B2 BRADYKININ RECEPTOR

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 17:41:01 GMT 2025` Edited by `admin` on `Tue Apr 01 17:41:01 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	XTI76G93Q3
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

B2 BRADYKININ RECEPTOR

Common Name

English

B2R

Preferred Name

English

BKR2

Common Name

English

BK-2 RECEPTOR

Common Name

English

BDKRB2

Common Name

English

Bradykinin B2 receptor

Common Name

English

Code System Code Type Description

UNIPROT

P30411

Created by admin on Tue Apr 01 17:41:01 GMT 2025 , Edited by admin on Tue Apr 01 17:41:01 GMT 2025

PRIMARY

FDA UNII

XTI76G93Q3

Created by admin on Tue Apr 01 17:41:01 GMT 2025 , Edited by admin on Tue Apr 01 17:41:01 GMT 2025

PRIMARY

From	To
1_130	1_211

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_30
N	1_39
N	1_207

Related Record Type Details


					189R4J5E0F

SSR-240612 FREE BASE

NON-INHIBITOR->OFF TARGET

Comments:

unable to antagonize inositol phosphate-1 formation induced by BK (3nM) activation of B2 receptor in human fibroblast MRC5 (IC50>1µM).

Amount:


					262AL91J0Y

FR-173657

INHIBITOR -> TARGET

Amount:


					0T8T4A440G

KALLIDIN

AGONIST -> TARGET

Amount:


					2MK663C346

LABRADIMIL

AGONIST -> TARGET

Amount:


					0WL827Z7AE

FASITIBANT

INHIBITOR -> TARGET

Amount:


					7PG89G35Q7

Icatibant

AGONIST -> TARGET

Amount:


					DV64B0PLEH

NPC-567

INHIBITOR -> TARGET

Comments:

Binding Assay

Qualification:

IC50

Amount:


					CLO4JRD21F

ANATIBANT

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					S8TIM42R2W

BRADYKININ

AGONIST -> TARGET

Comments:

Binding Assay

Qualification:

IC50

Amount:


					6151J4V7VX

DELTIBANT

INHIBITOR -> TARGET

Amount:

Structural Modifications

Modification Type	Location Site	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_369]	THREONINE PHOSPHATE	3L4WX7B1EI
AMINO ACID SUBSTITUTION	[1_373] [1_375]	DEXFOSFOSERINE	VI4F0K069V
AMINO ACID SUBSTITUTION	[1_156] [1_347]	TYROSINE O-PHOSPHATE	2R86C98KDX
AMINO ACID SUBSTITUTION	[1_366]	DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT	CHEMICAL