U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C5H6N2O2
Molecular Weight 126.1135
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of THYMINE

SMILES

Cc1cnc(nc1O)O

InChI

InChIKey=RWQNBRDOKXIBIV-UHFFFAOYSA-N
InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)

HIDE SMILES / InChI

Molecular Formula C5H6N2O2
Molecular Weight 126.1135
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Protection by ultraviolet A and B sunscreens against in situ dipyrimidine photolesions in human epidermis is comparable to protection against sunburn.
2000 Jul
Mechanisms and implications of the age-associated decrease in DNA repair capacity.
2000 Jul
Mechanisms of nitric oxide-induced cytotoxicity in normal human hepatocytes.
2001
A novel polymorphism IVS2+843C>T in the alternate promoter b1 of the human AE2 anion exchanger gene.
2001
A novel polymorphism (c288C>T) of the NPHS2 gene identified in a Taiwan Chinese family.
2001
Identification of genetic variants (g789C>T and G111S) in the human HSPB2 gene.
2001
Mechanism of oxidative DNA damage induced by carcinogenic 4-aminobiphenyl.
2001 Apr 1
Binding of nucleotides to nucleoside diphosphate kinase: a calorimetric study.
2001 Apr 17
The crystal structures of psoralen cross-linked DNAs: drug-dependent formation of Holliday junctions.
2001 Apr 20
15-mer DNA duplexes containing an abasic site are thermodynamically more stable with adjacent purines than with pyrimidines.
2001 Apr 3
Haplotype analyses with the human leucocyte antigen and tumour necrosis factor-alpha genes in narcolepsy families.
2001 Feb
Molecular diversity of quinolone resistance in genetically related clinical isolates of Staphylococcus aureus and susceptibility to newer quinolones.
2001 Feb
Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti-cancer drug 5-fluorouracil.
2001 Feb 15
An electrochemical evidence of free radicals formation from flutamide and its reactivity with endo/xenobiotics of pharmacological relevance.
2001 Jan
Minor groove functional groups are critical for the B-form conformation of duplex DNA.
2001 Jan 30
Exploring the role of the 5'-position of TSAO-T. Synthesis and anti-HIV evaluation of novel TSAO-T derivatives.
2001 Jun
Crystal structures of a ddATP-, ddTTP-, ddCTP, and ddGTP- trapped ternary complex of Klentaq1: insights into nucleotide incorporation and selectivity.
2001 Jun
Monoclonal antibody to single-stranded DNA: a potential tool for DNA repair studies.
2001 Jun 1
Stimulation of human endonuclease III by Y box-binding protein 1 (DNA-binding protein B). Interaction between a base excision repair enzyme and a transcription factor.
2001 Jun 15
A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity.
2001 Jun 19
Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma.
2001 Jun 29
Rapid detection of a common dihydropyrimidine dehydrogenase mutation associated with 5-fluorouracil toxicity and congenital thymine uraciluria using fluorogenic hybridization probes.
2001 Mar
A seminested PCR test for simultaneous detection of two common mutations (35delG and 167delT) in the connexin-26 gene.
2001 Mar
Solution structure of an A-tract DNA bend.
2001 Mar 9
Role of spinal alpha1-adrenoceptor subtypes in the bladder reflex in anesthetized rats.
2001 May
Oxidation of thymine to 5-formyluracil in DNA promotes misincorporation of dGMP and subsequent elongation of a mismatched primer terminus by DNA polymerase.
2001 May 11
DNA repair mechanism by photolyase: electron transfer path from the photolyase catalytic cofactor FADH(-) to DNA thymine dimer.
2001 May 21
Aminoethylprolyl (aep) PNA: mixed purine/pyrimidine oligomers and binding orientation preferences for PNA:DNA duplex formation.
2001 May 3
Pyrrolidine nucleic acids: DNA/PNA oligomers with 2-hydroxy/aminomethyl- 4-(thymin-1-yl)pyrrolidine-N-acetic acid.
2001 May 3
Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes.
2001 May 8
Mutations induced by 5-formyl-2'-deoxyuridine in Escherichia coli include base substitutions that can arise from mispairs of 5-formyluracil with guanine, cytosine and thymine.
2001 May 9
Patents
Substance Class Chemical
Created
by admin
on Sat Jun 26 03:46:20 UTC 2021
Edited
by admin
on Sat Jun 26 03:46:20 UTC 2021
Record UNII
QR26YLT7LT
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
THYMINE
INCI   MI   WHO-DD  
INCI  
Official Name English
5-METHYL URACIL
Systematic Name English
THYMINE [USP]
Common Name English
ZIDOVUDINE RELATED COMPOUND C
USP-RS  
Common Name English
STAVUINE IMPURITY A [WHO-IP]
Common Name English
THYMINE [INCI]
Common Name English
ZIDOVUDINE RELATED COMPOUND C [USP-RS]
Common Name English
THYMIN
Systematic Name English
ZIDOVUDINE RELATED COMPOUND C RS [USP]
Common Name English
ZIDOVUDINE IMPURITY C [WHO-IP]
Common Name English
THYMINE [WHO-DD]
Common Name English
NSC-168663
Code English
5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE (THYMINE)
Common Name English
ZIDOVUDINE SPECIFIED IMPURITY C [EP]
Common Name English
NSC-14705
Code English
THYMINE [MI]
Common Name English
5-METHYL-1,2,3,4-TETRAHYDROPYRIMIDINE-2,4-DIONE
Systematic Name English
Classification Tree Code System Code
LOINC 48157-2
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
LOINC 75153-7
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
LOINC 75121-4
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
NCI_THESAURUS C789
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
Code System Code Type Description
FDA UNII
QR26YLT7LT
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY
MERCK INDEX
M10823
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY Merck Index
PUBCHEM
1135
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY
CAS
65-71-4
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY
MESH
D013941
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY
ECHA (EC/EINECS)
200-616-1
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY
USP_CATALOG
1724532
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY USP-RS
DRUG BANK
DB03462
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY
NCI_THESAURUS
C881
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY
EPA CompTox
65-71-4
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY
WIKIPEDIA
THYMINE
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY
RXCUI
1368871
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY RxNorm
EVMPD
SUB27112
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY
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Calculation of percentage contents: – correction factor: multiply the peak area of impurity A by 0.7
CHROMATOGRAPHIC PURITY (HPLC/UV)
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ACTIVE MOIETY