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Details

Stereochemistry ACHIRAL
Molecular Formula C19H42N
Molecular Weight 284.5435
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 1

SHOW SMILES / InChI
Structure of CETRIMONIUM

SMILES

CCCCCCCCCCCCCCCC[N+](C)(C)C

InChI

InChIKey=RLGQACBPNDBWTB-UHFFFAOYSA-N
InChI=1S/C19H42N/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(2,3)4/h5-19H2,1-4H3/q+1

HIDE SMILES / InChI
Molecular Formula C19H42N
Molecular Weight 284.5435
Charge 1
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://www.americanpharmaceuticalreview.com/Featured-Articles/38886-Antimicrobial-Preservatives-Part-One-Choosing-a-Preservative-System/ | https://books.google.ru/books?id=EMrSBwAAQBAJ&printsec=frontcover&hl=ru#v=onepage&q&f=false | https://www.ncbi.nlm.nih.gov/pubmed/9880479 | http://www.medindia.net/doctors/drug_information/cetrimide.htm

Cetrimide is a quaternary ammonium compound. Cetrimide was first introduced as a combined cleanser and skin antiseptic by Barnes (1942). Cetrimide combines excellent detergent properties and minimal toxicity with a useful antiseptic action. Cetrimide affects membrane permeability allowing ‘leaking’ of essential cell constituents leading to cell death. This medication is a skin antiseptic and disinfectant prescribed for seborrhoeic dermatitis and wound cleansing. The cream has a bactericidal activity against gram-positive bacteria and incompatible with soaps and other anionic surfactants.

Originator

Imperial Chemical Industries
59
Curator's Comment: Cetrimide was first introduced as a combined cleanser and skin antiseptic by Barnes (1942). http://www.sciencedirect.com/science/article/pii/S0140673600701000 reference retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18132350

Approval Year

1999
174
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
Interacts
323
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8429
CETRIMIDE

Approved Use

Cetrimide is a skin antiseptic and disinfectant prescribed for seborrhoeic dermatitis and wound cleansing. The cream has a bactericidal activity against gram-positive bacteria and incompatible with soaps and other anionic surfactants.
Primary
Approved
8429
CETRIMIDE

Approved Use

Cetrimide is a skin antiseptic and disinfectant prescribed for seborrhoeic dermatitis and wound cleansing. The cream has a bactericidal activity against gram-positive bacteria and incompatible with soaps and other anionic surfactants.
PubMed

PubMed

TitleDatePubMed
Antiseptics and disinfectants: activity, action, and resistance.
1999 Jan
Patents

Patents

US6187290B1
9
US6284289B1
9

Sample Use Guides

In Vivo Use Guide
Wound cleansing - Topical : Adult: Apply 0.1-1% aqueous solution or 0.5% cream onto affected area. Seborrhoeic dermatitis - Topical : Adult: Apply 10% shampoo solution onto the scalp.
Route of Administration: Topical
In Vitro Use Guide
Cetrimide, at 30 ug/ml inhibited growth of Aspergillus niger.
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:40:24 UTC 2023
Edited
by admin
on Fri Dec 15 17:40:24 UTC 2023
Record UNII
Z7FF1XKL7A
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CETRIMONIUM
WHO-DD  
Common Name English
CETYLTRIMETHYLAMMONIUM CATION
Common Name English
HEXADECYLTRIMETHYLAMMONIUM ION
Common Name English
CETRIMONIUM CATION
Common Name English
Cetrimonium [WHO-DD]
Common Name English
HEXADECYLTRIMETHYLAMMONIUM CATION
Common Name English
CETYLTRIMETHYLAMMONIUM ION
Common Name English
HEXADECYLTRIMETHYLAMMONIUM
Systematic Name English
TRIMETHYLHEXADECYLAMMONIUM
Systematic Name English
CETYLTRIMETHYLAMMONIUM
Systematic Name English
PB-300
Code English
AMMONIUM, HEXADECYLTRIMETHYL-
Systematic Name English
CETRIMONIUM ION
Common Name English
1-HEXADECANAMINIUM, N,N,N-TRIMETHYL-
Systematic Name English
Classification Tree Code System Code
WHO-ATC R02AA17
Created by admin on Fri Dec 15 17:40:25 UTC 2023 , Edited by admin on Fri Dec 15 17:40:25 UTC 2023
WHO-VATC QD08AJ02
Created by admin on Fri Dec 15 17:40:25 UTC 2023 , Edited by admin on Fri Dec 15 17:40:25 UTC 2023
WHO-VATC QR02AA17
Created by admin on Fri Dec 15 17:40:25 UTC 2023 , Edited by admin on Fri Dec 15 17:40:25 UTC 2023
WHO-ATC D08AJ02
Created by admin on Fri Dec 15 17:40:25 UTC 2023 , Edited by admin on Fri Dec 15 17:40:25 UTC 2023
NCI_THESAURUS C28394
Created by admin on Fri Dec 15 17:40:25 UTC 2023 , Edited by admin on Fri Dec 15 17:40:25 UTC 2023
Code System Code Type Description
SMS_ID
100000084706
Created by admin on Fri Dec 15 17:40:25 UTC 2023 , Edited by admin on Fri Dec 15 17:40:25 UTC 2023
PRIMARY
PUBCHEM
2681
Created by admin on Fri Dec 15 17:40:25 UTC 2023 , Edited by admin on Fri Dec 15 17:40:25 UTC 2023
PRIMARY
DRUG BANK
DB01718
Created by admin on Fri Dec 15 17:40:25 UTC 2023 , Edited by admin on Fri Dec 15 17:40:25 UTC 2023
PRIMARY
FDA UNII
Z7FF1XKL7A
Created by admin on Fri Dec 15 17:40:25 UTC 2023 , Edited by admin on Fri Dec 15 17:40:25 UTC 2023
PRIMARY
NCI_THESAURUS
C79724
Created by admin on Fri Dec 15 17:40:25 UTC 2023 , Edited by admin on Fri Dec 15 17:40:25 UTC 2023
PRIMARY
EPA CompTox
DTXSID3047978
Created by admin on Fri Dec 15 17:40:25 UTC 2023 , Edited by admin on Fri Dec 15 17:40:25 UTC 2023
PRIMARY
CHEBI
39561
Created by admin on Fri Dec 15 17:40:25 UTC 2023 , Edited by admin on Fri Dec 15 17:40:25 UTC 2023
PRIMARY
MESH
C004322
Created by admin on Fri Dec 15 17:40:25 UTC 2023 , Edited by admin on Fri Dec 15 17:40:25 UTC 2023
PRIMARY
RXCUI
20614
Created by admin on Fri Dec 15 17:40:25 UTC 2023 , Edited by admin on Fri Dec 15 17:40:25 UTC 2023
PRIMARY RxNorm
CAS
6899-10-1
Created by admin on Fri Dec 15 17:40:25 UTC 2023 , Edited by admin on Fri Dec 15 17:40:25 UTC 2023
PRIMARY
DRUG CENTRAL
3082
Created by admin on Fri Dec 15 17:40:25 UTC 2023 , Edited by admin on Fri Dec 15 17:40:25 UTC 2023
PRIMARY
EVMPD
SUB01174MIG
Created by admin on Fri Dec 15 17:40:25 UTC 2023 , Edited by admin on Fri Dec 15 17:40:25 UTC 2023
PRIMARY
DAILYMED
Z7FF1XKL7A
Created by admin on Fri Dec 15 17:40:25 UTC 2023 , Edited by admin on Fri Dec 15 17:40:25 UTC 2023
PRIMARY
Related Record Type Details
Structure of CETRIMONIUM CHLORIDE
SALT/SOLVATE -> PARENT
Structure of CETRIMONIUM PENTACHLOROPHENOXIDE
SALT/SOLVATE -> PARENT
Structure of CETYLTRIMETHYLAMMONIUM OXYTETRACYCLINE
SALT/SOLVATE -> PARENT
Structure of CETRIMONIUM TOSYLATE
SALT/SOLVATE -> PARENT
Structure of CETRIMONIUM BROMIDE
SALT/SOLVATE -> PARENT
Structure of Hexadecyl trimethyl ammonium iodide
SALT/SOLVATE -> PARENT
Structure of CETYLTRIMETHYLAMMONIUM NAPROXENATE
SALT/SOLVATE -> PARENT
Structure of CETRIMONIUM STEARATE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of CETRIMONIUM
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