U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry UNKNOWN
Molecular Formula C17H14O4
Molecular Weight 282.2907
Optical Activity ( + )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OXINDANAC, (+)-

SMILES

OC(=O)C1CCC2=CC(C(=O)C3=CC=CC=C3)=C(O)C=C12

InChI

InChIKey=XMTKXTUIUKKGIL-UHFFFAOYSA-N
InChI=1S/C17H14O4/c18-15-9-13-11(6-7-12(13)17(20)21)8-14(15)16(19)10-4-2-1-3-5-10/h1-5,8-9,12,18H,6-7H2,(H,20,21)

HIDE SMILES / InChI

Molecular Formula C17H14O4
Molecular Weight 282.2907
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Oxindanac, a non-steroidal anti-inflammatory drug, and is a weak cyclooxygenase inhibitor possessed antipyretic activity. This drug is used as a veterinary inflammatory drug. In addition, oxindanac was studied in phase III clinical trials for the treatment of rheumatic disorders. However, this study was discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
High performance liquid chromatography and pharmacokinetics of the non-steroidal anti-inflammatory drug oxindanac in calves.
1994-06
The use of intradermal carrageenan in calves to estimate the dose of oxindanac, a nonsteroidal anti-inflammatory drug.
1993-10
The anti-oedematous efficacy of oxindanac equals that of paracetamol in acute postoperative inflammation; are weak cyclooxygenase inhibitors more effective than strong inhibitors?
1989
Patents

Patents

Sample Use Guides

Eight male volunteers receiving frusemide 40 mg b.d. were also given either oxindanac 300 mg b.d. or placebo in two consecutive periods separated by a treatment-free period, according to a randomized cross-over study design.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Mon Mar 31 23:08:02 GMT 2025
Edited
by admin
on Mon Mar 31 23:08:02 GMT 2025
Record UNII
PS75787KJI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
OXINDANAC, (+)-
Common Name English
1H-INDENE-1-CARBOXYLIC ACID, 5-BENZOYL-2,3-DIHYDRO-6-HYDROXY-, (+)-
Preferred Name English
(+)-5-BENZOYL-2,3-DIHYDRO-6-HYDROXY-1H-INDENE-1-CARBOXYLIC ACID
Common Name English
Code System Code Type Description
CAS
99910-67-5
Created by admin on Mon Mar 31 23:08:02 GMT 2025 , Edited by admin on Mon Mar 31 23:08:02 GMT 2025
PRIMARY
FDA UNII
PS75787KJI
Created by admin on Mon Mar 31 23:08:02 GMT 2025 , Edited by admin on Mon Mar 31 23:08:02 GMT 2025
PRIMARY
Related Record Type Details
ENANTIOMER -> ENANTIOMER
RACEMATE -> ENANTIOMER