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Details

Stereochemistry ACHIRAL
Molecular Formula C19H42N.Cl
Molecular Weight 319.996
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CETRIMONIUM CHLORIDE

SMILES

[Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C

InChI

InChIKey=WOWHHFRSBJGXCM-UHFFFAOYSA-M
InChI=1S/C19H42N.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(2,3)4;/h5-19H2,1-4H3;1H/q+1;/p-1

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C19H42N
Molecular Weight 284.5435
Charge 1
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://www.americanpharmaceuticalreview.com/Featured-Articles/38886-Antimicrobial-Preservatives-Part-One-Choosing-a-Preservative-System/ | https://books.google.ru/books?id=EMrSBwAAQBAJ&printsec=frontcover&hl=ru#v=onepage&q&f=false | https://www.ncbi.nlm.nih.gov/pubmed/9880479 | http://www.medindia.net/doctors/drug_information/cetrimide.htm

Cetrimide is a quaternary ammonium compound. Cetrimide was first introduced as a combined cleanser and skin antiseptic by Barnes (1942). Cetrimide combines excellent detergent properties and minimal toxicity with a useful antiseptic action. Cetrimide affects membrane permeability allowing ‘leaking’ of essential cell constituents leading to cell death. This medication is a skin antiseptic and disinfectant prescribed for seborrhoeic dermatitis and wound cleansing. The cream has a bactericidal activity against gram-positive bacteria and incompatible with soaps and other anionic surfactants.

Originator

Imperial Chemical Industries
59
Curator's Comment: Cetrimide was first introduced as a combined cleanser and skin antiseptic by Barnes (1942). http://www.sciencedirect.com/science/article/pii/S0140673600701000 reference retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18132350

Approval Year

1999
174
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
Interacts
323
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8429
CETRIMIDE

Approved Use

Cetrimide is a skin antiseptic and disinfectant prescribed for seborrhoeic dermatitis and wound cleansing. The cream has a bactericidal activity against gram-positive bacteria and incompatible with soaps and other anionic surfactants.
Primary
Approved
8429
CETRIMIDE

Approved Use

Cetrimide is a skin antiseptic and disinfectant prescribed for seborrhoeic dermatitis and wound cleansing. The cream has a bactericidal activity against gram-positive bacteria and incompatible with soaps and other anionic surfactants.
PubMed

PubMed

TitleDatePubMed
The effects of two quaternary ammonium compounds on citric acid and sterol synthesis in Aspergillus niger.
1963 Apr
Antiseptics and disinfectants: activity, action, and resistance.
1999 Jan
Patents

Patents

US6187290B1
9
US6284289B1
9

Sample Use Guides

In Vivo Use Guide
Wound cleansing - Topical : Adult: Apply 0.1-1% aqueous solution or 0.5% cream onto affected area. Seborrhoeic dermatitis - Topical : Adult: Apply 10% shampoo solution onto the scalp.
Route of Administration: Topical
In Vitro Use Guide
Cetrimide, at 30 ug/ml inhibited growth of Aspergillus niger.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:23:53 UTC 2023
Edited
by admin
on Fri Dec 15 15:23:53 UTC 2023
Record UNII
UC9PE95IBP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CETRIMONIUM CHLORIDE
II   INCI   MART.   WHO-DD  
INCI  
Official Name English
HEXADECYLTRIMETHYLAMMONIUM CHLORIDE
Systematic Name English
NIKKOL CA-2350
Brand Name English
PALMITYLTRIMETHYLAMMONIUM CHLORIDE
Systematic Name English
CETRIMONIUM CHLORIDE [INCI]
Common Name English
CETYLTRIMETHYLAMMONIUM CHLORIDE
Systematic Name English
N-HEXADECYLTRIMETHYLAMMONIUM CHLORIDE
Systematic Name English
JEEQUAT CT-29
Brand Name English
CETYL TRIMETHYL AMMONIUM CHLORIDE
Systematic Name English
CETYLTRIMETHYL AMMONIUM CHLORIDE
Systematic Name English
N,N,N-TRIMETHYL-1-HEXADECANAMINIUM CHLORIDE
Systematic Name English
TRIMETHYLHEXADECYLAMMONIUM CHLORIDE
HSDB  
Systematic Name English
VARISOFT 300
Brand Name English
ARQUAD PC 16-29W
Brand Name English
GENAMIN CTAC
Brand Name English
CETRIMONIUM CHLORIDE [II]
Common Name English
CETRIMONIUM CHLORIDE [MART.]
Common Name English
Cetrimonium chloride [WHO-DD]
Common Name English
TRIMETHYLHEXADECYLAMMONIUM CHLORIDE [HSDB]
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 69133
Created by admin on Fri Dec 15 15:23:53 UTC 2023 , Edited by admin on Fri Dec 15 15:23:53 UTC 2023
NCI_THESAURUS C28394
Created by admin on Fri Dec 15 15:23:53 UTC 2023 , Edited by admin on Fri Dec 15 15:23:53 UTC 2023
Code System Code Type Description
MESH
C004322
Created by admin on Fri Dec 15 15:23:53 UTC 2023 , Edited by admin on Fri Dec 15 15:23:53 UTC 2023
PRIMARY
EPA CompTox
DTXSID6026901
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PRIMARY
RXCUI
1311525
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PRIMARY RxNorm
CAS
112-02-7
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PRIMARY
HSDB
5553
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PRIMARY
CHEBI
53581
Created by admin on Fri Dec 15 15:23:53 UTC 2023 , Edited by admin on Fri Dec 15 15:23:53 UTC 2023
PRIMARY
NCI_THESAURUS
C83614
Created by admin on Fri Dec 15 15:23:53 UTC 2023 , Edited by admin on Fri Dec 15 15:23:53 UTC 2023
PRIMARY
DRUG BANK
DBSALT001770
Created by admin on Fri Dec 15 15:23:53 UTC 2023 , Edited by admin on Fri Dec 15 15:23:53 UTC 2023
PRIMARY
FDA UNII
UC9PE95IBP
Created by admin on Fri Dec 15 15:23:53 UTC 2023 , Edited by admin on Fri Dec 15 15:23:53 UTC 2023
PRIMARY
ECHA (EC/EINECS)
203-928-6
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PRIMARY
PUBCHEM
8154
Created by admin on Fri Dec 15 15:23:53 UTC 2023 , Edited by admin on Fri Dec 15 15:23:53 UTC 2023
PRIMARY
WIKIPEDIA
CETRIMONIUM CHLORIDE
Created by admin on Fri Dec 15 15:23:53 UTC 2023 , Edited by admin on Fri Dec 15 15:23:53 UTC 2023
PRIMARY
EVMPD
SUB13302MIG
Created by admin on Fri Dec 15 15:23:53 UTC 2023 , Edited by admin on Fri Dec 15 15:23:53 UTC 2023
PRIMARY
DAILYMED
UC9PE95IBP
Created by admin on Fri Dec 15 15:23:53 UTC 2023 , Edited by admin on Fri Dec 15 15:23:53 UTC 2023
PRIMARY
SMS_ID
100000076344
Created by admin on Fri Dec 15 15:23:53 UTC 2023 , Edited by admin on Fri Dec 15 15:23:53 UTC 2023
PRIMARY
Related Record Type Details
Structure of CETRIMONIUM
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of CETRIMONIUM
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