CLODAZON HYDROCHLORIDE ANHYDROUS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H20ClN3O.ClH
Molecular Weight	366.285
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of CLODAZON HYDROCHLORIDE ANHYDROUS

Structure Search

SMILES

Cl.CN(C)CCCN1C(=O)N(C2=C1C=CC(Cl)=C2)C3=CC=CC=C3

InChI

InChIKey=NQRQQRMSSZZIFE-UHFFFAOYSA-N

InChI=1S/C18H20ClN3O.ClH/c1-20(2)11-6-12-21-16-10-9-14(19)13-17(16)22(18(21)23)15-7-4-3-5-8-15;/h3-5,7-10,13H,6,11-12H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C18H20ClN3O
Molecular Weight	329.824
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5772001 | https://www.karger.com/Article/Abstract/467934

Clodazon (AW 142446) is an antidepressant drug investigated in Germany in the 1960s. In animal models, clodazon inhibits the catalepsy induced by tetrabenazine and it potentiates the effect of catecholamines, both effects being of the order experienced with imipramine. In clinical trials, about 2/3 of the patients showed a positive antidepressive effect with few side effects.

Approval Year

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:50:39 GMT 2025` Edited by `admin` on `Mon Mar 31 18:50:39 GMT 2025`
Record UNII	N0FW29BP3C
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLODAZON HYDROCHLORIDE ANHYDROUS

Common Name

English

2H-BENZIMIDAZOL-2-ONE,5-CHLORO-1-(3-(DIMETHYLAMINO)PROPYL)-1,3-DIHYDRO-3-PHENYL-, MONOHYDROCHLORIDE

Preferred Name

English

5-CHLORO-1-(3-(DIMETHYLAMINO)PROPYL)-3-PHENYL-2-BENZIMIDAZOLINONE MONOHYDROCHLORIDE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265