Details
Stereochemistry | ACHIRAL |
Molecular Formula | C5H7N3O |
Molecular Weight | 125.1288 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cc1cnc([nH]c1=N)O
InChI
InChIKey=LRSASMSXMSNRBT-UHFFFAOYSA-N
InChI=1S/C5H7N3O/c1-3-2-7-5(9)8-4(3)6/h2H,1H3,(H3,6,7,8,9)
Molecular Formula | C5H7N3O |
Molecular Weight | 125.1288 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Q8NFU7 Gene ID: 80312.0 Gene Symbol: TET1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/19372391 |
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Target ID: Q6N021 Gene ID: 54790.0 Gene Symbol: TET2 Target Organism: Homo sapiens (Human) |
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Target ID: O43151 Gene ID: NA Gene Symbol: TET3 Target Organism: Homo sapiens (Human) |
PubMed
Title | Date | PubMed |
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Methylation of a euchromatin-heterochromatin transition region in Arabidopsis thaliana chromosome 5 left arm. | 2002 |
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Phase-change related epigenetic and physiological changes in Pinus radiata D. Don. | 2002 Aug |
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Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors. | 2002 Aug 1 |
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Demethylation of classical satellite 2 and 3 DNA with chromosomal instability in senescent human fibroblasts. | 2002 Aug-Sep |
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Evaluation of a potential epigenetic biomarker by quantitative methyl-single nucleotide polymorphism analysis. | 2002 Dec |
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Distribution of 5-methylcytosine residues in 5S rRNA genes in Arabidopsis thaliana and Secale cereale. | 2002 Dec |
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Absence of global genomic cytosine methylation pattern erasure during medaka (Oryzias latipes) early embryo development. | 2002 Dec |
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Parental 5-methylcytosine methylation patterns are stable upon inter-species hybridization of Xiphophorus (Teleostei: Poeciliidae) fish. | 2002 Dec |
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5-Methylcytosine as a marker for the monitoring of DNA methylation. | 2002 Dec 5 |
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Structural effects of cytosine methylation on DNA sugar pucker studied by FTIR. | 2002 Dec 6 |
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DNA hypomethylation and methyltransferase expression in atherosclerotic lesions. | 2002 Feb |
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Signal and noise in bridging PCR. | 2002 Jul 18 |
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Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. | 2002 Jul 19 |
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Quantitative assessment of the use of modified nucleoside triphosphates in expression profiling: differential effects on signal intensities and impacts on expression ratios. | 2002 Jul 31 |
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Genomic comparisons among Escherichia coli strains B, K-12, and O157:H7 using IS elements as molecular markers. | 2002 Jul 9 |
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DNA sequence recognition by the antitumor drug ditercalinium. | 2002 Jul 9 |
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An overview of the analysis of DNA methylation in mammalian genomes. | 2002 Jun |
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Analysis of complex methylation data. | 2002 Jun |
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Measurement of genome wide DNA methylation by reversed-phase high-performance liquid chromatography. | 2002 Jun |
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Quantitative methylation analysis using methylation-sensitive single-nucleotide primer extension (Ms-SNuPE). | 2002 Jun |
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Profiling DNA methylation by melting analysis. | 2002 Jun |
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Identification and resolution of artifacts in bisulfite sequencing. | 2002 Jun |
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Inactivation of O6-methylguanine-DNA methyltransferase by promoter CpG island hypermethylation in gastric cancers. | 2002 Jun 17 |
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Aberrant methylation patterns at the two-cell stage as an indicator of early developmental failure. | 2002 Nov |
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Abrogation of upstream open reading frame-mediated translational control of a plant S-adenosylmethionine decarboxylase results in polyamine disruption and growth perturbations. | 2002 Nov 15 |
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Gene expression patterns vary in clonal cell cultures from Rett syndrome females with eight different MECP2 mutations. | 2002 Nov 5 |
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Mutagenicity of 5-formylcytosine, an oxidation product of 5-methylcytosine, in DNA in mammalian cells. | 2002 Oct |
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DNA methylation changes in leukaemia. | 2002 Oct |
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Repair of deaminated bases in DNA. | 2002 Oct 1 |
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DNA methylation: a profile of methods and applications. | 2002 Sep |
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Determination of methylation site of DNA-methyltransferase NlaX by a hybrid method. | 2002 Sep |
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Estradiol receptor potentiates, in vitro, the activity of 5-methylcytosine DNA glycosylase. | 2002 Sep 11 |
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Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase. | 2002 Sep 12 |
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RNA methyltransferases utilize two cysteine residues in the formation of 5-methylcytosine. | 2002 Sep 17 |
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Asymmetric directional mutation pressures in bacteria. | 2002 Sep 26 |
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Hypomethylation and hypermethylation of DNA in Wilms tumors. | 2002 Sep 26 |
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Specific methylation of the CpG-rich domains in the promoter of the human tissue transglutaminase gene. | 2002 Sep 4 |
|
Site-specific discrimination of Cytosine and 5-methylcytosine in duplex DNA by Peptide nucleic acids. | 2002 Sep 4 |
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Expression of various genes is controlled by DNA methylation during mammalian development. | 2003 Apr 1 |
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The epsilon-sarcoglycan gene (SGCE), mutated in myoclonus-dystonia syndrome, is maternally imprinted. | 2003 Feb |
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Transient decreases in methylation at 5'-cCGG-3' sequences in potato (Solanum tuberosum L.) meristem DNA during progression of tubers through dormancy precede the resumption of sprout growth. | 2003 Feb |
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Comparative study of the toxic effects of fumonisin B1 in rat C6 glioma cells and p53-null mouse embryo fibroblasts. | 2003 Feb 1 |
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Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase. | 2003 Jan 2 |
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Genome-wide epigenetic alterations in cloned bovine fetuses. | 2003 Mar |
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A systematic profile of DNA methylation in human cancer cell lines. | 2003 Mar 1 |
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Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity. | 2003 Mar 14 |
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Sequence context at human single nucleotide polymorphisms: overrepresentation of CpG dinucleotide at polymorphic sites and suppression of variation in CpG islands. | 2003 Mar 21 |
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Deamination of 5-methylcytosines within cyclobutane pyrimidine dimers is an important component of UVB mutagenesis. | 2003 Mar 21 |
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The main role of human thymine-DNA glycosylase is removal of thymine produced by deamination of 5-methylcytosine and not removal of ethenocytosine. | 2003 Mar 7 |
|
A potent cell-active allosteric inhibitor of murine DNA cytosine C5 methyltransferase. | 2003 Mar 7 |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Jun 26 08:41:46 UTC 2021
by
admin
on
Sat Jun 26 08:41:46 UTC 2021
|
Record UNII |
6R795CQT4H
|
Record Status |
Validated (UNII)
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Record Version |
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-
Download
Name | Type | Language | ||
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Systematic Name | English | ||
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Systematic Name | English | ||
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Code | English | ||
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Common Name | English |
Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C709
Created by
admin on Sat Jun 26 08:41:46 UTC 2021 , Edited by admin on Sat Jun 26 08:41:46 UTC 2021
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Code System | Code | Type | Description | ||
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6R795CQT4H
Created by
admin on Sat Jun 26 08:41:46 UTC 2021 , Edited by admin on Sat Jun 26 08:41:46 UTC 2021
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PRIMARY | |||
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5-METHYLCYTOSINE
Created by
admin on Sat Jun 26 08:41:46 UTC 2021 , Edited by admin on Sat Jun 26 08:41:46 UTC 2021
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PRIMARY | |||
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65040
Created by
admin on Sat Jun 26 08:41:46 UTC 2021 , Edited by admin on Sat Jun 26 08:41:46 UTC 2021
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PRIMARY | |||
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C129008
Created by
admin on Sat Jun 26 08:41:46 UTC 2021 , Edited by admin on Sat Jun 26 08:41:46 UTC 2021
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PRIMARY | |||
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M7392
Created by
admin on Sat Jun 26 08:41:46 UTC 2021 , Edited by admin on Sat Jun 26 08:41:46 UTC 2021
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PRIMARY | Merck Index | ||
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554-01-8
Created by
admin on Sat Jun 26 08:41:46 UTC 2021 , Edited by admin on Sat Jun 26 08:41:46 UTC 2021
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PRIMARY | |||
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209-058-3
Created by
admin on Sat Jun 26 08:41:46 UTC 2021 , Edited by admin on Sat Jun 26 08:41:46 UTC 2021
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PRIMARY | |||
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554-01-8
Created by
admin on Sat Jun 26 08:41:46 UTC 2021 , Edited by admin on Sat Jun 26 08:41:46 UTC 2021
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PRIMARY |
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SALT/SOLVATE -> PARENT |