CLODAZON

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H20ClN3O
Molecular Weight	329.824
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)CCCN1C(=O)N(C2=C1C=CC(Cl)=C2)C3=CC=CC=C3

InChI

InChIKey=VWXGRWMELBPMCU-UHFFFAOYSA-N

InChI=1S/C18H20ClN3O/c1-20(2)11-6-12-21-16-10-9-14(19)13-17(16)22(18(21)23)15-7-4-3-5-8-15/h3-5,7-10,13H,6,11-12H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C18H20ClN3O
Molecular Weight	329.824
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5772001 | https://www.karger.com/Article/Abstract/467934

Clodazon (AW 142446) is an antidepressant drug investigated in Germany in the 1960s. In animal models, clodazon inhibits the catalepsy induced by tetrabenazine and it potentiates the effect of catecholamines, both effects being of the order experienced with imipramine. In clinical trials, about 2/3 of the patients showed a positive antidepressive effect with few side effects.

Approval Year

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:54:47 GMT 2025` Edited by `admin` on `Mon Mar 31 17:54:47 GMT 2025`
Record UNII	X82H6JOC4H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLODAZON

Official Name

English

AW-142446 FREE BASE

Preferred Name

English

5-CHLORO-1-(3-(DIMETHYLAMINO)PROPYL)-3-PHENYL-2-BENZIMIDAZOLINONE

Systematic Name

English

clodazon [INN]

Common Name

English

2H-BENZIMIDAZOL-2-ONE,5-CHLORO-1-(3-(DIMETHYLAMINO)PROPYL)-1,3-DIHYDRO-3-PHENYL-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265