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Details

Stereochemistry ACHIRAL
Molecular Formula C10H11O3.Na
Molecular Weight 202.1823
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PROPYLPARABEN SODIUM

SMILES

[Na+].CCCOC(=O)C1=CC=C([O-])C=C1

InChI

InChIKey=IXMINYBUNCWGER-UHFFFAOYSA-M
InChI=1S/C10H12O3.Na/c1-2-7-13-10(12)8-3-5-9(11)6-4-8;/h3-6,11H,2,7H2,1H3;/q;+1/p-1

HIDE SMILES / InChI
Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C10H11O3
Molecular Weight 179.1925
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/24542410; http://www.ncbi.nlm.nih.gov/pubmed/576658; http://www.ukfoodguide.net/e216.htm

Propylparaben is a bacteriostatic and fungistatic agent used as a preservative in cosmetic products, food and drugs. As a food additive, it has the E number E216. To increase the activity and reduce its dose propylparaben is used in a mixture with other parabens and in combination with other types of preservatives. Propylparaben is a chemical allergen capable of producing immunologically mediated hypersensitivity reactions. Chemically it is an ester of p-hydroxybenzoic acid.

Approval Year

1961
146
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
Approved
8429
XILAPAK

Approved Use

For the management of hypertrophic tissues, keloid tissues, dermatitis and dermatoses

Launch Date

2017
Preventing
Basic research
Iscaguard® FPX2

Approved Use

Unknown
Preventing
Basic research
Iscaguard® FPX2

Approved Use

Unknown
Preventing
Basic research
Iscaguard® FPX2

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7 cells and expression of ERalpha and PR.
2001 Dec
Sorption of parabens by fluoropolymer or fluoropolymer laminated flexible tubing.
2001 Nov-Dec
Spalling and sorption of tubing for peristaltic pumps.
2002
Oestrogenic activity of parabens in MCF7 human breast cancer cells.
2002 Jan
[Analysis of preservatives in cosmetics by gas chromatography].
2002 May
Determination of cisapride, its oxidation product, propyl and butyl parabens in pharmaceutical dosage form by reversed-phase liquid chromatography.
2003 Dec 4
Determination of chlorpheniramine maleate and tincture ipecac in dosage form by liquid chromatography with ultraviolet detection.
2003 Jul-Aug
Potential use of antioxidants for control of growth and fumonisin production by Fusarium verticillioides and Fusarium proliferatum on whole maize grain.
2003 Jun 25
Simple high-performance liquid chromatographic assay for melphalan in perfusate, rat liver and tumour tissue.
2003 Oct
Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor.
2003 Oct
The physical stability of thermally-stressed phospholipid-based emulsions containing methyl, propyl and heptyl parabens as model drugs.
2003 Oct 20
Separation of preservatives in cosmetic products by micellar electrokinetic chromatography.
2004 Dec
Determination of combined p-hydroxy benzoic acid preservatives in a liquid pharmaceutical formulation by HPLC.
2004 Jan 27
[Synthesis of new mandelic acid derivatives with preservative action. Synthesis and acute toxicity study].
2004 Jan-Mar
Preventing sexual transmission of HIV: anti-HIV bioregulatory and homeostatic components of commercial sexual lubricants.
2004 Jul-Dec
Simultaneous determination of indinavir, ritonavir and saquinavir in plasma by high-performance liquid chromatography.
2004 Mar
Measurement of anti-HIV activity of marketed vaginal products and excipients using a PBMC-based in vitro assay.
2004 Mar
[In vitro susceptibility of a Staphylococcus spp. isolate to food preservatives].
2004 Oct-Dec
Compatibility of sennoside A and B with pharmaceutical excipients.
2004 Sep
HPLC analysis of generic antiretroviral drugs purchased in Rwanda.
2005
Estrogenic activity of cosmetic components in reporter cell lines: parabens, UV screens, and musks.
2005 Feb 27
A novel gradient HPLC method for simultaneous determination of ranitidine, methylparaben and propylparaben in oral liquid pharmaceutical formulation.
2005 Jul 15
Liquid chromatography and chemometric-assisted spectrophotometric methods for the analysis of two multicomponent mixtures containing cough suppressant drugs.
2005 Jul-Aug
Decrease in skin permeation and antibacterial effect of parabens by a polymeric additive, poly(2-methacryloyloxyethyl phosphorylcholine-co-butylmetacrylate).
2005 Mar
Determination of parabens in pharmaceutical formulations by solid-phase microextraction-ion mobility spectrometry.
2005 Sep 15
The importance of the cosolvent propylene glycol on the antimicrobial preservative efficacy of a pharmaceutical formulation by DOE-ruggedness testing.
2006
Application of ecotoxicogenomics for studying endocrine disruption in vertebrates and invertebrates.
2006 Apr
Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia.
2006 Aug
Parabens as urinary biomarkers of exposure in humans.
2006 Dec
Evaluation of xenoestrogenic potential of propylparaben in zebrafish (Danio rerio).
2006 Dec
Effect of formulation factors on in-vitro permeation of diclofenac from experimental and marketed aqueous eye drops through excised goat cornea.
2006 Dec
Simultaneous, stability indicating, HPLC-DAD determination of guaifenesin and methyl and propyl-parabens in cough syrup.
2006 Jun 7
Pharmaceutical excipients and the information on drug labels.
2006 May-Jun
Advantages of ultra performance liquid chromatography over high-performance liquid chromatography: comparison of different analytical approaches during analysis of diclofenac gel.
2006 Nov
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.
2006 Nov
Solid-phase extraction and HPLC analysis of methylparaben and propylparaben in a concentrated antibiotic suspension.
2006 Oct
Flow cytometric cell cycle analysis allows for rapid screening of estrogenicity in MCF-7 breast cancer cells.
2006 Oct
Development and validation of chemometrics-assisted spectrophotometric and liquid chromatographic methods for the simultaneous determination of two multicomponent mixtures containing bronchodilator drugs.
2007 Feb 19
Effect estimates and methodological quality of randomized controlled trials about prevention of alveolar osteitis following tooth extraction: a systematic review.
2007 Jan
Post-marketing assessment of content and efficacy of preservatives in artemisinin-derived antimalarial dry suspensions for paediatric use.
2007 Jan 26
Comparison of objective and sensory skin irritations of several cosmetic preservatives.
2007 Mar
Patents

