PROPYLPARABEN

US Previously Marketed

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H12O3
Molecular Weight	180.2005
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCOC(=O)C1=CC=C(O)C=C1

InChI

InChIKey=QELSKZZBTMNZEB-UHFFFAOYSA-N

InChI=1S/C10H12O3/c1-2-7-13-10(12)8-3-5-9(11)6-4-8/h3-6,11H,2,7H2,1H3

HIDE SMILES / InChI

Molecular Formula	C10H12O3
Molecular Weight	180.2005
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.fda.gov/cosmetics/productsingredients/ingredients/ucm128042.htm#What_are_parabens
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/24542410; http://www.ncbi.nlm.nih.gov/pubmed/576658; http://www.ukfoodguide.net/e216.htm

Propylparaben is a bacteriostatic and fungistatic agent used as a preservative in cosmetic products, food and drugs. As a food additive, it has the E number E216. To increase the activity and reduce its dose propylparaben is used in a mixture with other parabens and in combination with other types of preservatives. Propylparaben is a chemical allergen capable of producing immunologically mediated hypersensitivity reactions. Chemically it is an ester of p-hydroxybenzoic acid.

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
dermatitis 2 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f1b8a26a-dc63-4701-8a78-cc1f99fca1b3	Inactive ingredient	Approved 8429	XILAPAK Approved Use For the management of hypertrophic tissues, keloid tissues, dermatitis and dermatoses Launch Date 2017
Gram-negative bacterial skin infections 2 Sources: http://www.iscauk.com/parabens_cosmetic_preservatives.php	Preventing	Basic research	Iscaguard® FPX2 Approved Use Unknown
Gram-positive bacterial skin infections 2 Sources: http://www.iscauk.com/parabens_cosmetic_preservatives.php	Preventing	Basic research	Iscaguard® FPX2 Approved Use Unknown
Fungal skin infections 3 Sources: http://www.iscauk.com/parabens_cosmetic_preservatives.php	Preventing	Basic research	Iscaguard® FPX2 Approved Use Unknown

