THYMINE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H6N2O2
Molecular Weight	126.1135
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cc1cnc(nc1O)O

InChI

InChIKey=RWQNBRDOKXIBIV-UHFFFAOYSA-N

InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)

HIDE SMILES / InChI

Molecular Formula	C5H6N2O2
Molecular Weight	126.1135
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Utilization of amino acids in growing kidney proximal tubule cell cultures.	2001	11401333
A novel nonsense mutation of the GTP cyclohydrolase I gene in a family with dopa-responsive dystonia.	2001	11359069
Thymine-metal ion interactions: relevance for thymine quartet structures.	2001 Apr	11372196
Genotyping the -521C/T functional polymorphism in the promoter region of dopamine D4 receptor (DRD4) gene.	2001 Apr	11358133
Mass spectrometric evidence for mechanisms of fragmentation of charge-derivatized peptides.	2001 Apr	11322186
Inheritance of a stable mutation in a family with early-onset disease.	2001 Apr	11287778
Association study of CAG repeats in the KCNN3 gene in Japanese patients with schizophrenia, schizoaffective disorder and bipolar disorder.	2001 Apr 15	11311923
The crystal structures of psoralen cross-linked DNAs: drug-dependent formation of Holliday junctions.	2001 Apr 20	11302703
Superoxide dismutases enhance H2O2-induced DNA damage and alter its site specificity.	2001 Apr 27	11334889
15-mer DNA duplexes containing an abasic site are thermodynamically more stable with adjacent purines than with pyrimidines.	2001 Apr 3	11300765
N(1)-C(5')-linked dimer hydrates of 5-substituted uracils produced by anodic oxidation in aqueous solution.	2001 Apr 6	11281761
Biochemical characterization of uracil processing activities in the hyperthermophilic archaeon Pyrobaculum aerophilum.	2001 Aug 10	11399761
The eosinophil peroxidase-hydrogen peroxide-bromide system of human eosinophils generates 5-bromouracil, a mutagenic thymine analogue.	2001 Feb 20	11329272
Individual determination of the yield of the main UV-induced dimeric pyrimidine photoproducts in DNA suggests a high mutagenicity of CC photolesions.	2001 Feb 27	11327871
Synthesis of 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzenes: "thymine replacement" analogs of thymidine for evaluation as anticancer and antiviral agents.	2001 Jan-Feb	11303562
Exploring the role of the 5'-position of TSAO-T. Synthesis and anti-HIV evaluation of novel TSAO-T derivatives.	2001 Jun	11397508
Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization.	2001 Jun	11373625
Crystal structures of a ddATP-, ddTTP-, ddCTP, and ddGTP- trapped ternary complex of Klentaq1: insights into nucleotide incorporation and selectivity.	2001 Jun	11369861
Monoclonal antibody to single-stranded DNA: a potential tool for DNA repair studies.	2001 Jun 1	11374895
Stimulation of human endonuclease III by Y box-binding protein 1 (DNA-binding protein B). Interaction between a base excision repair enzyme and a transcription factor.	2001 Jun 15	11287425
A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity.	2001 Jun 19	11401544
Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma.	2001 Jun 29	11319228
Base sequence dependence of in vitro translesional DNA replication past a bulky lesion catalyzed by the exo- Klenow fragment of Pol I.	2001 Jun 5	11380261
Probing catalysis by Escherichia coli dTDP-glucose-4,6-dehydratase: identification and preliminary characterization of functional amino acid residues at the active site.	2001 Jun 5	11380254
Role of the Escherichia coli and human DNA glycosylases that remove 5-formyluracil from DNA in the prevention of mutations.	2001 Mar	11393886
The production and evaluation of antibodies for enzyme immunoassay of AZTTP.	2001 Mar	11393400
Low-dose, sublingual AZT-monophosphate therapy for HIV+ patients?	2001 Mar	11359372
Rapid detection of a common dihydropyrimidine dehydrogenase mutation associated with 5-fluorouracil toxicity and congenital thymine uraciluria using fluorogenic hybridization probes.	2001 Mar	11311218
The significance of dihydropyrimidine dehydrogenase (DPD) activity in bladder cancer.	2001 Mar	11290431
p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells.	2001 Mar 1	11280752
Design and characterization of asparagine- and lysine-containing alanine-based helical peptides that bind selectively to A.T base pairs of oligonucleotides immobilized on a 27 mhz quartz crystal microbalance.	2001 Mar 27	11297428
Myotonic dystrophy protein kinase (DMPK) gene expression in lymphocytes of patients with myotonic dystrophy.	2001 Mar-Apr	11343809
Construction of peptide conjugates with peptide nucleic acids containing an anthracene probe and their interactions with DNA.	2001 May	11377169
Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency.	2001 May	11350878
Fragmentation mechanisms of oligodeoxynucleotides: effects of replacing phosphates with methylphosphonates and thymines with other bases in T-rich sequences.	2001 May	11349956
Microuli, a family of miniature subterminal inverted-repeat transposable elements (MSITEs): transposition without terminal inverted repeats.	2001 May	11319273
Numerous gene rearrangements in the mitochondrial genome of the wallaby louse, Heterodoxus macropus (Phthiraptera).	2001 May	11319269
Role of spinal alpha1-adrenoceptor subtypes in the bladder reflex in anesthetized rats.	2001 May	11294762
Oxidative DNA damage induced by a metabolite of carcinogenic o-anisidine: enhancement of DNA damage and alteration in its sequence specificity by superoxide dismutase.	2001 May 1	11370671
An integrated system to study multiply substituted human immunodeficiency virus type 1 reverse transcriptase.	2001 May 1	11319828
Actinomycin D binds strongly to d(TGTCATTG), a single-stranded DNA devoid of GpC sites.	2001 May 1	11318644
Oxidation of thymine to 5-formyluracil in DNA promotes misincorporation of dGMP and subsequent elongation of a mismatched primer terminus by DNA polymerase.	2001 May 11	11278425
Recognition and kinetics for excision of a base lesion within clustered DNA damage by the Escherichia coli proteins Fpg and Nth.	2001 May 15	11341839
Backbone modifications of aromatic peptide nucleic acid (APNA ) monomers and their hybridization properties with DNA and RNA.	2001 May 18	11348119
DNA repair mechanism by photolyase: electron transfer path from the photolyase catalytic cofactor FADH(-) to DNA thymine dimer.	2001 May 21	11371177
Ether phospholipid-AZT conjugates possessing anti-HIV and antitumor cell activity. Synthesis, conformational analysis, and study of their thermal effects on membrane bilayers.	2001 May 24	11356105
Aminoethylprolyl (aep) PNA: mixed purine/pyrimidine oligomers and binding orientation preferences for PNA:DNA duplex formation.	2001 May 3	11348214
Pyrrolidine nucleic acids: DNA/PNA oligomers with 2-hydroxy/aminomethyl- 4-(thymin-1-yl)pyrrolidine-N-acetic acid.	2001 May 3	11348211
Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes.	2001 May 8	11330999
Mutations induced by 5-formyl-2'-deoxyuridine in Escherichia coli include base substitutions that can arise from mispairs of 5-formyluracil with guanine, cytosine and thymine.	2001 May 9	11336987