Patents

US2015373989
2

Sample Use Guides

In Vivo Use Guide
Typically used at levels ranging from 0.01 to 0.3%. Safe for use in cosmetic products at levels up to 25%.
Route of Administration: Topical
In Vitro Use Guide
Propylparaben (MIC-80% = 64 (mg/ml)) in combination with Fluconazole against Candida albicans
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:16:17 GMT 2023
Edited
by admin
on Fri Dec 15 16:16:17 GMT 2023
Record UNII
625NNB0G9N
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PROPYLPARABEN SODIUM
II   USAN  
USAN  
Official Name English
SODIUM PROPYL PARABEN
Common Name English
E-217
Code English
SODIUM PROPYL PARAHYDROXYBENZOATE
EP  
Systematic Name English
SODIUM PROPYL HYDROXYBENZOATE [MART.]
Common Name English
SODIUM PROPYLPARABEN [INCI]
Common Name English
BENZOIC ACID, 4-HYDROXY-, PROPYL ESTER, SODIUM SALT (1:1)
Systematic Name English
SODIUM PROPYL HYDROXYBENZOATE
MART.  
Systematic Name English
SODIUM PROPYL PARAHYDROXYBENZOATE [EP MONOGRAPH]
Common Name English
SODIUM PROPYL P-HYDROXYBENZOATE (E 217)
Common Name English
SODIUM PROPYLPARABEN
INCI  
INCI  
Official Name English
SODIUM PROPYL 4-HYDROXYBENZOATE
Systematic Name English
PROPYL P-HYDROXYBENZOATE, SODIUM SALT
Common Name English
BENZOIC ACID, 4-HYDROXY-, PROPYL ESTER, SODIUM SALT
Common Name English
PROPYLPARABEN SODIUM [II]
Common Name English
PROPYLPARABEN SODIUM [USAN]
Common Name English
E217
Code English
PROPYL 4-HYDROXYBENZOATE SODIUM SALT
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C92608
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
EU FOOD ADDITIVES E-217
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
EPA PESTICIDE CODE 61204
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
Code System Code Type Description
PUBCHEM
23679044
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
USAN
Y-36
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
EVMPD
SUB12310MIG
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
CAS
35285-69-9
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
RXCUI
1311574
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY RxNorm
EPA CompTox
DTXSID3042348
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
ECHA (EC/EINECS)
252-488-1
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
NCI_THESAURUS
C84116
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
ChEMBL
CHEMBL194014
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
DRUG BANK
DBSALT002754
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
FDA UNII
625NNB0G9N
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
SMS_ID
100000079322
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
DAILYMED
625NNB0G9N
Created by admin on Fri Dec 15 16:16:17 GMT 2023 , Edited by admin on Fri Dec 15 16:16:17 GMT 2023
PRIMARY
Related Record Type Details
Structure of PROPYLPARABEN
PARENT -> SALT/SOLVATE
NIH
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