PEMIGATINIB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H27F2N5O4
Molecular Weight	487.5
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PEMIGATINIB

Structure Search

SMILES

CCN1c2c(cnc3c2cc(CN4CCOCC4)[nH]3)CN(c5c(c(cc(c5F)OC)OC)F)C1=O

InChI

InChIKey=HCDMJFOHIXMBOV-UHFFFAOYSA-N

InChI=1S/C24H27F2N5O4/c1-4-30-21-14(11-27-23-16(21)9-15(28-23)13-29-5-7-35-8-6-29)12-31(24(30)32)22-19(25)17(33-2)10-18(34-3)20(22)26/h9-11H,4-8,12-13H2,1-3H3,(H,27,28)

HIDE SMILES / InChI

Molecular Formula	C24H27F2N5O4
Molecular Weight	487.5
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Jun 26 12:10:47 UTC 2021` Edited by `admin` on `Sat Jun 26 12:10:47 UTC 2021`
Record UNII	Y6BX7BL23K
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PEMIGATINIB

Official Name

English

3-(2,6-DIFLUORO-3,5-DIMETHOXYPHENYL)-1-ETHYL-8-(MORPHOLIN-4-YLMETHYL)-1,3,4,7-TETRAHYDRO-2H-PYRROLO(3',2':5,6)PYRIDO(4,3-D)PYRIMIDIN-2-ONE

Systematic Name

English

INCB-054828

Common Name

English

PEMIGATINIB [USAN]

Common Name

English

FGFR INHIBITOR INCB054828

Common Name

English

PEMIGATINIB [INN]

Common Name

English

PEMIGATINIB [WHO-DD]

Common Name

English

INCB054828

Code

English

2H-PYRROLO(3',2':5,6)PYRIDO(4,3-D)PYRIMIDIN-2-ONE, 3-(2,6-DIFLUORO-3,5-DIMETHOXYPHENYL)-1-ETHYL-1,3,4,7-TETRAHYDRO-8-(4-MORPHOLINYLMETHYL)-

Systematic Name

English

PEMAZYRE

Brand Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

624117

Created by admin on Sat Jun 26 12:10:47 UTC 2021 , Edited by admin on Sat Jun 26 12:10:47 UTC 2021

FDA ORPHAN DRUG

696419

Created by admin on Sat Jun 26 12:10:47 UTC 2021 , Edited by admin on Sat Jun 26 12:10:47 UTC 2021

NCI_THESAURUS

C129825

Created by admin on Sat Jun 26 12:10:47 UTC 2021 , Edited by admin on Sat Jun 26 12:10:47 UTC 2021

EU-Orphan Drug

EU/3/18/2066

Created by admin on Sat Jun 26 12:10:47 UTC 2021 , Edited by admin on Sat Jun 26 12:10:47 UTC 2021

NCI_THESAURUS

C1967

Created by admin on Sat Jun 26 12:10:47 UTC 2021 , Edited by admin on Sat Jun 26 12:10:47 UTC 2021

Code System Code Type Description

INN

10712

Created by admin on Sat Jun 26 12:10:47 UTC 2021 , Edited by admin on Sat Jun 26 12:10:47 UTC 2021

PRIMARY

CAS

1513857-77-6

Created by admin on Sat Jun 26 12:10:47 UTC 2021 , Edited by admin on Sat Jun 26 12:10:47 UTC 2021

PRIMARY

PUBCHEM

86705695

Created by admin on Sat Jun 26 12:10:47 UTC 2021 , Edited by admin on Sat Jun 26 12:10:47 UTC 2021

PRIMARY

RXCUI

2359268

Created by admin on Sat Jun 26 12:10:47 UTC 2021 , Edited by admin on Sat Jun 26 12:10:47 UTC 2021

PRIMARY

DRUG BANK

DB15102

Created by admin on Sat Jun 26 12:10:47 UTC 2021 , Edited by admin on Sat Jun 26 12:10:47 UTC 2021

PRIMARY

DRUG CENTRAL

5390

Created by admin on Sat Jun 26 12:10:47 UTC 2021 , Edited by admin on Sat Jun 26 12:10:47 UTC 2021

PRIMARY

FDA UNII

Y6BX7BL23K

Created by admin on Sat Jun 26 12:10:47 UTC 2021 , Edited by admin on Sat Jun 26 12:10:47 UTC 2021

PRIMARY

NCI_THESAURUS

C121553

Created by admin on Sat Jun 26 12:10:47 UTC 2021 , Edited by admin on Sat Jun 26 12:10:47 UTC 2021

PRIMARY

Related Record Type Details


					Y6BX7BL23K

EXCRETED UNCHANGED

Qualification:

FECAL

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Interaction Type:

MAJOR


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Comments:

In vitro, pemigatinib was 90.6% bound to human plasma proteins at concentrations ranging from 1 to 10 ?M.

Interaction Type:

BINDING

Amount:


					S344CKA15F

FIBROBLAST GROWTH FACTOR RECEPTOR 2

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					L01TYM08QX

FIBROBLAST GROWTH FACTOR RECEPTOR 3

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					Y6BX7BL23K

EXCRETED UNCHANGED

Qualification:

URINE

Amount:


					NJ44AXW7L9

FIBROBLAST GROWTH FACTOR RECEPTOR 1

TARGET -> INHIBITOR

Qualification:

IC50

Amount:

Related Record Type Details


					Y6BX7BL23K

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC

Tmax	PHARMACOKINETIC

Volume of Distribution	PHARMACOKINETIC