U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C5H6N2O2
Molecular Weight 126.1135
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of THYMINE

SMILES

Cc1cnc(nc1O)O

InChI

InChIKey=RWQNBRDOKXIBIV-UHFFFAOYSA-N
InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)

HIDE SMILES / InChI

Molecular Formula C5H6N2O2
Molecular Weight 126.1135
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Utilization of amino acids in growing kidney proximal tubule cell cultures.
2001
A novel nonsense mutation of the GTP cyclohydrolase I gene in a family with dopa-responsive dystonia.
2001
Thymine-metal ion interactions: relevance for thymine quartet structures.
2001 Apr
Genotyping the -521C/T functional polymorphism in the promoter region of dopamine D4 receptor (DRD4) gene.
2001 Apr
Mass spectrometric evidence for mechanisms of fragmentation of charge-derivatized peptides.
2001 Apr
Inheritance of a stable mutation in a family with early-onset disease.
2001 Apr
Association study of CAG repeats in the KCNN3 gene in Japanese patients with schizophrenia, schizoaffective disorder and bipolar disorder.
2001 Apr 15
The crystal structures of psoralen cross-linked DNAs: drug-dependent formation of Holliday junctions.
2001 Apr 20
Superoxide dismutases enhance H2O2-induced DNA damage and alter its site specificity.
2001 Apr 27
15-mer DNA duplexes containing an abasic site are thermodynamically more stable with adjacent purines than with pyrimidines.
2001 Apr 3
N(1)-C(5')-linked dimer hydrates of 5-substituted uracils produced by anodic oxidation in aqueous solution.
2001 Apr 6
Biochemical characterization of uracil processing activities in the hyperthermophilic archaeon Pyrobaculum aerophilum.
2001 Aug 10
The eosinophil peroxidase-hydrogen peroxide-bromide system of human eosinophils generates 5-bromouracil, a mutagenic thymine analogue.
2001 Feb 20
Individual determination of the yield of the main UV-induced dimeric pyrimidine photoproducts in DNA suggests a high mutagenicity of CC photolesions.
2001 Feb 27
Synthesis of 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzenes: "thymine replacement" analogs of thymidine for evaluation as anticancer and antiviral agents.
2001 Jan-Feb
Exploring the role of the 5'-position of TSAO-T. Synthesis and anti-HIV evaluation of novel TSAO-T derivatives.
2001 Jun
Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization.
2001 Jun
Crystal structures of a ddATP-, ddTTP-, ddCTP, and ddGTP- trapped ternary complex of Klentaq1: insights into nucleotide incorporation and selectivity.
2001 Jun
Monoclonal antibody to single-stranded DNA: a potential tool for DNA repair studies.
2001 Jun 1
Stimulation of human endonuclease III by Y box-binding protein 1 (DNA-binding protein B). Interaction between a base excision repair enzyme and a transcription factor.
2001 Jun 15
A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity.
2001 Jun 19
Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma.
2001 Jun 29
Base sequence dependence of in vitro translesional DNA replication past a bulky lesion catalyzed by the exo- Klenow fragment of Pol I.
2001 Jun 5
Probing catalysis by Escherichia coli dTDP-glucose-4,6-dehydratase: identification and preliminary characterization of functional amino acid residues at the active site.
2001 Jun 5
Role of the Escherichia coli and human DNA glycosylases that remove 5-formyluracil from DNA in the prevention of mutations.
2001 Mar
The production and evaluation of antibodies for enzyme immunoassay of AZTTP.
2001 Mar
Low-dose, sublingual AZT-monophosphate therapy for HIV+ patients?
2001 Mar
Rapid detection of a common dihydropyrimidine dehydrogenase mutation associated with 5-fluorouracil toxicity and congenital thymine uraciluria using fluorogenic hybridization probes.
2001 Mar
The significance of dihydropyrimidine dehydrogenase (DPD) activity in bladder cancer.
2001 Mar
p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells.
2001 Mar 1
Design and characterization of asparagine- and lysine-containing alanine-based helical peptides that bind selectively to A.T base pairs of oligonucleotides immobilized on a 27 mhz quartz crystal microbalance.
2001 Mar 27
Myotonic dystrophy protein kinase (DMPK) gene expression in lymphocytes of patients with myotonic dystrophy.
2001 Mar-Apr
Construction of peptide conjugates with peptide nucleic acids containing an anthracene probe and their interactions with DNA.
2001 May
Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency.
2001 May
Fragmentation mechanisms of oligodeoxynucleotides: effects of replacing phosphates with methylphosphonates and thymines with other bases in T-rich sequences.
