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Details

Stereochemistry ACHIRAL
Molecular Formula C7H6O3
Molecular Weight 138.1207
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 4-Hydroxybenzoic Acid

SMILES

OC(=O)C1=CC=C(O)C=C1

InChI

InChIKey=FJKROLUGYXJWQN-UHFFFAOYSA-N
InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)

HIDE SMILES / InChI
Molecular Formula C7H6O3
Molecular Weight 138.1207
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

2015
472
PubMed

PubMed

TitleDatePubMed
Antifungal constituents from the seeds of Allium fistulosum L.
2002-10-23
Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frameshift mutation in the pks15/1 gene.
2002-10-11
Evaluation of the health aspects of methyl paraben: a review of the published literature.
2002-10
Biodegradation of aromatic compounds by white rot and ectomycorrhizal fungal species and the accumulation of chlorinated benzoic acid in ectomycorrhizal pine seedlings.
2002-10
Acute toxicity, mutagenicity, and estrogenicity of biodegradation products of bisphenol-A.
2002-10
Kinetic, Raman, NMR, and site-directed mutagenesis studies of the Pseudomonas sp. strain CBS3 4-hydroxybenzoyl-CoA thioesterase active site.
2002-09-17
Oestrogenic activity of isobutylparaben in vitro and in vivo.
2002-09-05
Fast capillary electrochromatographic analysis of parabens and 4-hydroxybenzoic acid in drugs and cosmetics.
2002-09
Physiology of exopolysaccharide production by Azotobacter vinelandii from 4-hydroxybenzoic acid.
2002-09
The relative toxicity of substituted phenols reported in cigarette mainstream smoke.
2002-09
Germination inhibitory constituents from Erigeron annuus.
2002-09
On the application of 4-hydroxybenzoic acid as a trapping agent to study hydroxyl radical generation during cerebral ischemia and reperfusion.
2002-08-07
High level expression of chorismate pyruvate-lyase (UbiC) and HMG-CoA reductase in hairy root cultures of Lithospermum erythrorhizon.
2002-08
Assignment of absolute configuration of chiral carboxylic acids via exciton-coupled CD treatment: 4-phenylthioproline as a case study.
2002-08
Enhanced detection and characterization of protocatechuate 3,4-dioxygenase in Acinetobacter lwoffii K24 by proteomics using a column separation.
2002-07-26
X-ray crystallographic analyses of inhibitor and substrate complexes of wild-type and mutant 4-hydroxybenzoyl-CoA thioesterase.
2002-07-26
Pneumocystis carinii f. sp. carinii synthesizes de novo four homologs of ubiquinone.
2002-07-04
Role of protein flexibility in the catalytic cycle of p-hydroxybenzoate hydroxylase elucidated by the Pro293Ser mutant.
2002-07-02
An in vitro hydroxyl radical generation assay for microdialysis sampling calibration.
2002-07-01
Multiple operons connected with catabolism of aromatic compounds in Acinetobacter sp. strain ADP1 are under carbon catabolite repression.
2002-07
Effects of butyl paraben on the male reproductive system in mice.
2002-07
[The nature of melanin pigments from some micro- and macromycetes].
2002-06-19
Determination of free and total phenolic acids in plant-derived foods by HPLC with diode-array detection.
2002-06-19
Synthesis of antisense oligonucleotide-peptide conjugate targeting to GLUT-1 in HepG-2 and MCF-7 Cells.
2002-05-16
Antioxidant activity of phenolic compounds isolated from Mesona procumbens Hemsl.
2002-05-08
Novel fluorometric assay for hydroxyl radical prevention capacity using fluorescein as the probe.
2002-05-08
Reclassification of Clostridium hydroxybenzoicum as Sedimentibacter hydroxybenzoicus gen. nov., comb. nov., and description of Sedimentibacter saalensis sp. nov..
2002-05
Migration of monomers from liquid crystalline poly(p-hydroxybenzoic acid-co-2-hydroxy-6-naphthoic acid).
2002-05
4-Hydroxycinnamoyl-CoA hydratase/lyase, an enzyme of phenylpropanoid cleavage from Pseudomonas, causes formation of C(6)-C(1) acid and alcohol glucose conjugates when expressed in hairy roots of Datura stramonium L.
2002-05
Isolation from a shea cake digester of a tannin-tolerant Escherichia coli strain decarboxylating p-hydroxybenzoic and vanillic acids.
2002-05
Co-oxidation of p-hydroxybenzoic acid and atrazine by the Fenton's like system Fe(III)/H2O2.
2002-04-26
Antioxidative phenolic compounds isolated from almond skins (Prunus amygdalus Batsch).
2002-04-10
Phenolic compounds and antioxidant capacity of Georgia-grown blueberries and blackberries.
2002-04-10
The effect of ethanol on the simultaneous transport and metabolism of methyl p-hydroxybenzoate in excised skin of Yucatan micropig.
2002-04-02
Degradation of biphenyl by Mycobacterium sp. strain PYR-1.
2002-03
Agastinol and agastenol, novel lignans from Agastache rugosa and their evaluation in an apoptosis inhibition assay.
2002-03
Anaerobic biotransformation of tetrabromobisphenol A, tetrachlorobisphenol A, and bisphenol A in estuarine sediments.
2002-02-15
Retention of anions on silica-based metalloporphyrin stationary phases.
2002-02
Comment on "Oxidation of p-hydroxybenzoic acid by Fenton's reagent" by F.J. Rivas, F.J. Belran, J. Frades, and P. Buxeda.
2002-02
Chorismate lyase: kinetics and engineering for stability.
2002-01-31
Nonlinear analysis of dynamic binding in affinity capillary electrophoresis demonstrated for inclusion complexes of beta-cyclodextrin.
2002-01-11
Why phenolic acids are unlikely primary allelochemicals in rice.
2002-01
Aromatic amino acid biosynthesis and production of related compounds from p-hydroxyphenylpyruvic acid by rumen bacteria, protozoa and their mixture.
2002
Collective vibrational modes in biological molecules investigated by terahertz time-domain spectroscopy.
2002
Processes controlling the distribution and natural attenuation of dissolved phenolic compounds in a deep sandstone aquifer.
2001-12-15
Estimation of preservative concentrations in foods and their daily intake based on official inspection results in Japan in fiscal year 1998.
2001-12
Phenolic compounds in berries of black, red, green, and white currants (Ribes sp.).
2001-12
In vivo hepatoprotective activity of active fraction from ethanolic extract of Eclipta alba leaves.
2001-10
Effect of simple phenolic compounds on azoxymethane-induced aberrant crypt foci in rat colon.
2001
Pneumocystis carinii synthesizes four ubiquinone homologs: inhibition by atovaquone and bupravaquone but not by stigmatellin.
2001
Patents

Patents

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3
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6
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3
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3
JP2006225642A
4
JP2006504448A
3
JP2007269813A
3
JP2008143839A
4
JP2008174530A
3
JP2008266209A
3
JP2010037364A
4
JP2010248117A
3
JP2010528149A
4
JP2011246407A
3
JP2011525242A
3
JP4740542B2
7
JPH00374308A
3
JPH00678765A
3
JPH00759582A
3
JPH00812862A
4
Substance Class Chemical
Created
by admin
on Mon Mar 31 19:36:44 GMT 2025
Edited
by admin
on Mon Mar 31 19:36:44 GMT 2025
Record UNII
JG8Z55Y12H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
4-Hydroxybenzoic Acid
FHFI   HSDB   INCI  
INCI  
Official Name English
SALICYLIC ACID RELATED COMPOUND A [USP IMPURITY]
USP-RS  
Preferred Name English
SALICYLIC ACID IMPURITY A [EP IMPURITY]
Common Name English
ACETYLSALICYLIC ACID IMPURITY A [EP IMPURITY]
Common Name English
BENZOIC ACID, P-HYDROXY-
Common Name English
P-HYDROXYBENZOIC ACID [MI]
Common Name English
PROPYL HYDROXYBENZOATE IMPURITY A [EP IMPURITY]
Common Name English
4-CARBOXYPHENOL
Systematic Name English
P-CARBOXYPHENOL
Common Name English
4-HYDROXYBENZOIC ACID [FHFI]
Common Name English
PARAHYDROXYBENZOIC ACID
Systematic Name English
BENZOIC ACID, 4-HYDROXY-
Common Name English
PARABEN-ACID
Common Name English
P-SALICYLIC ACID
Common Name English
P-HYDROXYBENZOIC ACID
MI  
Common Name English
METHYL PARAHYDROXYBENZOATE IMPURITY A [EP IMPURITY]
Common Name English
SALICYLIC ACID RELATED COMPOUND A [USP-RS]
Common Name English
NSC-4961
Code English
FEMA NO. 3986
Code English
4-HYDROXYBENZOIC ACID [HSDB]
Common Name English
Classification Tree Code System Code
JECFA EVALUATION 4-HYDROXYBENZOIC ACID
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
Code System Code Type Description
RXCUI
1649527
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY RxNorm
CAS
99-96-7
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
WIKIPEDIA
4-HYDROXYBENZOIC ACID
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
FDA UNII
JG8Z55Y12H
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
HSDB
7233
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
EVMPD
SUB14772MIG
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
NSC
4961
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
SMS_ID
100000079746
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
DRUG BANK
DB04242
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
MERCK INDEX
m6120
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY Merck Index
PUBCHEM
135
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
CHEBI
30763
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
DAILYMED
JG8Z55Y12H
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
MESH
C038193
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
ECHA (EC/EINECS)
202-804-9
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
EPA CompTox
DTXSID3026647
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
JECFA MONOGRAPH
890
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
RS_ITEM_NUM
1609013
Created by admin on Mon Mar 31 19:36:44 GMT 2025 , Edited by admin on Mon Mar 31 19:36:44 GMT 2025
PRIMARY
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