U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C10H12O3
Molecular Weight 180.2005
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PROPYLPARABEN

SMILES

CCCOC(=O)C1=CC=C(O)C=C1

InChI

InChIKey=QELSKZZBTMNZEB-UHFFFAOYSA-N
InChI=1S/C10H12O3/c1-2-7-13-10(12)8-3-5-9(11)6-4-8/h3-6,11H,2,7H2,1H3

HIDE SMILES / InChI

Molecular Formula C10H12O3
Molecular Weight 180.2005
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/24542410; http://www.ncbi.nlm.nih.gov/pubmed/576658; http://www.ukfoodguide.net/e216.htm

Propylparaben is a bacteriostatic and fungistatic agent used as a preservative in cosmetic products, food and drugs. As a food additive, it has the E number E216. To increase the activity and reduce its dose propylparaben is used in a mixture with other parabens and in combination with other types of preservatives. Propylparaben is a chemical allergen capable of producing immunologically mediated hypersensitivity reactions. Chemically it is an ester of p-hydroxybenzoic acid.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
XILAPAK

Approved Use

For the management of hypertrophic tissues, keloid tissues, dermatitis and dermatoses

Launch Date

1.50940798E12
Preventing
Iscaguard® FPX2

Approved Use

Unknown
Preventing
Iscaguard® FPX2

Approved Use

Unknown
Preventing
Iscaguard® FPX2

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Simultaneous determination of quercetin, kaempferol and (E)-cinnamic acid in vegetative organs of Schisandra chinensis Baill. by HPLC.
2001 Mar
Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures.
2002 Aug
Sorption of benzoic acid, sorbic acid, benzyl alcohol, and benzalkonium chloride by flexible tubing.
2002 Jan
Oestrogenic activity of isobutylparaben in vitro and in vivo.
2002 Jul-Aug
Derivative spectrophotometric determination of droperidol in presence of parabens.
2002 Jun 20
Development of a multidose formulation for a humanized monoclonal antibody using experimental design techniques.
2003
Vasoactive properties of lignocaine administered by iontophoresis in human skin.
2003 Jan
Determination of chlorpheniramine maleate and tincture ipecac in dosage form by liquid chromatography with ultraviolet detection.
2003 Jul-Aug
Determination of methylparaben, propylparaben, triamcinolone acetonide and its degradation product in a topical cream by RP-HPLC.
2003 Jun
Simple high-performance liquid chromatographic assay for melphalan in perfusate, rat liver and tumour tissue.
2003 Oct
Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor.
2003 Oct
Determination of bifonazole in creams containing methyl- and propyl p-hydroxybenzoate by derivative spectrophotometric method.
2003 Sep 15
Propyl paraben inhibits voltage-dependent sodium channels and protects cardiomyocytes from ischemia-reperfusion injury.
2004 Apr 30
[Synthesis of new mandelic acid derivatives with preservative action. Synthesis and acute toxicity study].
2004 Jan-Mar
Preventing sexual transmission of HIV: anti-HIV bioregulatory and homeostatic components of commercial sexual lubricants.
2004 Jul-Dec
Simultaneous HPLC determination of ketoprofen and its degradation products in the presence of preservatives in pharmaceuticals.
2004 Nov 15
In vitro effect of phenolic antioxidants on germination, growth and aflatoxin B accumulation by peanut Aspergillus section Flavi.
2005
Estrogenic activity of cosmetic components in reporter cell lines: parabens, UV screens, and musks.
2005 Feb 27
The effects of parabens on the mechanosensitive channels of E. coli.
2005 Jul
Propyl paraben induces potassium efflux in Escherichia coli.
2005 Jun
The importance of the cosolvent propylene glycol on the antimicrobial preservative efficacy of a pharmaceutical formulation by DOE-ruggedness testing.
2006
Effect of formulation factors on in-vitro permeation of diclofenac from experimental and marketed aqueous eye drops through excised goat cornea.
2006 Dec
Simultaneous, stability indicating, HPLC-DAD determination of guaifenesin and methyl and propyl-parabens in cough syrup.
2006 Jun 7
A stability-indicating HPLC method for medroxyprogesterone acetate in bulk drug and injection formulation.
2006 Mar 18
Application and validation of chemometrics-assisted spectrophotometry and liquid chromatography for the simultaneous determination of six-component pharmaceuticals.
2006 May 3
Pharmaceutical excipients and the information on drug labels.
2006 May-Jun
Advantages of ultra performance liquid chromatography over high-performance liquid chromatography: comparison of different analytical approaches during analysis of diclofenac gel.
2006 Nov
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.
2006 Nov
Post-marketing assessment of content and efficacy of preservatives in artemisinin-derived antimalarial dry suspensions for paediatric use.
2007 Jan 26
Comparison of objective and sensory skin irritations of several cosmetic preservatives.
2007 Mar
Patents

Patents

Sample Use Guides

Typically used at levels ranging from 0.01 to 0.3%. Safe for use in cosmetic products at levels up to 25%.
Route of Administration: Topical
Propylparaben (MIC-80% = 64 (mg/ml)) in combination with Fluconazole against Candida albicans
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:22:02 UTC 2023
Edited
by admin
on Fri Dec 15 15:22:02 UTC 2023
Record UNII
Z8IX2SC1OH
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PROPYLPARABEN
FCC   HSDB   II   INCI   MI   USAN   USP-RS   VANDF   WHO-DD  
USAN   INCI  
Official Name English
PROPYLPARABEN [VANDF]
Common Name English
PROPYL PARAHYDROXYBENZOATE
EP  
Systematic Name English
PROPYLPARABEN E216
Common Name English
PROPYL PARA-HYDROXYBENZOATE
Common Name English
NSC-8511
Code English
NSC-23515
Code English
NIPASOL
Brand Name English
PROPYLPARABEN [USAN]
Common Name English
PARABEN P
Brand Name English
PROPYL P-HYDROXYBENZOATE [FHFI]
Common Name English
Propylparaben [WHO-DD]
Common Name English
PROPYL HYDROXYBENZOATE [MART.]
Common Name English
PROPYL (4-HYDROXYBENZOATE)
Systematic Name English
PROPYLPARABEN [USP-RS]
Common Name English
PROPYLPARABEN [II]
Common Name English
BENZOIC ACID, 4-HYDROXY-, PROPYL ESTER
Common Name English
PROPYLIS HYDROXYBENZOAS [WHO-IP LATIN]
Common Name English
PROPYLPARABEN [FCC]
Common Name English
PROPYL HYDROXYBENZOATE
MART.   WHO-IP  
Systematic Name English
FEMA NO. 2951
Code English
METHYL PARAHYDROXYBENZOATE IMPURITY C [EP IMPURITY]
Common Name English
PROPYL PARAHYDROXYBENZOATE [EP IMPURITY]
Common Name English
PROPYL PARAHYDROXYBENZOATE [JAN]
Common Name English
NIPAGIN P
Brand Name English
PROPYL P-HYDROXYBENZOATE
FHFI  
Common Name English
TEGOSEPT P
Common Name English
PROPYLPARABEN [HSDB]
Common Name English
PROPYL HYDROXYBENZOATE [WHO-IP]
Common Name English
PROPYL PARAHYDROXYBENZOATE [EP MONOGRAPH]
Common Name English
PROPAGIN
Brand Name English
PARATEXIN P
Brand Name English
NIPAZOL
Brand Name English
PROPYL PARABEN [VANDF]
Common Name English
PROPYLPARABEN [MI]
Common Name English
PROPYLPARABEN [INCI]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C92608
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
NDF-RT N0000185508
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
CFR 21 CFR 184.1670
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
CFR 21 CFR 172.515
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
EU FOOD ADDITIVES E-216
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
EPA PESTICIDE CODE 61203
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
Code System Code Type Description
EVMPD
SUB12242MIG
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
NSC
8511
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
NSC
23515
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
DRUG BANK
DB14177
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
ECHA (EC/EINECS)
202-307-7
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
DAILYMED
Z8IX2SC1OH
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
PUBCHEM
7175
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
NCI_THESAURUS
C76730
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
NDF-RT
N0000175629
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY Increased Histamine Release [PE]
EVMPD
SUB169805
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
PROPYLPARABEN
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY Description: Colourless crystals or a white, crystalline powder; odourless or with a faintly aromatic odour. Solubility: Very slightly soluble in water; slightly soluble in boiling water; freely soluble in ethanol (~750 g/l) TS and ether R. Category: Antimicrobial preservative. Storage: Propyl hydroxybenzoate should be kept in a well-closed container. Additional information: Propyl hydroxybenzoate is normally used in combination with other hydroxybenzoates. Requirement: Propyl hydroxybenzoate contains not less than 99.0% and not more than the equivalent of 101.0% of C10H12O3, calculated withreference to the dried substance.
MERCK INDEX
m9247
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY Merck Index
WIKIPEDIA
PROPYLPARABEN
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
USAN
Y-36
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
RS_ITEM_NUM
1577008
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
SMS_ID
100000079299
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
NDF-RT
N0000171131
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY Allergens [Chemical/Ingredient]
NDF-RT
N0000184306
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY Cell-mediated Immunity [PE]
DRUG CENTRAL
2307
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
HSDB
203
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
CAS
94-13-3
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
EPA CompTox
DTXSID4022527
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
FDA UNII
Z8IX2SC1OH
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
CHEBI
32063
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
RXCUI
34706
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY RxNorm
MESH
C006068
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
ChEMBL
CHEMBL194014
Created by admin on Fri Dec 15 15:22:02 UTC 2023 , Edited by admin on Fri Dec 15 15:22:02 UTC 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
Related Record Type Details
IMPURITY -> PARENT
IMPURITY -> PARENT
IMPURITY -> PARENT
IMPURITY -> PARENT
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
ACTIVE MOIETY