2001 May
Microuli, a family of miniature subterminal inverted-repeat transposable elements (MSITEs): transposition without terminal inverted repeats.
2001 May
Numerous gene rearrangements in the mitochondrial genome of the wallaby louse, Heterodoxus macropus (Phthiraptera).
2001 May
Role of spinal alpha1-adrenoceptor subtypes in the bladder reflex in anesthetized rats.
2001 May
Oxidative DNA damage induced by a metabolite of carcinogenic o-anisidine: enhancement of DNA damage and alteration in its sequence specificity by superoxide dismutase.
2001 May 1
An integrated system to study multiply substituted human immunodeficiency virus type 1 reverse transcriptase.
2001 May 1
Actinomycin D binds strongly to d(TGTCATTG), a single-stranded DNA devoid of GpC sites.
2001 May 1
Oxidation of thymine to 5-formyluracil in DNA promotes misincorporation of dGMP and subsequent elongation of a mismatched primer terminus by DNA polymerase.
2001 May 11
Recognition and kinetics for excision of a base lesion within clustered DNA damage by the Escherichia coli proteins Fpg and Nth.
2001 May 15
Backbone modifications of aromatic peptide nucleic acid (APNA ) monomers and their hybridization properties with DNA and RNA.
2001 May 18
DNA repair mechanism by photolyase: electron transfer path from the photolyase catalytic cofactor FADH(-) to DNA thymine dimer.
2001 May 21
Ether phospholipid-AZT conjugates possessing anti-HIV and antitumor cell activity. Synthesis, conformational analysis, and study of their thermal effects on membrane bilayers.
2001 May 24
Aminoethylprolyl (aep) PNA: mixed purine/pyrimidine oligomers and binding orientation preferences for PNA:DNA duplex formation.
2001 May 3
Pyrrolidine nucleic acids: DNA/PNA oligomers with 2-hydroxy/aminomethyl- 4-(thymin-1-yl)pyrrolidine-N-acetic acid.
2001 May 3
Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes.
2001 May 8
Mutations induced by 5-formyl-2'-deoxyuridine in Escherichia coli include base substitutions that can arise from mispairs of 5-formyluracil with guanine, cytosine and thymine.
2001 May 9
Patents
Substance Class Chemical
Created
by admin
on Sat Jun 26 03:46:20 UTC 2021
Edited
by admin
on Sat Jun 26 03:46:20 UTC 2021
Record UNII
QR26YLT7LT
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
THYMINE
INCI   MI   WHO-DD  
INCI  
Official Name English
5-METHYL URACIL
Systematic Name English
THYMINE [USP]
Common Name English
ZIDOVUDINE RELATED COMPOUND C
USP-RS  
Common Name English
STAVUINE IMPURITY A [WHO-IP]
Common Name English
THYMINE [INCI]
Common Name English
ZIDOVUDINE RELATED COMPOUND C [USP-RS]
Common Name English
THYMIN
Systematic Name English
ZIDOVUDINE RELATED COMPOUND C RS [USP]
Common Name English
ZIDOVUDINE IMPURITY C [WHO-IP]
Common Name English
THYMINE [WHO-DD]
Common Name English
NSC-168663
Code English
5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE (THYMINE)
Common Name English
ZIDOVUDINE SPECIFIED IMPURITY C [EP]
Common Name English
NSC-14705
Code English
THYMINE [MI]
Common Name English
5-METHYL-1,2,3,4-TETRAHYDROPYRIMIDINE-2,4-DIONE
Systematic Name English
Classification Tree Code System Code
LOINC 48157-2
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
LOINC 75153-7
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
LOINC 75121-4
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
NCI_THESAURUS C789
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
Code System Code Type Description
FDA UNII
QR26YLT7LT
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY
MERCK INDEX
M10823
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY Merck Index
PUBCHEM
1135
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY
CAS
65-71-4
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY
MESH
D013941
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY
ECHA (EC/EINECS)
200-616-1
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY
USP_CATALOG
1724532
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY USP-RS
DRUG BANK
DB03462
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY
NCI_THESAURUS
C881
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY
EPA CompTox
65-71-4
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY
WIKIPEDIA
THYMINE
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY
RXCUI
1368871
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY RxNorm
EVMPD
SUB27112
Created by admin on Sat Jun 26 03:46:20 UTC 2021 , Edited by admin on Sat Jun 26 03:46:20 UTC 2021
PRIMARY
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