THYMINE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H6N2O2
Molecular Weight	126.1133
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CNC(=O)NC1=O

InChI

InChIKey=RWQNBRDOKXIBIV-UHFFFAOYSA-N

InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)

HIDE SMILES / InChI

Molecular Formula	C5H6N2O2
Molecular Weight	126.1133
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Adenine-induced selective apoptosis toward HIV chronically infected cells in vitro.	2000 Jul 14	10891366
Utilization of amino acids in growing kidney proximal tubule cell cultures.	2001	11401333
Mechanisms of nitric oxide-induced cytotoxicity in normal human hepatocytes.	2001	11170241
A novel polymorphism IVS2+843C>T in the alternate promoter b1 of the human AE2 anion exchanger gene.	2001	11139268
Ionization mechanism of oligonucleotides in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.	2001	11135425
Thymine-metal ion interactions: relevance for thymine quartet structures.	2001 Apr	11372196
Phylogeny, function, and evolution of the cupins, a structurally conserved, functionally diverse superfamily of proteins.	2001 Apr	11264412
Binding of nucleotides to nucleoside diphosphate kinase: a calorimetric study.	2001 Apr 17	11294625
15-mer DNA duplexes containing an abasic site are thermodynamically more stable with adjacent purines than with pyrimidines.	2001 Apr 3	11300765
Characterization of DNA damage at purine residues in oligonucleotides and calf thymus DNA induced by the mutagen 1-nitrosoindole-3-acetonitrile.	2001 Feb	11258964
Confounded cytosine! Tinkering and the evolution of DNA.	2001 Feb	11252956
Haplotype analyses with the human leucocyte antigen and tumour necrosis factor-alpha genes in narcolepsy families.	2001 Feb	11235856
Metastable decay of negatively charged oligodeoxynucleotides analyzed with ultraviolet matrix-assisted laser desorption/ionization post-source decay and deuterium exchange.	2001 Feb	11212003
Enhanced S phase delay and inhibition of replication of an undamaged shuttle vector in UVC-irradiated xeroderma pigmentosum variant.	2001 Feb	11181443
The eosinophil peroxidase-hydrogen peroxide-bromide system of human eosinophils generates 5-bromouracil, a mutagenic thymine analogue.	2001 Feb 20	11329272
Determination of high-energy phosphate compounds and inorganic phosphate by reversed-phase high-performance liquid chromatography: evaluation of myocardial metabolic status in aerobically perfused and hypoxic mouse heart.	2001 Feb 25	11236078
Individual determination of the yield of the main UV-induced dimeric pyrimidine photoproducts in DNA suggests a high mutagenicity of CC photolesions.	2001 Feb 27	11327871
Enhanced loop DNA folding induced by thymine-CH3 group contact and perpendicular guanine-thymine interaction.	2001 Jan	11246853
Mutagenic effects of 5-formyluracil on a plasmid vector during replication in Escherichia coli.	2001 Jan	11213350
An electrochemical evidence of free radicals formation from flutamide and its reactivity with endo/xenobiotics of pharmacological relevance.	2001 Jan	11206916
MNGIE: from nuclear DNA to mitochondrial DNA.	2001 Jan	11166160
A study of peptide--peptide interaction by matrix-assisted laser desorption/ionization.	2001 Jan	11142364
The transport of a reversible proton pump antagonist, 5, 6-dimethyl-2-(4-Fluorophenylamino)-4-(1-methyl-1,2,3, 4-tetrahydroisoquinoline-2-yl) pyrimidine hydrochloride (YH1885), across caco-2 cell monolayers.	2001 Jan	11124230
Interferon gamma-dependent induction of thymidine phosphorylase/platelet-derived endothelial growth factor through gamma-activated sequence-like element in human macrophages.	2001 Jan 15	11212233
Minor groove functional groups are critical for the B-form conformation of duplex DNA.	2001 Jan 30	11170418
Conformation and dynamics of abasic sites in DNA investigated by time-resolved fluorescence of 2-aminopurine.	2001 Jan 30	11170417
Synthesis of 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzenes: "thymine replacement" analogs of thymidine for evaluation as anticancer and antiviral agents.	2001 Jan-Feb	11303562
Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization.	2001 Jun	11373625
Stimulation of human endonuclease III by Y box-binding protein 1 (DNA-binding protein B). Interaction between a base excision repair enzyme and a transcription factor.	2001 Jun 15	11287425
A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity.	2001 Jun 19	11401544
Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma.	2001 Jun 29	11319228
The production and evaluation of antibodies for enzyme immunoassay of AZTTP.	2001 Mar	11393400
The significance of dihydropyrimidine dehydrogenase (DPD) activity in bladder cancer.	2001 Mar	11290431
A seminested PCR test for simultaneous detection of two common mutations (35delG and 167delT) in the connexin-26 gene.	2001 Mar	11257213
No detectable DNA excision repair in UV-exposed hepatocytes from two catfish species.	2001 Mar	11255108
Patterns of p53 G-->T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke.	2001 Mar	11238174
Affinity of mismatch-binding protein MutS for heteroduplexes containing different mismatches.	2001 Mar 15	11237867
The crystal structure of dTDP-D-Glucose 4,6-dehydratase (RmlB) from Salmonella enterica serovar Typhimurium, the second enzyme in the dTDP-l-rhamnose pathway.	2001 Mar 16	11243820
Design and characterization of asparagine- and lysine-containing alanine-based helical peptides that bind selectively to A.T base pairs of oligonucleotides immobilized on a 27 mhz quartz crystal microbalance.	2001 Mar 27	11297428
Solution structure of an A-tract DNA bend.	2001 Mar 9	11237619
Myotonic dystrophy protein kinase (DMPK) gene expression in lymphocytes of patients with myotonic dystrophy.	2001 Mar-Apr	11343809
Fragmentation mechanisms of oligodeoxynucleotides: effects of replacing phosphates with methylphosphonates and thymines with other bases in T-rich sequences.	2001 May	11349956
Microuli, a family of miniature subterminal inverted-repeat transposable elements (MSITEs): transposition without terminal inverted repeats.	2001 May	11319273
Numerous gene rearrangements in the mitochondrial genome of the wallaby louse, Heterodoxus macropus (Phthiraptera).	2001 May	11319269
Role of spinal alpha1-adrenoceptor subtypes in the bladder reflex in anesthetized rats.	2001 May	11294762
Oxidative DNA damage induced by a metabolite of carcinogenic o-anisidine: enhancement of DNA damage and alteration in its sequence specificity by superoxide dismutase.	2001 May 1	11370671
An integrated system to study multiply substituted human immunodeficiency virus type 1 reverse transcriptase.	2001 May 1	11319828
Ether phospholipid-AZT conjugates possessing anti-HIV and antitumor cell activity. Synthesis, conformational analysis, and study of their thermal effects on membrane bilayers.	2001 May 24	11356105
Aminoethylprolyl (aep) PNA: mixed purine/pyrimidine oligomers and binding orientation preferences for PNA:DNA duplex formation.	2001 May 3	11348214
Mutations induced by 5-formyl-2'-deoxyuridine in Escherichia coli include base substitutions that can arise from mispairs of 5-formyluracil with guanine, cytosine and thymine.	2001 May 9	11336987

Patents

Substance Class	Chemical Created by `admin` on `Wed Jul 05 22:32:21 UTC 2023` Edited by `admin` on `Wed Jul 05 22:32:21 UTC 2023`
Record UNII	QR26YLT7LT
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

THYMINE

Official Name

English

5-METHYL URACIL

Systematic Name

English

ZIDOVUDINE RELATED COMPOUND C

Common Name

English

THYMINE [USP IMPURITY]

Common Name

English

Thymine [WHO-DD]

Common Name

English

STAVUINE IMPURITY A [WHO-IP]

Common Name

English

THYMINE [INCI]

Common Name

English

ZIDOVUDINE RELATED COMPOUND C [USP-RS]

Common Name

English

THYMIN

Systematic Name

English

ZIDOVUDINE IMPURITY C [WHO-IP]

Common Name

English

ZIDOVUDINE IMPURITY C [EP IMPURITY]

Common Name

English

ZIDOVUDINE RELATED COMPOUND C [USP IMPURITY]

Common Name

English

NSC-168663

Code

English

5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE (THYMINE)

Common Name

English

NSC-14705

Code

English

THYMINE [MI]

Common Name

English

5-METHYL-1,2,3,4-TETRAHYDROPYRIMIDINE-2,4-DIONE

Systematic Name

English

Classification Tree Code System Code

LOINC

48157-2

Created by admin on Wed Jul 05 22:32:22 UTC 2023 , Edited by admin on Wed Jul 05 22:32:22 UTC 2023

LOINC

75153-7

Created by admin on Wed Jul 05 22:32:22 UTC 2023 , Edited by admin on Wed Jul 05 22:32:22 UTC 2023

LOINC

75121-4

Created by admin on Wed Jul 05 22:32:22 UTC 2023 , Edited by admin on Wed Jul 05 22:32:22 UTC 2023

NCI_THESAURUS

C789

Created by admin on Wed Jul 05 22:32:22 UTC 2023 , Edited by admin on Wed Jul 05 22:32:22 UTC 2023

Code System Code Type Description

FDA UNII

QR26YLT7LT

Created by admin on Wed Jul 05 22:32:22 UTC 2023 , Edited by admin on Wed Jul 05 22:32:22 UTC 2023

PRIMARY

MERCK INDEX

M10823

Created by admin on Wed Jul 05 22:32:22 UTC 2023 , Edited by admin on Wed Jul 05 22:32:22 UTC 2023

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Merck Index

PUBCHEM

1135

Created by admin on Wed Jul 05 22:32:22 UTC 2023 , Edited by admin on Wed Jul 05 22:32:22 UTC 2023

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CAS

65-71-4

Created by admin on Wed Jul 05 22:32:21 UTC 2023 , Edited by admin on Wed Jul 05 22:32:21 UTC 2023

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NSC

168663

Created by admin on Wed Jul 05 22:32:22 UTC 2023 , Edited by admin on Wed Jul 05 22:32:22 UTC 2023

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MESH

D013941

Created by admin on Wed Jul 05 22:32:22 UTC 2023 , Edited by admin on Wed Jul 05 22:32:22 UTC 2023

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ECHA (EC/EINECS)

200-616-1

Created by admin on Wed Jul 05 22:32:22 UTC 2023 , Edited by admin on Wed Jul 05 22:32:22 UTC 2023

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SMS_ID

100000091723

Created by admin on Wed Jul 05 22:32:22 UTC 2023 , Edited by admin on Wed Jul 05 22:32:22 UTC 2023

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DRUG BANK

DB03462

Created by admin on Wed Jul 05 22:32:22 UTC 2023 , Edited by admin on Wed Jul 05 22:32:22 UTC 2023

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NCI_THESAURUS

C881

Created by admin on Wed Jul 05 22:32:22 UTC 2023 , Edited by admin on Wed Jul 05 22:32:22 UTC 2023

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RS_ITEM_NUM

1724532

Created by admin on Wed Jul 05 22:32:22 UTC 2023 , Edited by admin on Wed Jul 05 22:32:22 UTC 2023

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DAILYMED

QR26YLT7LT

Created by admin on Wed Jul 05 22:32:22 UTC 2023 , Edited by admin on Wed Jul 05 22:32:22 UTC 2023

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CHEBI

17821

Created by admin on Wed Jul 05 22:32:21 UTC 2023 , Edited by admin on Wed Jul 05 22:32:21 UTC 2023

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EPA CompTox

DTXSID4052342

Created by admin on Wed Jul 05 22:32:22 UTC 2023 , Edited by admin on Wed Jul 05 22:32:22 UTC 2023

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WIKIPEDIA

THYMINE

Created by admin on Wed Jul 05 22:32:22 UTC 2023 , Edited by admin on Wed Jul 05 22:32:22 UTC 2023

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RXCUI

1368871

Created by admin on Wed Jul 05 22:32:22 UTC 2023 , Edited by admin on Wed Jul 05 22:32:22 UTC 2023

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RxNorm

NSC

14705

Created by admin on Wed Jul 05 22:32:22 UTC 2023 , Edited by admin on Wed Jul 05 22:32:22 UTC 2023

PRIMARY

EVMPD

SUB27112

Created by admin on Wed Jul 05 22:32:21 UTC 2023 , Edited by admin on Wed Jul 05 22:32:21 UTC 2023

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