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Details

Stereochemistry ACHIRAL
Molecular Formula C10H11O3.Na
Molecular Weight 202.1823
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PROPYLPARABEN SODIUM

SMILES

[Na+].CCCOC(=O)C1=CC=C([O-])C=C1

InChI

InChIKey=IXMINYBUNCWGER-UHFFFAOYSA-M
InChI=1S/C10H12O3.Na/c1-2-7-13-10(12)8-3-5-9(11)6-4-8;/h3-6,11H,2,7H2,1H3;/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C10H11O3
Molecular Weight 179.1925
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/24542410; http://www.ncbi.nlm.nih.gov/pubmed/576658; http://www.ukfoodguide.net/e216.htm

Propylparaben is a bacteriostatic and fungistatic agent used as a preservative in cosmetic products, food and drugs. As a food additive, it has the E number E216. To increase the activity and reduce its dose propylparaben is used in a mixture with other parabens and in combination with other types of preservatives. Propylparaben is a chemical allergen capable of producing immunologically mediated hypersensitivity reactions. Chemically it is an ester of p-hydroxybenzoic acid.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
XILAPAK

Approved Use

For the management of hypertrophic tissues, keloid tissues, dermatitis and dermatoses

Launch Date

2017
Preventing
Iscaguard® FPX2

Approved Use

Unknown
Preventing
Iscaguard® FPX2

Approved Use

Unknown
Preventing
Iscaguard® FPX2

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Development of a multidose formulation for a humanized monoclonal antibody using experimental design techniques.
2003
Simultaneous determination of methylparaben, propylparaben, hydrocortisone acetate and its degradation products in a topical cream by RP-HPLC.
2003 Aug 8
Estrogenic effect of propylparaben (propylhydroxybenzoate) in rainbow trout Oncorhynchus mykiss after exposure via food and water.
2003 Dec
Effect of UV screens and preservatives on vitellogenin and choriogenin production in male medaka (Oryzias latipes).
2003 Dec 15
In vivo and in vitro estrogen bioactivities of alkyl parabens.
2003 Jul
Determination of chlorpheniramine maleate and tincture ipecac in dosage form by liquid chromatography with ultraviolet detection.
2003 Jul-Aug
Simple high-performance liquid chromatographic assay for melphalan in perfusate, rat liver and tumour tissue.
2003 Oct
Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor.
2003 Oct
Reversed-phase porous silica rods, an alternative approach to high-performance liquid chromatographic separation using the sequential injection chromatography technique.
2003 Oct 10
The physical stability of thermally-stressed phospholipid-based emulsions containing methyl, propyl and heptyl parabens as model drugs.
2003 Oct 20
Determination of bifonazole in creams containing methyl- and propyl p-hydroxybenzoate by derivative spectrophotometric method.
2003 Sep 15
Propyl paraben inhibits voltage-dependent sodium channels and protects cardiomyocytes from ischemia-reperfusion injury.
2004 Apr 30
Separation of preservatives in cosmetic products by micellar electrokinetic chromatography.
2004 Dec
Determination of combined p-hydroxy benzoic acid preservatives in a liquid pharmaceutical formulation by HPLC.
2004 Jan 27
[Synthesis of new mandelic acid derivatives with preservative action. Synthesis and acute toxicity study].
2004 Jan-Mar
HPLC determination of estradiol, its degradation product, and preservatives in new topical formulation Estrogel HBF.
2004 Jul
Simultaneous determination of indinavir, ritonavir and saquinavir in plasma by high-performance liquid chromatography.
2004 Mar
Measurement of anti-HIV activity of marketed vaginal products and excipients using a PBMC-based in vitro assay.
2004 Mar
Simultaneous HPLC determination of ketoprofen and its degradation products in the presence of preservatives in pharmaceuticals.
2004 Nov 15
[In vitro susceptibility of a Staphylococcus spp. isolate to food preservatives].
2004 Oct-Dec
Morphometric analysis of mice uteri treated with the preservatives methyl, ethyl, propyl, and butylparaben.
2004 Sep
Compatibility of sennoside A and B with pharmaceutical excipients.
2004 Sep
High performance liquid chromatographic determination of oxeladin citrate and oxybutynin hydrochloride and their degradation products.
2005 Aug
A novel gradient HPLC method for simultaneous determination of ranitidine, methylparaben and propylparaben in oral liquid pharmaceutical formulation.
2005 Jul 15
Propyl paraben induces potassium efflux in Escherichia coli.
2005 Jun
The use of colloidal microgels as a (trans)dermal drug delivery system.
2005 Mar 23
Development and validation of a stability indicating HPLC method for determination of lisinopril, lisinopril degradation product and parabens in the lisinopril extemporaneous formulation.
2005 Mar 9
Simultaneous determination of preservatives (benzoic acid, sorbic acid, methylparaben and propylparaben) in foodstuffs using high-performance liquid chromatography.
2005 May 6
Rapid and sensitive determination of indapamide in human blood by liquid chromatography with electrospray ionization mass spectrometric detection: application to a bioequivalence study.
2005 Nov
A new validated method for the simultaneous determination of benzocaine, propylparaben and benzyl alcohol in a bioadhesive gel by HPLC.
2005 Oct 4
Stability indicating reversed-phase liquid chromatographic determination of metronidazole benzoate and diloxanide furoate as bulk drug and in suspension dosage form.
2005 Sep 15
A comparison of performance of various analytical columns in pharmaceutical analysis: conventional C18 and high throughput C18 zorbax columns.
2005 Sep 23
The importance of the cosolvent propylene glycol on the antimicrobial preservative efficacy of a pharmaceutical formulation by DOE-ruggedness testing.
2006
Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia.
2006 Aug
Parabens as urinary biomarkers of exposure in humans.
2006 Dec
Evaluation of xenoestrogenic potential of propylparaben in zebrafish (Danio rerio).
2006 Dec
Separation and determination of clotrimazole, methylparaben and propylparaben in pharmaceutical preparation by micellar electrokinetic chromatography.
2006 Jan 23
HPLC determination of calcium pantothenate and two preservatives in topical cream.
2006 May 3
Stability indicating simultaneous determination of domperidone (DP), methylparaben (MP) and propylparaben by high performance liquid chromatography (HPLC).
2006 May 3
Application and validation of chemometrics-assisted spectrophotometry and liquid chromatography for the simultaneous determination of six-component pharmaceuticals.
2006 May 3
Development and validation of a simple reversed-phase high-performance liquid chromatography method for the determination of testosterone in serum of males.
2006 May 3
Pharmaceutical excipients and the information on drug labels.
2006 May-Jun
The influence of physicochemical properties of preservative compounds on their distribution into various phases of oil in water submicron emulsion.
2006 May-Jun
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.
2006 Nov
Solid-phase extraction and HPLC analysis of methylparaben and propylparaben in a concentrated antibiotic suspension.
2006 Oct
Flow cytometric cell cycle analysis allows for rapid screening of estrogenicity in MCF-7 breast cancer cells.
2006 Oct
Development and validation of chemometrics-assisted spectrophotometric and liquid chromatographic methods for the simultaneous determination of two multicomponent mixtures containing bronchodilator drugs.
2007 Feb 19
Effect estimates and methodological quality of randomized controlled trials about prevention of alveolar osteitis following tooth extraction: a systematic review.
2007 Jan
Controlled drug release from pellets containing water-insoluble drugs dissolved in a self-emulsifying system.
2007 Jan
Assay of artemether, methylparaben and propylparaben in a formulated paediatric antimalarial dry suspension.
2007 Jan 17
Patents

