OXINDANAC

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H14O4
Molecular Weight	282.2907
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)C1CCC2=C1C=C(O)C(=C2)C(=O)C3=CC=CC=C3

InChI

InChIKey=XMTKXTUIUKKGIL-UHFFFAOYSA-N

InChI=1S/C17H14O4/c18-15-9-13-11(6-7-12(13)17(20)21)8-14(15)16(19)10-4-2-1-3-5-10/h1-5,8-9,12,18H,6-7H2,(H,20,21)

HIDE SMILES / InChI

Molecular Formula	C17H14O4
Molecular Weight	282.2907
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2687006 | https://www.ncbi.nlm.nih.gov/pubmed/2603808 | https://adisinsight.springer.com/drugs/800000981

Oxindanac, a non-steroidal anti-inflammatory drug, and is a weak cyclooxygenase inhibitor possessed antipyretic activity. This drug is used as a veterinary inflammatory drug. In addition, oxindanac was studied in phase III clinical trials for the treatment of rheumatic disorders. However, this study was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
The anti-oedematous efficacy of oxindanac equals that of paracetamol in acute postoperative inflammation; are weak cyclooxygenase inhibitors more effective than strong inhibitors?	1989	2517495
The use of intradermal carrageenan in calves to estimate the dose of oxindanac, a nonsteroidal anti-inflammatory drug.	1993 Oct	8269358
High performance liquid chromatography and pharmacokinetics of the non-steroidal anti-inflammatory drug oxindanac in calves.	1994 Jun	7933056

Patents

Sample Use Guides

In Vivo Use Guide

Eight male volunteers receiving frusemide 40 mg b.d. were also given either oxindanac 300 mg b.d. or placebo in two consecutive periods separated by a treatment-free period, according to a randomized cross-over study design.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:55:46 GMT 2023` Edited by `admin` on `Fri Dec 15 15:55:46 GMT 2023`
Record UNII	ZY400R3BNT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OXINDANAC

Official Name

English

1H-INDENE-1-CARBOXYLIC ACID, 5-BENZOYL-2,3-DIHYDRO-6-HYDROXY-

Systematic Name

English

CGP-6258

Code

English

OXINDANAC [MART.]

Common Name

English

oxindanac [INN]

Common Name

English

5-BENZOYL-6-METHOXY-1-INDANCARBOXYLIC ACID

Systematic Name

English

(±)-5-BENZOYL-6-HYDROXY-1-INDANCARBOXYLIC ACID

Systematic Name

English

OXINDAZAC

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257