CLODAZON HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H20ClN3O.ClH.H2O
Molecular Weight	384.3
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.Cl.CN(C)CCCN1C(=O)N(C2=CC(Cl)=CC=C12)C3=CC=CC=C3

InChI

InChIKey=KUSWMSGQGZMJGX-UHFFFAOYSA-N

InChI=1S/C18H20ClN3O.ClH.H2O/c1-20(2)11-6-12-21-16-10-9-14(19)13-17(16)22(18(21)23)15-7-4-3-5-8-15;;/h3-5,7-10,13H,6,11-12H2,1-2H3;1H;1H2

HIDE SMILES / InChI

Molecular Formula	C18H20ClN3O
Molecular Weight	329.824
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5772001 | https://www.karger.com/Article/Abstract/467934

Clodazon (AW 142446) is an antidepressant drug investigated in Germany in the 1960s. In animal models, clodazon inhibits the catalepsy induced by tetrabenazine and it potentiates the effect of catecholamines, both effects being of the order experienced with imipramine. In clinical trials, about 2/3 of the patients showed a positive antidepressive effect with few side effects.

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:34:53 GMT 2023` Edited by `admin` on `Fri Dec 15 16:34:53 GMT 2023`
Record UNII	FSF9L5AH4G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLODAZON HYDROCHLORIDE

Official Name

English

CLODAZON HYDROCHLORIDE [USAN]

Common Name

English

HUF-2446

Code

English

AW-14'2446

Code

English

CLODAZON HCL

Common Name

English

2H-BENZIMIDAZOL-2-ONE,5-CHLORO-1-(3-(DIMETHYLAMINO)PROPYL)-1,3-DIHYDRO-3-PHENYL-, MONOHYDROCHLORIDE, MONOHYDRATE

Systematic Name

English

AW-142446

Code

English

5-Chloro-1-[3-(dimethylamino)propyl]-3-phenyl-2-benzimidazolinone monohydrochloride monohydrate

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265