Patents

Substance Class	Chemical Created by `admin` on `Sat Jun 26 03:46:20 UTC 2021` Edited by `admin` on `Sat Jun 26 03:46:20 UTC 2021`
Record UNII	QR26YLT7LT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

THYMINE

Official Name

English

5-METHYL URACIL

Systematic Name

English

THYMINE [USP]

Common Name

English

ZIDOVUDINE RELATED COMPOUND C

Common Name

English

STAVUINE IMPURITY A [WHO-IP]

Common Name

English

THYMINE [INCI]

Common Name

English

ZIDOVUDINE RELATED COMPOUND C [USP-RS]

Common Name

English

THYMIN

Systematic Name

English

ZIDOVUDINE RELATED COMPOUND C RS [USP]

Common Name

English

ZIDOVUDINE IMPURITY C [WHO-IP]

Common Name

English

THYMINE [WHO-DD]

Common Name

English

NSC-168663

Code

English

5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE (THYMINE)

Common Name

English

ZIDOVUDINE SPECIFIED IMPURITY C [EP]

Common Name

English

NSC-14705

Code

English

THYMINE [MI]

Common Name

English

5-METHYL-1,2,3,4-TETRAHYDROPYRIMIDINE-2,4-DIONE

Systematic Name

English

Classification Tree Code System Code

LOINC

48157-2