Bradykinin, a pro-inflammatory mediator is also a neuromediator and regulator of several vascular and renal functions. Bradykinin can act as a vasoactive substance along with histamine in inflammation and swelling as it is a potent vasodilator. In addition, it triggers the release of other mediators such as nitric oxide in inflammatory and cancer tissues. Bradykinin acts via specific cell surface receptors: bradykinin receptor, B1 and B2 that are G-protein coupled receptors of the seven-transmembrane domain family. It was shown that increased plasma levels of bradykinin lead to the angioedema as the common major clinical manifestation. Bradykinin was also studied in heart transplant recipients and in obesity patients, but these studies were terminated or withdrawn for different reasons. Bradykinin is also an important growth factor for many cancers. Bradykinin antagonists showed higher potency than standard anti-cancer drugs, without evident toxicity to the hosts, that is why they have great promise for the development of new anti-cancer drugs.
Approval Year
Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 16:25:41 UTC 2023
by
admin
on
Sat Dec 16 16:25:41 UTC 2023
|
Protein Type | PEPTIDE |
Protein Sub Type | Other|KININ |
Sequence Origin | HUMAN |
Sequence Type | COMPLETE |
Record UNII |
S8TIM42R2W
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
LOINC |
1983-6
Created by
admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
3165
Created by
admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
|
PRIMARY | |||
|
DB12126
Created by
admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
|
PRIMARY | |||
|
m2634
Created by
admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
|
PRIMARY | Merck Index | ||
|
200-398-8
Created by
admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
|
PRIMARY | |||
|
BRADYKININ
Created by
admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
|
PRIMARY | |||
|
C316
Created by
admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
|
PRIMARY | |||
|
D001920
Created by
admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
|
PRIMARY | |||
|
S8TIM42R2W
Created by
admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
|
PRIMARY | |||
|
DTXSID50893681
Created by
admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
|
PRIMARY | |||
|
58-82-2
Created by
admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
|
PRIMARY | |||
|
439201
Created by
admin on Sat Dec 16 16:25:41 UTC 2023 , Edited by admin on Sat Dec 16 16:25:41 UTC 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
INHIBITOR OF EXPRESSION->TARGET |
|
||
|
SALT/SOLVATE -> PARENT |
|
||
|
TARGET -> AGONIST |
Binding Assay
IC50
|
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |
|
Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
---|---|---|---|---|---|---|
Molecular Formula | CHEMICAL |
|
||||
MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
|