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Details

Stereochemistry ACHIRAL
Molecular Formula C24H27F2N5O4
Molecular Weight 487.4991
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PEMIGATINIB

SMILES

CCN1C(=O)N(CC2=CN=C3NC(CN4CCOCC4)=CC3=C12)C5=C(F)C(OC)=CC(OC)=C5F

InChI

InChIKey=HCDMJFOHIXMBOV-UHFFFAOYSA-N
InChI=1S/C24H27F2N5O4/c1-4-30-21-14(11-27-23-16(21)9-15(28-23)13-29-5-7-35-8-6-29)12-31(24(30)32)22-19(25)17(33-2)10-18(34-3)20(22)26/h9-11H,4-8,12-13H2,1-3H3,(H,27,28)

HIDE SMILES / InChI

Molecular Formula C24H27F2N5O4
Molecular Weight 487.4991
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Substance Class Chemical
Created
by admin
on Mon Oct 21 20:50:18 UTC 2019
Edited
by admin
on Mon Oct 21 20:50:18 UTC 2019
Record UNII
Y6BX7BL23K
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PEMIGATINIB
INN   USAN  
Official Name English
3-(2,6-DIFLUORO-3,5-DIMETHOXYPHENYL)-1-ETHYL-8-(MORPHOLIN-4-YLMETHYL)-1,3,4,7-TETRAHYDRO-2H-PYRROLO(3',2':5,6)PYRIDO(4,3-D)PYRIMIDIN-2-ONE
Systematic Name English
INCB-054828
Common Name English
PEMIGATINIB [USAN]
Common Name English
FGFR INHIBITOR INCB054828
Common Name English
PEMIGATINIB [INN]
Common Name English
PEMIGATINIB [WHO-DD]
Common Name English
INCB054828
Code English
2H-PYRROLO(3',2':5,6)PYRIDO(4,3-D)PYRIMIDIN-2-ONE, 3-(2,6-DIFLUORO-3,5-DIMETHOXYPHENYL)-1-ETHYL-1,3,4,7-TETRAHYDRO-8-(4-MORPHOLINYLMETHYL)-
Systematic Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 624117
Created by admin on Mon Oct 21 20:50:18 UTC 2019 , Edited by admin on Mon Oct 21 20:50:18 UTC 2019
NCI_THESAURUS C129825
Created by admin on Mon Oct 21 20:50:18 UTC 2019 , Edited by admin on Mon Oct 21 20:50:18 UTC 2019
EU-Orphan Drug EU/3/18/2066
Created by admin on Mon Oct 21 20:50:18 UTC 2019 , Edited by admin on Mon Oct 21 20:50:18 UTC 2019
NCI_THESAURUS C1967
Created by admin on Mon Oct 21 20:50:18 UTC 2019 , Edited by admin on Mon Oct 21 20:50:18 UTC 2019
Code System Code Type Description
INN
10712
Created by admin on Mon Oct 21 20:50:18 UTC 2019 , Edited by admin on Mon Oct 21 20:50:18 UTC 2019
PRIMARY
CAS
1513857-77-6
Created by admin on Mon Oct 21 20:50:18 UTC 2019 , Edited by admin on Mon Oct 21 20:50:18 UTC 2019
PRIMARY
PUBCHEM
86705695
Created by admin on Mon Oct 21 20:50:18 UTC 2019 , Edited by admin on Mon Oct 21 20:50:18 UTC 2019
PRIMARY
NCI_THESAURUS
C121553
Created by admin on Mon Oct 21 20:50:18 UTC 2019 , Edited by admin on Mon Oct 21 20:50:18 UTC 2019
PRIMARY
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TARGET -> INHIBITOR
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ACTIVE MOIETY