Details
Stereochemistry | ACHIRAL |
Molecular Formula | C20H24N2OS.ClH |
Molecular Weight | 376.943 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CCC(=O)C1=CC2=C(SC3=C(C=CC=C3)N2CCCN(C)C)C=C1
InChI
InChIKey=ZFWVWZODBGTOIL-UHFFFAOYSA-N
InChI=1S/C20H24N2OS.ClH/c1-4-18(23)15-10-11-20-17(14-15)22(13-7-12-21(2)3)16-8-5-6-9-19(16)24-20;/h5-6,8-11,14H,4,7,12-13H2,1-3H3;1H
Molecular Formula | C20H24N2OS |
Molecular Weight | 340.482 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Propionylpromazine is used as a neuroleptic to combat stress in pets and farm animals. The main use is to combat stress in the transport of pigs. Propionylpromazine was in common use in veterinary practice in the 1950s and 1960s. Propionylpromazine is of interest to JECFA because of the illicit use at pharmacological dosage (< 1 mg/kg i.m.) in the immediate pre-slaughter period.
CNS Activity
Sources: http://www.sigmaaldrich.com/catalog/product/sigma/p7780?lang=en®ion=RUhttp://www.fao.org/fileadmin/user_upload/vetdrug/docs/41-4-propionylpromazine.pdf
Curator's Comment: D2 dopamine receptor antagonist; phenothiazine antipsychotic.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL5131 |
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Target ID: CHEMBL5131 |
357.0 µM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Propiopromazine Approved UseIndications for use. For oral administration as a tranquilizer. As an aid in handling difficult, excited, and unruly dogs, and in controlling excessive kennel barking, car sickness, and severe dermatitis. It is also indicated for use in minor surgery and prior to routine examinations, laboratory procedures, and diagnostic procedures. |
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Sources: https://www.ncbi.nlm.nih.gov/pubmed/1078293 |
Primary | TRANVET Approved UsePropionylpromazine is used as a neuroleptic to combat stress in pets and farm animals. The main use is to combat stress in the transport of pigs. Launch Date1960 |
PubMed
Title | Date | PubMed |
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Gas chromatographic-mass spectrometric analysis of veterinary tranquillizers in urine: evaluation of method performance. | 1999 Oct 29 |
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Spectrophotometric determination of vanadium(V) in minerals, steels, soil and biological samples using phenothiazine derivatives. | 2001 Aug |
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[Acute normovolemic hemodilution (ANH). Der Anaesthesist (2000) 49: 939-948]. | 2001 Aug |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.law.cornell.edu/cfr/text/21/520.2002
Dogs: Administer 0.5 to 2.0 milligrams per pound of body weight once or twice daily, depending upon the degree of tranquilization desired.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11407019
10 uM Propiopromazine produced 95-100% inactivation of Trypanosoma cruzi trypanothione reductase (TR).
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:24:23 GMT 2023
by
admin
on
Fri Dec 15 15:24:23 GMT 2023
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Record UNII |
U0BND6SD2I
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C29710
Created by
admin on Fri Dec 15 15:24:23 GMT 2023 , Edited by admin on Fri Dec 15 15:24:23 GMT 2023
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CFR |
21 CFR 522.2002
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DBSALT001697
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DTXSID4045187
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24351
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C84114
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U0BND6SD2I
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7681-67-6
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C026328
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Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |