolism, lipid ...
Status:
US Approved Rx (2017)
First marketed in 1937

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Testosterone is a steroid sex hormone found in both men and women. In men, testosterone is produced primarily by the Leydig (interstitial) cells of the testes when stimulated by luteinizing hormone (LH). It functions to stimulate spermatogenesis, pro...
Status:
US Approved Rx (1976)
First marketed in 1937

Class (Stereo):
CHEMICAL (ABSOLUTE)



Amphetamine is also prescribed in enantiopure and prodrug form as dextroamphetamine and lisdexamfetamine respectively. Lisdexamfetamine is structurally different from amphetamine, and is inactive until it metabolizes into dextroamphetamine. Dextroamp...
Status:
US Previously Marketed
First marketed in 1937

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Adiphenine is a ternary amino ligand. It is used as a local anesthetic that reduces the frequency of acetylcholine-induced single-channel currents. It was originally introduced as a spasmolytic agent. Adiphenine reduced the muscle tone of the gastroi...
Status:
US Previously Marketed
First marketed in 1937

Class (Stereo):
CHEMICAL (ACHIRAL)


Iodopyracet (Diodone) is a radiocontrast agent used in urography before 1950. Renal clearance of iodopyracet is characterized by supply-limited elimination at low plasma concentrations and capacity-limited elimination at high plasma levels. Iodopyrac...
Status:
US Previously Marketed
First marketed in 1937

Class (Stereo):
CHEMICAL (RACEMIC)



Diperodon is one of several phenylurethane derivatives of dialkyl amino alcohols which have demonstrated significant local anaesthetic activity.
Status:
US Previously Marketed
First marketed in 1937

Class (Stereo):
CHEMICAL (ACHIRAL)



Adrenalone is a keton form of the natural substrate epinephrine. Adrenalone is evidently formed in vivo by hydrolytic cleavage of the diester by esterases. It is an adrenergic receptor agonist. Adrenalone inhibits the norepinephrine synthesis and dop...
Status:
US Previously Marketed
First marketed in 1937

Class (Stereo):
CHEMICAL (ACHIRAL)



Phenylmercuric borate is classified as antimicrobial preservative. It is bactericidal against many Gram-positive and Gram-negative species. Fungicidal activity has been demonstrated against Candida albicans and Aspergillus niger. Phenylmercuric borat...
Status:
US Previously Marketed
First marketed in 1937

Class (Stereo):
CHEMICAL (ABSOLUTE)



Pantothenic acid (known as Vitamin B5) is a water-soluble member of the B-vitamin family that is converted into 4’-phosphopantetheine, which is then converted to co-enzyme A (CoA) via adenosine triphosphate. Pantothenic acid regulates epidermal barri...
mixture
Status:
US Previously Marketed
First marketed in 1937

Class:
MIXTURE