U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C7H6O3
Molecular Weight 138.121
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 4-HYDROXYBENZOIC ACID

SMILES

c1cc(ccc1C(=O)O)O

InChI

InChIKey=FJKROLUGYXJWQN-UHFFFAOYSA-N
InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)

HIDE SMILES / InChI
Molecular Formula C7H6O3
Molecular Weight 138.121
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
116683
PubMed

PubMed

TitleDatePubMed
Characterization of sago palm (Metroxylon sagu) lignin by analytical pyrolysis.
2001 Apr
Purification and properties of p-hydroxybenzoate hydroxylases from Rhodococcus strains.
2001 Aug
Methodological setup to study allelochemical translocation in radish seedlings.
2001 Aug
Comamonas testosteroni BR6020 possesses a single genetic locus for extradiol cleavage of protocatechuate.
2001 Aug
The crystal structure of chorismate lyase shows a new fold and a tightly retained product.
2001 Aug 15
Estimation of preservative concentrations in foods and their daily intake based on official inspection results in Japan in fiscal year 1998.
2001 Dec
Phenolic compounds in berries of black, red, green, and white currants (Ribes sp.).
2001 Dec
Microbial synthesis of p-hydroxybenzoic acid from glucose.
2001 Dec
Processes controlling the distribution and natural attenuation of dissolved phenolic compounds in a deep sandstone aquifer.
2001 Dec 15
Non-ionic micellar affinity capillary electrophoresis for analysis of interactions between micelles and drugs.
2001 Feb
Oxidation of p-hydroxybenzoic acid by Fenton's reagent.
2001 Feb
Analysis of the pobA and pobR genes controlling expression of p-hydroxybenzoate hydroxylase in Azotobacter chroococcum.
2001 Feb 7
Influence of nutritional and environmental factors on polysaccharide production by Azotobacter vinelandii cultured on 4-hydroxybenzoic acid.
2001 Jul
Rerouting the plant phenylpropanoid pathway by expression of a novel bacterial enoyl-CoA hydratase/lyase enzyme function.
2001 Jul
Selective and quantitative analysis of 4-hydroxybenzoate preservatives by microemulsion electrokinetic chromatography.
2001 Jul 27
Synergistic interactions of multiple mutations on catalysis during the hydroxylation reaction of p-hydroxybenzoate hydroxylase: studies of the Lys297Met, Asn300Asp, and Tyr385Phe mutants reconstituted with 8-Cl-flavin.
2001 Jul 31
Determination of organic acids of low molecular weight and phosphate in soil by capillary electrophoresis.
2001 Jul-Aug
Regulation of the p-hydroxybenzoic acid hydroxylase gene (pobA) in plant-growth-promoting Pseudomonas putida WCS358.
2001 Jun
[Bergenia crassifolia (L.) Fritsch in vitro].
2001 Mar
Kinetics of the reaction between ozone and phenolic acids present in agro-industrial wastewaters.
2001 Mar
In vivo hepatoprotective activity of active fraction from ethanolic extract of Eclipta alba leaves.
2001 Oct
Kinetic model for phenolic compound oxidation by Fenton's reagent.
2001 Oct
Ubiquinone biosynthesis in microorganisms.
2001 Sep 25
Aromatic amino acid biosynthesis and production of related compounds from p-hydroxyphenylpyruvic acid by rumen bacteria, protozoa and their mixture.
2002
Antioxidative phenolic compounds isolated from almond skins (Prunus amygdalus Batsch).
2002 Apr 10
The effect of ethanol on the simultaneous transport and metabolism of methyl p-hydroxybenzoate in excised skin of Yucatan micropig.
2002 Apr 2
High level expression of chorismate pyruvate-lyase (UbiC) and HMG-CoA reductase in hairy root cultures of Lithospermum erythrorhizon.
2002 Aug
Retention of anions on silica-based metalloporphyrin stationary phases.
2002 Feb
Comment on "Oxidation of p-hydroxybenzoic acid by Fenton's reagent" by F.J. Rivas, F.J. Belran, J. Frades, and P. Buxeda.
2002 Feb
Why phenolic acids are unlikely primary allelochemicals in rice.
2002 Jan
Multiple operons connected with catabolism of aromatic compounds in Acinetobacter sp. strain ADP1 are under carbon catabolite repression.
2002 Jul
An in vitro hydroxyl radical generation assay for microdialysis sampling calibration.
2002 Jul 1
Oestrogenic activity of isobutylparaben in vitro and in vivo.
2002 Jul-Aug
Determination of free and total phenolic acids in plant-derived foods by HPLC with diode-array detection.
2002 Jun 19
Reclassification of Clostridium hydroxybenzoicum as Sedimentibacter hydroxybenzoicus gen. nov., comb. nov., and description of Sedimentibacter saalensis sp. nov..
2002 May
4-Hydroxycinnamoyl-CoA hydratase/lyase, an enzyme of phenylpropanoid cleavage from Pseudomonas, causes formation of C(6)-C(1) acid and alcohol glucose conjugates when expressed in hairy roots of Datura stramonium L.
2002 May
Antioxidant activity of phenolic compounds isolated from Mesona procumbens Hemsl.
2002 May 8
Novel fluorometric assay for hydroxyl radical prevention capacity using fluorescein as the probe.
2002 May 8
On the application of 4-hydroxybenzoic acid as a trapping agent to study hydroxyl radical generation during cerebral ischemia and reperfusion.
2002 May-Jun
[The nature of melanin pigments from some micro- and macromycetes].
2002 May-Jun
Evaluation of the health aspects of methyl paraben: a review of the published literature.
2002 Oct
Biodegradation of aromatic compounds by white rot and ectomycorrhizal fungal species and the accumulation of chlorinated benzoic acid in ectomycorrhizal pine seedlings.
2002 Oct
Acute toxicity, mutagenicity, and estrogenicity of biodegradation products of bisphenol-A.
2002 Oct
Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frameshift mutation in the pks15/1 gene.
2002 Oct 11
Antifungal constituents from the seeds of Allium fistulosum L.
2002 Oct 23
Fast capillary electrochromatographic analysis of parabens and 4-hydroxybenzoic acid in drugs and cosmetics.
2002 Sep
Physiology of exopolysaccharide production by Azotobacter vinelandii from 4-hydroxybenzoic acid.
2002 Sep
The relative toxicity of substituted phenols reported in cigarette mainstream smoke.
2002 Sep
Germination inhibitory constituents from Erigeron annuus.
2002 Sep
Kinetic, Raman, NMR, and site-directed mutagenesis studies of the Pseudomonas sp. strain CBS3 4-hydroxybenzoyl-CoA thioesterase active site.
2002 Sep 17
Patents

Patents

JP1016724A
2
JP1016823A
3
JP1051431A
2
JP1056727A
2
JP1069624A
2
JP2000044457A
3
JP2000080177A
2
JP2000143501A
6
JP2000192331A
4
JP2000351897A
2
JP2000351898A
2
JP2001072750A
2
JP2001089314A
2
JP2001097847A
2
JP2001261927A
2
JP2002068924A
2
JP2002338408A
2
JP2002512267A
3
JP2003183373A
2
JP2003313403A
2
JP2004002697A
2
JP2004043336A
2
JP2004050649A
2
JP2004189977A
2
JP2004196665A
5
JP2004215586A
2
JP2004217890A
2
JP2004250620A
3
JP2004277305A
2
JP2004307444A
2
JP2004315496A
24
JP2004352993A
2
JP2005281409A
6
JP2006043941A
2
JP2006083391A
2
JP2006225642A
3
JP2006504448A
2
JP2007269813A
2
JP2008143839A
3
JP2008174530A
2
JP2008266209A
2
JP2010037364A
3
JP2010248117A
2
JP2010528149A
3
JP2011246407A
2
JP2011525242A
2
JP4740542B2
6
JPH00374308A
2
JPH00678765A
2
JPH00759582A
2
JPH00812862A
3
Substance Class Chemical
Created
by admin
on Sat Jun 26 13:30:16 UTC 2021
Edited
by admin
on Sat Jun 26 13:30:16 UTC 2021
Record UNII
JG8Z55Y12H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
4-HYDROXYBENZOIC ACID
FHFI   HSDB   INCI  
INCI  
Official Name English
SALICYLIC ACID RELATED COMPOUND A [USP]
USP-RS  
Common Name English
4-HYDROXYBENZOIC ACID [INCI]
Common Name English
BENZOIC ACID, P-HYDROXY-
Common Name English
PROPYL HYDROXYBENZOATE IMPURITY A [EP]
Common Name English
METHYL PARAHYDROXYBENZOATE IMPURITY A [EP]
Common Name English
ACETYLSALICYLIC ACID IMPURITY A [EP]
Common Name English
P-HYDROXYBENZOIC ACID [MI]
Common Name English
SALICYLIC ACID IMPURITY A [EP]
Common Name English
4-CARBOXYPHENOL
Systematic Name English
P-CARBOXYPHENOL
Common Name English
4-HYDROXYBENZOIC ACID [FHFI]
Common Name English
PARAHYDROXYBENZOIC ACID
Systematic Name English
BENZOIC ACID, 4-HYDROXY-
Common Name English
PARABEN-ACID
Common Name English
P-SALICYLIC ACID
Common Name English
P-HYDROXYBENZOIC ACID
MI  
Common Name English
SALICYLIC ACID RELATED COMPOUND A [USP-RS]
Common Name English
NSC-4961
Code English
FEMA NO. 3986
Code English
4-HYDROXYBENZOIC ACID [HSDB]
Common Name English
Classification Tree Code System Code
JECFA EVALUATION 4-HYDROXYBENZOIC ACID
Created by admin on Sat Jun 26 13:30:17 UTC 2021 , Edited by admin on Sat Jun 26 13:30:17 UTC 2021
Code System Code Type Description
RXCUI
1649527
Created by admin on Sat Jun 26 13:30:17 UTC 2021 , Edited by admin on Sat Jun 26 13:30:17 UTC 2021
PRIMARY RxNorm
CAS
99-96-7
Created by admin on Sat Jun 26 13:30:17 UTC 2021 , Edited by admin on Sat Jun 26 13:30:17 UTC 2021
