PROPYLPARABEN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H12O3
Molecular Weight	180.2005
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CCCOC(=O)C1=CC=C(O)C=C1

InChI

InChIKey=QELSKZZBTMNZEB-UHFFFAOYSA-N

InChI=1S/C10H12O3/c1-2-7-13-10(12)8-3-5-9(11)6-4-8/h3-6,11H,2,7H2,1H3

HIDE SMILES / InChI

Molecular Formula	C10H12O3
Molecular Weight	180.2005
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

Propylparaben is a bacteriostatic and fungistatic agent used as a preservative in cosmetic products, food and drugs. As a food additive, it has the E number E216. To increase the activity and reduce its dose propylparaben is used in a mixture with other parabens and in combination with other types of preservatives. Propylparaben is a chemical allergen capable of producing immunologically mediated hypersensitivity reactions. Chemically it is an ester of p-hydroxybenzoic acid.

Approval Year

Conditions

Conditions

Condition	Modality	Highest Phase	Product
dermatitis 2	Inactive ingredient	Approved 8,429	XILAPAK
Gram-negative bacterial skin infections 2	Preventing	Basic research	Iscaguard® FPX2
Gram-positive bacterial skin infections 2	Preventing	Basic research	Iscaguard® FPX2
Fungal skin infections 3	Preventing	Basic research	Iscaguard® FPX2

PubMed

Show entries

Title	Date	PubMed
[Competitive binding of some alkyl p-hydroxybenzoates to human estrogen receptor alpha and beta].	2000 Dec	11193391
ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7 cells and expression of ERalpha and PR.	2001 Dec	11696396
Safety assessment of propyl paraben: a review of the published literature.	2001 Jun	11346481
The first example of a paraben-dependent antibody to an Rh protein.	2001 Mar	11274592
Simultaneous determination of quercetin, kaempferol and (E)-cinnamic acid in vegetative organs of Schisandra chinensis Baill. by HPLC.	2001 Mar	11248500