PROPIONYLPROMAZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H24N2OS
Molecular Weight	340.482
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC(=O)C1=CC2=C(SC3=C(C=CC=C3)N2CCCN(C)C)C=C1

InChI

InChIKey=ZQTVCQIJTREKSP-UHFFFAOYSA-N

InChI=1S/C20H24N2OS/c1-4-18(23)15-10-11-20-17(14-15)22(13-7-12-21(2)3)16-8-5-6-9-19(16)24-20/h5-6,8-11,14H,4,7,12-13H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C20H24N2OS
Molecular Weight	340.482
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1364508 | https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=520.2002http://www.fao.org/fileadmin/user_upload/vetdrug/docs/41-4-propionylpromazine.pdf | http://www.inchem.org/documents/jecfa/jecmono/v29je11.htm

Propionylpromazine is used as a neuroleptic to combat stress in pets and farm animals. The main use is to combat stress in the transport of pigs. Propionylpromazine was in common use in veterinary practice in the 1950s and 1960s. Propionylpromazine is of interest to JECFA because of the illicit use at pharmacological dosage (< 1 mg/kg i.m.) in the immediate pre-slaughter period.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Dopamine D2 receptor 297 Target ID: CHEMBL217 Sources: https://www.scbt.com/scbt/product/propionylpromazine-hydrochloride-7681-67-6 \| https://www.ncbi.nlm.nih.gov/pubmed/22949700 \| http://www.sigmaaldrich.com/catalog/product/sigma/p7780?lang=en®ion=RU	Antagonist 2778
Trypanothione reductase 5 Target ID: CHEMBL5131 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11407019 \| https://www.ncbi.nlm.nih.gov/pubmed/11328673	Inhibitor 8297
Trypanothione reductase 5 Target ID: CHEMBL5131 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9457238 \| https://www.ncbi.nlm.nih.gov/pubmed/11407019	Inhibitor 8297	357.0 µM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Anxiety 267 Sources: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=520.2002	Primary		Approved 8429	Propiopromazine Approved Use Indications for use. For oral administration as a tranquilizer. As an aid in handling difficult, excited, and unruly dogs, and in controlling excessive kennel barking, car sickness, and severe dermatitis. It is also indicated for use in minor surgery and prior to routine examinations, laboratory procedures, and diagnostic procedures.
Stress 11 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1078293	Primary		Approved 8429	TRANVET Approved Use Propionylpromazine is used as a neuroleptic to combat stress in pets and farm animals. The main use is to combat stress in the transport of pigs. Launch Date -2.95920009E11

PubMed

Title	Date	PubMed
Effects of electroanesthesia and a phenothiazine tranquilizer on thermoregulation in the sheep.	1977 Mar	15489
[Inactivation of Trypanosoma cruzi trypanothione reductase by phenothiazine cationic free radicals].	2001 Jan-Mar	11407019
Development of a rapid screening test for veterinary sedatives and the beta-blocker carazolol in porcine kidney by ELISA.	2004 Feb	14752562
Comprehensive screening and quantification of veterinary drugs in milk using UPLC-ToF-MS.	2008 Jul	18491081
Effects of inosine on reperfusion injury after cardiopulmonary bypass.	2010 Nov 8	21059208

Patents

Sample Use Guides

In Vivo Use Guide

Dogs: Administer 0.5 to 2.0 milligrams per pound of body weight once or twice daily, depending upon the degree of tranquilization desired.

Route of Administration: Oral

In Vitro Use Guide

10 uM Propiopromazine produced 95-100% inactivation of Trypanosoma cruzi trypanothione reductase (TR).

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:20:02 UTC 2023` Edited by `admin` on `Fri Dec 15 16:20:02 UTC 2023`
Record UNII	Y1BCT334I7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PROPIONYLPROMAZINE

Common Name

English

PROPIONYLPROMAZINE [MI]

Common Name

English

PROPIONYLPROMAZIME

Common Name

English

PROPIONYLPROMAZINE [MART.]

Common Name

English

PROPIOPROMAZINE

Common Name

English

1-PROPANONE, 1-(10-(3-(DIMETHYLAMINO)PROPYL)PHENOTHIAZIN-2-YL)-

Systematic Name

English

1-(10-(3-(DIMETHYLAMINO)PROPYL)-10H-PHENOTHIAZIN-2-YL)PROPAN-1-ONE

Systematic Name

English

1-PROPANONE, 1-(10-(3-(DIMETHYLAMINO)PROPYL)-10H-PHENOTHIAZIN-2-YL)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29710