PRIMARY
WIKIPEDIA
4-HYDROXYBENZOIC ACID
Created by admin on Sat Jun 26 13:30:17 UTC 2021 , Edited by admin on Sat Jun 26 13:30:17 UTC 2021
PRIMARY
USP_CATALOG
1609013
Created by admin on Sat Jun 26 13:30:17 UTC 2021 , Edited by admin on Sat Jun 26 13:30:17 UTC 2021
PRIMARY USP-RS
FDA UNII
JG8Z55Y12H
Created by admin on Sat Jun 26 13:30:17 UTC 2021 , Edited by admin on Sat Jun 26 13:30:17 UTC 2021
PRIMARY
HSDB
7233
Created by admin on Sat Jun 26 13:30:17 UTC 2021 , Edited by admin on Sat Jun 26 13:30:17 UTC 2021
PRIMARY
EVMPD
SUB14772MIG
Created by admin on Sat Jun 26 13:30:17 UTC 2021 , Edited by admin on Sat Jun 26 13:30:17 UTC 2021
PRIMARY
DRUG BANK
DB04242
Created by admin on Sat Jun 26 13:30:17 UTC 2021 , Edited by admin on Sat Jun 26 13:30:17 UTC 2021
PRIMARY
MERCK INDEX
M6120
Created by admin on Sat Jun 26 13:30:17 UTC 2021 , Edited by admin on Sat Jun 26 13:30:17 UTC 2021
PRIMARY Merck Index
PUBCHEM
135
Created by admin on Sat Jun 26 13:30:17 UTC 2021 , Edited by admin on Sat Jun 26 13:30:17 UTC 2021
PRIMARY
MESH
C038193
Created by admin on Sat Jun 26 13:30:17 UTC 2021 , Edited by admin on Sat Jun 26 13:30:17 UTC 2021
PRIMARY
ECHA (EC/EINECS)
202-804-9
Created by admin on Sat Jun 26 13:30:17 UTC 2021 , Edited by admin on Sat Jun 26 13:30:17 UTC 2021
PRIMARY
EPA CompTox
99-96-7
Created by admin on Sat Jun 26 13:30:17 UTC 2021 , Edited by admin on Sat Jun 26 13:30:17 UTC 2021
PRIMARY
Related Record Type Details
Structure of SODIUM PARABEN
SALT/SOLVATE -> PARENT
Structure of POTASSIUM PARABEN
SALT/SOLVATE -> PARENT
VACCINIUM MYRTILLUS LEAF
PARENT -> CONSTITUENT ALWAYS PRESENT
GALIUM APARINE WHOLE
PARENT -> CONSTITUENT ALWAYS PRESENT
MENYANTHES TRIFOLIATA LEAF
PARENT -> CONSTITUENT ALWAYS PRESENT
CENTAURIUM ERYTHRAEA WHOLE
PARENT -> CONSTITUENT ALWAYS PRESENT
Related Record Type Details
Structure of METHYLPARABEN
PARENT -> IMPURITY
correction factor: for the calculation of content, multiply the peak area of impurity A by 1.4
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of PROPYLPARABEN
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of ASPIRIN
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of SALICYLIC ACID
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of SALICYLIC ACID
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
Ph.Eur.; USP
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966