Elsunersen

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 10:15:27 GMT 2025` Edited by `admin` on `Wed Apr 02 10:15:27 GMT 2025`
Nucleic Acid Type	OLIGONUCLEOTIDE
Sequence Origin	SYNTHETIC
Sequence Type	COMPLETE
Record UNII	Y7F46E73CU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Elsunersen

Official Name

English

(all-P-ambo)-2'-O-(2-methoxyethyl)-5-methyl-P-thiocytidylyl-(3'?5')-2'-O-(2-methoxyethyl)-5-methylcytidylyl-(3'?5')-2'-O-(2-methoxyethyl)adenylyl-(3'?5')-2'-O-(2-methoxyethyl)-5-methylcytidylyl-(3'?5')-2'-O-(2-methoxyethyl)guanylyl-(3'?5')-2'-O-(2-methox

Preferred Name

English

elsunersen [INN]

Common Name

English

DNA, d([2?-O-(2-methoxyethyl)](m<sup>5</sup>rC-sp-m<sup>5</sup>rC-rA-<sup>5</sup>rC-rG-rA)-<sup>5</sup>C-s<sup>p</sup>-A-s<sup>p</sup>-T-<sup>p</sup>-A-<sup>p</sup>-T-<sup>p</sup>-T-<sup>p</sup>-T-<sup>p</sup>-T-<sup>p</sup>-T-<sup>p</sup>-m<sup>5</sup>C

Common Name

English

Code System Code Type Description

FDA UNII

Y7F46E73CU

Created by admin on Wed Apr 02 10:15:27 GMT 2025 , Edited by admin on Wed Apr 02 10:15:27 GMT 2025

PRIMARY

INN

12610

Created by admin on Wed Apr 02 10:15:27 GMT 2025 , Edited by admin on Wed Apr 02 10:15:27 GMT 2025

PRIMARY

SMS_ID

300000037998

Created by admin on Wed Apr 02 10:15:27 GMT 2025 , Edited by admin on Wed Apr 02 10:15:27 GMT 2025

PRIMARY

CAS

2756001-75-7

Created by admin on Wed Apr 02 10:15:27 GMT 2025 , Edited by admin on Wed Apr 02 10:15:27 GMT 2025

PRIMARY

NCI_THESAURUS

C206907

Created by admin on Wed Apr 02 10:15:27 GMT 2025 , Edited by admin on Wed Apr 02 10:15:27 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methoxyethyl ribose	1_1-1_6;1_17-1_20	10 / 20
Deoxyribose (DNA)	1_7-1_16	10 / 20

Linkage	Site Range	Site Count
Phosphate	1_3-1_7;1_18	6 / 19
Phosporothioate	1_2;1_8-1_17;1_19-1_20	13 / 19

Related Record Type Details


					Y7F46E73CU

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE BASE SUBSTITUTION	[1_1] [1_2] [1_4] [1_7] [1_16] [1_19]				5-METHYLCYTOSINE	6R795CQT4H
NUCLEOSIDE BASE SUBSTITUTION	[1_17]				THYMINE	QR26YLT7LT