THYMINE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H6N2O2
Molecular Weight	126.1133
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CNC(=O)NC1=O

InChI

InChIKey=RWQNBRDOKXIBIV-UHFFFAOYSA-N

InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)

HIDE SMILES / InChI

Molecular Formula	C5H6N2O2
Molecular Weight	126.1133
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Biochemical characterization of uracil processing activities in the hyperthermophilic archaeon Pyrobaculum aerophilum.	2001-08-10	11399761
Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma.	2001-06-29	11319228
A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity.	2001-06-19	11401544
Stimulation of human endonuclease III by Y box-binding protein 1 (DNA-binding protein B). Interaction between a base excision repair enzyme and a transcription factor.	2001-06-15	11287425
Base sequence dependence of in vitro translesional DNA replication past a bulky lesion catalyzed by the exo- Klenow fragment of Pol I.	2001-06-05	11380261
Probing catalysis by Escherichia coli dTDP-glucose-4,6-dehydratase: identification and preliminary characterization of functional amino acid residues at the active site.	2001-06-05	11380254
Monoclonal antibody to single-stranded DNA: a potential tool for DNA repair studies.	2001-06-01	11374895
Exploring the role of the 5'-position of TSAO-T. Synthesis and anti-HIV evaluation of novel TSAO-T derivatives.	2001-06	11397508
Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization.	2001-06	11373625
Crystal structures of a ddATP-, ddTTP-, ddCTP, and ddGTP- trapped ternary complex of Klentaq1: insights into nucleotide incorporation and selectivity.	2001-06	11369861
Ether phospholipid-AZT conjugates possessing anti-HIV and antitumor cell activity. Synthesis, conformational analysis, and study of their thermal effects on membrane bilayers.	2001-05-24	11356105
DNA repair mechanism by photolyase: electron transfer path from the photolyase catalytic cofactor FADH(-) to DNA thymine dimer.	2001-05-21	11371177
Backbone modifications of aromatic peptide nucleic acid (APNA ) monomers and their hybridization properties with DNA and RNA.	2001-05-18	11348119
Recognition and kinetics for excision of a base lesion within clustered DNA damage by the Escherichia coli proteins Fpg and Nth.	2001-05-15	11341839
Myotonic dystrophy protein kinase (DMPK) gene expression in lymphocytes of patients with myotonic dystrophy.	2001-05-10	11343809
Mutations induced by 5-formyl-2'-deoxyuridine in Escherichia coli include base substitutions that can arise from mispairs of 5-formyluracil with guanine, cytosine and thymine.	2001-05-09	11336987
Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes.	2001-05-08	11330999
Aminoethylprolyl (aep) PNA: mixed purine/pyrimidine oligomers and binding orientation preferences for PNA:DNA duplex formation.	2001-05-03	11348214
Pyrrolidine nucleic acids: DNA/PNA oligomers with 2-hydroxy/aminomethyl- 4-(thymin-1-yl)pyrrolidine-N-acetic acid.	2001-05-03	11348211
Oxidative DNA damage induced by a metabolite of carcinogenic o-anisidine: enhancement of DNA damage and alteration in its sequence specificity by superoxide dismutase.	2001-05-01	11370671
An integrated system to study multiply substituted human immunodeficiency virus type 1 reverse transcriptase.	2001-05-01	11319828
Actinomycin D binds strongly to d(TGTCATTG), a single-stranded DNA devoid of GpC sites.	2001-05-01	11318644
Catechol estrogens induce oxidative DNA damage and estradiol enhances cell proliferation.	2001-05-01	11291067
Construction of peptide conjugates with peptide nucleic acids containing an anthracene probe and their interactions with DNA.	2001-05	11377169
Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency.	2001-05	11350878
Fragmentation mechanisms of oligodeoxynucleotides: effects of replacing phosphates with methylphosphonates and thymines with other bases in T-rich sequences.	2001-05	11349956
Microuli, a family of miniature subterminal inverted-repeat transposable elements (MSITEs): transposition without terminal inverted repeats.	2001-05	11319273
Numerous gene rearrangements in the mitochondrial genome of the wallaby louse, Heterodoxus macropus (Phthiraptera).	2001-05	11319269
Role of spinal alpha1-adrenoceptor subtypes in the bladder reflex in anesthetized rats.	2001-05	11294762
Superoxide dismutases enhance H2O2-induced DNA damage and alter its site specificity.	2001-04-27	11334889
The crystal structures of psoralen cross-linked DNAs: drug-dependent formation of Holliday junctions.	2001-04-20	11302703
Synthesis of 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzenes: "thymine replacement" analogs of thymidine for evaluation as anticancer and antiviral agents.	2001-04-17	11303562
Binding of nucleotides to nucleoside diphosphate kinase: a calorimetric study.	2001-04-17	11294625
Association study of CAG repeats in the KCNN3 gene in Japanese patients with schizophrenia, schizoaffective disorder and bipolar disorder.	2001-04-15	11311923
N(1)-C(5')-linked dimer hydrates of 5-substituted uracils produced by anodic oxidation in aqueous solution.	2001-04-06	11281761
15-mer DNA duplexes containing an abasic site are thermodynamically more stable with adjacent purines than with pyrimidines.	2001-04-03	11300765
Thymine-metal ion interactions: relevance for thymine quartet structures.	2001-04	11372196
Genotyping the -521C/T functional polymorphism in the promoter region of dopamine D4 receptor (DRD4) gene.	2001-04	11358133
Mass spectrometric evidence for mechanisms of fragmentation of charge-derivatized peptides.	2001-04	11322186
Inheritance of a stable mutation in a family with early-onset disease.	2001-04	11287778
Design and characterization of asparagine- and lysine-containing alanine-based helical peptides that bind selectively to A.T base pairs of oligonucleotides immobilized on a 27 mhz quartz crystal microbalance.	2001-03-27	11297428
Role of the Escherichia coli and human DNA glycosylases that remove 5-formyluracil from DNA in the prevention of mutations.	2001-03	11393886
The production and evaluation of antibodies for enzyme immunoassay of AZTTP.	2001-03	11393400
Low-dose, sublingual AZT-monophosphate therapy for HIV+ patients?	2001-03	11359372
Rapid detection of a common dihydropyrimidine dehydrogenase mutation associated with 5-fluorouracil toxicity and congenital thymine uraciluria using fluorogenic hybridization probes.	2001-03	11311218
The significance of dihydropyrimidine dehydrogenase (DPD) activity in bladder cancer.	2001-03	11290431
Individual determination of the yield of the main UV-induced dimeric pyrimidine photoproducts in DNA suggests a high mutagenicity of CC photolesions.	2001-02-27	11327871
The eosinophil peroxidase-hydrogen peroxide-bromide system of human eosinophils generates 5-bromouracil, a mutagenic thymine analogue.	2001-02-20	11329272
Utilization of amino acids in growing kidney proximal tubule cell cultures.	2001	11401333
A novel nonsense mutation of the GTP cyclohydrolase I gene in a family with dopa-responsive dystonia.	2001	11359069

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:34:49 GMT 2025` Edited by `admin` on `Mon Mar 31 17:34:49 GMT 2025`
Record UNII	QR26YLT7LT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ZIDOVUDINE RELATED COMPOUND C

Preferred Name

English

THYMINE

Official Name

English

5-METHYL URACIL

Systematic Name

English

THYMINE [USP IMPURITY]

Common Name

English

Thymine [WHO-DD]

Common Name

English

STAVUINE IMPURITY A [WHO-IP]

Common Name

English

ZIDOVUDINE RELATED COMPOUND C [USP-RS]

Common Name

English

THYMIN

Systematic Name

English

ZIDOVUDINE IMPURITY C [WHO-IP]

Common Name

English

ZIDOVUDINE IMPURITY C [EP IMPURITY]

Common Name

English

ZIDOVUDINE RELATED COMPOUND C [USP IMPURITY]

Common Name

English

NSC-168663

Code

English

5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE (THYMINE)

Common Name

English

NSC-14705

Code

English

THYMINE [MI]

Common Name

English

5-METHYL-1,2,3,4-TETRAHYDROPYRIMIDINE-2,4-DIONE

Systematic Name

English

Classification Tree Code System Code

LOINC

48157-2