Details
Stereochemistry | ACHIRAL |
Molecular Formula | C10H11O3.Na |
Molecular Weight | 202.1823 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].CCCOC(=O)C1=CC=C([O-])C=C1
InChI
InChIKey=IXMINYBUNCWGER-UHFFFAOYSA-M
InChI=1S/C10H12O3.Na/c1-2-7-13-10(12)8-3-5-9(11)6-4-8;/h3-6,11H,2,7H2,1H3;/q;+1/p-1
Molecular Formula | Na |
Molecular Weight | 22.9898 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C10H11O3 |
Molecular Weight | 179.1925 |
Charge | -1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: http://www.fda.gov/cosmetics/productsingredients/ingredients/ucm128042.htm#What_are_parabensCurator's Comment: Description was created based on several sources, including
http://www.ncbi.nlm.nih.gov/pubmed/24542410;
http://www.ncbi.nlm.nih.gov/pubmed/576658;
http://www.ukfoodguide.net/e216.htm
Sources: http://www.fda.gov/cosmetics/productsingredients/ingredients/ucm128042.htm#What_are_parabens
Curator's Comment: Description was created based on several sources, including
http://www.ncbi.nlm.nih.gov/pubmed/24542410;
http://www.ncbi.nlm.nih.gov/pubmed/576658;
http://www.ukfoodguide.net/e216.htm
Propylparaben is a bacteriostatic and fungistatic agent used as a preservative in cosmetic products, food and drugs. As a food additive, it has the E number E216. To increase the activity and reduce its dose propylparaben is used in a mixture with other parabens and in combination with other types of preservatives. Propylparaben is a chemical allergen capable of producing immunologically mediated hypersensitivity reactions. Chemically it is an ester of p-hydroxybenzoic acid.
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Inactive ingredient | XILAPAK Approved UseFor the management of hypertrophic tissues, keloid tissues, dermatitis and dermatoses Launch Date2017 |
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Preventing | Iscaguard® FPX2 Approved UseUnknown |
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Preventing | Iscaguard® FPX2 Approved UseUnknown |
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Preventing | Iscaguard® FPX2 Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Estrogenic effect of propylparaben (propylhydroxybenzoate) in rainbow trout Oncorhynchus mykiss after exposure via food and water. | 2003 Dec |
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Effect of UV screens and preservatives on vitellogenin and choriogenin production in male medaka (Oryzias latipes). | 2003 Dec 15 |
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In vivo and in vitro estrogen bioactivities of alkyl parabens. | 2003 Jul |
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Simple high-performance liquid chromatographic assay for melphalan in perfusate, rat liver and tumour tissue. | 2003 Oct |
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Propyl paraben inhibits voltage-dependent sodium channels and protects cardiomyocytes from ischemia-reperfusion injury. | 2004 Apr 30 |
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Separation of preservatives in cosmetic products by micellar electrokinetic chromatography. | 2004 Dec |
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[Synthesis of new mandelic acid derivatives with preservative action. Synthesis and acute toxicity study]. | 2004 Jan-Mar |
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HPLC determination of estradiol, its degradation product, and preservatives in new topical formulation Estrogel HBF. | 2004 Jul |
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Preventing sexual transmission of HIV: anti-HIV bioregulatory and homeostatic components of commercial sexual lubricants. | 2004 Jul-Dec |
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Simultaneous determination of indinavir, ritonavir and saquinavir in plasma by high-performance liquid chromatography. | 2004 Mar |
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Measurement of anti-HIV activity of marketed vaginal products and excipients using a PBMC-based in vitro assay. | 2004 Mar |
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Simultaneous HPLC determination of ketoprofen and its degradation products in the presence of preservatives in pharmaceuticals. | 2004 Nov 15 |
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[In vitro susceptibility of a Staphylococcus spp. isolate to food preservatives]. | 2004 Oct-Dec |
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Morphometric analysis of mice uteri treated with the preservatives methyl, ethyl, propyl, and butylparaben. | 2004 Sep |
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Compatibility of sennoside A and B with pharmaceutical excipients. | 2004 Sep |
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HPLC analysis of generic antiretroviral drugs purchased in Rwanda. | 2005 |
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In vitro effect of phenolic antioxidants on germination, growth and aflatoxin B accumulation by peanut Aspergillus section Flavi. | 2005 |
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High performance liquid chromatographic determination of oxeladin citrate and oxybutynin hydrochloride and their degradation products. | 2005 Aug |
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Estrogenic activity of cosmetic components in reporter cell lines: parabens, UV screens, and musks. | 2005 Feb 27 |
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The effects of parabens on the mechanosensitive channels of E. coli. | 2005 Jul |
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A novel gradient HPLC method for simultaneous determination of ranitidine, methylparaben and propylparaben in oral liquid pharmaceutical formulation. | 2005 Jul 15 |
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Liquid chromatography and chemometric-assisted spectrophotometric methods for the analysis of two multicomponent mixtures containing cough suppressant drugs. | 2005 Jul-Aug |
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A review of the endocrine activity of parabens and implications for potential risks to human health. | 2005 Jun |
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Propyl paraben induces potassium efflux in Escherichia coli. | 2005 Jun |
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Decrease in skin permeation and antibacterial effect of parabens by a polymeric additive, poly(2-methacryloyloxyethyl phosphorylcholine-co-butylmetacrylate). | 2005 Mar |
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The use of colloidal microgels as a (trans)dermal drug delivery system. | 2005 Mar 23 |
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Development and validation of a stability indicating HPLC method for determination of lisinopril, lisinopril degradation product and parabens in the lisinopril extemporaneous formulation. | 2005 Mar 9 |
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Simultaneous determination of preservatives (benzoic acid, sorbic acid, methylparaben and propylparaben) in foodstuffs using high-performance liquid chromatography. | 2005 May 6 |
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Rapid and sensitive determination of indapamide in human blood by liquid chromatography with electrospray ionization mass spectrometric detection: application to a bioequivalence study. | 2005 Nov |
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A new validated method for the simultaneous determination of benzocaine, propylparaben and benzyl alcohol in a bioadhesive gel by HPLC. | 2005 Oct 4 |
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Determination of parabens in pharmaceutical formulations by solid-phase microextraction-ion mobility spectrometry. | 2005 Sep 15 |
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Stability indicating reversed-phase liquid chromatographic determination of metronidazole benzoate and diloxanide furoate as bulk drug and in suspension dosage form. | 2005 Sep 15 |
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A comparison of performance of various analytical columns in pharmaceutical analysis: conventional C18 and high throughput C18 zorbax columns. | 2005 Sep 23 |
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The importance of the cosolvent propylene glycol on the antimicrobial preservative efficacy of a pharmaceutical formulation by DOE-ruggedness testing. | 2006 |
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Application of ecotoxicogenomics for studying endocrine disruption in vertebrates and invertebrates. | 2006 Apr |
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Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia. | 2006 Aug |
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Effect of formulation factors on in-vitro permeation of diclofenac from experimental and marketed aqueous eye drops through excised goat cornea. | 2006 Dec |
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Separation and determination of clotrimazole, methylparaben and propylparaben in pharmaceutical preparation by micellar electrokinetic chromatography. | 2006 Jan 23 |
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Simultaneous, stability indicating, HPLC-DAD determination of guaifenesin and methyl and propyl-parabens in cough syrup. | 2006 Jun 7 |
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A stability-indicating HPLC method for medroxyprogesterone acetate in bulk drug and injection formulation. | 2006 Mar 18 |
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Expression profiling of estrogen-responsive genes in breast cancer cells treated with alkylphenols, chlorinated phenols, parabens, or bis- and benzoylphenols for evaluation of estrogenic activity. | 2006 May 25 |
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HPLC determination of calcium pantothenate and two preservatives in topical cream. | 2006 May 3 |
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Stability indicating simultaneous determination of domperidone (DP), methylparaben (MP) and propylparaben by high performance liquid chromatography (HPLC). | 2006 May 3 |
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Application and validation of chemometrics-assisted spectrophotometry and liquid chromatography for the simultaneous determination of six-component pharmaceuticals. | 2006 May 3 |
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Development and validation of a simple reversed-phase high-performance liquid chromatography method for the determination of testosterone in serum of males. | 2006 May 3 |
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Pharmaceutical excipients and the information on drug labels. | 2006 May-Jun |
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The influence of physicochemical properties of preservative compounds on their distribution into various phases of oil in water submicron emulsion. | 2006 May-Jun |
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Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 Nov |
|
Post-marketing assessment of content and efficacy of preservatives in artemisinin-derived antimalarial dry suspensions for paediatric use. | 2007 Jan 26 |
|
Comparison of objective and sensory skin irritations of several cosmetic preservatives. | 2007 Mar |
Patents
Substance Class |
Chemical
Created
by
admin
on
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on
Fri Dec 15 16:16:17 GMT 2023
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Record UNII |
625NNB0G9N
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Record Status |
Validated (UNII)
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NCI_THESAURUS |
C92608
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EU FOOD ADDITIVES |
E-217
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EPA PESTICIDE CODE |
61204
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23679044
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Y-36
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SUB12310MIG
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35285-69-9
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1311574
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DTXSID3042348
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252-488-1
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C84116
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CHEMBL194014
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DBSALT002754
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625NNB0G9N
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625NNB0G9N
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Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |