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Details

Stereochemistry ACHIRAL
Molecular Formula C4H7NO4
Molecular Weight 133.1027
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IMINODIACETIC ACID

SMILES

OC(=O)CNCC(O)=O

InChI

InChIKey=NBZBKCUXIYYUSX-UHFFFAOYSA-N
InChI=1S/C4H7NO4/c6-3(7)1-5-2-4(8)9/h5H,1-2H2,(H,6,7)(H,8,9)

HIDE SMILES / InChI

Molecular Formula C4H7NO4
Molecular Weight 133.1027
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Disodium iminodiacetate is a salt of iminodiacetic acid (IDA). The iminodiacetate anion can act as a tridentate ligand to form a metal complex with two, fused, five-membered chelate rings. Iminodiacetic acid is used to diagnose problems of the liver, gallbladder and bile ducts in an imaging procedure, called as hepatobiliary iminodiacetic acid (HIDA) scan. A nuclear medicine scanner tracks the flow of the tracer from the liver into the gallbladder and small intestine and creates computer images. In addition, iminodiacetate is a part of the iminodiacetate-modified poly-L-lysine dendrimer (IMPLD), a fluorescent bone-imaging agent. IMPLD is used in the diagnosis of bone tumors, or to be used for the delivery of chemotherapy drugs or therapeutic agents. Bones differ from other body tissues in their unique calcium mineral composition, which consists mainly of hydroxyapatite (HA). IDA functionalization could be used as a general approach to bone targeting by increasing affinity for HA, enabling the transport of other molecules or particles to bones.

Approval Year

PubMed

PubMed

TitleDatePubMed
Kinetics and mechanisms of EDTA photocatalytic degradation with TiO2.
2001
Acalculous cholecystitis in a two year old.
2001 Apr-Jun
Chromatographic separation of proteins on metal immobilized iminodiacetic acid-bound molded monolithic rods of macroporous poly(glycidyl methacrylate-co-ethylene dimethacrylate).
2001 Aug 17
Ion chromatography on chelating stationary phases: separation of alkali metals.
2001 Jul 6
Diagnostic accuracy of 99Tcm-HIDA with cholecystokinin and gallbladder ejection fraction in acalculous gallbladder disease.
2001 Jun
Structural studies of lanthanide (III) complexes with oxydiacetic acid and iminodiacetic acid in aqueous solution by EXAFS.
2001 Mar 1
Preparation of acetylated pyranoid glycals from glycosyl halides by chromium(II) complexes under aqueous biphasic conditions.
2001 Nov 21
A novel[2 + 3]cycloaddition reaction: singlet oxygen mediated formation of 1,3-dipole from iminodiacetic acid dimethyl ester and its addition to maleimides.
2001 Sep 21
Inductively coupled plasma mass spectrometric determination of heavy metals in sea-water samples after pre-treatment with a chelating resin disk by an on-line flow injection method.
2002 Jun
Synthesis and characterization of uranyl compounds with iminodiacetate and oxydiacetate displaying variable denticity.
2002 May 20
Electrochemiluminescent biosensors array for the concomitant detection of choline, glucose, glutamate, lactate, lysine and urate.
2003 Dec 30
Use of complexing agents for effective ion-exchange separation of Co(II)/Ni(II) from aqueous solutions.
2003 Feb
Direct chromatographic capture of enzyme from crude homogenate using immobilized metal affinity chromatography on a continuous supermacroporous adsorbent.
2003 Feb 7
Does this patient have acute cholecystitis?
2003 Jan 1
Versatile routes to C-2- and C-6-functionalized glucose derivatives of iminodiacetic acid.
2003 Jan 24
Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating succinyl hydroxamate and iminodiacetic acid hydroxamate moieties.
2003 Jun
Optimization of immobilized metal ion affinity chromatography for single-step purification of recombinant ovine growth hormone expressed in Escherichia coli.
2003 May 23
Efficient inclusion body processing using chemical extraction and high gradient magnetic fishing.
2003 May-Jun
Immobilized metal-ion chelating capillary microreactor for peptide mapping analysis of proteins by matrix assisted laser desorption/ ionization-time of flight-mass spectrometry.
2003 Nov
Functional and structural study on chelator-induced suppression of S2/S1 FTIR spectrum in photosynthetic oxygen-evolving complex.
2003 Oct 1
Cd(II) sensing in water using novel aromatic iminodiacetate based fluorescent chemosensors.
2003 Oct 30
Primary duodenogastric reflux in children and adolescents.
2003 Sep
Hexafluoroacetone as protecting and activating reagent: site-selective functionalization of iminodiacetic acid.
2004 Dec
Alternative quality control for technetium-99m IDA complexes.
2004 Dec
Control of peptide structure and recognition by Fe(III)-induced helix destabilization.
2004 Dec 8
Therapeutic efficacy of laparoscopic cholecystectomy in the treatment of biliary dyskinesia.
2004 Feb
Modelling of the acid-base properties of natural and synthetic adsorbent materials used for heavy metal removal from aqueous solutions.
2004 Feb
Performance evaluation of two chelating ion-exchange sorbents for the fractionation of labile and inert metal species from aquatic media.
2004 Jan
Ion exchange properties of monolithic and particle type iminodiacetic acid modified silica.
2004 Jul
Immobilization of oriented protein molecules on poly(ethylene glycol)-coated Si(111).
2004 Jul
Solution-phase combinatorial synthesis of nonpeptide bradykinin antagonists.
2004 Jul 1
Polystyrene monolithic column functionalized with copper-iminodiacetate complex as a stationary phase for open tubular capillary electrochromatography.
2004 Jul 30
Analysis of myoglobin adsorption to Cu(II)-IDA and Ni(II)-IDA functionalized Langmuir monolayers by grazing incidence neutron and X-ray techniques.
2004 Mar 30
Chemical extraction and direct adsorptive purification of recombinant human antigen Ro52.
2004 May
A new bis(3-hydroxy-4-pyridinone)-IDA derivative as a potential therapeutic chelating agent. Synthesis, metal-complexation and biological assays.
2004 Nov 7
Isolation and growth characteristics of an EDTA-degrading member of the alpha-subclass of Proteobacteria.
2004 Oct
High-buffering capacity, hydrolytically stable, low-pI isoelectric membranes for isoelectric trapping separations.
2004 Oct
Purification and identification of water-soluble phosphopeptides from cheese using Fe(III) affinity chromatography and mass spectrometry.
2004 Oct 20
Protein surface-assisted enhancement in the binding affinity of an inhibitor for recombinant human carbonic anhydrase-II.
2004 Sep 8
Purification of a catalase from Thermus thermophilus via IMAC chromatography: effect of the support.
2004 Sep-Oct
Measurement of Wee kinase activity.
2005
Arsenic speciation in water samples containing high levels of copper: removal of copper interference affecting arsine generation by continuous flow solid phase chelation.
2005 Apr
Aqua(2,2'-bi-1H-imidazole)chlorocopper(II) chloro(iminodiacetato)copper(II) monohydrate.
2005 Jan
Speciation of chromium(III) and cobalt(III) (amino)carboxylate complexes using capillary electrophoresis.
2005 Jan 1
Multivalent carbocyanine molecular probes: synthesis and applications.
2005 Jan-Feb
A luminescent receptor with affinity for N-terminal histidine in peptides in aqueous solution.
2005 Mar 16
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:12:19 GMT 2023
Edited
by admin
on Fri Dec 15 18:12:19 GMT 2023
Record UNII
XQM2L81M8Z
Record Status Validated (UNII)
Record Version
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Name Type Language
IMINODIACETIC ACID
HSDB   MI  
Systematic Name English
AMINODIACETIC ACID
Common Name English
IMINODIACETIC ACID [HSDB]
Common Name English
NSC-18467
Code English
IMINODIETHANOIC ACID
Systematic Name English
IMINODIACETIC ACID [MI]
Common Name English
IDA
Common Name English
N-(CARBOXYMETHYL)GLYCINE
Systematic Name English
Code System Code Type Description
PUBCHEM
8897
Created by admin on Fri Dec 15 18:12:20 GMT 2023 , Edited by admin on Fri Dec 15 18:12:20 GMT 2023
PRIMARY
CHEBI
24786
Created by admin on Fri Dec 15 18:12:20 GMT 2023 , Edited by admin on Fri Dec 15 18:12:20 GMT 2023
PRIMARY
MESH
C008109
Created by admin on Fri Dec 15 18:12:20 GMT 2023 , Edited by admin on Fri Dec 15 18:12:20 GMT 2023
PRIMARY
NSC
18467
Created by admin on Fri Dec 15 18:12:20 GMT 2023 , Edited by admin on Fri Dec 15 18:12:20 GMT 2023
PRIMARY
ECHA (EC/EINECS)
205-555-4
Created by admin on Fri Dec 15 18:12:20 GMT 2023 , Edited by admin on Fri Dec 15 18:12:20 GMT 2023
PRIMARY
WIKIPEDIA
IMINODIACETIC ACID
Created by admin on Fri Dec 15 18:12:20 GMT 2023 , Edited by admin on Fri Dec 15 18:12:20 GMT 2023
PRIMARY
HSDB
2852
Created by admin on Fri Dec 15 18:12:20 GMT 2023 , Edited by admin on Fri Dec 15 18:12:20 GMT 2023
PRIMARY
MERCK INDEX
m6229
Created by admin on Fri Dec 15 18:12:20 GMT 2023 , Edited by admin on Fri Dec 15 18:12:20 GMT 2023
PRIMARY Merck Index
CAS
142-73-4
Created by admin on Fri Dec 15 18:12:20 GMT 2023 , Edited by admin on Fri Dec 15 18:12:20 GMT 2023
PRIMARY
EPA CompTox
DTXSID2027098
Created by admin on Fri Dec 15 18:12:20 GMT 2023 , Edited by admin on Fri Dec 15 18:12:20 GMT 2023
PRIMARY
FDA UNII
XQM2L81M8Z
Created by admin on Fri Dec 15 18:12:20 GMT 2023 , Edited by admin on Fri Dec 15 18:12:20 GMT 2023
PRIMARY
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