Patents

Sample Use Guides

Typically used at levels ranging from 0.01 to 0.3%. Safe for use in cosmetic products at levels up to 25%.
Route of Administration: Topical
Propylparaben (MIC-80% = 64 (mg/ml)) in combination with Fluconazole against Candida albicans
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:16:17 GMT 2023
Edited
by admin
on Fri Dec 15 16:16:17 GMT 2023
Record UNII
625NNB0G9N
Record Status Validated (UNII)
Record Version
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Name Type Language
PROPYLPARABEN SODIUM
II   USAN  
USAN  
Official Name English
SODIUM PROPYL PARABEN
Common Name English
E-217
Code English
SODIUM PROPYL PARAHYDROXYBENZOATE
EP  
Systematic Name English
SODIUM PROPYL HYDROXYBENZOATE [MART.]
Common Name English
SODIUM PROPYLPARABEN [INCI]
Common Name English
BENZOIC ACID, 4-HYDROXY-, PROPYL ESTER, SODIUM SALT (1:1)
Systematic Name English
SODIUM PROPYL HYDROXYBENZOATE
MART.  
Systematic Name English
SODIUM PROPYL PARAHYDROXYBENZOATE [EP MONOGRAPH]
Common Name English
SODIUM PROPYL P-HYDROXYBENZOATE (E 217)
Common Name English
SODIUM PROPYLPARABEN
INCI  
INCI  
Official Name English
SODIUM PROPYL 4-HYDROXYBENZOATE
Systematic Name English
PROPYL P-HYDROXYBENZOATE, SODIUM SALT
Common Name English
BENZOIC ACID, 4-HYDROXY-, PROPYL ESTER, SODIUM SALT
Common Name English
PROPYLPARABEN SODIUM [II]
Common Name English
PROPYLPARABEN SODIUM [USAN]
Common Name English
E217
Code English
PROPYL 4-HYDROXYBENZOATE SODIUM SALT
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C92608
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
EU FOOD ADDITIVES E-217
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
EPA PESTICIDE CODE 61204
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
Code System Code Type Description
PUBCHEM
23679044
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
USAN
Y-36
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
EVMPD
SUB12310MIG
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
CAS
35285-69-9
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
RXCUI
1311574
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY RxNorm
EPA CompTox
DTXSID3042348
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
ECHA (EC/EINECS)
252-488-1
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
NCI_THESAURUS
C84116
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
ChEMBL
CHEMBL194014
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
DRUG BANK
DBSALT002754
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
FDA UNII
625NNB0G9N
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
SMS_ID
100000079322
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
DAILYMED
625NNB0G9N
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE