Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C5H7N3O |
| Molecular Weight | 125.1288 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cc1cnc([nH]c1=N)O
InChI
InChIKey=LRSASMSXMSNRBT-UHFFFAOYSA-N
InChI=1S/C5H7N3O/c1-3-2-7-5(9)8-4(3)6/h2H,1H3,(H3,6,7,8,9)
| Molecular Formula | C5H7N3O |
| Molecular Weight | 125.1288 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: Q8NFU7 Gene ID: 80312.0 Gene Symbol: TET1 Target Organism: Homo sapiens (Human) |
|||
Target ID: Q6N021 Gene ID: 54790.0 Gene Symbol: TET2 Target Organism: Homo sapiens (Human) |
|||
Target ID: O43151 Gene ID: NA Gene Symbol: TET3 Target Organism: Homo sapiens (Human) |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Methylation of a euchromatin-heterochromatin transition region in Arabidopsis thaliana chromosome 5 left arm. | 2002 |
|
| Phase-change related epigenetic and physiological changes in Pinus radiata D. Don. | 2002 Aug |
|
| Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors. | 2002 Aug 1 |
|
| Demethylation of classical satellite 2 and 3 DNA with chromosomal instability in senescent human fibroblasts. | 2002 Aug-Sep |
|
| Evaluation of a potential epigenetic biomarker by quantitative methyl-single nucleotide polymorphism analysis. | 2002 Dec |
|
| Distribution of 5-methylcytosine residues in 5S rRNA genes in Arabidopsis thaliana and Secale cereale. | 2002 Dec |
|
| Absence of global genomic cytosine methylation pattern erasure during medaka (Oryzias latipes) early embryo development. | 2002 Dec |
|
| Parental 5-methylcytosine methylation patterns are stable upon inter-species hybridization of Xiphophorus (Teleostei: Poeciliidae) fish. | 2002 Dec |
|
| 5-Methylcytosine as a marker for the monitoring of DNA methylation. | 2002 Dec 5 |
|
| Structural effects of cytosine methylation on DNA sugar pucker studied by FTIR. | 2002 Dec 6 |
|
| DNA hypomethylation and methyltransferase expression in atherosclerotic lesions. | 2002 Feb |
|
| Signal and noise in bridging PCR. | 2002 Jul 18 |
|
| Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. | 2002 Jul 19 |
|
| Quantitative assessment of the use of modified nucleoside triphosphates in expression profiling: differential effects on signal intensities and impacts on expression ratios. | 2002 Jul 31 |
|
| Genomic comparisons among Escherichia coli strains B, K-12, and O157:H7 using IS elements as molecular markers. | 2002 Jul 9 |
|
| DNA sequence recognition by the antitumor drug ditercalinium. | 2002 Jul 9 |
|
| An overview of the analysis of DNA methylation in mammalian genomes. | 2002 Jun |
|
| Analysis of complex methylation data. | 2002 Jun |
|
| Measurement of genome wide DNA methylation by reversed-phase high-performance liquid chromatography. | 2002 Jun |
|
| Quantitative methylation analysis using methylation-sensitive single-nucleotide primer extension (Ms-SNuPE). | 2002 Jun |
|
| Profiling DNA methylation by melting analysis. | 2002 Jun |
|
| Identification and resolution of artifacts in bisulfite sequencing. | 2002 Jun |
|
| Inactivation of O6-methylguanine-DNA methyltransferase by promoter CpG island hypermethylation in gastric cancers. | 2002 Jun 17 |
|
| Aberrant methylation patterns at the two-cell stage as an indicator of early developmental failure. | 2002 Nov |
|
| Abrogation of upstream open reading frame-mediated translational control of a plant S-adenosylmethionine decarboxylase results in polyamine disruption and growth perturbations. | 2002 Nov 15 |
|
| Gene expression patterns vary in clonal cell cultures from Rett syndrome females with eight different MECP2 mutations. | 2002 Nov 5 |
|
| Mutagenicity of 5-formylcytosine, an oxidation product of 5-methylcytosine, in DNA in mammalian cells. | 2002 Oct |
|
| DNA methylation changes in leukaemia. | 2002 Oct |
|
| Repair of deaminated bases in DNA. | 2002 Oct 1 |
|
| DNA methylation: a profile of methods and applications. | 2002 Sep |
|
| Determination of methylation site of DNA-methyltransferase NlaX by a hybrid method. | 2002 Sep |
|
| Estradiol receptor potentiates, in vitro, the activity of 5-methylcytosine DNA glycosylase. | 2002 Sep 11 |
|
| Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase. | 2002 Sep 12 |
|
| RNA methyltransferases utilize two cysteine residues in the formation of 5-methylcytosine. | 2002 Sep 17 |
|
| Asymmetric directional mutation pressures in bacteria. | 2002 Sep 26 |
|
| Hypomethylation and hypermethylation of DNA in Wilms tumors. | 2002 Sep 26 |
|
| Specific methylation of the CpG-rich domains in the promoter of the human tissue transglutaminase gene. | 2002 Sep 4 |
|
| Site-specific discrimination of Cytosine and 5-methylcytosine in duplex DNA by Peptide nucleic acids. | 2002 Sep 4 |
|
| Expression of various genes is controlled by DNA methylation during mammalian development. | 2003 Apr 1 |
|
| The epsilon-sarcoglycan gene (SGCE), mutated in myoclonus-dystonia syndrome, is maternally imprinted. | 2003 Feb |
|
| Transient decreases in methylation at 5'-cCGG-3' sequences in potato (Solanum tuberosum L.) meristem DNA during progression of tubers through dormancy precede the resumption of sprout growth. | 2003 Feb |
|
| Comparative study of the toxic effects of fumonisin B1 in rat C6 glioma cells and p53-null mouse embryo fibroblasts. | 2003 Feb 1 |
|
| Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase. | 2003 Jan 2 |
|
| Genome-wide epigenetic alterations in cloned bovine fetuses. | 2003 Mar |
|
| A systematic profile of DNA methylation in human cancer cell lines. | 2003 Mar 1 |
|
| Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity. | 2003 Mar 14 |
|
| Sequence context at human single nucleotide polymorphisms: overrepresentation of CpG dinucleotide at polymorphic sites and suppression of variation in CpG islands. | 2003 Mar 21 |
|
| Deamination of 5-methylcytosines within cyclobutane pyrimidine dimers is an important component of UVB mutagenesis. | 2003 Mar 21 |
|
| The main role of human thymine-DNA glycosylase is removal of thymine produced by deamination of 5-methylcytosine and not removal of ethenocytosine. | 2003 Mar 7 |
|
| A potent cell-active allosteric inhibitor of murine DNA cytosine C5 methyltransferase. | 2003 Mar 7 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Jun 26 08:41:46 UTC 2021
by
admin
on
Sat Jun 26 08:41:46 UTC 2021
|
| Record UNII |
6R795CQT4H
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Systematic Name | English | ||
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Systematic Name | English | ||
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Code | English | ||
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Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
NCI_THESAURUS |
C709
Created by
admin on Sat Jun 26 08:41:46 UTC 2021 , Edited by admin on Sat Jun 26 08:41:46 UTC 2021
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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6R795CQT4H
Created by
admin on Sat Jun 26 08:41:46 UTC 2021 , Edited by admin on Sat Jun 26 08:41:46 UTC 2021
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PRIMARY | |||
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5-METHYLCYTOSINE
Created by
admin on Sat Jun 26 08:41:46 UTC 2021 , Edited by admin on Sat Jun 26 08:41:46 UTC 2021
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PRIMARY | |||
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65040
Created by
admin on Sat Jun 26 08:41:46 UTC 2021 , Edited by admin on Sat Jun 26 08:41:46 UTC 2021
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PRIMARY | |||
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C129008
Created by
admin on Sat Jun 26 08:41:46 UTC 2021 , Edited by admin on Sat Jun 26 08:41:46 UTC 2021
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PRIMARY | |||
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M7392
Created by
admin on Sat Jun 26 08:41:46 UTC 2021 , Edited by admin on Sat Jun 26 08:41:46 UTC 2021
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PRIMARY | Merck Index | ||
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554-01-8
Created by
admin on Sat Jun 26 08:41:46 UTC 2021 , Edited by admin on Sat Jun 26 08:41:46 UTC 2021
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PRIMARY | |||
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209-058-3
Created by
admin on Sat Jun 26 08:41:46 UTC 2021 , Edited by admin on Sat Jun 26 08:41:46 UTC 2021
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PRIMARY | |||
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554-01-8
Created by
admin on Sat Jun 26 08:41:46 UTC 2021 , Edited by admin on Sat Jun 26 08:41:46 UTC 2021
|
PRIMARY |
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|---|---|---|---|---|
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SALT/SOLVATE -> PARENT |
