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Details

Stereochemistry ACHIRAL
Molecular Formula C10H11O3.Na
Molecular Weight 202.1823
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PROPYLPARABEN SODIUM

SMILES

[Na+].CCCOC(=O)C1=CC=C([O-])C=C1

InChI

InChIKey=IXMINYBUNCWGER-UHFFFAOYSA-M
InChI=1S/C10H12O3.Na/c1-2-7-13-10(12)8-3-5-9(11)6-4-8;/h3-6,11H,2,7H2,1H3;/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C10H11O3
Molecular Weight 179.1925
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/24542410; http://www.ncbi.nlm.nih.gov/pubmed/576658; http://www.ukfoodguide.net/e216.htm

Propylparaben is a bacteriostatic and fungistatic agent used as a preservative in cosmetic products, food and drugs. As a food additive, it has the E number E216. To increase the activity and reduce its dose propylparaben is used in a mixture with other parabens and in combination with other types of preservatives. Propylparaben is a chemical allergen capable of producing immunologically mediated hypersensitivity reactions. Chemically it is an ester of p-hydroxybenzoic acid.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
XILAPAK

Approved Use

For the management of hypertrophic tissues, keloid tissues, dermatitis and dermatoses

Launch Date

2017
Preventing
Iscaguard® FPX2

Approved Use

Unknown
Preventing
Iscaguard® FPX2

Approved Use

Unknown
Preventing
Iscaguard® FPX2

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Estrogenic effect of propylparaben (propylhydroxybenzoate) in rainbow trout Oncorhynchus mykiss after exposure via food and water.
2003 Dec
Effect of UV screens and preservatives on vitellogenin and choriogenin production in male medaka (Oryzias latipes).
2003 Dec 15
In vivo and in vitro estrogen bioactivities of alkyl parabens.
2003 Jul
Simple high-performance liquid chromatographic assay for melphalan in perfusate, rat liver and tumour tissue.
2003 Oct
Propyl paraben inhibits voltage-dependent sodium channels and protects cardiomyocytes from ischemia-reperfusion injury.
2004 Apr 30
Separation of preservatives in cosmetic products by micellar electrokinetic chromatography.
2004 Dec
[Synthesis of new mandelic acid derivatives with preservative action. Synthesis and acute toxicity study].
2004 Jan-Mar
HPLC determination of estradiol, its degradation product, and preservatives in new topical formulation Estrogel HBF.
2004 Jul
Preventing sexual transmission of HIV: anti-HIV bioregulatory and homeostatic components of commercial sexual lubricants.
2004 Jul-Dec
Simultaneous determination of indinavir, ritonavir and saquinavir in plasma by high-performance liquid chromatography.
2004 Mar
Measurement of anti-HIV activity of marketed vaginal products and excipients using a PBMC-based in vitro assay.
2004 Mar
Simultaneous HPLC determination of ketoprofen and its degradation products in the presence of preservatives in pharmaceuticals.
2004 Nov 15
[In vitro susceptibility of a Staphylococcus spp. isolate to food preservatives].
2004 Oct-Dec
Morphometric analysis of mice uteri treated with the preservatives methyl, ethyl, propyl, and butylparaben.
2004 Sep
Compatibility of sennoside A and B with pharmaceutical excipients.
2004 Sep
HPLC analysis of generic antiretroviral drugs purchased in Rwanda.
2005
In vitro effect of phenolic antioxidants on germination, growth and aflatoxin B accumulation by peanut Aspergillus section Flavi.
2005
High performance liquid chromatographic determination of oxeladin citrate and oxybutynin hydrochloride and their degradation products.
2005 Aug
Estrogenic activity of cosmetic components in reporter cell lines: parabens, UV screens, and musks.
2005 Feb 27
The effects of parabens on the mechanosensitive channels of E. coli.
2005 Jul
A novel gradient HPLC method for simultaneous determination of ranitidine, methylparaben and propylparaben in oral liquid pharmaceutical formulation.
2005 Jul 15
Liquid chromatography and chemometric-assisted spectrophotometric methods for the analysis of two multicomponent mixtures containing cough suppressant drugs.
2005 Jul-Aug
A review of the endocrine activity of parabens and implications for potential risks to human health.
2005 Jun
Propyl paraben induces potassium efflux in Escherichia coli.
2005 Jun
Decrease in skin permeation and antibacterial effect of parabens by a polymeric additive, poly(2-methacryloyloxyethyl phosphorylcholine-co-butylmetacrylate).
2005 Mar
The use of colloidal microgels as a (trans)dermal drug delivery system.
2005 Mar 23
Development and validation of a stability indicating HPLC method for determination of lisinopril, lisinopril degradation product and parabens in the lisinopril extemporaneous formulation.
2005 Mar 9
Simultaneous determination of preservatives (benzoic acid, sorbic acid, methylparaben and propylparaben) in foodstuffs using high-performance liquid chromatography.
2005 May 6
Rapid and sensitive determination of indapamide in human blood by liquid chromatography with electrospray ionization mass spectrometric detection: application to a bioequivalence study.
2005 Nov
A new validated method for the simultaneous determination of benzocaine, propylparaben and benzyl alcohol in a bioadhesive gel by HPLC.
2005 Oct 4
Determination of parabens in pharmaceutical formulations by solid-phase microextraction-ion mobility spectrometry.
2005 Sep 15
Stability indicating reversed-phase liquid chromatographic determination of metronidazole benzoate and diloxanide furoate as bulk drug and in suspension dosage form.
2005 Sep 15
A comparison of performance of various analytical columns in pharmaceutical analysis: conventional C18 and high throughput C18 zorbax columns.
2005 Sep 23
The importance of the cosolvent propylene glycol on the antimicrobial preservative efficacy of a pharmaceutical formulation by DOE-ruggedness testing.
2006
Application of ecotoxicogenomics for studying endocrine disruption in vertebrates and invertebrates.
2006 Apr
Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia.
2006 Aug
Effect of formulation factors on in-vitro permeation of diclofenac from experimental and marketed aqueous eye drops through excised goat cornea.
2006 Dec
Separation and determination of clotrimazole, methylparaben and propylparaben in pharmaceutical preparation by micellar electrokinetic chromatography.
2006 Jan 23
Simultaneous, stability indicating, HPLC-DAD determination of guaifenesin and methyl and propyl-parabens in cough syrup.
2006 Jun 7
A stability-indicating HPLC method for medroxyprogesterone acetate in bulk drug and injection formulation.
2006 Mar 18
Expression profiling of estrogen-responsive genes in breast cancer cells treated with alkylphenols, chlorinated phenols, parabens, or bis- and benzoylphenols for evaluation of estrogenic activity.
2006 May 25
HPLC determination of calcium pantothenate and two preservatives in topical cream.
2006 May 3
Stability indicating simultaneous determination of domperidone (DP), methylparaben (MP) and propylparaben by high performance liquid chromatography (HPLC).
2006 May 3
Application and validation of chemometrics-assisted spectrophotometry and liquid chromatography for the simultaneous determination of six-component pharmaceuticals.
2006 May 3
Development and validation of a simple reversed-phase high-performance liquid chromatography method for the determination of testosterone in serum of males.
2006 May 3
Pharmaceutical excipients and the information on drug labels.
2006 May-Jun
The influence of physicochemical properties of preservative compounds on their distribution into various phases of oil in water submicron emulsion.
2006 May-Jun
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.
2006 Nov
Post-marketing assessment of content and efficacy of preservatives in artemisinin-derived antimalarial dry suspensions for paediatric use.
2007 Jan 26
Comparison of objective and sensory skin irritations of several cosmetic preservatives.
2007 Mar
Patents

Patents

Sample Use Guides

Typically used at levels ranging from 0.01 to 0.3%. Safe for use in cosmetic products at levels up to 25%.
Route of Administration: Topical
Propylparaben (MIC-80% = 64 (mg/ml)) in combination with Fluconazole against Candida albicans
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:16:17 GMT 2023
Edited
by admin
on Fri Dec 15 16:16:17 GMT 2023
Record UNII
625NNB0G9N
Record Status Validated (UNII)
Record Version
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Name Type Language
PROPYLPARABEN SODIUM
II   USAN  
USAN  
Official Name English
SODIUM PROPYL PARABEN
Common Name English
E-217
Code English
SODIUM PROPYL PARAHYDROXYBENZOATE
EP  
Systematic Name English
SODIUM PROPYL HYDROXYBENZOATE [MART.]
Common Name English
SODIUM PROPYLPARABEN [INCI]
Common Name English
BENZOIC ACID, 4-HYDROXY-, PROPYL ESTER, SODIUM SALT (1:1)
Systematic Name English
SODIUM PROPYL HYDROXYBENZOATE
MART.  
Systematic Name English
SODIUM PROPYL PARAHYDROXYBENZOATE [EP MONOGRAPH]
Common Name English
SODIUM PROPYL P-HYDROXYBENZOATE (E 217)
Common Name English
SODIUM PROPYLPARABEN
INCI  
INCI  
Official Name English
SODIUM PROPYL 4-HYDROXYBENZOATE
Systematic Name English
PROPYL P-HYDROXYBENZOATE, SODIUM SALT
Common Name English
BENZOIC ACID, 4-HYDROXY-, PROPYL ESTER, SODIUM SALT
Common Name English
PROPYLPARABEN SODIUM [II]
Common Name English
PROPYLPARABEN SODIUM [USAN]
Common Name English
E217
Code English
PROPYL 4-HYDROXYBENZOATE SODIUM SALT
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C92608
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
EU FOOD ADDITIVES E-217
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
EPA PESTICIDE CODE 61204
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
Code System Code Type Description
PUBCHEM
23679044
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
USAN
Y-36
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
EVMPD
SUB12310MIG
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
CAS
35285-69-9
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
RXCUI
1311574
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY RxNorm
EPA CompTox
DTXSID3042348
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
ECHA (EC/EINECS)
252-488-1
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
NCI_THESAURUS
C84116
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
ChEMBL
CHEMBL194014
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
DRUG BANK
DBSALT002754
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
FDA UNII
625NNB0G9N
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
SMS_ID
100000079322
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
DAILYMED
625NNB0G9N
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE