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Details

Stereochemistry ACHIRAL
Molecular Formula C7H6O3
Molecular Weight 138.1207
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 4-Hydroxybenzoic Acid

SMILES

OC(=O)C1=CC=C(O)C=C1

InChI

InChIKey=FJKROLUGYXJWQN-UHFFFAOYSA-N
InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)

HIDE SMILES / InChI

Molecular Formula C7H6O3
Molecular Weight 138.1207
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Purification and properties of p-hydroxybenzoate hydroxylases from Rhodococcus strains.
2001 Aug
Processes controlling the distribution and natural attenuation of dissolved phenolic compounds in a deep sandstone aquifer.
2001 Dec 15
Oxidation of p-hydroxybenzoic acid by Fenton's reagent.
2001 Feb
Synthesis, characterization and in vitro degradation of a new family of alternate poly(ester-anhydrides) based on aliphatic and aromatic diacids.
2001 Feb
Analytical control of a pharmaceutical formulation of sodium picosulfate by capillary zone electrophoresis.
2001 Feb 10
Analysis of the pobA and pobR genes controlling expression of p-hydroxybenzoate hydroxylase in Azotobacter chroococcum.
2001 Feb 7
Polyacrylamides as hydrophilic selectors in non-aqueous capillary electrophoresis.
2001 Jan 5
Synergistic interactions of multiple mutations on catalysis during the hydroxylation reaction of p-hydroxybenzoate hydroxylase: studies of the Lys297Met, Asn300Asp, and Tyr385Phe mutants reconstituted with 8-Cl-flavin.
2001 Jul 31
Tagetolone and tagetenolone: two phytotoxic polyketides from Alternaria tagetica.
2001 Mar
Kinetics of the reaction between ozone and phenolic acids present in agro-industrial wastewaters.
2001 Mar
Pneumocystis carinii f. sp. carinii synthesizes de novo four homologs of ubiquinone.
2001 Mar-Apr
Separation of a phenol carboxylating organism from a two-member, strict anaerobic co-culture.
2001 May
Microbial transformations of p-coumaric acid by Bacillus megaterium and Curvularia lunata.
2001 Nov
Biomimetic transport of simple olive biophenol and analogues through model biological membranes by differential scanning calorimetry.
2001 Nov
A novel protein elicitor (PaNie) from Pythium aphanidermatum induces multiple defense responses in carrot, Arabidopsis, and tobacco.
2001 Nov
Molecularly imprinted polymer using-p-hydroxybenzoic acid, p-hydroxyphenylacetic acid and p-hydroxyphenylpropionic acid as templates.
2001 Nov-Dec
Aromatic amino acid biosynthesis and production of related compounds from p-hydroxyphenylpyruvic acid by rumen bacteria, protozoa and their mixture.
2002
The trans-anethole degradation pathway in an Arthrobacter sp.
2002 Apr 5
Comment on "Oxidation of p-hydroxybenzoic acid by Fenton's reagent" by F.J. Rivas, F.J. Belran, J. Frades, and P. Buxeda.
2002 Feb
Agastinol and agastenol, novel lignans from Agastache rugosa and their evaluation in an apoptosis inhibition assay.
2002 Mar
Antioxidant activity of phenolic compounds isolated from Mesona procumbens Hemsl.
2002 May 8
Novel fluorometric assay for hydroxyl radical prevention capacity using fluorescein as the probe.
2002 May 8
Synthesis of antisense oligonucleotide-peptide conjugate targeting to GLUT-1 in HepG-2 and MCF-7 Cells.
2002 May-Jun
Evaluation of the health aspects of methyl paraben: a review of the published literature.
2002 Oct
Biodegradation of aromatic compounds by white rot and ectomycorrhizal fungal species and the accumulation of chlorinated benzoic acid in ectomycorrhizal pine seedlings.
2002 Oct
Acute toxicity, mutagenicity, and estrogenicity of biodegradation products of bisphenol-A.
2002 Oct
Antifungal constituents from the seeds of Allium fistulosum L.
2002 Oct 23
Fast capillary electrochromatographic analysis of parabens and 4-hydroxybenzoic acid in drugs and cosmetics.
2002 Sep
Physiology of exopolysaccharide production by Azotobacter vinelandii from 4-hydroxybenzoic acid.
2002 Sep
The relative toxicity of substituted phenols reported in cigarette mainstream smoke.
2002 Sep
Kinetic, Raman, NMR, and site-directed mutagenesis studies of the Pseudomonas sp. strain CBS3 4-hydroxybenzoyl-CoA thioesterase active site.
2002 Sep 17
Patents
Substance Class Chemical
Created
by admin
on Mon Mar 31 19:36:44 GMT 2025
Edited
by admin
on Mon Mar 31 19:36:44 GMT 2025
Record UNII
JG8Z55Y12H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
4-Hydroxybenzoic Acid
FHFI   HSDB   INCI  
INCI  
Official Name English
SALICYLIC ACID RELATED COMPOUND A [USP IMPURITY]
USP-RS  
Preferred Name English
SALICYLIC ACID IMPURITY A [EP IMPURITY]
Common Name English
ACETYLSALICYLIC ACID IMPURITY A [EP IMPURITY]
Common Name English
BENZOIC ACID, P-HYDROXY-
Common Name English
P-HYDROXYBENZOIC ACID [MI]
Common Name English
PROPYL HYDROXYBENZOATE IMPURITY A [EP IMPURITY]
Common Name English
4-CARBOXYPHENOL
Systematic Name English
P-CARBOXYPHENOL
Common Name English
4-HYDROXYBENZOIC ACID [FHFI]
Common Name English
PARAHYDROXYBENZOIC ACID
Systematic Name English
BENZOIC ACID, 4-HYDROXY-
Common Name English
PARABEN-ACID
Common Name English
P-SALICYLIC ACID
Common Name English
P-HYDROXYBENZOIC ACID
MI  
Common Name English
METHYL PARAHYDROXYBENZOATE IMPURITY A [EP IMPURITY]
Common Name English
SALICYLIC ACID RELATED COMPOUND A [USP-RS]
Common Name English
NSC-4961
Code English
FEMA NO. 3986
Code English
4-HYDROXYBENZOIC ACID [HSDB]
Common Name English
Classification Tree Code System Code
JECFA EVALUATION 4-HYDROXYBENZOIC ACID
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
Code System Code Type Description
RXCUI
1649527
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY RxNorm
CAS
99-96-7
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
WIKIPEDIA
4-HYDROXYBENZOIC ACID
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
FDA UNII
JG8Z55Y12H
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
HSDB
7233
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
EVMPD
SUB14772MIG
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
NSC
4961
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
SMS_ID
100000079746
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
DRUG BANK
DB04242
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
MERCK INDEX
m6120
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY Merck Index
PUBCHEM
135
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
CHEBI
30763
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
DAILYMED
JG8Z55Y12H
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
MESH
C038193
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
ECHA (EC/EINECS)
202-804-9
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
EPA CompTox
DTXSID3026647
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
JECFA MONOGRAPH
890
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
RS_ITEM_NUM
1609013
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
PARENT -> CONSTITUENT ALWAYS PRESENT
PARENT -> CONSTITUENT ALWAYS PRESENT
PARENT -> CONSTITUENT ALWAYS PRESENT
PARENT -> CONSTITUENT ALWAYS PRESENT
Related Record Type Details
PARENT -> IMPURITY
correction factor: for the calculation of content, multiply the peak area of impurity A by 1.4
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP