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Details

Stereochemistry ABSOLUTE
Molecular Formula 2C25H43N13O10.3H2O4S
Molecular Weight 1665.615
Optical Activity UNSPECIFIED
Defined Stereocenters 14 / 14
E/Z Centers 2
Charge 0

SHOW SMILES / InChI
Structure of ENVIOMYCIN SULFATE

SMILES

OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.[H][C@@]1(CCNC(=N)N1)[C@]2([H])NC(=O)\C(NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CNC2=O)NC(=O)C[C@@H](N)[C@H](O)CCN)=C\NC(N)=O.[H][C@@]3(CCNC(=N)N3)[C@]4([H])NC(=O)\C(NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CNC4=O)NC(=O)C[C@@H](N)[C@H](O)CCN)=C\NC(N)=O

InChI

InChIKey=DZKQVWCTFCSEKF-QOEBQMAPSA-N
InChI=1S/2C25H43N13O10.3H2O4S/c2*26-3-1-16(41)10(27)5-17(42)33-12-6-31-23(47)18(11-2-4-30-24(28)37-11)38-20(44)13(7-32-25(29)48)34-21(45)14(8-39)36-22(46)15(9-40)35-19(12)43;3*1-5(2,3)4/h2*7,10-12,14-16,18,39-41H,1-6,8-9,26-27H2,(H,31,47)(H,33,42)(H,34,45)(H,35,43)(H,36,46)(H,38,44)(H3,28,30,37)(H3,29,32,48);3*(H2,1,2,3,4)/b2*13-7-;;;/t2*10-,11-,12+,14+,15+,16-,18+;;;/m11.../s1

HIDE SMILES / InChI

Molecular Formula C25H43N13O10
Molecular Weight 685.69
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 7 / 7
E/Z Centers 2
Optical Activity UNSPECIFIED

Molecular Formula H2O4S
Molecular Weight 98.078
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including: https://www.ncbi.nlm.nih.gov/pubmed/2539957 | https://www.ncbi.nlm.nih.gov/pubmed/17571483

Enviomycin, antimicrobial drug, was isolated in Japan from fermentation broth of Syteptomyces griseoverticillatus var tuberacticus. This drug, a water-soluble, basic peptide, is effective against tubercle bacilli as well as some gram-positive and gram-negative bacteria. It is related to viomycin and cepreomycin in some of its physicochemical properties. It is used for the treatment of Mycobacterium avium caused lung diseases.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
[A case of pulmonary Mycobacterium fortuitum infection successfully treated with Kampo treatments].
2006 Aug
[Case of pulmonary multi-drug resistant tuberculosis with left destroyed lung, treated with pneumonectomy].
2007 Jul
[Case of multi-drug resistant pulmonary tuberculosis with bilateral cavitary lesions successfully treated by surgical treatment].
2007 Nov
Patents

Sample Use Guides

1 g/day three times weekly
Route of Administration: Unknown
In Vitro Use Guide
Enviomycin is bactericidal against Mycobacterium avium strain 13887 with MIC=1.6 ug/ml.
Substance Class Chemical
Created
by admin
on Sat Dec 16 05:22:52 GMT 2023
Edited
by admin
on Sat Dec 16 05:22:52 GMT 2023
Record UNII
67846BXW65
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ENVIOMYCIN SULFATE
JAN   MI   WHO-DD  
Common Name English
ENVIOMYCIN SULFATE [MI]
Common Name English
TUBERACTIN
Brand Name English
Enviomycin sulfate [WHO-DD]
Common Name English
ENVIOMYCIN SULFATE [JAN]
Common Name English
VIOMYCIN, 1-((3R,4R)-4-HYDROXY-3,6-DIAMINOHEXANOIC ACID)-6-(L-2-(2-AMINO-1,4,5,6-TETRAHYDRO-4-PYRIMIDINYL)GLYCINE)-, (R)-, SULFATE (2:3) (SALT)
Common Name English
CYCLO((2Z)-3-((AMINOCARBONYL)AMINO)-2,3-DIDEHYDROALANYL-(2S)-2-((4R)-2-AMINO-3,4,5,6-TETRAHYDRO-4-PYRIMIDINYL)GLYCYL-(2S)-2-(((3R,4R)-3,6-DIAMINO-4-HYDROXY-1-OXOHEXYL)AMINO)-.BETA.-ALANYL-L-SERYL-L-SERYL), SULFATE (2:3)
Code English
Code System Code Type Description
ChEMBL
CHEMBL2146142
Created by admin on Sat Dec 16 05:22:52 GMT 2023 , Edited by admin on Sat Dec 16 05:22:52 GMT 2023
PRIMARY
EPA CompTox
DTXSID10202038
Created by admin on Sat Dec 16 05:22:52 GMT 2023 , Edited by admin on Sat Dec 16 05:22:52 GMT 2023
PRIMARY
MERCK INDEX
m4924
Created by admin on Sat Dec 16 05:22:52 GMT 2023 , Edited by admin on Sat Dec 16 05:22:52 GMT 2023
PRIMARY Merck Index
EVMPD
SUB21807
Created by admin on Sat Dec 16 05:22:52 GMT 2023 , Edited by admin on Sat Dec 16 05:22:52 GMT 2023
PRIMARY
SMS_ID
100000086037
Created by admin on Sat Dec 16 05:22:52 GMT 2023 , Edited by admin on Sat Dec 16 05:22:52 GMT 2023
PRIMARY
PUBCHEM
71587175
Created by admin on Sat Dec 16 05:22:52 GMT 2023 , Edited by admin on Sat Dec 16 05:22:52 GMT 2023
PRIMARY
DRUG BANK
DBSALT001086
Created by admin on Sat Dec 16 05:22:52 GMT 2023 , Edited by admin on Sat Dec 16 05:22:52 GMT 2023
PRIMARY
FDA UNII
67846BXW65
Created by admin on Sat Dec 16 05:22:52 GMT 2023 , Edited by admin on Sat Dec 16 05:22:52 GMT 2023
PRIMARY
CAS
53760-33-1
Created by admin on Sat Dec 16 05:22:52 GMT 2023 , Edited by admin on Sat Dec 16 05:22:52 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY