THYMINE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H6N2O2
Molecular Weight	126.1135
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cc1cnc(nc1O)O

InChI

InChIKey=RWQNBRDOKXIBIV-UHFFFAOYSA-N

InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)

HIDE SMILES / InChI

Molecular Formula	C5H6N2O2
Molecular Weight	126.1135
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Protection by ultraviolet A and B sunscreens against in situ dipyrimidine photolesions in human epidermis is comparable to protection against sunburn.	2000 Jul	10886505
Mechanisms and implications of the age-associated decrease in DNA repair capacity.	2000 Jul	10877825
Mechanisms of nitric oxide-induced cytotoxicity in normal human hepatocytes.	2001	11170241
A novel polymorphism IVS2+843C>T in the alternate promoter b1 of the human AE2 anion exchanger gene.	2001	11139268
A novel polymorphism (c288C>T) of the NPHS2 gene identified in a Taiwan Chinese family.	2001	11139267
Identification of genetic variants (g789C>T and G111S) in the human HSPB2 gene.	2001	11139265
Mechanism of oxidative DNA damage induced by carcinogenic 4-aminobiphenyl.	2001 Apr 1	11275476
Binding of nucleotides to nucleoside diphosphate kinase: a calorimetric study.	2001 Apr 17	11294625
The crystal structures of psoralen cross-linked DNAs: drug-dependent formation of Holliday junctions.	2001 Apr 20	11302703
15-mer DNA duplexes containing an abasic site are thermodynamically more stable with adjacent purines than with pyrimidines.	2001 Apr 3	11300765
Haplotype analyses with the human leucocyte antigen and tumour necrosis factor-alpha genes in narcolepsy families.	2001 Feb	11235856
Molecular diversity of quinolone resistance in genetically related clinical isolates of Staphylococcus aureus and susceptibility to newer quinolones.	2001 Feb	11157899
Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti-cancer drug 5-fluorouracil.	2001 Feb 15	11179210
An electrochemical evidence of free radicals formation from flutamide and its reactivity with endo/xenobiotics of pharmacological relevance.	2001 Jan	11206916
Minor groove functional groups are critical for the B-form conformation of duplex DNA.	2001 Jan 30	11170418
Exploring the role of the 5'-position of TSAO-T. Synthesis and anti-HIV evaluation of novel TSAO-T derivatives.	2001 Jun	11397508
Crystal structures of a ddATP-, ddTTP-, ddCTP, and ddGTP- trapped ternary complex of Klentaq1: insights into nucleotide incorporation and selectivity.	2001 Jun	11369861
Monoclonal antibody to single-stranded DNA: a potential tool for DNA repair studies.	2001 Jun 1	11374895
Stimulation of human endonuclease III by Y box-binding protein 1 (DNA-binding protein B). Interaction between a base excision repair enzyme and a transcription factor.	2001 Jun 15	11287425
A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity.	2001 Jun 19	11401544
Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma.	2001 Jun 29	11319228
Rapid detection of a common dihydropyrimidine dehydrogenase mutation associated with 5-fluorouracil toxicity and congenital thymine uraciluria using fluorogenic hybridization probes.	2001 Mar	11311218
A seminested PCR test for simultaneous detection of two common mutations (35delG and 167delT) in the connexin-26 gene.	2001 Mar	11257213
Solution structure of an A-tract DNA bend.	2001 Mar 9	11237619
Role of spinal alpha1-adrenoceptor subtypes in the bladder reflex in anesthetized rats.	2001 May	11294762
Oxidation of thymine to 5-formyluracil in DNA promotes misincorporation of dGMP and subsequent elongation of a mismatched primer terminus by DNA polymerase.	2001 May 11	11278425
DNA repair mechanism by photolyase: electron transfer path from the photolyase catalytic cofactor FADH(-) to DNA thymine dimer.	2001 May 21	11371177
Aminoethylprolyl (aep) PNA: mixed purine/pyrimidine oligomers and binding orientation preferences for PNA:DNA duplex formation.	2001 May 3	11348214
Pyrrolidine nucleic acids: DNA/PNA oligomers with 2-hydroxy/aminomethyl- 4-(thymin-1-yl)pyrrolidine-N-acetic acid.	2001 May 3	11348211
Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes.	2001 May 8	11330999
Mutations induced by 5-formyl-2'-deoxyuridine in Escherichia coli include base substitutions that can arise from mispairs of 5-formyluracil with guanine, cytosine and thymine.	2001 May 9	11336987

Patents

Substance Class	Chemical Created by `admin` on `Sat Jun 26 03:46:20 UTC 2021` Edited by `admin` on `Sat Jun 26 03:46:20 UTC 2021`
Record UNII	QR26YLT7LT
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

THYMINE

Official Name

English

5-METHYL URACIL

Systematic Name

English

THYMINE [USP]

Common Name

English

ZIDOVUDINE RELATED COMPOUND C

Common Name

English

STAVUINE IMPURITY A [WHO-IP]

Common Name

English

THYMINE [INCI]

Common Name

English

ZIDOVUDINE RELATED COMPOUND C [USP-RS]

Common Name

English

THYMIN

Systematic Name

English

ZIDOVUDINE RELATED COMPOUND C RS [USP]

Common Name

English

ZIDOVUDINE IMPURITY C [WHO-IP]

Common Name

English

THYMINE [WHO-DD]

Common Name

English

NSC-168663

Code

English

5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE (THYMINE)

Common Name

English

ZIDOVUDINE SPECIFIED IMPURITY C [EP]

Common Name

English

NSC-14705

Code

English

THYMINE [MI]

Common Name

English

5-METHYL-1,2,3,4-TETRAHYDROPYRIMIDINE-2,4-DIONE

Systematic Name

English

Classification Tree Code System Code

LOINC

48157-2