PubMed

Title	Date	PubMed
In vivo and in vitro estrogen bioactivities of alkyl parabens.	2003 Jul	15697177
Separation of preservatives in cosmetic products by micellar electrokinetic chromatography.	2004 Dec	15636528
[Synthesis of new mandelic acid derivatives with preservative action. Synthesis and acute toxicity study].	2004 Jan-Mar	15688782
[In vitro susceptibility of a Staphylococcus spp. isolate to food preservatives].	2004 Oct-Dec	16004236
Morphometric analysis of mice uteri treated with the preservatives methyl, ethyl, propyl, and butylparaben.	2004 Sep	15941009
HPLC analysis of generic antiretroviral drugs purchased in Rwanda.	2005	17176547
In vitro effect of phenolic antioxidants on germination, growth and aflatoxin B accumulation by peanut Aspergillus section Flavi.	2005	16108810
High performance liquid chromatographic determination of oxeladin citrate and oxybutynin hydrochloride and their degradation products.	2005 Aug	16023117
The effects of parabens on the mechanosensitive channels of E. coli.	2005 Jul	15770478
A novel gradient HPLC method for simultaneous determination of ranitidine, methylparaben and propylparaben in oral liquid pharmaceutical formulation.	2005 Jul 15	15967306
Liquid chromatography and chemometric-assisted spectrophotometric methods for the analysis of two multicomponent mixtures containing cough suppressant drugs.	2005 Jul-Aug	16152922
A review of the endocrine activity of parabens and implications for potential risks to human health.	2005 Jun	16097138
Propyl paraben induces potassium efflux in Escherichia coli.	2005 Jun	15824091
Decrease in skin permeation and antibacterial effect of parabens by a polymeric additive, poly(2-methacryloyloxyethyl phosphorylcholine-co-butylmetacrylate).	2005 Mar	15744096
The use of colloidal microgels as a (trans)dermal drug delivery system.	2005 Mar 23	15725560
Development and validation of a stability indicating HPLC method for determination of lisinopril, lisinopril degradation product and parabens in the lisinopril extemporaneous formulation.	2005 Mar 9	15740917
Simultaneous determination of preservatives (benzoic acid, sorbic acid, methylparaben and propylparaben) in foodstuffs using high-performance liquid chromatography.	2005 May 6	15909546
Rapid and sensitive determination of indapamide in human blood by liquid chromatography with electrospray ionization mass spectrometric detection: application to a bioequivalence study.	2005 Nov	16320942
A new validated method for the simultaneous determination of benzocaine, propylparaben and benzyl alcohol in a bioadhesive gel by HPLC.	2005 Oct 4	16039086
Determination of parabens in pharmaceutical formulations by solid-phase microextraction-ion mobility spectrometry.	2005 Sep 15	16159125
Stability indicating reversed-phase liquid chromatographic determination of metronidazole benzoate and diloxanide furoate as bulk drug and in suspension dosage form.	2005 Sep 15	16055294
A comparison of performance of various analytical columns in pharmaceutical analysis: conventional C18 and high throughput C18 zorbax columns.	2005 Sep 23	16130729
The importance of the cosolvent propylene glycol on the antimicrobial preservative efficacy of a pharmaceutical formulation by DOE-ruggedness testing.	2006	16895838
Application of ecotoxicogenomics for studying endocrine disruption in vertebrates and invertebrates.	2006 Apr	16818254
Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia.	2006 Aug	16869867
Parabens as urinary biomarkers of exposure in humans.	2006 Dec	17185273
Evaluation of xenoestrogenic potential of propylparaben in zebrafish (Danio rerio).	2006 Dec	17159791
Effect of formulation factors on in-vitro permeation of diclofenac from experimental and marketed aqueous eye drops through excised goat cornea.	2006 Dec	17139162
Separation and determination of clotrimazole, methylparaben and propylparaben in pharmaceutical preparation by micellar electrokinetic chromatography.	2006 Jan 23	16095858
Simultaneous analysis of antioxidants and preservatives in cosmetics by supercritical fluid extraction combined with liquid chromatography-mass spectrometry.	2006 Jul 7	16513127
Simultaneous, stability indicating, HPLC-DAD determination of guaifenesin and methyl and propyl-parabens in cough syrup.	2006 Jun 7	16497471
A stability-indicating HPLC method for medroxyprogesterone acetate in bulk drug and injection formulation.	2006 Mar 18	16242876
Expression profiling of estrogen-responsive genes in breast cancer cells treated with alkylphenols, chlorinated phenols, parabens, or bis- and benzoylphenols for evaluation of estrogenic activity.	2006 May 25	16280211
HPLC determination of calcium pantothenate and two preservatives in topical cream.	2006 May 3	16473491
Stability indicating simultaneous determination of domperidone (DP), methylparaben (MP) and propylparaben by high performance liquid chromatography (HPLC).	2006 May 3	16464558
Application and validation of chemometrics-assisted spectrophotometry and liquid chromatography for the simultaneous determination of six-component pharmaceuticals.	2006 May 3	16414231
Development and validation of a simple reversed-phase high-performance liquid chromatography method for the determination of testosterone in serum of males.	2006 May 3	16406451
Pharmaceutical excipients and the information on drug labels.	2006 May-Jun	17119779
The influence of physicochemical properties of preservative compounds on their distribution into various phases of oil in water submicron emulsion.	2006 May-Jun	17089686
Simple determination of betamethasone and chloramphenicol in a pharmaceutical preparation using a short monolithic column coupled to a sequential injection system.	2006 Nov	17154130
Advantages of ultra performance liquid chromatography over high-performance liquid chromatography: comparison of different analytical approaches during analysis of diclofenac gel.	2006 Nov	17154123
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.	2006 Nov	16497524
Solid-phase extraction and HPLC analysis of methylparaben and propylparaben in a concentrated antibiotic suspension.	2006 Oct	17012122
Flow cytometric cell cycle analysis allows for rapid screening of estrogenicity in MCF-7 breast cancer cells.	2006 Oct	16797915
Development and validation of chemometrics-assisted spectrophotometric and liquid chromatographic methods for the simultaneous determination of two multicomponent mixtures containing bronchodilator drugs.	2007 Feb 19	17046190
Effect estimates and methodological quality of randomized controlled trials about prevention of alveolar osteitis following tooth extraction: a systematic review.	2007 Jan	17178488
Controlled drug release from pellets containing water-insoluble drugs dissolved in a self-emulsifying system.	2007 Jan	17056237
Assay of artemether, methylparaben and propylparaben in a formulated paediatric antimalarial dry suspension.	2007 Jan 17	17074460
Post-marketing assessment of content and efficacy of preservatives in artemisinin-derived antimalarial dry suspensions for paediatric use.	2007 Jan 26	17257400
Comparison of objective and sensory skin irritations of several cosmetic preservatives.	2007 Mar	17295686

Patents

Sample Use Guides

In Vivo Use Guide

Typically used at levels ranging from 0.01 to 0.3%. Safe for use in cosmetic products at levels up to 25%.

Route of Administration: Topical

In Vitro Use Guide

Propylparaben (MIC-80% = 64 (mg/ml)) in combination with Fluconazole against Candida albicans

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:22:02 GMT 2023` Edited by `admin` on `Fri Dec 15 15:22:02 GMT 2023`
Record UNII	Z8IX2SC1OH
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PROPYLPARABEN

Official Name

English

PROPYLPARABEN [VANDF]

Common Name

English

PROPYL PARAHYDROXYBENZOATE

Systematic Name

English

PROPYLPARABEN E216

Common Name

English

PROPYL PARA-HYDROXYBENZOATE

Common Name

English

NSC-8511

Code

English

NSC-23515

Code

English

NIPASOL

Brand Name

English

PROPYLPARABEN [USAN]

Common Name

English

PARABEN P

Brand Name

English

PROPYL P-HYDROXYBENZOATE [FHFI]

Common Name

English

Propylparaben [WHO-DD]

Common Name

English

PROPYL HYDROXYBENZOATE [MART.]

Common Name

English

PROPYL (4-HYDROXYBENZOATE)

Systematic Name

English

PROPYLPARABEN [USP-RS]

Common Name

English

PROPYLPARABEN [II]

Common Name

English

BENZOIC ACID, 4-HYDROXY-, PROPYL ESTER

Common Name

English

PROPYLIS HYDROXYBENZOAS [WHO-IP LATIN]

Common Name

English

PROPYLPARABEN [FCC]

Common Name

English

PROPYL HYDROXYBENZOATE

Systematic Name

English

FEMA NO. 2951

Code

English

METHYL PARAHYDROXYBENZOATE IMPURITY C [EP IMPURITY]

Common Name

English

PROPYL PARAHYDROXYBENZOATE [EP IMPURITY]

Common Name

English

PROPYL PARAHYDROXYBENZOATE [JAN]

Common Name

English

NIPAGIN P

Brand Name

English

PROPYL P-HYDROXYBENZOATE

Common Name

English

TEGOSEPT P

Common Name

English

PROPYLPARABEN [HSDB]

Common Name

English

PROPYL HYDROXYBENZOATE [WHO-IP]

Common Name

English

PROPYL PARAHYDROXYBENZOATE [EP MONOGRAPH]

Common Name

English

PROPAGIN

Brand Name

English

PARATEXIN P

Brand Name

English

NIPAZOL

Brand Name

English

PROPYL PARABEN [VANDF]

Common Name

English

PROPYLPARABEN [MI]

Common Name

English

PROPYLPARABEN [INCI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C92608