ENVIOMYCIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H43N13O10
Molecular Weight	685.69
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NCC[C@@H](O)[C@H](N)CC(=O)N[C@H]1CNC(=O)[C@@H](NC(=O)\C(NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC1=O)=C\NC(N)=O)[C@H]2CCNC(=N)N2

InChI

InChIKey=HPWIIERXAFODPP-GHBBWTPBSA-N

InChI=1S/C25H43N13O10/c26-3-1-16(41)10(27)5-17(42)33-12-6-31-23(47)18(11-2-4-30-24(28)37-11)38-20(44)13(7-32-25(29)48)34-21(45)14(8-39)36-22(46)15(9-40)35-19(12)43/h7,10-12,14-16,18,39-41H,1-6,8-9,26-27H2,(H,31,47)(H,33,42)(H,34,45)(H,35,43)(H,36,46)(H,38,44)(H3,28,30,37)(H3,29,32,48)/b13-7-/t10-,11-,12+,14+,15+,16-,18+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C25H43N13O10
Molecular Weight	685.69
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	2
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4308717
Curator's Comment: description was created based on several sources, including: https://www.ncbi.nlm.nih.gov/pubmed/2539957 | https://www.ncbi.nlm.nih.gov/pubmed/17571483

Enviomycin, antimicrobial drug, was isolated in Japan from fermentation broth of Syteptomyces griseoverticillatus var tuberacticus. This drug, a water-soluble, basic peptide, is effective against tubercle bacilli as well as some gram-positive and gram-negative bacteria. It is related to viomycin and cepreomycin in some of its physicochemical properties. It is used for the treatment of Mycobacterium avium caused lung diseases.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Group I intron splicing 2 Target ID: GO:0000372 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7509881	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Tuberculosis 83 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6276611 https://www.ncbi.nlm.nih.gov/pubmed/2539957	Curative		Not Provided 511	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
[Case of multi-drug resistant pulmonary tuberculosis with bilateral cavitary lesions successfully treated by surgical treatment].	2007-11	18078108
[Case of pulmonary multi-drug resistant tuberculosis with left destroyed lung, treated with pneumonectomy].	2007-07	17695788
[A case of pulmonary Mycobacterium fortuitum infection successfully treated with Kampo treatments].	2006-08	16972656

Patents

Sample Use Guides

In Vivo Use Guide

1 g/day three times weekly

Route of Administration: Unknown

In Vitro Use Guide

Enviomycin is bactericidal against Mycobacterium avium strain 13887 with MIC=1.6 ug/ml.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:25:12 GMT 2025` Edited by `admin` on `Mon Mar 31 18:25:12 GMT 2025`
Record UNII	XU299C23A2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TUBERACTINOMYCIN N

Preferred Name

English

ENVIOMYCIN

Official Name

English

((15-(3,6-DIAMINO-4-HYDROXYHEXANAMIDO)-3-(HEXAHYDRO-2-IMINO-4-PYRIMIDINYL)-9,12-BIS(HYDROXYMETHYL-2,5,8,11,14-PENTAOXO-1,4,7,10,13-PENTAAZACYCLOHEXADEC-6-YLIDENE)METHYL)UREA

Common Name

English

ENVIOMYCIN [MI]

Common Name

English

Enviomycin [WHO-DD]

Common Name

English

enviomycin [INN]

Common Name

English

ENVIOMYCIN [MART.]

Common Name

English

TUBERACTINOMYCIN N [MI]

Common Name

English

Code System Code Type Description

DRUG CENTRAL

3180