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Details

Stereochemistry ACHIRAL
Molecular Formula C20H24N2OS
Molecular Weight 340.482
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PROPIONYLPROMAZINE

SMILES

CCC(=O)C1=CC=C2SC3=CC=CC=C3N(CCCN(C)C)C2=C1

InChI

InChIKey=ZQTVCQIJTREKSP-UHFFFAOYSA-N
InChI=1S/C20H24N2OS/c1-4-18(23)15-10-11-20-17(14-15)22(13-7-12-21(2)3)16-8-5-6-9-19(16)24-20/h5-6,8-11,14H,4,7,12-13H2,1-3H3

HIDE SMILES / InChI

Molecular Formula C20H24N2OS
Molecular Weight 340.482
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Propionylpromazine is used as a neuroleptic to combat stress in pets and farm animals. The main use is to combat stress in the transport of pigs. Propionylpromazine was in common use in veterinary practice in the 1950s and 1960s. Propionylpromazine is of interest to JECFA because of the illicit use at pharmacological dosage (< 1 mg/kg i.m.) in the immediate pre-slaughter period.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
357.0 µM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Propiopromazine
Primary
TRANVET

PubMed

Sample Use Guides

In Vivo Use Guide
Dogs: Administer 0.5 to 2.0 milligrams per pound of body weight once or twice daily, depending upon the degree of tranquilization desired.
Route of Administration: Oral
In Vitro Use Guide
10 uM Propiopromazine produced 95-100% inactivation of Trypanosoma cruzi trypanothione reductase (TR).
Substance Class Chemical
Record UNII
Y1BCT334I7
Record Status Validated (UNII)
Record Version