U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Bradykinin, a pro-inflammatory mediator is also a neuromediator and regulator of several vascular and renal functions. Bradykinin can act as a vasoactive substance along with histamine in inflammation and swelling as it is a potent vasodilator. In addition, it triggers the release of other mediators such as nitric oxide in inflammatory and cancer tissues. Bradykinin acts via specific cell surface receptors: bradykinin receptor, B1 and B2 that are G-protein coupled receptors of the seven-transmembrane domain family. It was shown that increased plasma levels of bradykinin lead to the angioedema as the common major clinical manifestation. Bradykinin was also studied in heart transplant recipients and in obesity patients, but these studies were terminated or withdrawn for different reasons. Bradykinin is also an important growth factor for many cancers. Bradykinin antagonists showed higher potency than standard anti-cancer drugs, without evident toxicity to the hosts, that is why they have great promise for the development of new anti-cancer drugs.

Approval Year

PubMed

PubMed

TitleDatePubMed
Cytokine-mediated inflammatory hyperalgesia limited by interleukin-10.
1995 Jun
Patents
Substance Class Protein
Created
by admin
on Sat Dec 16 16:25:41 UTC 2023
Edited
by admin
on Sat Dec 16 16:25:41 UTC 2023
Protein Type PEPTIDE
Protein Sub Type Other|KININ
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
S8TIM42R2W
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BRADYKININ
MART.   MI  
Common Name English
BRS-640
Code English
ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG
Common Name English
CALLIDIN I
Common Name English
KALLIDIN I
Common Name English
BRADYKININ [MART.]
Common Name English
KALLIDIN-9
Common Name English
BRADYKININ [MI]
Common Name English
Classification Tree Code System Code
LOINC 1983-6
Created by admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
Code System Code Type Description
CHEBI
3165
Created by admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
PRIMARY
DRUG BANK
DB12126
Created by admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
PRIMARY
MERCK INDEX
m2634
Created by admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
200-398-8
Created by admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
PRIMARY
WIKIPEDIA
BRADYKININ
Created by admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
PRIMARY
NCI_THESAURUS
C316
Created by admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
PRIMARY
MESH
D001920
Created by admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
PRIMARY
FDA UNII
S8TIM42R2W
Created by admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
PRIMARY
EPA CompTox
DTXSID50893681
Created by admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
PRIMARY
CAS
58-82-2
Created by admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
PRIMARY
PUBCHEM
439201
Created by admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
PRIMARY
Related Record Type Details
INHIBITOR OF EXPRESSION->TARGET
SALT/SOLVATE -> PARENT
TARGET -> AGONIST
Binding Assay
IC50
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL